Introduction 1987 1987 1991 1988 2005 1987 1990 2002 1995 1995 2000 1997 2005 Aph-1b Aph-1b Aph-1b 2005 2002 Aph-1b 2005 Aph-1b 1999 2002 2007 1990 Aph-1b Materials and methods Experimental animals 1990 1990 Arbitrarily primed-PCR Rsa Rsa Hpa Rsa Msp Hpa C Msp 1990 2 32 Taq Cloning and sequencing of AP-PCR fragments 32 Sequencing and genotyping of chromosomal region 9q22 2 Taq Quantification and statistics t Results AP-PCR DNA fingerprint patterns of the APO-SUS and APO-UNSUS rat genomes and epigenomes Rsa Hpa 1 Rsa Msp Hpa Hpa Fig. 1 Rsa Hpa Rsa Msp Msp Msp  Genetic variations between the APO-SUS and APO-UNSUS rat genomes 2 Rsa Msp Rsa Msp 2 Fig. 2 A Rsa Hpa B Rsa Hpa Rsa Msp Msp Msp Hpa C EcoR Mbo  Aph-1b Aph-1b 2005 1988 1983 EcoR Mbo n n 2 2 Epigenetic variations between the APO-SUS and APO-UNSUS rat genomes Rsa Hpa 3 n P n P n Fig. 3 A Rsa Hpa B P n P n n  Chromosomal localizations of the genetic and epigenetic variations between the APO-SUS and -UNSUS rat genomes myosin 1b 4 n n Fig. 4 Nucleotide sequence of chromosomal region 9q22, corresponding to product 3, in APO-SUS and APO-UNSUS rats. APO-SUS/-UNSUS genomic variations are indicated between brackets; the first nucleotide represents the APO-UNSUS sequence, the second nucleotide the APO-SUS sequence. The nucleotide sequences corresponding to the annealing sites of arbitrary primer AP-777 are underlined  The newly identified genetic and epigenetic variations, and apomorphine susceptibility in Wistar rats Aph-1b Aph-1b Aph-1b Aph-1b n n 5 Fig. 5 A   B  5 5 5 Discussion 2002 Aph-1b Aph-1b 2005 Aph-1b myosin 1b 2004 Aph-1b Aph-1b 2005 2001 2006 Aph-1b 2006b 2006a Aph-1b Aph-1b Aph-1b Aph-1b Aph-1b In conclusion, the present findings suggest that psychopathological disturbances may be the result of multiple genetic as well as epigenetic factors. We infer that our newly identified variations are susceptibility loci for schizophrenia-like features in the rat and may give new insights into the genetic and epigenetic background of complex neurodevelopmental disorders.