Historical notes and a rising incidence 3 24 41 22 45 6 15 31 36 39 41 24 44 1 8 17 26 Table 1 Incidence data on intraductal papillary-mucinous neoplasms Author Period 1 Number of incidence Period 2 Number of incidence 43 1987–2001 58 2001–2003 78 47 1988–2000 63 2001–2003 37 Our series 1981–2000 55 2001–2007 50 50 Adenoma-carcinoma sequence 7 26 40 43 43 Prognosis after resection 2 12 16 43 2 12 16 43 47 13 29 40 43 Table 2 a   Noninvasive Invasive 77–100% 36–46% No recurrence 93–98.7% 52–70% Recurrence 1.3–7% 30–48% Local up to 6% 8–48% Distant (metastases) 1% 12% Both 0% 10–48% a 12 43 47 12 43 47 48 2 40 13 48 Histological type and prognosis 49 3 4 18 28 32 33 18 3 9 1 5 28 5 Fig. 1 a b c d e f g h  Table 3 Histopathological data on 105 intraductal papillary-mucinous neoplasms collected during a period of 26 years IPMN n n n n Noninvasive (65%) n n n n Adenoma 9 12 1 5 Borderline 7 18 2 1 Carcinoma in situ 4 5 0 4 Invasive (35%) n n n n 3 1 4 2 1 2 20 34 35 37 38 42 37 1 9 10 25 33 46 46 3 2 46 Fig. 2 IPMN of the gastric type showing severe cellular atypia and MUC5 positivity  21 14 3 27 4 19 Fig. 3 PanIN-1 lesion associated with lobular fibrosis  Fig. 4 Small multicystic duct-associated lesion in the periphery of pancreatic tissue suggestive of an IPMN of the gastric type but difficult to distinguish from a large PanIN-1 lesion  11 30 Summary and perspectives 1 23 51 52