The study of genetic markers of aging is of current importance in gerontology. Data of long-liver residents of Ajara Autonomous Republic have been investigated with the aim of establishing genetic markers associated with longevity. 10 blood antigens - A, B, C, c, D, E, e, K, M, N of ABO, Rh-Hr, K, MN blood group systems have been investigated. The investigation made it possible to single out group erythrocyte pheno- and genotypic variants being in correlative relation with longevity. In particular O(I), A(II), K+, M+ belong to such phenotypic groups. Distribution of blood groups among different age groups was analysed. Rh antigens C, D, E were found to be associated with longevity.