Our widgets for functional genomics use Orange, a data mining
and machine learning suite. Orange can be accessed through scripting in
Python,
or by visual programming in Orange Canvas.
In functional genomics, we have also designed a web-based tool for mutant data analysis called GenePath (also featured
in Science's NetWatch).
Cho et al. (1998) reported that more than 25% of the genes displaying
periodic transcript levels were positioned directly adjacent to another gene
induced in the same cell cycle phase. To illustrate one such example, the "Genome
Map" widget is used. Two adjacent genes on the chromosome 12, CDC46
(YLR274W) and PIG1 (YLR273C) are both present in the selected group of
M/G1 genes. Their transcription start sites are located on the opposite
strands less than 500 base pairs apart, therefore the genes share a common DNA
region for the upstream regulatory sequence.
"Expression Profiles" widget
is used to show that the two genes are coexpressed.
"Go Term Finder" widget is used to
demonstrate functional unrelatedness of the CDC46 and PIG1.