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Data set name: lung

Original data set (Bhattacharjee et al.)
Data set for Orange

Brief description:: This classification model was built to distinguish between four different lung tumors (adenocarcinomas, small-cell lung carcinomas, squamous cell carcinomas and carcinoids) and normal lung tissue on the basis of DNA expression signatures.

Platform: Affymetrix Human Genome U95Av2 Array

Diagnostic classes:: - adenocarcinoma (AD): 139 examples (68.5%); - normal lung (NL): 17 examples (8.4%); - small cell lung cancer (SMCL): 6 examples (3.0%); - squamous cell carcinoma (SQ): 21 examples (10.3%); - pulmonary carcinoid (COID): 20 examples (9.9%)

Number of genes: 12600
Number of samples: 203

Predictive accuracy with 10-fold cross validation (classifying using the best projection with eight attributes):: Classification accuracy: 94.07%; Area under curve (AUC): 0.995

Following are the three best-ranked visualization with eight, six and four attributes in respect to the visualization score, that is, visualizations where examples from different diagnostic classes are best separated:

	Score: 92.28% Genes: 37741_at: pyrroline-5-carboxylate reductase 1, PYCR1 35276_at: claudin 4, CLDN4 613_at: "keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)", KRT5 36133_at: desmoplakin, DSP 40619_at: ubiquitin-conjugating enzyme E2S, UBE2S 37398_at: Platelet/endothelial cell adhesion molecule (CD31 antigen), PECAM1 36160_s_at: "protein tyrosine phosphatase, receptor type, N polypeptide 2", PTPRN2 40825_at: "microtubule-associated protein, RP/EB family, member 3", MAPRE3
	Score: 92.80% Genes: 37741_at: pyrroline-5-carboxylate reductase 1, PYCR1 36105_at: carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen), CEACAM6 1814_at: "transforming growth factor, beta receptor II (70/80kDa)", TGFBR2 36160_s_at: "protein tyrosine phosphatase, receptor type, N polypeptide 2", PTPRN2 39990_at: "ISL1 transcription factor, LIM/homeodomain, (islet-1)", ISL1 613_at: "keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)", KRT5
	Score: 85.15% Genes: 36105_at: carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen), CEACAM6 32542_at: four and a half LIM domains 1, FHL1 39990_at: "ISL1 transcription factor, LIM/homeodomain, (islet-1)", ISL1 31791_at: tumor protein p73-like, TP73L

Attribute ranking

Following is the histogram of genes showing how often are they present in one of the top 100 radviz visualizations with 8 attributes.

Genes:
613_at: "keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)", KRT5
41231_f_at: high-mobility group nucleosomal binding domain 2, HMGN2
37741_at: pyrroline-5-carboxylate reductase 1, PYCR1
31791_at: tumor protein p73-like, TP73L
35868_at: advanced glycosylation end product-specific receptor, AGER
893_at: ubiquitin-conjugating enzyme E2S, UBE2S
35276_at: claudin 4, CLDN4
268_at: platelet/endothelial cell adhesion molecule (CD31 antigen), PECAM1
36105_at: carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen), CEACAM6
894_g_at: ubiquitin-conjugating enzyme E2S, UBE2S
40237_at: "pleckstrin homology-like domain, family A, member 2", PHLDA2
1814_at: "transforming growth factor, beta receptor II (70/80kDa)", TGFBR2
36119_at: "caveolin 1, caveolae protein, 22kDa", CAV1
37398_at: Platelet/endothelial cell adhesion molecule (CD31 antigen), PECAM1
32542_at: four and a half LIM domains 1, FHL1
36569_at: "C-type lectin domain family 3, member B", CLEC3B
39990_at: "ISL1 transcription factor, LIM/homeodomain, (islet-1)", ISL1
40304_at: dystonin, DST
38261_at: "ATP-binding cassette, sub-family C (CFTR/MRP), member 3", ABCC3
33693_at: desmoglein 3 (pemphigus vulgaris antigen), DSG3