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Data set name: GSE2443

Original data set (GSE2443)
Data set for Orange

Brief description:: After an initial response to androgen ablation, most prostate tumors recur, ultimately progressing to highly aggressive androgen-independent cancer. Our classification model was built with gene expression profiles of 10 androgen-independent primary prostate tumor biopsies and 10 primary, untreated androgen-dependent tumors.

Platform: Affymetrix GeneChip Human Genome U133 Array Set HG-U133A

Diagnostic classes:: - androgen dependent tumor (dependent): 10 examples (50.0%); - androgen - independent tumor (independent): 10 examples (50.0%)

Number of genes: 12627
Number of samples: 20
Note: From the originally measured 22283 probe sets we removed genes that were not present (P) in at least one sample

Predictive accuracy with 10-fold cross validation (classifying using the best projection with eight attributes):: Classification accuracy: 65.00%; Area under curve (AUC): 0.800

Following are the three best-ranked visualization with eight, six and four attributes in respect to the visualization score, that is, visualizations where examples from different diagnostic classes are best separated:

	Score: 99.98% Genes: 217595_at: G1 to S phase transition 1, GSPT1 203815_at: glutathione S-transferase theta 1, GSTT1 209389_x_at: diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein), DBI 203103_s_at: PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae), PRPF19 212254_s_at: dystonin, DST 204556_s_at: DAZ interacting protein 1, DZIP1 201604_s_at: protein phosphatase 1, regulatory (inhibitor) subunit 12A, PPP1R12A 208982_at: Platelet/endothelial cell adhesion molecule (CD31 antigen), PECAM1
	Score: 99.98% Genes: 203103_s_at: PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae), PRPF19 203815_at: glutathione S-transferase theta 1, GSTT1 221844_x_at 208982_at: Platelet/endothelial cell adhesion molecule (CD31 antigen), PECAM1 201604_s_at: protein phosphatase 1, regulatory (inhibitor) subunit 12A, PPP1R12A 215016_x_at: dystonin, DST
	Score: 99.98% Genes: 221844_x_at 203815_at: glutathione S-transferase theta 1, GSTT1 204556_s_at: DAZ interacting protein 1, DZIP1 201604_s_at: protein phosphatase 1, regulatory (inhibitor) subunit 12A, PPP1R12A

Attribute ranking

Following is the histogram of genes showing how often are they present in one of the top 100 radviz visualizations with 8 attributes.

Genes:
214021_x_at: Integrin, beta 5, ITGB5
201604_s_at: protein phosphatase 1, regulatory (inhibitor) subunit 12A, PPP1R12A
203815_at: glutathione S-transferase theta 1, GSTT1
204556_s_at: DAZ interacting protein 1, DZIP1
218674_at: hypothetical protein FLJ13611, FLJ13611
201812_s_at: translocase of outer mitochondrial membrane 7 homolog (yeast) /// hypothetical protein LOC201725, TOMM7 /// LOC201725
221844_x_at
208982_at: Platelet/endothelial cell adhesion molecule (CD31 antigen), PECAM1
212254_s_at: dystonin, DST
214061_at: WD repeat domain 67, WDR67
209389_x_at: diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein), DBI
203477_at: collagen, type XV, alpha 1, COL15A1
AFFX-r2-Hs28SrRNA-3_at
212158_at: syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan), SDC2
214307_at: homogentisate 1,2-dioxygenase (homogentisate oxidase), HGD
215016_x_at: dystonin, DST
221800_s_at: hypothetical protein FLJ22175, FLJ22175
217595_at: G1 to S phase transition 1, GSPT1
203103_s_at: PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae), PRPF19
AFFX-r2-Hs18SrRNA-5_at