Data set name: GSE412

Brief description:

The childhood ALL data set (GSE412) includes gene expression information on 110 childhood acute lymphoblastic leukemia samples. For this data set we induced models for two different classification problems. With the first model we try to distinguish between childhood acute lymphoblastic leukemia cells based on changes in gene expression before and after treatment, regardless of the type of treatment used.

Platform: Affymetrix GeneChip Human Genome U95 Version [1 or 2] Set HG-U95A

Diagnostic classes:

- before therapy (before Th): 50 examples (45.5%)

- after therapy (after Th): 60 examples (54.5%)

Predictive accuracy with 10-fold cross validation (classifying using the best projection with eight attributes):

Classification accuracy: 92.73%

Area under curve (AUC): 0.960

	Score: 98.95% Genes: 38414_at: CDC20 cell division cycle 20 homolog (S. cerevisiae), CDC20 35590_s_at: gastric inhibitory polypeptide receptor, GIPR 34457_at: solute carrier family 30 (zinc transporter), member 3, SLC30A3 37226_at: BCL2/adenovirus E1B 19kDa interacting protein 1, BNIP1 33143_s_at: solute carrier family 16 (monocarboxylic acid transporters), member 3, SLC16A3 38464_at: glucosidase I, GCS1 838_s_at: ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast), UBE2I 32264_at: granzyme M (lymphocyte met-ase 1), GZMM
	Score: 98.46% Genes: 35590_s_at: gastric inhibitory polypeptide receptor, GIPR 37905_r_at: Guanine nucleotide binding protein-like 1, GNL1 38447_at: adrenergic, beta, receptor kinase 1, ADRBK1 838_s_at: ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast), UBE2I 36822_at: TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa, TAF15 36651_at: acid phosphatase 2, lysosomal, ACP2
	Score: 97.90% Genes: 37226_at: BCL2/adenovirus E1B 19kDa interacting protein 1, BNIP1 35590_s_at: gastric inhibitory polypeptide receptor, GIPR 838_s_at: ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast), UBE2I 38464_at: glucosidase I, GCS1

Attribute ranking

Following is the histogram of genes showing how often are they present in one of the top 100 radviz visualizations with 8 attributes.

Genes: 838_s_at: ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast), UBE2I 35590_s_at: gastric inhibitory polypeptide receptor, GIPR 36822_at: TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa, TAF15 36161_at: adaptor-related protein complex 2, beta 1 subunit, AP2B1 725_i_at 37226_at: BCL2/adenovirus E1B 19kDa interacting protein 1, BNIP1 34457_at: solute carrier family 30 (zinc transporter), member 3, SLC30A3 38464_at: glucosidase I, GCS1 36651_at: acid phosphatase 2, lysosomal, ACP2 37905_r_at: Guanine nucleotide binding protein-like 1, GNL1 39420_at: DNA-damage-inducible transcript 3, DDIT3 33143_s_at: solute carrier family 16 (monocarboxylic acid transporters), member 3, SLC16A3 38447_at: adrenergic, beta, receptor kinase 1, ADRBK1 33069_f_at: UDP glucuronosyltransferase 2 family, polypeptide B15, UGT2B15 33870_at: jumonji domain containing 1B, JMJD1B 36223_at: Splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated), SFPQ 39332_at: tubulin, beta polypeptide paralog, RP11-506K6.1 41117_s_at: Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2, SLC9A3R2 32264_at: granzyme M (lymphocyte met-ase 1), GZMM 39994_at: chemokine (C-C motif) receptor 1, CCR1