Data set name: GSE1987

Brief description:

The classification model for the lung_SQ_AD data set was built with Adenocarcinoma, Squamous cell carcinoma and normal lung tissue samples from the original dataset (GSE1987). The Adenosquamous sample was added to the Adenocarcinoma class. The metastasis samples were excluded from our analysis, because of their small number (3 samples).

Platform: Affymetrix GeneChip Human Genome U95 Version [1 or 2] Set HG-U95A

Diagnostic classes:

- Squamous cell carcinoma (Squamous): 17 examples (50.0%)

- Adenocarcinoma (Adenocarcinoma): 8 examples (23.5%)

- Normal lung tissue (Normal): 9 examples (26.5%)

Predictive accuracy with 10-fold cross validation (classifying using the best projection with eight attributes):

Classification accuracy: 65.83%

Area under curve (AUC): 0.763

	Score: 99.14% Genes: 35454_at: phospholipase C-like 4, PLCL4 36280_at: granzyme K (serine protease, granzyme 3; tryptase II), GZMK 34301_r_at: keratin 17, KRT17 36186_at: RNA binding protein S1, serine-rich domain, RNPS1 34800_at: leucine-rich repeats and immunoglobulin-like domains 1, LRIG1 34928_at: zinc finger protein 205, ZNF205 36939_at: glycoprotein M6A, GPM6A 37983_at: angiotensin II receptor, type 1, AGTR1
	Score: 98.06% Genes: 36280_at: granzyme K (serine protease, granzyme 3; tryptase II), GZMK 34301_r_at: keratin 17, KRT17 36244_at: zinc finger protein 239, ZNF239 38582_at: serine protease inhibitor, Kazal type 1, SPINK1 37196_at: cadherin 5, type 2, VE-cadherin (vascular epithelium), CDH5 37983_at: angiotensin II receptor, type 1, AGTR1
	Score: 93.84% Genes: 35454_at: phospholipase C-like 4, PLCL4 34301_r_at: keratin 17, KRT17 41453_at: discs, large homolog 3 (neuroendocrine-dlg, Drosophila), DLG3 1186_at: growth differentiation factor 10, GDF10

Attribute ranking

Following is the histogram of genes showing how often are they present in one of the top 100 radviz visualizations with 8 attributes.

Genes: 41453_at: discs, large homolog 3 (neuroendocrine-dlg, Drosophila), DLG3 36883_at: keratin 13, KRT13 37196_at: cadherin 5, type 2, VE-cadherin (vascular epithelium), CDH5 36021_at: lymphoid enhancer-binding factor 1, LEF1 38379_at: glycoprotein (transmembrane) nmb, GPNMB 37983_at: angiotensin II receptor, type 1, AGTR1 37582_at: keratin 15, KRT15 34301_r_at: keratin 17, KRT17 1186_at: growth differentiation factor 10, GDF10 40092_at: bromodomain adjacent to zinc finger domain, 2A, BAZ2A 34342_s_at: secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), SPP1 34194_at: Chloride intracellular channel 5, CLIC5 32971_at: chromosome 9 open reading frame 61, C9orf61 35630_at: lethal giant larvae homolog 2 (Drosophila), LLGL2 1343_s_at: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3, SERPINB3 2027_at: S100 calcium binding protein A2, S100A2 37160_at: small proline-rich protein 1B (cornifin), SPRR1B 37473_at: keratin 16 (focal non-epidermolytic palmoplantar keratoderma), KRT16 32633_at: islet cell autoantigen 1, 69kDa, ICA1 575_s_at: tumor-associated calcium signal transducer 1, TACSTD1