Introduction ADIPOQ 1 2 3 4 5 9 ADIPOR1 ADIPOR2 10 Adipor1 Adipor2 10 ADIPOR1 ADIPOR2 10 11 ADIPOR1 ADIPOR2 11 ADIPOR1 12 ADIPOR1 ADIPOR2 13 14 ADIPOR1 15 16 ADIPOR2 15 Subjects and methods Participants Severe insulin resistance cohort 2 ADIPOR1 ADIPOR2 Cambridgeshire Case–Control Study 17 1c EPIC-Norfolk participants 18 19 1c 1c Ely Study 20 125 PCR and sequencing 21 Electronic supplementary material 1 Genotyping SNP selection Genotyping and quality control 22 2 χ p p ADIPOR1 ADIPOR2 Statistical analysis 2 1 Fig. 1 LD ADIPOR1 a ADIPOR2 b SNPs bold type SNPs SNPs boxes black for coding open for untranslated lines LD r 2 below shade of grey blocks white black r 2 a b a b ADIPOR2  Results ADIPOR1 ADIPOR2 23 ADIPOR1 ADIPOR2 3 ADIPOR1 ADIPOR2 n n 1 ADIPOR1 ADIPOR2 ADIPOR1 ADIPOR2 r 2 1 1 ADIPOR1 p 4 ADIPOR2 4 Table 1 ADIPOR1 ADIPOR2 Gene  SNP Allele Cases Controls Odds ratio p p 1/2 11 (%) 12 (%) 22 (%) 11 (%)  12 (%)  22 (%) (95% CI) ADIPOR1 rs6666089 G/A 378 (47.6) 340 (42.8) 76 (9.6) 536 (46.2) 525 (45.2) 100 (8.6) 1.00 (0.86,1.15) 0.9601 0.750 rs1539355 A/G 374 (46.6) 346 (43.1) 82 (10.2) 558 (45.9) 547 (45.0) 111 (9.1) 1.02 (0.89,1.18) 0.7350 0.649 rs2275738 C/T 277 (34.4) 379 (47.1) 149 (18.5) 395 (34.0) 551 (47.4) 216 (18.6) 0.97 (0.85,1.1) 0.6109 0.496 IVS3+85 C/G 707 (92.1) 61 (7.9) 0 (0) 1046 (92.6) 82 (7.3) 2 (0.2) 1.03 (0.73,1.45) 0.8721 0.654 rs2275735 C/T 763 (92.0) 66 (8.0) 0 (0) 1152 (93.5) 79 (6.4) 1 (0.1) 1.24 (0.88,1.75) 0.2239 0.228 rs1342387 C/T 249 (30.4) 414 (50.5) 156 (19.0) 362 (29.5) 634 (51.7) 231 (18.8) 0.96 (0.85,1.1) 0.5909 0.603 rs10581 G/A 741 (93.8) 46 (5.8) 3 (0.4) 1079 (95.7) 46 (4.1) 3 (0.3) 1.35 (0.92,1.97) 0.1281 0.466 rs7539542 C/G 373 (47.4) 336 (42.7) 78 (9.9) 554 (46.9) 510 (43.2) 117 (9.9) 1.00 (0.87,1.15) 0.9566 0.193 rs2185781 C/T 532 (63.6) 256 (30.6) 49 (5.9) 789 (63.8) 398 (32.2) 50 (4.0) 1.08 (0.92,1.26) 0.3425 0.495 ADIPOR2 rs1029629 A/C 353 (44.6) 372 (47.0) 67 (8.5) 537 (44.9) 528 (44.1) 132 (11.0) 0.94 (0.81,1.08) 0.3497 0.265 rs11061971 A/T 228 (28.1) 409 (50.4) 174 (21.5) 349 (29.5) 589 (49.7) 246 (20.8) 1.05 (0.93,1.20) 0.4394 0.092 rs4766415 A/T 207 (25.6) 411 (50.7) 192 (23.7) 323 (27.1) 586 (49.2) 282 (23.7) 1.04 (0.92,1.19) 0.5159 0.074 rs767870 A/G 575 (71.3) 214 (26.5) 18 (2.2) 857 (72.3) 310 (26.1) 19 (1.6) 1.08 (0.9,1.3) 0.3843 0.095 rs2286384 G/C 214 (25.7) 429 (51.5) 190 (22.8) 329 (26.8) 618 (50.3) 282 (22.9) 1.03 (0.9,1.17) 0.6837 * rs2286383 C/T 237 (28.6) 418 (50.4) 174 (21.0) 368 (30.1) 602 (49.2) 253 (20.7) 1.05 (0.92,1.19) 0.4598 0.068 I290 C/A 618 (75.2) 193 (23.5) 11 (1.3) 940 (77.9) 252 (21.0) 14 (1.2) 1.18 (0.97,1.44) 0.0985 0.118 rs9805042 C/T 603 (75.8) 180 (22.6) 12 (1.5) 900 (79.0) 225 (19.8) 14 (1.2) 1.17 (0.96,1.43) 0.1282 0.051 rs2286382 G/A 791 (94.5) 45 (5.4) 1 (0.1) 1159 (94.2) 71 (5.8) 0 (0) 0.98 (0.67,1.43) 0.9054 0.664 rs12342 C/T 370 (44.6) 376 (45.3) 84 (10.1) 543 (44.3) 540 (44.1) 142 (11.6) 0.96 (0.84,1.1) 0.5461 0.398 rs1044471 C/T 227 (27.8) 420 (51.5) 169 (20.7) 334 (27.6) 592 (49.0) 282 (23.3) 0.93 (0.82,1.05) 0.2500 0.115 rs2286380 A/T 621 (77.0) 176 (21.8) 10 (1.2) 947 (79.0) 238 (19.8) 15 (0.0125) 1.12 (0.91,1.37) 0.2762 0.155 rs13219 T/C 251 (30.2) 403 (48.4) 178 (21.4) 369 (30.1) 618 (50.4) 238 (19.4) 1.04 (0.91,1.18) 0.5610 0.276 rs2286379 T/C 259 (31.0) 399 (47.7) 178 (21.3) 376 (30.6) 614 (50.0) 239 (19.4) 1.03 (0.91,1.17) 0.6427 0.269 rs3815325 G/A 490 (60.6) 273 (33.7) 46 (5.7) 712 (58.7) 437 (36.0) 64 (5.3) 0.96 (0.82,1.11) 0.5785 0.263 11 12 22 p p p Discussion n n ADIPOR1 ADIPOR2 ADIPOR1 ADIPOR2 n ADIPOR1 ADIPOR2 ADIPOR1 12 15 16 12 14 13 ADIPOR1 ADIPOR2 ADIPOR2 14 15 13 p p 13 ADIPOR1 ADIPOR2 16 24 ADIPOR1 1c 24 1c 25 ADIPOR1 p 16 D r 2 p p 16 24 26 ADIPOR1 ADIPOR2 ADIPOR1 27 ADIPOR1 ADIPOR2 ADIPOR1 ADIPOR2 ADIPOR1 ADIPOR2 ADIPOR1 ADIPOR2 n n n n ADIPOR1 ADIPOR2 Electronic supplementary material Below is the link to the electronic supplementary material. 
 Table 1 ADIPOR1 ADIPOR2 Table 2 Genotyping assay results for case-control studies (DOC 61 kb) Table 3 ADIPOR1 ADIPOR2 Table 4 ADIPOR1 ADIPOR2