Demographic data of 218 centenarians in Hungary were collected, and 123 were examined by a medical team. This data showed that the centenarians are from families with a history of longevity. A larger proportion of the centenarians live in the capital, Budapest, than in the rural areas. The centenarians are mostly manual workers (rural) and nonmanual workers. Most of them live with their families. The centenarians are healthier than the general population, drug consumption is low, and they have good adaptative abilities. We compared the clinical laboratory findings of the centenarians with that of 60-80 year olds. Though age-related changes were present in the centenarians, these age-related biological changes did not hinder them from reaching very old age. Finally, we found a few differences in the immunological, clinical laboratory, and morphological profiles of this population. We anticipate more extensive elaboration on this data in future publications.