The malignant cells in T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LL) are morphologically indistinguishable, and they share the expression of common cell surface antigens and cytogenetic characteristics. However, despite these similarities, differences in the clinical behavior of T-ALL and T-LL are observed. The model was built with global gene expression profiles of malignant T-cell precursors of T-ALL and T-LL.
Platform: Affymetrix GeneChip Human Genome U133 Array Set HG-U133A
Following are the three best-ranked visualization with eight, six and four attributes in respect to the visualization score, that is, visualizations where examples from different diagnostic classes are best separated:
Score: 99.99% Genes: 201163_s_at: insulin-like growth factor binding protein 7, IGFBP7 217757_at: alpha-2-macroglobulin, A2M 203382_s_at: apolipoprotein E, APOE 206702_at: TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal), TEK 200732_s_at: protein tyrosine phosphatase type IVA, member 1, PTP4A1 222044_at 202168_at: TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, TAF9 89948_at: chromosome 20 open reading frame 67, C20orf67