Introduction 7 f 1 f 2 f 2 f 1 17 2 10 11 f 1 f 2 f 1 f 2 f 1 f 2 f 2 f 1 Materials and methods Experiments were performed in eight guinea pigs (Harlan Laboratories, The Netherlands; body weight 350–450 g) with a positive Preyer reflex. Animal care and use were in accordance with the principles of the declaration of Helsinki and approved by the animal experiment committee (protocol number 3047/3103). 17 9 f 1 f 2 f 2 f 1 11 12 f 1 f 2 f 2 f 1 f 1 f 2 f 2 f 1 ® f 1 f 2 f 1 f 2 f 2 f 1 f 1 Results n n \documentclass[12pt]{minimal}
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$$ a\exp ( - t/\tau ) + c. $$\end{document} 1 2 4 \documentclass[12pt]{minimal}
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$$ a\exp ( - t/\tau )/[1 + b\{ 1 - \exp ( - t/\tau )\} ] + c. $$\end{document} 13 τ Fig. 1 a n gray Standard error bars t b filled circles broken line τ c  Fig. 2 a n f 1 gray Standard error bars t b f 1 filled circles broken line τ c f 1  1 1 f 1 2 f 1 2 f 1 τ 2 τ f 1 f 2 3 f 1 f 2 f 1 f 2 3 Fig. 3 a n f 1 f 2 gray Standard error bars t b f 1 f 2 filled circles broken line τ c f 1 f 2  4 f 1 f 2 f 1 4 τ 4 f 1 f 2 Fig. 4 a n f 1 f 2 f 1 gray Standard error bars t b f 1 f 2 f 1 filled circles broken line τ c f 1 f 2 f 1  5 f 2 f 1 f 1 f 2 f 1 f 2 f 1 Fig. 5 n f 2 f 1 f 1 gray  Discussion 2 14 f 1 16 f 1 f 2 f 1 f 2 11 3 f 1 f 2 f 1 f 2 6 f 1 f 2 7 2 3 4 f 1 f 2 f 1 f 2 τ 9 f 1 f 2 f 2 f 1 f 2 f 1 4 5 f 1 f 2 1 f 1 f 2 f 1 f 2 f 1 1 f 1 f 2 15 Anyhow, the observed changes are small. Changes of overall inner ear fluid pressure have minor effects on cochlear function. It may be that creating an artificial endolymphatic hydrops, by injecting artificial endolymph into scala media instead of scala tympani, has a larger effect. This is currently tested in further research, which will hopefully give insight into diseases with pathologically changed inner ear fluid volumes, as in Ménière’s disease.