Data set name: MLL

Brief description:

Mixed-lineage leukemias (MLL) are a subset of human acute lymphoblastic leukemias with a chromosomal translocation involving the mixed-lineage leukemia gene. MLL translocations are typically found in infant leukemias and in chemotherapy-induced leukemias and have a particularly poor prognosis. The original research on this dataset (Armstrong et al.) suggested, that MLL have a highly uniform and distinct pattern that clearly distinguishes them from conventional acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Our classification model also shows clear separation of the three diagnostic classes (ALL, AML and MLL leukemias) based on gene expression values.

Platform: Affymetrix Human Genome U95Av2 Array

Diagnostic classes:

- acute lymphoblastic leukemia (ALL): 24 examples (33.3%)

- mixed-lineage leukemia (MLL): 20 examples (27.8%)

- acute myeloid leukemia (AML): 28 examples (38.9%)

Predictive accuracy with 10-fold cross validation (classifying using the best projection with eight attributes):

Classification accuracy: 91.61%

Area under curve (AUC): 0.973

	Score: 99.89% Genes: 1389_at: "membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)", MME 39556_at: "spectrin, beta, non-erythrocytic 1", SPTBN1 963_at: "ligase IV, DNA, ATP-dependent", LIG4 1065_at: fms-related tyrosine kinase 3, FLT3 1914_at: cyclin A1, CCNA1 39598_at: "gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked)", GJB1 239_at: cathepsin D (lysosomal aspartyl peptidase), CTSD 1894_f_at: ---, ---
	Score: 99.64% Genes: 1389_at: "membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)", MME 963_at: "ligase IV, DNA, ATP-dependent", LIG4 1065_at: fms-related tyrosine kinase 3, FLT3 36777_at: "killer cell lectin-like receptor subfamily K, member 1", KLRK1 39598_at: "gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked)", GJB1 239_at: cathepsin D (lysosomal aspartyl peptidase), CTSD
	Score: 98.83% Genes: 1389_at: "membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)", MME 963_at: "ligase IV, DNA, ATP-dependent", LIG4 34306_at: muscleblind-like (Drosophila), MBNL1 39448_r_at: B7 gene, B7

Attribute ranking

Following is the histogram of genes showing how often are they present in one of the top 100 radviz visualizations with 8 attributes.

Genes: 1389_at: "membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)", MME 34306_at: muscleblind-like (Drosophila), MBNL1 36162_at: basigin (OK blood group), BSG 963_at: "ligase IV, DNA, ATP-dependent", LIG4 39598_at: "gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked)", GJB1 40797_at: ADAM metallopeptidase domain 10, ADAM10 39448_r_at: B7 gene, B7 1894_f_at: ---, --- 39931_at: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3, DYRK3 32847_at: "myosin, light polypeptide kinase", MYLK 36239_at: "POU domain, class 2, associating factor 1", POU2AF1 39556_at: "spectrin, beta, non-erythrocytic 1", SPTBN1 34168_at: "deoxynucleotidyltransferase, terminal", DNTT 40570_at: forkhead box O1A (rhabdomyosarcoma), FOXO1A 39385_at: "alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)", ANPEP 266_s_at: CD24 antigen (small cell lung carcinoma cluster 4 antigen), CD24 39011_at: endosulfine alpha, ENSA 1065_at: fms-related tyrosine kinase 3, FLT3 39318_at: T-cell leukemia/lymphoma 1A, TCL1A 32872_at: Transcription factor 4, TCF4