Introduction Drosophila Fossett and Schulz, 2001; Nemer and Nemer, 2001 GATA4 5 6 Grepin et al., 1997, 1995 GATA4 Xenopus Jiang and Evans, 1996; Latinkic et al., 2003 GATA4 Holtzinger and Evans, 2005; Kuo et al., 1997; Molkentin et al., 1997; Narita et al., 1996 GATA6 Holtzinger and Evans, 2005; Kuo et al., 1997; Molkentin et al., 1997; Narita et al., 1996; Pu et al., 2004 GATA5 6 Xenopus in vivo GATA5 Nemer and Nemer, 2002 GATA5 Reiter et al., 1999 faust tm236 GATA5 GATA4 faust tm23 GATA5 GATA4 GATA5 GATA4 5 GATA6 GATA6 Kabrun et al., 1997; Koutsourakis et al., 1999; Kuo et al., 1997; Molkentin, 2000; Molkentin et al., 1997; Morrisey et al., 1997 GATA6 Xenopus Peterkin et al., 2003 GATA6 GATA6 Peterkin et al., 2003 GATA6 Xenopus in vivo Xenopus Xenopus Materials and methods In situ hybridisation of whole-mounted and sectioned embryos Xenopus Nieuwkoop and Faber, 1967; Westerfield, 1993 Ciau-Uitz et al., 2000; Jowett, 2001; Walmsley et al., 1994 MyoD Krox20 Morpholino (MO) injection Xenopus Afouda et al. (2005) Holtzinger and Evans (2005) Xenopus Afouda et al. (2005) Xenopus Peterkin et al. (2003) Peterkin et al., 2003 Xenopus Results Xenopus Xenopus Peterkin et al., 2003 Xenopus Nemer et al., 1999 Xenopus Peterkin et al., 2003; Afouda et al., 2005 Xenopus laevis Afouda et al., 2005; Peterkin et al., 2003 Xenopus Fig. 1 Myosin Light Chain 2 MLC GATA4 Kuo et al., 1997; Molkentin et al., 1997 GATA5 faust Reiter et al., 1999 Xenopus Peterkin et al., 2003 Afouda et al., 2005; Alexander et al., 1999; Molkentin et al., 1997; Narita et al., 1997; Reiter et al., 1999; Weber et al., 2000 Nkx2.5 Tbx5 cardiac actin CA MLC Peterkin et al., 2003 Fig. 1 Figs. 1 Fig. 1 Peterkin et al., 2003 Xenopus Sox17α Afouda et al., 2005 Afouda et al., 2005 Xenopus Xenopus GATA6 GATA4 Kuo et al., 1997; Molkentin et al., 1997; Narita et al., 1996; Watt et al., 2004 Xenopus GATA5 GATA6 Xenopus MLC Nkx2.5 Fig. 2 Fig. 2 n Figs. 2 Figs. 2 MLC Xenopu Xenopus Xenopus Peterkin et al., 2003 Nkx2.5 n Fig. 3 Nkx2.5 n Fig. 3 Nkx2.5 Fig. 3 Nkx2.3 n Fig. 3 Fig. 3 Fig. 3 Xenopus GATA4 is not essential for induction or differentiation of zebrafish myocardium GATA5 faust Reiter et al., 1999 Xenopus Peterkin et al., 2003 GATA4 GATA5 GATA6 Supplementary Figs. 1 GATA5 Supplementary Figs. 1 Supplementary Fig. 1 faust Supplementary Fig. 1 Peterkin et al., 2003 nkx2.5 ventricular myosin heavy chain vmhc cardiac myosin light chain 2 cmlc2 Fig. 4 faust Peterkin et al., 2003; Reiter et al., 1999 Xenopus Peterkin et al., 2003; Reiter et al., 1999 Fig. 4 nkx2.5 vmhc cmlc2 faust n Holtzinger and Evans (2005) GATA factor redundancy in zebrafish myocardium Xenopus Fig. 4 Figs. 4 Xenopus n Xenopus Fig. 4 GATA4 Fig. 5 Fig. 5 GATA4 n Fig. 5 GATA4 nkx2.5 Fig. 5 GATA4 Xenopus GATA activity is required for induction of the myocardial programme in zebrafish Xenopus Peterkin et al., 2003 nkx2.5 faust Reiter et al., 1999 nkx2.5 Fig. 6 faust Reiter et al., 1999 GATA4 hrt tbx5 tbx5 Figs. 6 nkx2.7 Fig. 6 Xenopus nkx2.7 Discussion Redundancy GATA4 5 6 Sakai et al., 1998 Jiang et al., 1998; Kuo et al., 1997; Molkentin et al., 1997; Narita et al., 1996; Watt et al., 2004 Xenopus Xenopus Xenopus Fig. 5 Patient and McGhee, 2002 Nowak et al., 1997 Afouda et al., 2005; Capo-Chichi et al., 2005; Ketola et al., 2004; Molkentin, 2000; Yang et al., 2002 GATA4 5 6 The primary GATA factor Xenopus Xenopus Xenopus Nkx2.5 Peterkin et al., 2003 Nkx2.5 Reiter et al., 1999 Xenopus Alexandrovich et al., 2006 GATA5 Nemer and Nemer, 2002 Jiang et al., 1998 Xenopus Drosophila pannier Nkx2.5 tinman Gajewski et al., 2001; Klinedinst and Bodmer, 2003 Med1 2 Nkx2.5 ceh22 Broitman-Maduro et al., 2006; Maduro et al., 2001; Rodaway and Patient, 2001 GATA5 GATA6 Xenopus GATA4 6 Fletcher et al., in press; Rodaway et al., 1999 Xenopus GATA5 Weber et al., 2000 GATA6 GATA4 Xenopus Feedback loops and timing Davidson et al., 2002 Lee et al., 2002; Milo et al., 2002; Shen-Orr et al., 2002 Bhalla and Iyengar, 1999 Drosophila pannier tinman Gajewski et al., 2001; Klinedinst and Bodmer, 2003 Brewer et al., 2005; Davis et al., 2000; Lien et al., 1999; Molkentin et al., 2000 Davidson and Erwin, 2006 Drosophila Nkx2.5/tinman GATA/pannier Nkx2.5 Xenopus Fig. 7 Xenopus GATA5 Reiter et al., 2001 Xenopus Walters et al., 2001 Xenopus Fig. 7 Peterkin, 2003 Drosophila Drosophila tinman pannier tinman pannier pannier Dpp tinman pannier Fig. 7 Sorrentino et al., 2005 Appendix A Supplementary material Supplementary Fig. 1 Xenopus Xenopus GATA5 vmhc nkx2.5 faust tm236a  Materials and methods  Appendix A Supplementary data doi:10.1016/j.ydbio.2007.08.018