Following up on growing evidence that higher levels of conscientiousness are associated with greater health protection, the authors conducted a meta-analysis of the association between conscientiousness-related traits and longevity. Using a random-effects analysis model, the authors statistically combined 20 independent samples. In addition, the authors used fixed-effects analyses to examine specific facets of conscientiousness and study characteristics as potential moderators of this relationship. Effect sizes were computed for each individual sample as the correlation coefficient r, based on the relationship between conscientiousness and mortality risk (all-cause mortality risk, longevity, or length of survival). Higher levels of conscientiousness were significantly and positively related to longevity (r = .11, 95% confidence interval = .05-.17). Associations were strongest for the achievement (persistent, industrious) and order (organized, disciplined) facets of conscientiousness. Results strongly support the importance of conscientiousness-related traits to health across the life span. Future research and interventions should consider how individual differences in conscientiousness may cause and be shaped by health-relevant biopsychosocial events across many years.