Data set name: GSE2535

Brief description:

Imatinib induces complete cytogenetic response in the majority of patients with chronic myeloid leukemia (CML) in chronic phase. However, a subgroup of patients doesn't respond to standard treatment with imatinib. Clinically, it would be advantageous to identify such patients in advance, since they may benefit from more aggressive therapy.

Platform: Affymetrix GeneChip Human Genome U95 Version [1 or 2] Set HG-U95A

Diagnostic classes:

- non-responder to imatinib treatment (Non-Responder): 12 examples (42.9%)

- responder to imatinib treatment (Responder): 16 examples (57.1%)

Predictive accuracy with 10-fold cross validation (classifying using the best projection with eight attributes):

Classification accuracy: 60.00%

Area under curve (AUC): 0.525

	Score: 99.78% Genes: 33134_at: adenylate cyclase 3, ADCY3 39062_at: protective protein for beta-galactosidase (galactosialidosis), PPGB 34384_at: ATP-binding cassette, sub-family C (CFTR/MRP), member 1, ABCC1 32156_at: poliovirus receptor-related 2 (herpesvirus entry mediator B), PVRL2 31661_at: ring finger protein 5, RNF5 40589_at: syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2), SNTB2 32231_at: Hypothetical protein FLJ12610, FLJ12610 31556_at: T cell receptor alpha chain (TCRA) mRNA, TCRA-AV1S2 J32 AC allele,
	Score: 99.40% Genes: 32156_at: poliovirus receptor-related 2 (herpesvirus entry mediator B), PVRL2 33134_at: adenylate cyclase 3, ADCY3 39062_at: protective protein for beta-galactosidase (galactosialidosis), PPGB 35037_at: solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, SLC28A1 40589_at: syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2), SNTB2 1851_s_at: Fas ligand (TNF superfamily, member 6), FASLG
	Score: 97.19% Genes: 39062_at: protective protein for beta-galactosidase (galactosialidosis), PPGB 33134_at: adenylate cyclase 3, ADCY3 40589_at: syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2), SNTB2 32231_at: Hypothetical protein FLJ12610, FLJ12610

Attribute ranking

Following is the histogram of genes showing how often are they present in one of the top 100 radviz visualizations with 8 attributes.

Genes: 40589_at: syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2), SNTB2 33134_at: adenylate cyclase 3, ADCY3 1851_s_at: Fas ligand (TNF superfamily, member 6), FASLG 39062_at: protective protein for beta-galactosidase (galactosialidosis), PPGB 32156_at: poliovirus receptor-related 2 (herpesvirus entry mediator B), PVRL2 34335_at: ephrin-B2, EFNB2 39064_at: 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase), MTHFS 31556_at: T cell receptor alpha chain (TCRA) mRNA, TCRA-AV1S2 J32 AC allele, 34384_at: ATP-binding cassette, sub-family C (CFTR/MRP), member 1, ABCC1 41166_at: immunoglobulin heavy constant mu, IGHM 35037_at: solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, SLC28A1 995_g_at: protein tyrosine phosphatase, receptor type, M, PTPRM 1745_at 33999_f_at: hypothetical protein LOC90925, LOC90925 35369_at: deltex 4 homolog (Drosophila), DTX4 35305_at: X-prolyl aminopeptidase (aminopeptidase P) 1, soluble, XPNPEP1 32089_at: sperm associated antigen 6, SPAG6 36780_at: clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J), CLU 33670_at: Estrogen receptor 1, ESR1 35771_at: deformed epidermal autoregulatory factor 1 (Drosophila), DEAF1