This study was conducted to evaluate the effects of different glucose concentration on the survival and growth rate of juvenile hard clam, Meretrix lyrata. Juvenile clams M lyrata were cultured with algae from a tilapia-greenwater system and different concentrations of glucose (0, 35, and 70microg.l-1). After 70 days of culture, highest survival rate was obtained with 35microg.l-1 glucose supplementation (99.5-100%). However, in highest concentration of glucose, weight gain and shell length of clams reached highest values (p<0.05). Our findings showed that supplementation of probiotics and suitable glucose concentration in the nursery period could increase survival and growth rate of clams.