In-stent restenosis is a frequent complication, especially in the superficial femoral artery (SFA). If in-stent restenosis occurs there are several therapeutic options available such as conservative therapy and endovascular or surgical intervention. Endovascular reintervention of in- or peri-stent occlusive disease is one of the less invasive options. Endovascular therapy means passage through the occluded stent (recanalization) by additional means and redilatation or restenting of the lesion. In some cases passage of the occluded stent is not possible. 1 2 An internet search for articles describing equivalent cases revealed no results. No publications on subintimal passage of a reoccluded stent and double-barrel stenting were found in the literature. Case Report 1 2 Fig. 1. See text.  Fig. 2. See text.  The patient presented in 2004 with progressive complaints of the right leg. The patient’s maximum walking distance was 800 m but he smoked 5–10 cigarettes a day. As consistent medication the patient was on antihypertensive drugs, 40 mg simvastatin (10 mg Zocor, MSD) as well as 100 mg carbasalaatcalcium (Ascal Cardio, Viatris). There was no cardiopulmonary comorbidity. Right pedal pulses were absent with a normal pulse at the right groin. Blood pressure was 160/95 mmHg. The maximum walking distance was 160 m with a drop in the ankle/brachial index (ABI) after excercise of 0.62 to 0.23 on the right side and 0.98 to 0.55 on the left side. In conclusion, this patient had peripheral arterial occlusive disease (PaOD) staged as Fontaine class 2a. A color Doppler ultrasound (CCDS) examination of the right femoropopliteal arteries revealed in- and peri-stent restenosis with a peak systolic volume (PSV) ratio of 5.7 and distal in-stent occlusion noted over 4 cm. At that time the patient could not be persuaded to undergo any intervention and was managed conservatively. In March 2005 the patient presented again with unchanged symptoms. On physical examination the walking distance was now 240 m with an ABI drop after excercise of 0.44 to 0.22 on the right side and 0.91 to 0.52 on the left side. The patient and his attending physician discussed endovascular treatment such as recanalization of the affected vessel with PTA and/or additional stenting as a proper next option for his PaOD Fontaine class 2a lifestyle-limiting symptoms. In April 2005, an endovascular percutaneous intervention of the right SFA was performed at the Department of Radiology in our hospital. Because the patient was overweight an antegrade puncture was not a good option and the right SFA was approached by a crossover technique from the contralateral side. The right leg vessels were visualized angiographically demonstrating a stenosis of approximately 70% at the origin on the right SFA. More distally in the SFA an occlusion was noticed reaching from 4 cm proximal of the occluded stent to the upper border of the patella (The total length of this lesion was approximately 11 cm.) The 5 Fr Brite Tip sheath (Cordis, New York, USA) in the right femoral artery was changed for a long 6 Fr Balkin Up & Over flexorsheath (Cook, Bloomington, IN, USA). The sheath tip was placed in the left external iliac artery, just above the hip joint. First a PTA was performed at the origin of the SFA with a 6.0/40.0 mm balloon (Pheron, Biotronik, Switzerland) after an intravenous (IV) injection of 2,500 IU heparin, with a satisfactory angiographic result. However, it proved impossible, after several catheter-guidewire manipulation efforts, to recanalize the occluded stent with a 0.035-inch J-shaped Terumo (Terumo, USA) guidewire. Next the occluded stent was bypassed subintimally PIER-wise and the native lumen successfully re-entered just distal to the occlusion. The neo-lumen thus created was predilated with an unsatisfactory result due to recoil and consequently stented with a self-expandable 6.0/60.0 mm and a 6.0/80.0 mm stent (Absolute, Guidant, Indianapolis, IN, USA). Post-dilatation was performed with a 6.0 mm Pheron balloon. Angiographic verification of the treated arterial segment revealed an acceptable angiographic result and good runoff to patent vessels below the knee. The 2,500 IU heparin was antagonized by an IV injection of 2,500 IU protamine. The angiographic sheath was withdrawn and the puncture site managed by manual compression for 10 min without any problems. The procedure was carried out without any minor or major events or complications. One day after the procedure the patient underwent CCDS proving patency of the treated proximal SFA and newly inserted stents with no residual stenotic segments. The ABI on the right side was 1.0 and on the left side was 1.1. The patient reported a slightly painful sensation on the upper-medial side of his lower (treated) limb. On his planned check-up at the department of surgery in May 2005 the patient reported himself very satisfied with the result. The pain sensations had disappeared and there were no more limitations to his walking distance.In August 2005 his ABI on the right side was 0.85 with a drop, after exercise, to 0.25. On the left side his ABI was 0.88 with a drop, after exercise, to 0.62. On color Doppler ultrasound investigation a patent secondary stent segment and no new stenotic lesions were observed and a normal flow pattern was described. Discussion Peri- and in-stent restenosis is a common and well-known complication in the SFA region. There are several therapeutic options to solve this problem including endovascular treatment and bypass surgery. Because of our patient’s physical condition and his lifestyle-hampering symptomatology we chose was endovascular treatment in an attempt to recanalize the affected stent. During the procedure it proved impossible after several attempts to recanalize the occluded stent in the SFA, probably because of already organized and fibrosed thrombus material in the stent. The crossover was not the cause of this failure, since the pushability and steerability of the guidewire-catheter assembly was sufficient. No angioplasty could be performed in the occluded stent. After several attempts we finally managed to pass the occluded stent subintimally, successfully re-entering the native lumen distally and creating a neo-lumen side-by-side with the primary occluded stent. The neo-lumen was stented to create enough radial force to prevent its elastic recoil. Two self-expandable stents were positioned in a double-barrel fashion alongside the previously occluded stent with proper clinical and angiographic result. A retrograde puncture was preferred because of the lower complication rate compared with an antegrade approach in this obese male. Moreover a crossover introducer sheath assembly creates more possibilities for easier catheter-guidewire manipulations. Conclusion 3 1 2