GO Term Finder widget

"Go Term Finder" widget is used here to demonstrate functional unrelatedness of the CDC46 and PIG1, confirming the proposed model of adjacent genes' coexpression given by Cho and coworkers. They proposed that adjacent genes were coexpressed in their experiment because of the effect of upstream regulatory sequence sharing or local positional effects on gene transcription, rather than because of functional relatedness. While CDC46 is involved in the processes of DNA replication initiation, DNA unwinding, establishment of chromatin silencing and pre-replicative complex formation and maintenance, PIG1 is involved in the process of regulation of glycogen biosynthesis � the genes are thus functionally unrelated, according to GO annotation, however, as shown in the "Expression Profiles" widget, they are coexpressed.