Data set name: lung

Brief description:

This classification model was built to distinguish between four different lung tumors (adenocarcinomas, small-cell lung carcinomas, squamous cell carcinomas and carcinoids) and normal lung tissue on the basis of DNA expression signatures.

Platform: Affymetrix Human Genome U95Av2 Array

Diagnostic classes:

- adenocarcinoma (AD): 139 examples (68.5%)

- normal lung (NL): 17 examples (8.4%)

- small cell lung cancer (SMCL): 6 examples (3.0%)

- squamous cell carcinoma (SQ): 21 examples (10.3%)

- pulmonary carcinoid (COID): 20 examples (9.9%)

Predictive accuracy with 10-fold cross validation (classifying using the best projection with eight attributes):

Classification accuracy: 94.07%

Area under curve (AUC): 0.995

	Score: 92.28% Genes: 37741_at: pyrroline-5-carboxylate reductase 1, PYCR1 35276_at: claudin 4, CLDN4 613_at: "keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)", KRT5 36133_at: desmoplakin, DSP 40619_at: ubiquitin-conjugating enzyme E2S, UBE2S 37398_at: Platelet/endothelial cell adhesion molecule (CD31 antigen), PECAM1 36160_s_at: "protein tyrosine phosphatase, receptor type, N polypeptide 2", PTPRN2 40825_at: "microtubule-associated protein, RP/EB family, member 3", MAPRE3
	Score: 92.80% Genes: 37741_at: pyrroline-5-carboxylate reductase 1, PYCR1 36105_at: carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen), CEACAM6 1814_at: "transforming growth factor, beta receptor II (70/80kDa)", TGFBR2 36160_s_at: "protein tyrosine phosphatase, receptor type, N polypeptide 2", PTPRN2 39990_at: "ISL1 transcription factor, LIM/homeodomain, (islet-1)", ISL1 613_at: "keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)", KRT5
	Score: 85.15% Genes: 36105_at: carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen), CEACAM6 32542_at: four and a half LIM domains 1, FHL1 39990_at: "ISL1 transcription factor, LIM/homeodomain, (islet-1)", ISL1 31791_at: tumor protein p73-like, TP73L

Attribute ranking

Following is the histogram of genes showing how often are they present in one of the top 100 radviz visualizations with 8 attributes.

Genes: 613_at: "keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)", KRT5 41231_f_at: high-mobility group nucleosomal binding domain 2, HMGN2 37741_at: pyrroline-5-carboxylate reductase 1, PYCR1 31791_at: tumor protein p73-like, TP73L 35868_at: advanced glycosylation end product-specific receptor, AGER 893_at: ubiquitin-conjugating enzyme E2S, UBE2S 35276_at: claudin 4, CLDN4 268_at: platelet/endothelial cell adhesion molecule (CD31 antigen), PECAM1 36105_at: carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen), CEACAM6 894_g_at: ubiquitin-conjugating enzyme E2S, UBE2S 40237_at: "pleckstrin homology-like domain, family A, member 2", PHLDA2 1814_at: "transforming growth factor, beta receptor II (70/80kDa)", TGFBR2 36119_at: "caveolin 1, caveolae protein, 22kDa", CAV1 37398_at: Platelet/endothelial cell adhesion molecule (CD31 antigen), PECAM1 32542_at: four and a half LIM domains 1, FHL1 36569_at: "C-type lectin domain family 3, member B", CLEC3B 39990_at: "ISL1 transcription factor, LIM/homeodomain, (islet-1)", ISL1 40304_at: dystonin, DST 38261_at: "ATP-binding cassette, sub-family C (CFTR/MRP), member 3", ABCC3 33693_at: desmoglein 3 (pemphigus vulgaris antigen), DSG3