Data set name: GSE1577

Brief description:

The malignant cells in T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LL) are morphologically indistinguishable, and they share the expression of common cell surface antigens and cytogenetic characteristics. However, despite these similarities, differences in the clinical behavior of T-ALL and T-LL are observed. The model was built with global gene expression profiles of malignant T-cell precursors of T-ALL and T-LL.

Platform: Affymetrix GeneChip Human Genome U133 Array Set HG-U133A

Diagnostic classes:

- T-cell lymphoblastic lymphoma (T-LL): 9 examples (47.4%)

- T-cell acute lymphoblastic leukemia (T-ALL): 10 examples (52.6%)

Predictive accuracy with 10-fold cross validation (classifying using the best projection with eight attributes):

Classification accuracy: 95.00%

Area under curve (AUC): 1.000

	Score: 99.99% Genes: 201163_s_at: insulin-like growth factor binding protein 7, IGFBP7 217757_at: alpha-2-macroglobulin, A2M 203382_s_at: apolipoprotein E, APOE 206702_at: TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal), TEK 200732_s_at: protein tyrosine phosphatase type IVA, member 1, PTP4A1 222044_at 202168_at: TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, TAF9 89948_at: chromosome 20 open reading frame 67, C20orf67
	Score: 99.99% Genes: 209290_s_at: nuclear factor I/B, NFIB 202112_at: von Willebrand factor, VWF 209289_at: Nuclear factor I/B, NFIB 89948_at: chromosome 20 open reading frame 67, C20orf67 200668_s_at: ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), UBE2D3 222044_at
	Score: 99.99% Genes: 201163_s_at: insulin-like growth factor binding protein 7, IGFBP7 202112_at: von Willebrand factor, VWF 200732_s_at: protein tyrosine phosphatase type IVA, member 1, PTP4A1 202021_x_at: putative translation initiation factor, SUI1

Attribute ranking

Following is the histogram of genes showing how often are they present in one of the top 100 radviz visualizations with 8 attributes.

Genes: 200668_s_at: ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), UBE2D3 209120_at: nuclear receptor subfamily 2, group F, member 2, NR2F2 201163_s_at: insulin-like growth factor binding protein 7, IGFBP7 209290_s_at: nuclear factor I/B, NFIB 202168_at: TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, TAF9 218462_at: brix domain containing 5, BXDC5 200732_s_at: protein tyrosine phosphatase type IVA, member 1, PTP4A1 202112_at: von Willebrand factor, VWF 206702_at: TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal), TEK 218398_at: mitochondrial ribosomal protein S30, MRPS30 202021_x_at: putative translation initiation factor, SUI1 210639_s_at: APG5 autophagy 5-like (S. cerevisiae), APG5L 222044_at 217757_at: alpha-2-macroglobulin, A2M 218576_s_at: dual specificity phosphatase 12, DUSP12 202776_at: estrogen receptor binding protein, ERBP 203382_s_at: apolipoprotein E, APOE 89948_at: chromosome 20 open reading frame 67, C20orf67 209289_at: Nuclear factor I/B, NFIB