Morbidity and longevity among the middle-aged and elderly are affected by a variety of factors including genetics, social class, diet, smoking practice, alcohol consumption, and physical activity. Additionally, in some individuals and communities, the factors of attitude, regularity of life and religiosity appear important. In this contribution, some behavioural and metabolic ramifications of adverse attitude are discussed, and some examples are given of benefits conferred in populations, past and present, marked by regularity of life and religiosity. Comments are made on the possibility of persons making changes in the traits described.