Introduction 1 3 4 5 6 2 7 8 9 10 11 12 13 14 15 16 17 18 ApoSense ApoSense ApoSense ApoSense ApoSense ApoSense Materials and methods Male Sprague-Dawley rats weighing 180–250 g and 8- to 10-week-old C57Bl mice (Harlan Laboratories, Jerusalem, Israel) were used for these experiments. All experimental protocols were performed according to the Guiding Principles for Research Involving Animals, and approved by the local Animal Care Committee; the experiments described in this manuscript also comply with the current laws of Israel. ApoSense ApoSense N N L 3 1 3 3 −4 M ApoSense 2 6 M M M 6 M M M ApoSense ApoSense 19 21 Rat renal ischemia–reperfusion (I/R) model 12 Ex Em M 3 Rat model of radiocontrast-induced distal tubular necrosis (DTN) N L 22 22 23 4 23 Sepsis model in the mouse 24 25 Statistical analysis t p Results ApoSense 1 ApoSense 26 2 Fig. 1 Concomitant confocal imaging of HeLa cell undergoing apoptosis by DDC (green fluorescence) and annexin V (red fluorescence). DDC accumulates within the cytoplasm of the apoptotic cell while annexin V is attached to the external membrane  Fig. 2 red line black line green line  ApoSense 3 3 3 p 4 4 27 30 4 4 4 4 arrow Fig. 3 a,b a b c,d c d e  Fig. 4 a left right b left right c right left arrow  3 5 p p Fig. 5 3 3 3 n Asterisks 3 p p  Radiocontrast-induced distal tubular necrosis 23 22 23 31 6 7 ApoSense 6 7 6 7 6 Fig. 6 a b c d upper panel d lower panel OM IM SP  Fig. 7 VR red stars black stars a left panel a right panel b left panel right panel  Cecal ligature/perforation-induced sepsis 32 33 8 8 8 Fig. 8 a left a right b left, arrows b right c right b left c left  Discussion ApoSense ApoSense ApoSense ApoSense 1 2 ApoSense ApoSense 3 ApoSense 4 ApoSense 4 ApoSense 34 ApoSense 6 7 4 5 ApoSense ApoSense 8 35 36 ApoSense ApoSense 3 ApoSense 18 ApoSense ApoSense ApoSense ApoSense 37 39 40 41 42 43 44 45 46 ApoSense ApoSense