Data set name: DLBCL

Brief description:

Diffuse large B-cell lymphomas (DLBCL) and follicular lymphomas (FL) are two B-cell lineage malignancies that have very different clinical presentations, natural histories and response to therapy. However, FLs frequently evolve over time and acquire the morphologic and clinical features of DLBCLs and some subsets of DLBCLs have chromosomal translocations characteristic of FLs. The gene-expression based classification model was built to distinguish between these two lymphomas.

Platform: Affymetrix HuGeneFL array

Diagnostic classes:

- Diffuse large B-cell lymphoma (DLBCL): 58 examples (75.3%)

- Follicular lymphoma (FL): 19 examples (24.7%)

Predictive accuracy with 10-fold cross validation (classifying using the best projection with eight attributes):

Classification accuracy: 90.89%

Area under curve (AUC): 0.944

	Score: 96.15% Genes: M57710_at: "lectin, galactoside-binding, soluble, 3 (galectin 3) /// galectin-3 internal gene", LGALS3 /// GALIG D79997_at: maternal embryonic leucine zipper kinase, MELK HG1980-HT2023_at: ---, --- U28386_at: "karyopherin alpha 2 (RAG cohort 1, importin alpha 1)", KPNA2 Z21966_at: "POU domain, class 6, transcription factor 1", POU6F1 D87119_at: tribbles homolog 2 (Drosophila), TRIB2 S73591_at: thioredoxin interacting protein, TXNIP X03689_s_at: eukaryotic translation elongation factor 1 alpha 1, EEF1A1
	Score: 95.78% Genes: M57710_at: "lectin, galactoside-binding, soluble, 3 (galectin 3) /// galectin-3 internal gene", LGALS3 /// GALIG X62078_at: GM2 ganglioside activator, GM2A X02152_at: lactate dehydrogenase A, LDHA D87119_at: tribbles homolog 2 (Drosophila), TRIB2 M94880_f_at: "major histocompatibility complex, class I, A", HLA-A Z21966_at: "POU domain, class 6, transcription factor 1", POU6F1
	Score: 94.81% Genes: M63138_at: cathepsin D (lysosomal aspartyl peptidase), CTSD L02426_at: "proteasome (prosome, macropain) 26S subunit, ATPase, 1", PSMC1 M94880_f_at: "major histocompatibility complex, class I, A", HLA-A L42324_at: G protein-coupled receptor 18, GPR18

Attribute ranking

Following is the histogram of genes showing how often are they present in one of the top 100 radviz visualizations with 8 attributes.

Genes: X16983_at: "integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)", ITGA4 X02152_at: lactate dehydrogenase A, LDHA M94880_f_at: "major histocompatibility complex, class I, A", HLA-A Z21966_at: "POU domain, class 6, transcription factor 1", POU6F1 J03909_at: "interferon, gamma-inducible protein 30", IFI30 D87119_at: tribbles homolog 2 (Drosophila), TRIB2 HG417-HT417_s_at: ---, --- M22382_at: heat shock 60kDa protein 1 (chaperonin), HSPD1 L17131_rna1_at: high mobility group AT-hook 1, HMGA1 L42324_at: G protein-coupled receptor 18, GPR18 X56494_at: "pyruvate kinase, muscle", PKM2 M63138_at: cathepsin D (lysosomal aspartyl peptidase), CTSD Z11793_at: "selenoprotein P, plasma, 1", SEPP1 D82348_at: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, ATIC AB002409_at: chemokine (C-C motif) ligand 21, CCL21 HG1980-HT2023_at: ---, --- M14328_s_at: "enolase 1, (alpha)", ENO1 J04173_at: phosphoglycerate mutase 1 (brain), PGAM1 X03689_s_at: eukaryotic translation elongation factor 1 alpha 1, EEF1A1 D78134_at: cold inducible RNA binding protein, CIRBP