Introduction CTLA4 PTPN22 IL2RA IFIH1 1 2 3 4 IGF1 5 IGF1 6 7 IGF1 IGF1 Materials and methods Polymorphism identification 8 Tag-SNP selection R 2 9 ESM R 2 Genotyping p Populations studied All DNA samples were collected after ethics approval and informed consent had been obtained. Type 1 diabetes family collection 8 ALSPAC www.alspac.bris.ac.uk www.dtu.ox.ac.uk/homa/ Statistical analysis IGF1 www.stata.com/ www.r-project.org/ www-gene.cimr.cam.ac.uk/clayton/software/ 9 IGF1 10 IGF1 R 2 IGF1 IGF1 6 7 Materials and methods Results IGF1 1 1 Table 1 IGF1 Parameter Tag-SNP a rs6214 rs3730220 s6219 Sequence AAATAACT[-/AT]CTCAAATA GACTTAAC[A/G]TGTTTTCT CAGGTTGG[A/T]CTCAAACT AACCTCAA[A/G]CTGTCTAC Allele coding, 1 (minor)/2 Ins/Del A/G T/A A/G MAF in parents 0.277 0.443 0.493 0.0769 Minor allele transmissions Transmitted 815 1309 915 446 b 790 1386 942 446 Genotype 2/2 Transmitted 1,150 (53.1) 947 (33.3) 798 (33.0) 2,501 (84.8) b 3,478 (53.6) 2,724 (31.9) 2,352 (32.4 7,489 (84.6) Genotype 2/1 Transmitted 849 (39.2) 1,382 (48.5) 885 (36.6) 423 (14.3) b 2,541 (39.1) 4,226 (49.5) 2,685 (37.0) 1,297 (14.7) Genotype 1/1 Transmitted 166 (7.7) 519 (18.2) 737 (30.5) 27 (0.91) b 476 (7.3) 1,594 (18.7) 2,223 (30.6) 67 (0.8) OR for minor allele (95% CI) 1.03 (0.93–1.14) 0.94 (0.87–1.01) 0.97 (0.89–1.06) 1.00 (0.88–1.14) a b 8 p IGF1 IGF1 χ 4 2 p 1 IGF1 10 p 2 Wellcome Trust Case Control Consortium data 1 IGF1 3 Association with IGF-1 concentrations IGF1 R 2 p R 2 p 4 2 IGF1 4 IGF1 5 Table 2 IGF1 Parameter n Genotype (%) p rs35140968   I/D (58) I/I (35) D/D (7)    At birth 315 88.1 (2.8) 91.1 (3.6) 105.0 (8.9) 0.179  7 or 8 years 547 147.8 (2.9) 147.3 (3.9) 157.4 (9.1) 0.581 rs6214   G/G (34) G/A (50) A/A (16)    At birth 305 88.6 (3.6) 87.7 (3.2) 102.43 (5.30) 0.048  7 or 8 years 556 144.1 (4.0) 148.9 (3.1) 155.83 (5.70) 0.239 rs3730220   A/A (38) A/T (54) T/T (9)    Birth 299 94.1 (3.8) 88.6 (2.9) 89.6 (7.4) 0.509  7 or 8 years 548 152.0 (3.8) 145.7 (3.0) 141.8 (8.1) 0.331 rs6219   G/G (84) */A (16)    Birth 300 91.0 (2.4) 85.0 (5.7) 0.329  7 or 8 years 547 150.1 (2.5) 138.8 (5.8) 0.072 rs2946831   T/T (89) */G (11)    Birth 294 90.0 (2.3) 95.2 (7.2) 0.501  7 or 8 years 541 148.0 (2.4) 153.9 (7.1) 0.432 rs3730204   T/T (97) */C (3)    Birth 294 111.3 (13.5) 90.3 (2.3) 0.126  7 or 8 years 548 173.8 (12.9) 147.5 (2.3) 0.046 rs12579108   C/C (97) */A (3)    Birth 301 90.0 (2.2) 101.4 (12.1) 0.358  7 or 8 years 554 147.6 (2.3) 176.8 (15.9) 0.017 Values are mean (SE) for IGF-1 concentration and per cent for genotype *Additive models, adjusted for age and sex Discussion IGF1 9 IGF1 IGF1 IGF1 6 7 6 7 IGF1 8 IGF1 IGF1 IGF1 IGF1 IGF1 IGF1 Electronic supplementary material Below is the link to the electronic supplementary material.
 ESM Table 1 IGF1 ESM Table 2 IGF1 ESM Table 3 IGF1 ESM Table 4 Multilocus test for associations with IGF-1 protein levels, childhood growth and glucose metabolism in a representative birth cohort (PDF 17.1 KB) ESM Table 5 IGF1 ESM Table 6 ESM Text (PDF 81.3 KB)