1 Introduction Pickering et al., 2000 C1qa −/− Botto et al., 1998 C1qa −/− Mitchell et al., 2002 Mitchell et al., 2002 C1qa −/− Cortes-Hernandez et al., 2004 Prodeus et al., 1998 Botto et al., 1998 Casciola-Rosen et al., 1994 Korb and Ahearn, 1997; Mevorach et al., 1998; Nauta et al., 2004; Quartier et al., 2005; Taylor et al., 2000 HEL HEL Ferry et al., 2006 HEL Cutler et al., 2001; Prodeus et al., 1998 Prodeus et al., 1998 Cutler et al., 2001 Cutler et al., 2001 Chen et al., 1995 H lpr lpr H H Radic et al., 1991 H H H H L Prak and Weigert, 1995 H L Chen et al., 1997a H L Prak and Weigert, 1995 H Chen et al., 1995; Erikson et al., 1991 Fukuyama et al., 2005; Sekiguchi et al., 2002 Sekiguchi et al., 2002 H L lpr lpr Brard et al., 1999 lpr H H L Fas 3 H 2 Materials and methods 2.1 Mice C1qa −/− Mitchell et al., 2002 H Chen et al., 1995 L Prak and Weigert, 1995 H L C1qa −/− H H L C1qa +/− C1qa −/− − H Erikson et al., 1991 L Carmack et al., 1991 2.2 Flow cytometry H Gay et al., 1993 2.3 Serological analyses Cortes-Hernandez et al., 2004 Burlingame and Rubin, 1990; Emlen et al., 1990 3 + H Gay et al., 1993 H 2.4 Renal assessment Carlucci et al., 2007 2.5 Statistics U p 3 Results 3.1 Expression of Tg autoantibodies Mitchell et al., 2002 H L H L C1qa −/− Steeves and Marion, 2004 H L Gay et al., 1993 H L Gay et al., 1993 H L H H L C1qa −/− H L p H C1qa −/− H p + H H H H L C1qa −/− H L + H L H Fig. 1 H L C1qa −/− + H C1qa −/− + H Fig. 1 + Fig. 1 H L C1qa −/− H L Fig. 2 H L C1qa −/− Fig. 2 H H H C1q −/− Fig. 2 Supporting information Table S1 3.2 Renal assessment H L H Mitchell et al., 2002 Mitchell et al., 2002 H L C1qa −/− p H C1qa −/− p 3.3 Flow cytometric analysis of splenic and peritoneal B cells Table 1 Li et al., 2002 H H L Fig. 3 + t p Table 1 H C1qa −/− H Fig. 3 + t p Table 1 H L + t p Table 1 Fig. 3 + t p Fig. 3 Fagarasan et al., 2000 H C1qa H p H L C1qa −/− H L p Table 1 H C1qa H Table 1 H L Table 1 p H L H L H H L Table 1 + + 4 Discussion H L H H H L H L H lpr lpr Brard et al., 1999; Chen et al., 1995; Erikson et al., 1991; Fukuyama et al., 2005; Sekiguchi et al., 2002 Yaa Merino et al., 1989 lpr gld Cohen and Eisenberg, 1991 + H L + H L Mandik-Nayak et al., 1999, 2000 HEL Nijnik et al., 2006 H L Mandik-Nayak et al., 1999 HEL Nijnik et al., 2006 Rudolph et al., 2002 H L + H L H L H + H L C1qa −/− H L H C1qa −/− + H Li et al., 2002; Mandik-Nayak et al., 1997, 1999, 2006; Qian et al., 2004; Wen et al., 2005 Chen et al., 1997b; Li et al., 2002 Grimaldi et al., 2001; Mackay et al., 1999; Wither et al., 2000 Amano et al., 2003; Samardzic et al., 2002 H L Wen et al., 2005 H H L + Oliver et al., 1999 H C1qa −/− H L C1qa −/− + + 2 Murakami et al., 1995 Atencio et al., 2004 H C1qa −/− Table 1 H L C1qa −/− + H Ferry et al., 2007 H C1qa −/− Appendix A Supplementary data doi:10.1016/j.molimm.2007.06.162 Appendix A Supplementary data