Data set name: GSE967

Brief description:

In the second model using the GSE967 data set we subdivided the rhabdomyosarcoma samples into embryonal rhabdomyosarcomas (eRMS) and alveolar rhabdomyosarcomas (aRMS), so that we had three diagnostic classes (EWS, eRMS and aRMS).

Platform: Affymetrix GeneChip Human Genome U95 Version [1 or 2] Set HG-U95A

Diagnostic classes:

- Ewing's sarcoma (EWS): 11 examples (47.8%)

- embryonal rhabdomyosarcoma (eRMS): 3 examples (13.0%)

- alveolar rhabdomyosarcoma (aRMS): 9 examples (39.1%)

Predictive accuracy with 10-fold cross validation (classifying using the best projection with eight attributes):

Classification accuracy: 78.33%

Area under curve (AUC): 0.840

	Score: 99.96% Genes: 38277_at: protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta), PPP3CB 34877_at: Janus kinase 1 (a protein tyrosine kinase), JAK1 1487_at: estrogen-related receptor alpha, ESRRA 39325_at: left-right determination factor 2, LEFTY2 35663_at: neuronal pentraxin II, NPTX2 260_at: quinoid dihydropteridine reductase, QDPR 39084_at: enolase 3 (beta, muscle), ENO3 38730_at: myosin phosphatase-Rho interacting protein, M-RIP
	Score: 99.95% Genes: 40468_at: formin binding protein 1, FNBP1 41138_at: CD99 antigen, CD99 1487_at: estrogen-related receptor alpha, ESRRA 35663_at: neuronal pentraxin II, NPTX2 33404_at: CAP, adenylate cyclase-associated protein, 2 (yeast), CAP2 35266_at: bladder cancer associated protein, BLCAP
	Score: 99.88% Genes: 31432_g_at: Fc fragment of IgG, receptor, transporter, alpha, FCGRT 34198_at: protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase), PTPN13 33803_at: thrombomodulin, THBD 35321_at: tousled-like kinase 2, TLK2

Attribute ranking

Following is the histogram of genes showing how often are they present in one of the top 100 radviz visualizations with 8 attributes.

Genes: 40570_at: forkhead box O1A (rhabdomyosarcoma), FOXO1A 33803_at: thrombomodulin, THBD 31432_g_at: Fc fragment of IgG, receptor, transporter, alpha, FCGRT 34877_at: Janus kinase 1 (a protein tyrosine kinase), JAK1 34198_at: protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase), PTPN13 41138_at: CD99 antigen, CD99 40795_at: titin, TTN 1487_at: estrogen-related receptor alpha, ESRRA 38650_at: insulin-like growth factor binding protein 5, IGFBP5 41215_s_at: inhibitor of DNA binding 2, dominant negative helix-loop-helix protein /// inhibitor of DNA binding 2B, dominant negative helix-loop-helix protein, ID2 /// ID2B 39721_at: ephrin-B1, EFNB1 38277_at: protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta), PPP3CB 35321_at: tousled-like kinase 2, TLK2 37539_at: ral guanine nucleotide dissociation stimulator-like 1, RGL1 36734_at: small proline-rich protein 2D, SPRR2D 39084_at: enolase 3 (beta, muscle), ENO3 36119_at: caveolin 1, caveolae protein, 22kDa, CAV1 38730_at: myosin phosphatase-Rho interacting protein, M-RIP 35663_at: neuronal pentraxin II, NPTX2 41454_at: heme binding protein 2, HEBP2