Imatinib induces complete cytogenetic response in the majority of patients with chronic myeloid leukemia (CML) in chronic phase. However, a subgroup of patients doesn't respond to standard treatment with imatinib. Clinically, it would be advantageous to identify such patients in advance, since they may benefit from more aggressive therapy.
Platform: Affymetrix GeneChip Human Genome U95 Version [1 or 2] Set HG-U95A
Diagnostic classes:
- non-responder to imatinib treatment (Non-Responder): 12 examples (42.9%)
- responder to imatinib treatment (Responder): 16 examples (57.1%)
Number of genes: 12625 Number of samples: 28
Predictive accuracy with 10-fold cross validation (classifying using the best projection with eight attributes):
Following are the three best-ranked visualization with eight, six and four attributes in respect to the visualization score, that is, visualizations where examples from different diagnostic classes are best separated:
Score: 99.78% Genes: 33134_at: adenylate cyclase 3, ADCY3 39062_at: protective protein for beta-galactosidase (galactosialidosis), PPGB 34384_at: ATP-binding cassette, sub-family C (CFTR/MRP), member 1, ABCC1 32156_at: poliovirus receptor-related 2 (herpesvirus entry mediator B), PVRL2 31661_at: ring finger protein 5, RNF5 40589_at: syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2), SNTB2 32231_at: Hypothetical protein FLJ12610, FLJ12610 31556_at: T cell receptor alpha chain (TCRA) mRNA, TCRA-AV1S2 J32 AC allele,
Score: 99.40% Genes: 32156_at: poliovirus receptor-related 2 (herpesvirus entry mediator B), PVRL2 33134_at: adenylate cyclase 3, ADCY3 39062_at: protective protein for beta-galactosidase (galactosialidosis), PPGB 35037_at: solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, SLC28A1 40589_at: syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2), SNTB2 1851_s_at: Fas ligand (TNF superfamily, member 6), FASLG
Score: 97.19% Genes: 39062_at: protective protein for beta-galactosidase (galactosialidosis), PPGB 33134_at: adenylate cyclase 3, ADCY3 40589_at: syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2), SNTB2 32231_at: Hypothetical protein FLJ12610, FLJ12610
Attribute ranking
Following is the histogram of genes showing how often are they present in one of the top 100 radviz visualizations with 8 attributes.