Introduction 1 2 4 5 7 8 9 10 5 6 7 2 4 11 Methods Subjects and study design 12 n t 13 Assays 5 7 14 Statistical analysis p Results Pharmacokinetic data 1 t Fig. 1 t circles triangles squares t  Novel prohormone biomarkers t 2 t p t t t p t p p p t Fig. 2 t open circles triangles squares filled circles t p NS  Discussion 9 5 7 7 15 16 11 17 18 19 18 20 13 13