Introduction 1 2 CDH1 3 4 4 8 CDH1 CDH1 9 CDH1 CDH1 Methods CDH1 1 BRCA1 BRCA2 PTEN CDH1 Fig. 1 a b  Results 6 CDH1 1 10 CDH1 CDH1 Discussion E-cadherin CDH1 11 12 13 14 15 16 17 18 19 CDH1 20 21 CDH1 22 23 11 23 24 CDH1 7 2 CDH1 CDH1 25 26 26 Fig. 2 CDH1 CDH1 CDH1 CDH1 4 9 CDH1  Lobular breast cancer and diffuse gastric cancer: loss of E-cadherin 27 BRCA1 2 TP53 PTEN 28 CHK2 BRIP1 PALB2 ATM 29 32 33 33 34 35 36 37 CDH1 38 CDH1 38 39 11 CDH1 11 CDH1 2 CDH1 CDH1 P 2 - CDH1 40 41 CDH1 9 CDH1 42 43 Lobular breast cancer and HDGC BRCA1 2 4 5 4 6 8 CDH1 44 CDH1 45 46 47 CDH1 4 CDH1 CDH1 CDH1 CDH1 9 CDH1 CDH1 CDH1 BRCA2 CDH1 CDH1 CDH1 4 47 33 48 49 50 CDH1 51 52 Management of hereditary diffuse gastric cancer 4 47 CDH1 CDH1 53 54 4 55 56 4 57 Conclusion 1 p53 58 CDH1 Table 1 Other syndromes with familial susceptibility to breast and gastric cancers Syndrome Mode of inheritance Associated gene(s) Sites of primary cancer(s) Evidence for association with the syndrome  BRCA2 Hereditary Breast/Ovarian Cancer AD BRCA2    59  60  61  62  BRCA2 63 BRCA1 Hereditary Breast/Ovarian Cancer AD BRCA1   64  64 Peutz-Jeghers Syndrome AD STK 11 Gastrointestinal (GI) tract 65  65 Cowden Syndrome AD PTEN   66 67  68 Li-Fraumeni Syndrome AD TP53  CHK2       69  70  TP53 CDH1 71 73  CHK2 29 74 Familial Adenomatous Polyposis AD APC    76  APC 77 78  APC 43 Lynch Syndrome (Hereditary Nonpolyposis Colon Cancer (HNPCC)) AD hMSH2  hMLH1  hMSH6  hPMS1  hPMS2            MLH1 MSH2 76  hMLH1 79  hMLH1 80  hMSH2 hMSH2 81  82  Ataxia-telangiectasia (AT) AR ATM White blood cells ATM 32  83 85  86 Xeroderma pigmentosum AR XPA  ERCC3 (XPB)  XPC  ERCC2(XPD)  DDB2(XPE)  ERCC4(XPF)  ERCC5(XPG)  POLH(XP-V)  87 88 Werner Syndrome AR WRN   89  WRN WRN TP53 90 AD = autosomal dominant, AR = autosomal recessive CDH1 CDH1 CDH1 CDH1 CDH1