1 Introduction 1 Freund et al., 2003 1 Katona et al., 1999, 2006; Kawamura et al., 2006 1 Nyiri et al., 2005; Kawamura et al., 2006 1 2+ 2+ Wilson et al., 2001; Diana and Marty, 2003 1 1 1 Hájos et al., 2001 Hoffman and Lupica, 2000; Ohno-Shosaku et al., 2002; Hájos and Freund, 2002 1 1 Hájos and Freund, 2002 1 1 Ohno-Shosaku et al., 2002; Domenici et al., 2006; Takahashi and Castillo, 2006 1 Hájos et al., 2005 2 Methods 1 3 2 2 2 4 2 2 3 2 2 2 4 2 Hájos et al., 2005 http://www.superte.ch n 50 f x a x c b a x e d c e f x a x c b c 50 tatistica Picrotoxin, WIN 55,212-2 and WIN 55,212-3 were purchased from Sigma-Aldrich, AM251 was obtained from Tocris, while ω-conotoxin GVIA and ω-agatonix IVA from Alomone Labs. For all experiments, WIN-55,212-2 was dissolved in 0.1N HCl giving a 20 mM stock solution stored at 4 °C. AM251 was dissolved in DMSO (100 mM) and stored at −20 °C. WIN 55,212-3 dissolved in DMSO (100 mM) was stored at 4 °C. From these stock solutions, the final dilution of drugs was done in ACSF containing picrotoxin under constant stirring and the prepared solution was bath applied. In control solutions, the vehicle was diluted in the same concentration as in the solutions containing drugs. Bovine serum albumin (BSA) was added in a concentration of 0.1 mg/ml to the solutions used for experiments with WIN 55,212-3. 3 Results Fig. 1 50 Fig. 1 1 Fig. 1 50 Fig. 1 Fig. 1 50 Fig. 1 1 1 Fig. 1 50 Fig. 1 1 1 1 1 Fig. 2 n p 1 1 n p Figs. 2 n p n p 1 Figs. 2 n p 1 Figs. 2 n p 1 Shen and Thayer, 1998 2+ 1 n n Fig. 1 n n p U 1 2+ 1 2+ 2+ 2+ n p Fig. 3 n p Fig. 3 1 2+ 4 Discussion 1 1 1 2+ 1 Shen et al., (1996) Misner and Sullivan, 1999; Al-Hayani and Davies, 2000; Hájos and Freund, 2002; Ohno-Shosaku et al., 2002; Hoffman et al., 2003 Levenes et al., 1998; Takahashi and Linden, 2000 Domenici et al., 2006 Azad et al., 2003; Domenici et al., 2006 Gerdeman and Lovinger, 2001; Huang et al., 2001 1 Katona et al., 1999; Hájos et al., 2000 1 Hájos et al., 2001; Kofalvi et al., 2003 1 Katona et al., 1999; Hájos et al., 2000; Nyiri et al., 2005 1 Hájos et al., 2000, 2001; Varma et al., 2001; Wilson et al., 2001 Hájos and Freund (2002) 1 Katona et al., 2006; Kawamura et al., 2006 1 1 Ohno-Shosaku et al., 2002; Domenici et al., 2006; Takahashi and Castillo, 2006 1 2+ 1 Shen and Thayer, 1998; Kofalvi et al., 2007 1 Ohno-Shosaku et al., 2002 1 1 Kawamura et al., 2006 1 Hoffman et al. (2005) 1 Domenici et al., 2006; Takahashi and Castillo, 2006 Takahashi and Linden, 2000; Robbe et al., 2001; Hájos and Freund, 2002; Hoffman et al., 2005 1 Hájos et al., 2005 Ohno-Shosaku et al., 2002 Felder et al., 1995 1 Hájos et al., 2001; Pistis et al., 2004; Kofalvi et al., 2005; Matyas et al., 2006 2+ Shen and Thayer, 1998; Kofalvi et al., 2007 1 2+ 1 1 2+ Wilson et al., 2001 1 n 1 n n Hájos and Freund, 2002 1 1 2+ 1 2+ 1 2+ 2+ 1 Chemin et al., 2001; Fisyunov et al., 2006 1 Ohno-Shosaku et al., 2002; Straiker and Mackie, 2005 Rouach and Nicoll, 2003 1 2+ Haller et al., 2007