Diffuse large B-cell lymphomas (DLBCL) and follicular lymphomas (FL) are two B-cell lineage malignancies that have very different clinical presentations, natural histories and response to therapy. However, FLs frequently evolve over time and acquire the morphologic and clinical features of DLBCLs and some subsets of DLBCLs have chromosomal translocations characteristic of FLs. The gene-expression based classification model was built to distinguish between these two lymphomas.
Platform: Affymetrix HuGeneFL array
- Diffuse large B-cell lymphoma (DLBCL): 58 examples (75.3%)
- Follicular lymphoma (FL): 19 examples (24.7%)
Number of genes: 7070 Number of samples: 77
Predictive accuracy with 10-fold cross validation (classifying using the best projection with eight attributes):
Following are the three best-ranked visualization with eight, six and four attributes in respect to the visualization score, that is, visualizations where examples from different diagnostic classes are best separated: