Tsien, Roger Y

Publication with MISMATCHING institution:

Lin MZ, Tsien RY (2010) TimeSTAMP tagging of newly synthesized proteins. Current Protocols in Protein Science.
[IF=1.128, Cited=5, 20155731].
Davalos D, Baeten KM, Whitney MA, ..., Akassoglou K (2014) Early detection of thrombin activity in neuroinflammatory
disease. Annals of Neurology. [IF=2.769, Cited=59, 24740641].
Tsien RY (2009) Constructing and exploiting the fluorescent protein paintbox (Nobel Lecture). Angewandte Chemie -
International Edition. [IF=2.456, Cited=148, 19565590].
Friedman B, Whitney MA, Savariar EN, ..., Corr M (2017) Detection of Subclinical Arthritis in Mice by a
Thrombin Receptor-Derived Imaging Agent. Arthritis and Rheumatology. [IF=3.262, Cited=2, 29164814].
Hussain T, Savariar EN, Diaz-Perez JA, ..., Nguyen QT (2015) Surgical molecular navigation with ratiometric activatable
cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers. Head and Neck.
[IF=1.334, Cited=12, 25521629].
Civitelli R, Bacskai BJ, Mahaut-Smith MP, ..., Tsien RY (1994) Single-cell analysis of cyclic AMP response to
parathyroid hormone in osteoblastic cells. Journal of Bone and Mineral Research. [IF=1.839, Cited=19, 7817824].
Orosco RK, Savariar EN, Weissbrod PA, ..., Nguyen QT (2016) Molecular targeting of papillary thyroid carcinoma with
fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model. Journal of
Surgical Oncology. [IF=1.036, Cited=4, 26799257].
Tsien RY, Harootunian AT (1990) Practical design criteria for a dynamic ratio imaging system. Cell Calcium. [IF=1.002,
Cited=92, 2354507].
Tsien RY, Bacskai BJ, Adams SR (1993) FRET for studying intracellular signalling. Trends in Cell Biology. [IF=3.592,
Cited=51, 14731760].
Adams SR, Mackey MR, Ramachandra R, ..., Tsien RY (2016) Multicolor Electron Microscopy for Simultaneous Visualization
of Multiple Molecular Species. Cell Chemical Biology. [IF=1.446, Cited=32, 27818300].
Tsien RY (2005) Building and breeding molecules to spy on cells and tumors. FEBS Letters. [IF=0.871, Cited=148, 15680976].
Raju SC, Hauff SJ, Lemieux AJ, ..., Nguyen QT (2015) Combined TP53 mutation/3p loss correlates with decreased
radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma. Oral Oncology. [IF=1.497,
Cited=10, 25735654].
Hingorani DV, Lemieux AJ, Acevedo JR, ..., Nguyen QT (2017) Early detection of squamous cell carcinoma in carcinogen
induced oral cancer rodent model by ratiometric activatable cell penetrating peptides. Oral Oncology. [IF=1.497,
Cited=4, 28688684].
Rodriguez EA, Campbell RE, Lin JY, ..., Tsien RY (2016) The Growing and Glowing Toolbox of Fluorescent and Photoactive
Proteins. Trends in Biochemical Sciences. [IF=2.462, Cited=255, 27814948].
Rodriguez EA, Wang Y, Crisp JL, ..., Ting R (2016) New Dioxaborolane Chemistry Enables [(18)F]-Positron-Emitting,
Fluorescent [(18)F]-Multimodality Biomolecule Generation from the Solid Phase. Bioconjugate Chemistry. [IF=0.921,
Cited=14, 27064381].
Jahromi AH, Wang C, Adams SR, ..., Ahrens ET (2018) Fluorous-Soluble Metal Chelate for Sensitive Fluorine-19 Magnetic
Resonance Imaging Nanoemulsion Probes. ACS Nano. [IF=2.423, Cited=19, 30525446].
Ting R, Aguilera TA, Crisp JL, ..., Tsien RY (2010) Fast 18F labeling of a near-infrared fluorophore enables positron
emission tomography and optical imaging of sentinel lymph nodes. Bioconjugate Chemistry. [IF=0.921, Cited=50, 20873712].
Weinstain R, Kanter J, Friedman B, ..., Tsien RY (2013) Fluorescent ligand for human progesterone receptor imaging in
live cells. Bioconjugate Chemistry. [IF=0.921, Cited=5, 23600997].
Shu X, Shaner NC, Yarbrough CA, ..., Remington SJ (2006) Novel chromophores and buried charges control color in mFruits.
Biochemistry. [IF=0.753, Cited=264, 16893165].
Ai Hw, Shaner NC, Cheng Z, ..., Campbell RE (2007) Exploration of new chromophore structures leads to the identification
of improved blue fluorescent proteins. Biochemistry. [IF=0.753, Cited=157, 17444659].
Wachter RM, King BA, Heim R, ..., Remington SJ (1997) Crystal structure and photodynamic behavior of the blue emission
variant Y66H/Y145F of green fluorescent protein. Biochemistry. [IF=0.753, Cited=70, 9245407].
Burdette SC, Walkup GK, Spingler B, ..., Lippard SJ (2001) Fluorescent sensors for Zn(2+) based on a fluorescein
platform: synthesis, properties and intracellular distribution. Journal of the American Chemical Society. [IF=2.573,
Cited=267, 11493056].
Adams SR, Campbell RE, Gross LA, ..., Tsien RY (2002) New biarsenical ligands and tetracysteine motifs for protein
labeling in vitro and in vivo: synthesis and biological applications. Journal of the American Chemical Society.
[IF=2.573, Cited=501, 12022841].
Gao W, Xing B, Tsien RY, Rao J (2003) Novel fluorogenic substrates for imaging beta-lactamase gene expression. Journal
of the American Chemical Society. [IF=2.573, Cited=100, 16220906].
Babendure JR, Adams SR, Tsien RY (2003) Aptamers switch on fluorescence of triphenylmethane dyes. Journal of the
American Chemical Society. [IF=2.573, Cited=212, 14640641].
Weinstain R, Savariar EN, Felsen CN, Tsien RY (2014) In vivo targeting of hydrogen peroxide by activatable cell-
penetrating peptides. Journal of the American Chemical Society. [IF=2.573, Cited=92, 24377760].
Madani F, Lind J, Damberg P, ..., Gräslund AO (2009) Hairpin structure of a biarsenical-tetracysteine motif determined
by NMR spectroscopy. Journal of the American Chemical Society. [IF=2.573, Cited=33, 19281235].
Dempsey GT, Bates M, Kowtoniuk WE, ..., Zhuang X (2009) Photoswitching mechanism of cyanine dyes. Journal of the
American Chemical Society. [IF=2.573, Cited=154, 19961226].
Nabavi S, Fox R, Proulx CD, ..., Malinow R (2014) Engineering a memory with LTD and LTP. Nature. [IF=11.591, Cited=473, 24896183].
Chung HK, Jacobs CL, Huo Y, ..., Lin MZ (2015) Tunable and reversible drug control of protein production via a self-
excising degron. Nature Chemical Biology. [IF=2.623, Cited=113, 26214256].
Ngo JT, Adams SR, Deerinck TJ, ..., Tsien RY (2016) Click-EM for imaging metabolically tagged nonprotein biomolecules.
Nature Chemical Biology. [IF=2.623, Cited=39, 27110681].
Adams SR, Yang HC, Savariar EN, ..., Advani SJ (2016) Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively
radiosensitize. Nature Communications. [IF=3.268, Cited=34, 27698471].
Kislukhin AA, Xu H, Adams SR, ..., Ahrens ET (2016) Paramagnetic fluorinated nanoemulsions for sensitive cellular
fluorine-19 magnetic resonance imaging. Nature Materials. [IF=6.645, Cited=56, 26974409].
Inagaki HK, Jung Y, Hoopfer ED, ..., Anderson DJ (2013) Optogenetic control of Drosophila using a red-shifted
channelrhodopsin reveals experience-dependent influences on courtship. Nature Methods. [IF=10.009, Cited=142, 24363022].
Rodriguez EA, Tran GN, Gross LA, ..., Tsien RY (2016) A far-red fluorescent protein evolved from a cyanobacterial
phycobiliprotein. Nature Methods. [IF=10.009, Cited=86, 27479328].
Adamantidis A, Arber S, Bains JS, ..., Wilson RI (2015) Optogenetics: 10 years after ChR2 in neurons--views from the
community. Nature Neuroscience. [IF=4.893, Cited=73, 26308981].
Maiti A, Buffalo CZ, Saurabh S, ..., Rodriguez EA (2023) Structural and photophysical characterization of the small
ultra-red fluorescent protein. Nature Communications. [IF=3.268, Cited=1, 37438348].
Aguilera TA, Olson ES, Timmers MM, ..., Tsien RY (2009) Systemic in vivo distribution of activatable cell penetrating
peptides is superior to that of cell penetrating peptides. Integrative Biology (United Kingdom). [IF=0.524, Cited=98, 20023744].
Olson ES, Aguilera TA, Jiang T, ..., Tsien RY (2009) In vivo characterization of activatable cell penetrating peptides
for targeting protease activity in cancer. Integrative Biology (United Kingdom). [IF=0.524, Cited=132, 20023745].
Tsien RY (2010) Nobel lecture: constructing and exploiting the fluorescent protein paintbox. Integrative Biology (United
Kingdom). [IF=0.524, Cited=20, 20473386].
Olson ES, Whitney MA, Friedman B, ..., Nguyen QT (2012) In vivo fluorescence imaging of atherosclerotic plaques with
activatable cell-penetrating peptides targeting thrombin activity. Integrative Biology (United Kingdom). [IF=0.524,
Cited=35, 22534729].
Asmis R, Randriamampita C, Tsien RY, Dennis EA (1994) Intracellular Ca2+, inositol 1,4,5-trisphosphate and additional
signalling in the stimulation by platelet-activating factor of prostaglandin E2 formation in P388D1 macrophage-like
cells. Biochemical Journal. [IF=0.852, Cited=21, 8141766].
Wang L, Jackson WC, Steinbach PA, Tsien RY (2004) Evolution of new nonantibody proteins via iterative somatic
hypermutation. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=242, 15556995].
Jin C, Reed JC, Tsien RY (2004) Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved
genetically encoded fluorescent sensor. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=410, 15585581].
Jiang T, Olson ES, Nguyen QT, ..., Tsien RY (2004) Tumor imaging by means of proteolytic activation of cell-penetrating
peptides. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=407, 15601762].
Honda A, Adams SR, Sawyer CL, ..., Dostmann WR (2001) Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate
revealed by a genetically encoded, fluorescent indicator. Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=139, 11226257].
Saucerman JJ, Zhang J, Martin JC, ..., McCulloch AD (2006) Systems analysis of PKA-mediated phosphorylation gradients in
live cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=95, 16905651].
Gaietta GM, Giepmans BNG, Deerinck TJ, ..., Ellisman MH (2006) Golgi twins in late mitosis revealed by genetically
encoded tags for live cell imaging and correlated electron microscopy. Proceedings of the National Academy of Sciences
of the United States of America. [IF=2.765, Cited=80, 17101980].
Hauser CT, Tsien RY (2007) A hexahistidine-Zn2+-dye label reveals STIM1 surface exposure. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=95, 17360414].
Hires SA, Zhu Y, Tsien RY (2008) Optical measurement of synaptic glutamate spillover and reuptake by linker optimized
glutamate-sensitive fluorescent reporters. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=163, 18332427].
Lin MZ, Glenn JS, Tsien RY (2008) A drug-controllable tag for visualizing newly synthesized proteins in cells and whole
animals. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=43, 18511556].
Campbell RE, Tour O, Steinbach PA, ..., Tsien RY (2002) A monomeric red fluorescent protein. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=1000, 12060735].
Nguyen QT, Olson ES, Aguilera TA, ..., Tsien RY (2010) Surgery with molecular fluorescence imaging using activatable
cell-penetrating peptides decreases residual cancer and improves survival. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=252, 20160097].
Olson ES, Jiang T, Aguilera TA, ..., Tsien RY (2010) Activatable cell penetrating peptides linked to nanoparticles as
dual probes for in vivo fluorescence and MR imaging of proteases. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=287, 20160077].
Miller EW, Lin JY, Frady EP, ..., Tsien RY (2012) Optically monitoring voltage in neurons by photo-induced electron
transfer through molecular wires. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=157, 22308458].
Qi YB, Garren EJ, Shu X, ..., Jin Y (2012) Photo-inducible cell ablation in Caenorhabditis elegans using the genetically
encoded singlet oxygen generating protein miniSOG. Proceedings of the National Academy of Sciences of the United States
of America. [IF=2.765, Cited=120, 22532663].
Lev-Ram V, Wong ST, Storm DR, Tsien RY (2002) A new form of cerebellar long-term potentiation is postsynaptic and
depends on nitric oxide but not cAMP. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=189, 12048250].
Butko MT, Savas JN, Friedman B, ..., Tsien RY (2013) In vivo quantitative proteomics of somatosensory cortical synapses
shows which protein levels are modulated by sensory deprivation. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=45, 23382246].
Shani E, Weinstain R, Zhang Y, ..., Estelle M (2013) Gibberellins accumulate in the elongating endodermal cells of
Arabidopsis root. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=95, 23382232].
Tsien RY (2013) Very long-term memories may be stored in the pattern of holes in the perineuronal net. Proceedings of
the National Academy of Sciences of the United States of America. [IF=2.765, Cited=117, 23832785].
Glasgow HL, Whitney MA, Gross LA, ..., Tsien RY (2016) Laminin targeting of a peripheral nerve-highlighting peptide
enables degenerated nerve visualization. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=13, 27791138].
Hasegawa S, Jackson WC, Tsien RY, Rao J (2003) Imaging Tetrahymena ribozyme splicing activity in single live mammalian
cells. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=18, 14645710].
Ting AY, Ting A, Kain KH, ..., Tsien RY (2001) Genetically encoded fluorescent reporters of protein tyrosine kinase
activities in living cells. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=252, 11752449].
Zhang J, Ma Y, Taylor SS, Tsien RY (2001) Genetically encoded reporters of protein kinase A activity reveal impact of
substrate tethering. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=352, 11752448].
Lev-Ram V, Mehta SB, Kleinfeld D, Tsien RY (2003) Reversing cerebellar long-term depression. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=85, 14671315].
Lipscombe D, Madison DV, Poenie M, ..., Tsien RW (1988) Spatial distribution of calcium channels and cytosolic calcium
transients in growth cones and cell bodies of sympathetic neurons. Proceedings of the National Academy of Sciences of
the United States of America. [IF=2.765, Cited=142, 2451249].
Heim R, Prasher DC, Tsien RY (1994) Wavelength mutations and posttranslational autoxidation of green fluorescent
protein. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=811, 7809066].
Brejc K, Sixma TK, Kitts PA, ..., Remington SJ (1997) Structural basis for dual excitation and photoisomerization of the
Aequorea victoria green fluorescent protein. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=307, 9122190].
Llopis J, McCaffery JM, Miyawaki A, ..., Tsien RY (1998) Measurement of cytosolic, mitochondrial, and Golgi pH in single
living cells with green fluorescent proteins. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=586, 9618493].
Baird GS, Zacharias DA, Tsien RY (1999) Circular permutation and receptor insertion within green fluorescent proteins.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=504, 10500161].
Furuta T, Wang SS, Dantzker JL, ..., Tsien RY (1999) Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting
groups with biologically useful cross-sections for two photon photolysis. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=241, 9990000].
Miyawaki A, Griesbeck O, Heim R, Tsien RY (1999) Dynamic and quantitative Ca2+ measurements using improved cameleons.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=482, 10051607].
Baird GS, Zacharias DA, Tsien RY (2000) Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent
protein from coral. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=484, 11050229].
Gross LA, Baird GS, Hoffman RC, ..., Tsien RY (2000) The structure of the chromophore within DsRed, a red fluorescent
protein from coral. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=294, 11050230].
Heikal AA, Hess ST, Baird GS, ..., Webb WW (2000) Molecular spectroscopy and dynamics of intrinsically fluorescent
proteins: coral red (dsRed) and yellow (Citrine). Proceedings of the National Academy of Sciences of the United States
of America. [IF=2.765, Cited=168, 11050231].
Llopis J, Westin S, Ricote M, ..., Glass CK (2000) Ligand-dependent interactions of coactivators steroid receptor
coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be
imaged in live cells and are required for transcription. Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=78, 10760302].
Sammak PJ, Adams SR, Harootunian AT, ..., Tsien RY (1992) Intracellular cyclic AMP not calcium, determines the direction
of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging. Journal of Cell Biology.
[IF=1.509, Cited=84, 1348251].
LaMorte VJ, Harootunian AT, Spiegel AM, ..., Feramisco JR (1993) Mediation of growth factor induced DNA synthesis and
calcium mobilization by Gq and Gi2. Journal of Cell Biology. [IF=1.509, Cited=65, 8458876].
Deerinck TJ, Martone ME, Lev-Ram V, ..., Ellisman MH (1994) Fluorescence photooxidation with eosin: a method for high
resolution immunolocalization and in situ hybridization detection for light and electron microscopy. Journal of Cell
Biology. [IF=1.509, Cited=104, 7519623].
Lin P, Yao Y, Hofmeister R, ..., Farquhar MG (1999) Overexpression of CALNUC (nucleobindin) increases agonist and
thapsigargin releasable Ca2+ storage in the Golgi. Journal of Cell Biology. [IF=1.509, Cited=84, 10209024].
Violin JD, Zhang J, Tsien RY, Newton AC (2003) A genetically encoded fluorescent reporter reveals oscillatory
phosphorylation by protein kinase C. Journal of Cell Biology. [IF=1.509, Cited=354, 12782683].
Yao Y, Tsien RY (1997) Calcium current activated by depletion of calcium stores in Xenopus oocytes. Journal of General
Physiology. [IF=0.994, Cited=46, 9222897].
Harootunian AT, Adams SR, Wen W, ..., Tsien RY (1993) Movement of the free catalytic subunit of cAMP-dependent protein
kinase into and out of the nucleus can be explained by diffusion. Molecular Biology of the Cell. [IF=0.848, Cited=114, 8298196].
Jorgenson LA, Newsome WT, Anderson DJ, ..., Wingfield JC (2015) The BRAIN Initiative: developing technology to catalyse
neuroscience discovery. Philosophical Transactions of the Royal Society B: Biological Sciences. [IF=1.629, Cited=90, 25823863].
Lemieux SP, Lev-Ram V, Tsien RY, Ellisman MH (2023) Perineuronal nets and the neuronal extracellular matrix can be
imaged by genetically encoded labeling of HAPLN1 in vitro and in vivo. None. [IF=None, Cited=0, 38076839].
Zacharias DA, Violin JD, Newton AC, Tsien RY (2002) Partitioning of lipid-modified monomeric GFPs into membrane
microdomains of live cells. Science. [IF=7.729, Cited=1000, 11988576].
Gaietta G, Deerinck TJ, Adams SR, ..., Ellisman MH (2002) Multicolor and electron microscopic imaging of connexin
trafficking. Science. [IF=7.729, Cited=537, 11964472].
Giepmans BNG, Adams SR, Ellisman MH, Tsien RY (2006) The fluorescent toolbox for assessing protein location and
function. Science. [IF=7.729, Cited=1000, 16614209].
Shu X, Royant A, Lin MZ, ..., Tsien RY (2009) Mammalian expression of infrared fluorescent proteins engineered from a
bacterial phytochrome. Science. [IF=7.729, Cited=369, 19423828].
Harootunian AT, Kao JP, Paranjape S, Tsien RY (1991) Generation of calcium oscillations in fibroblasts by positive
feedback between calcium and IP3. Science. [IF=7.729, Cited=187, 1986413].
Ormö M, Cubitt AB, Kallio K, ..., Remington SJ (1996) Crystal structure of the Aequorea victoria green fluorescent
protein. Science. [IF=7.729, Cited=1000, 8703075].
Zlokarnik G, Negulescu PA, Knapp TE, ..., Tsien RY (1998) Quantitation of transcription and clonal selection of single
living cells with beta-lactamase as reporter. Science. [IF=7.729, Cited=376, 9417030].
Tsien RY, Miyawaki A (1998) Seeing the machinery of live cells. Science. [IF=7.729, Cited=80, 9669950].
Griffin BA, Adams SR, Tsien RY (1998) Specific covalent labeling of recombinant protein molecules inside live cells.
Science. [IF=7.729, Cited=809, 9657724].
Siegel RM, Frederiksen JK, Zacharias DA, ..., Lenardo MJ (2000) Fas preassociation required for apoptosis signaling and
dominant inhibition by pathogenic mutations. Science. [IF=7.729, Cited=372, 10875918].
Allen GJ, Chu SP, Chu S, ..., Schroeder JI (2000) Alteration of stimulus-specific guard cell calcium oscillations and
stomatal closing in Arabidopsis det3 mutant. Science. [IF=7.729, Cited=255, 11009417].
Bacskai BJ, Hochner B, Mahaut-Smith M, ..., Tsien RY (1993) Spatially resolved dynamics of cAMP and protein kinase A
subunits in Aplysia sensory neurons. Science. [IF=7.729, Cited=310, 7682336].
Siegel RM, Chan FK, Zacharias DA, ..., Lenardo MJ (2000) Measurement of molecular interactions in living cells by
fluorescence resonance energy transfer between variants of the green fluorescent protein. None. [IF=None, Cited=59, 11752595].
Tsien RY (1998) The green fluorescent protein. Annual Review of Biochemistry. [IF=5.273, Cited=1000, 9759496].
Tsien RW, Tsien RY (1990) Calcium channels, stores, and oscillations. None. [IF=None, Cited=648, 2177344].
Tsien RY (1992) Intracellular signal transduction in four dimensions: from molecular design to physiology. None.
[IF=None, Cited=49, 1329539].
Felsen CN, Savariar EN, Whitney M, Tsien RY (2014) Detection and monitoring of localized matrix metalloproteinase
upregulation in a murine model of asthma. American Journal of Physiology - Lung Cellular and Molecular Physiology.
[IF=0.96, Cited=14, 24508733].
Ouyang M, Huang H, Shaner NC, ..., Wang Y (2010) Simultaneous visualization of protumorigenic Src and MT1-MMP activities
with fluorescence resonance energy transfer. Cancer Research. [IF=1.624, Cited=81, 20197470].
Savariar EN, Felsen CN, Nashi N, ..., Nguyen QT (2012) Real-time in vivo molecular detection of primary tumors and
metastases with ratiometric activatable cell-penetrating peptides. Cancer Research. [IF=1.624, Cited=88, 23188503].
Buckel L, Savariar EN, Crisp JL, ..., Advani SJ (2015) Tumor radiosensitization by monomethyl auristatin E: mechanism of
action and targeted delivery. Cancer Research. [IF=1.624, Cited=37, 25681274].
Ray P, De A, Min JJ, ..., Gambhir SS (2004) Imaging tri-fusion multimodality reporter gene expression in living
subjects. Cancer Research. [IF=1.624, Cited=185, 14973078].
Crisp JL, Savariar EN, Glasgow HL, ..., Tsien RY (2014) Dual targeting of integrin αvβ3 and matrix metalloproteinase-2
for optical imaging of tumors and chemotherapeutic delivery. Molecular Cancer Therapeutics. [IF=1.04, Cited=50, 24737028].
Hauff SJ, Raju SC, Orosco RK, ..., Nguyen QT (2014) Matrix-metalloproteinases in head and neck carcinoma-cancer genome
atlas analysis and fluorescence imaging in mice. Otolaryngology - Head and Neck Surgery. [IF=1.877, Cited=19, 25091190].
Chen S, Cui J, Jiang T, ..., Gu Z (2015) Gelatinase activity imaged by activatable cell-penetrating peptides in cell-
based and in vivo models of stroke. Journal of Cerebral Blood Flow and Metabolism. [IF=1.519, Cited=11, 26681768].
Wang Y, An FF, Chan M, ..., Ting R (2017) ¹⁸F-positron-emitting/fluorescent labeled erythrocytes allow
imaging of internal hemorrhage in a murine intracranial hemorrhage model. Journal of Cerebral Blood Flow and Metabolism.
[IF=1.519, Cited=10, 28054494].
Li CJ, Heim R, Lu P, ..., Chang DC (1999) Dynamic redistribution of calmodulin in HeLa cells during cell division as
revealed by a GFP-calmodulin fusion protein technique. Journal of Cell Science. [IF=0.99, Cited=61, 10212150].
Harootunian AT, Kao JP, Adams SR, Tsien RY (1990) Imaging and manipulation of cytosolic ions and messengers during cell
activation. None. [IF=None, Cited=1, 2084112].
Levin RA, Felsen CN, Yang J, ..., Tsien RY (2014) An optimized triple modality reporter for quantitative in vivo tumor
imaging and therapy evaluation. PLoS ONE. [IF=1.253, Cited=10, 24816650].
Hussain T, Mastrodimos MB, Raju SC, ..., Nguyen QT (2015) Fluorescently labeled peptide increases identification of
degenerated facial nerve branches during surgery and improves functional outcome. PLoS ONE. [IF=1.253, Cited=13, 25751149].
Malone CD, Olson ES, Mattrey RF, ..., Nguyen QT (2015) Tumor Detection at 3 Tesla with an Activatable Cell Penetrating
Peptide Dendrimer (ACPPD-Gd), a T1 Magnetic Resonance (MR) Molecular Imaging Agent. PLoS ONE. [IF=1.253, Cited=7, 26336058].
Hua N, Baik F, Pham T, ..., Hamilton JA (2015) Identification of High-Risk Plaques by MRI and Fluorescence Imaging in a
Rabbit Model of Atherothrombosis. PLoS ONE. [IF=1.253, Cited=9, 26448434].
Hingorani DV, Lippert CN, Crisp JL, ..., Ellies LG (2018) Impact of MMP-2 and MMP-9 enzyme activity on wound healing,
tumor growth and RACPP cleavage. PLoS ONE. [IF=1.253, Cited=24, 30248101].
Palida SF, Butko MT, Ngo JT, ..., Tsien RY (2015) PKMζ, but not PKCλ, is rapidly synthesized and degraded at the
neuronal synapse. Journal of Neuroscience. [IF=1.471, Cited=20, 25995463].
Tsien RY (2006) Breeding and building molecules to spy on cells and tumors. Keio Journal of Medicine. [IF=1.024,
Cited=11, 17191067].
Miampamba M, Liu J, Harootunian A, ..., González JE (2017) Sensitive in vivo Visualization of Breast Cancer Using
Ratiometric Protease-activatable Fluorescent Imaging Agent, AVB-620. Theranostics. [IF=1.893, Cited=35, 28900516].
Hingorani DV, Whitney MA, Friedman B, ..., Nguyen QT (2018) Nerve-targeted probes for fluorescence-guided intraoperative
imaging. Theranostics. [IF=1.893, Cited=28, 30128049].
Tsien RY (2003) Imagining imaging's future. Nature Reviews Molecular Cell Biology. [IF=19.213, Cited=0, 14587522].
Tsien RY (None) Breeding molecules to spy on cells. None. [IF=None, Cited=0, 15984552].

Publication with MISSING institution:

Chan FK, Siegel RM, Zacharias D, ..., Lenardo MJ (2001) Fluorescence resonance energy transfer analysis of cell surface
receptor interactions and signaling using spectral variants of the green fluorescent protein. None. [IF=None, Cited=68, 11500853].
Whitney M, Savariar EN, Friedman B, ..., Tsien RY (2012) Ratiometric activatable cell-penetrating peptides provide rapid
in vivo readout of thrombin activation. Angewandte Chemie - International Edition. [IF=2.456, Cited=50, 23080482].
Furuta T, Takeuchi H, Isozaki M, ..., Tsien RY (2004) Bhc-cNMPs as either water-soluble or membrane-permeant
photoreleasable cyclic nucleotides for both one- and two-photon excitation. ChemBioChem. [IF=0.691, Cited=38, 15300837].
Chused TM, Wilson HA, Greenblatt D, ..., Finkelman FD (1987) Flow cytometric analysis of murine splenic B lymphocyte
cytosolic free calcium response to anti-IgM and anti-IgD. None. [IF=None, Cited=38, 3497786].
Poenie M, Tsien RY, Schmitt-Verhulst AM (1987) Sequential activation and lethal hit measured by [Ca2+]i in individual
cytolytic T cells and targets. EMBO Journal. [IF=2.114, Cited=134, 3499312].
Wu AP, Whitney MA, Crisp JL, ..., Nguyen QT (2011) Improved facial nerve identification with novel fluorescently labeled
probe. Laryngoscope. [IF=1.63, Cited=25, 21328585].
Raz E, Zlokarnik G, Tsien RY, Driever W (1998) beta-lactamase as a marker for gene expression in live zebrafish embryos.
Developmental Biology. [IF=0.815, Cited=11, 9808780].
Griffin BA, Adams SR, Tsien RY (2015) How FlAsH got its sparkle: historical recollections of the biarsenical-
tetracysteine tag. Methods in Molecular Biology. [IF=0.413, Cited=2, 25560064].
Briggman KL, Kristan WB, González JE, ..., Tsien RY (2015) Monitoring Integrated Activity of Individual Neurons Using
FRET-Based Voltage-Sensitive Dyes. Advances in Experimental Medicine and Biology. [IF=0.945, Cited=3, 26238052].
Tsien RY, Hladky SB (1978) A quantitative resolution of the spectra of a membrane potential indicator, diS-C3-(5), bound
to cell components and to red blood cells. Journal of Membrane Biology. [IF=0.733, Cited=24, 625049].
Tsien RY, Rink TJ (1980) Neutral carrier ion-selective microelectrodes for measurement of intracellular free calcium.
None. [IF=None, Cited=278, 7407109].
Rink TJ, Montecucco C, Hesketh TR, Tsien RY (1980) Lymphocyte membrane potential assessed with fluorescent probes. None.
[IF=None, Cited=202, 6153065].
Rink TJ, Smith SW, Tsien RY (1982) Cytoplasmic free Ca2+ in human platelets: Ca2+ thresholds and Ca-independent
activation for shape-change and secretion. FEBS Letters. [IF=0.871, Cited=298, 6816632].
Wen W, Meinkoth JL, Tsien RY, Taylor SS (1995) Identification of a signal for rapid export of proteins from the nucleus.
Cell. [IF=8.479, Cited=760, 7634336].
Tsien RY, Rink TJ, Poenie M (1985) Measurement of cytosolic free Ca2+ in individual small cells using fluorescence
microscopy with dual excitation wavelengths. Cell Calcium. [IF=1.002, Cited=361, 3874696].
Harootunian AT, Kao JP, Paranjape S, ..., Tsien RY (1991) Cytosolic Ca2+ oscillations in REF52 fibroblasts:
Ca(2+)-stimulated IP3 production or voltage-dependent Ca2+ channels as key positive feedback elements. Cell Calcium.
[IF=1.002, Cited=28, 1647875].
Tsien RY, Rink TJ (1981) Ca2+-selective electrodes: a novel PVC-gelled neutral carrier mixture compared with other
currently available sensors. Journal of Neuroscience Methods. [IF=0.87, Cited=67, 7253701].
Tsien RY (1988) Fluorescence measurement and photochemical manipulation of cytosolic free calcium. Trends in
Neurosciences. [IF=3.343, Cited=119, 2469158].
Lipscombe D, Madison DV, Poenie M, ..., Tsien RY (1988) Imaging of cytosolic Ca2+ transients arising from Ca2+ stores
and Ca2+ channels in sympathetic neurons. Neuron. [IF=3.346, Cited=236, 2856095].
Ranganathan R, Bacskai BJ, Tsien RY, Zuker CS (1994) Cytosolic calcium transients: spatial localization and role in
Drosophila photoreceptor cell function. Neuron. [IF=3.346, Cited=88, 7946332].
Lev-Ram V, Makings LR, Keitz PF, ..., Tsien RY (1995) Long-term depression in cerebellar Purkinje neurons results from
coincidence of nitric oxide and depolarization-induced Ca2+ transients. Neuron. [IF=3.346, Cited=120, 7646893].
Bacskai BJ, Wallén P, Lev-Ram V, ..., Tsien RY (1995) Activity-related calcium dynamics in lamprey motoneurons as
revealed by video-rate confocal microscopy. Neuron. [IF=3.346, Cited=47, 7826636].
Tsien RY (1978) A virial expansion for discrete charges buried in a membrane. Biophysical Journal. [IF=0.842, Cited=9, 728530].
Tsien RY, Hladky SB (1982) Ion repulsion within membranes. Biophysical Journal. [IF=0.842, Cited=11, 7104450].
Tsien RY, Zucker RS (1986) Control of cytoplasmic calcium with photolabile tetracarboxylate 2-nitrobenzhydrol chelators.
Biophysical Journal. [IF=0.842, Cited=46, 3098316].
Kao JP, Tsien RY (1988) Ca2+ binding kinetics of fura-2 and azo-1 from temperature-jump relaxation measurements.
Biophysical Journal. [IF=0.842, Cited=98, 3382715].
González JE, Tsien RY (1995) Voltage sensing by fluorescence resonance energy transfer in single cells. Biophysical
Journal. [IF=0.842, Cited=92, 8534797].
Brown EB, Shear JB, Shear JB, ..., Webb WW (1999) Photolysis of caged calcium in femtoliter volumes using two-photon
excitation. Biophysical Journal. [IF=0.842, Cited=84, 9876162].
Fan GY, Fujisaki H, Miyawaki A, ..., Ellisman MH (1999) Video-rate scanning two-photon excitation fluorescence
microscopy and ratio imaging with cameleons. Biophysical Journal. [IF=0.842, Cited=119, 10233058].
Lin JY, Lin MZ, Steinbach P, Tsien RY (2009) Characterization of engineered channelrhodopsin variants with improved
properties and kinetics. Biophysical Journal. [IF=0.842, Cited=412, 19254539].
Ou HD, Kwiatkowski W, Deerinck TJ, ..., O'Shea CC (2012) A structural basis for the assembly and functions of a viral
polymer that inactivates multiple tumor suppressors. Cell. [IF=8.479, Cited=59, 23063122].
Giacomello M, Kortemme T, Hires SA, ..., Tsien RY (2006) Ca2+ indicators based on computationally redesigned calmodulin-
peptide pairs. None. [IF=None, Cited=319, 16720273].
Martin BR, Deerinck TJ, Ellisman MH, ..., Tsien RY (2007) Isoform-specific PKA dynamics revealed by dye-triggered
aggregation and DAKAP1alpha-mediated localization in living cells. None. [IF=None, Cited=38, 17884635].
Lin MZ, McKeown MR, Ng HL, ..., Tsien RY (2009) Autofluorescent proteins with excitation in the optical window for
intravital imaging in mammals. None. [IF=None, Cited=145, 19942140].
Chae HJ, Kim HR, Xu C, ..., Reed JC (2004) BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress.
Molecular Cell. [IF=2.773, Cited=196, 15304216].
Lin JY, Sann SB, Zhou K, ..., Tsien RY (2013) Optogenetic inhibition of synaptic release with chromophore-assisted light
inactivation (CALI). Neuron. [IF=3.346, Cited=102, 23889931].
Miyawaki A, Tsien RY (2000) Monitoring protein conformations and interactions by fluorescence resonance energy transfer
between mutants of green fluorescent protein. None. [IF=None, Cited=237, 11045004].
Wu MM, Llopis J, Adams SR, ..., Tsien RY (2000) Studying organelle physiology with fusion protein-targeted avidin and
fluorescent biotin conjugates. None. [IF=None, Cited=15, 11045008].
Griffin BA, Adams SR, Jones J, Tsien RY (2000) Fluorescent labeling of recombinant proteins in living cells with FlAsH.
None. [IF=None, Cited=138, 11045009].
Arancio O, Kiebler M, Lee CJ, ..., Hawkins RD (1996) Nitric oxide acts directly in the presynaptic neuron to produce
long-term potentiation in cultured hippocampal neurons. Cell. [IF=8.479, Cited=229, 8978607].
Yao Y, Ferrer-Montiel AV, Montal M, Tsien RY (1999) Activation of store-operated Ca2+ current in Xenopus oocytes
requires SNAP-25 but not a diffusible messenger. Cell. [IF=8.479, Cited=156, 10481912].
Lev-Ram V, Jiang T, Wood J, ..., Tsien RY (1997) Synergies and coincidence requirements between NO, cGMP, and Ca2+ in
the induction of cerebellar long-term depression. Neuron. [IF=3.346, Cited=149, 9208868].
Cacciatore TW, Brodfuehrer PD, Gonzalez JE, ..., Kleinfeld D (1999) Identification of neural circuits by imaging
coherent electrical activity with FRET-based dyes. Neuron. [IF=3.346, Cited=50, 10433258].
Kerr R, Lev-Ram V, Baird G, ..., Schafer WR (2000) Optical imaging of calcium transients in neurons and pharyngeal
muscle of C. elegans. Neuron. [IF=3.346, Cited=247, 10896155].
Tsai PS, Friedman B, Ifarraguerri AI, ..., Kleinfeld D (2003) All-optical histology using ultrashort laser pulses.
Neuron. [IF=3.346, Cited=102, 12848930].
Arancio O, Lev-Ram V, Tsien RY, ..., Hawkins RD (1996) Nitric oxide acts as a retrograde messenger during long-term
potentiation in cultured hippocampal neurons. None. [IF=None, Cited=22, 9089501].
Zacharias DA, Baird GS, Tsien RY (2000) Recent advances in technology for measuring and manipulating cell signals.
Current Opinion in Neurobiology. [IF=1.341, Cited=52, 10851181].
Heim R, Tsien RY (1996) Engineering green fluorescent protein for improved brightness, longer wavelengths and
fluorescence resonance energy transfer. Current Biology. [IF=1.81, Cited=708, 8673464].
Rizzuto R, Brini M, De Giorgi F, ..., Pozzan T (1996) Double labelling of subcellular structures with organelle-targeted
GFP mutants in vivo. Current Biology. [IF=1.81, Cited=125, 8673465].
Thomas D, Lipp P, Tovey SC, ..., Bootman MD (2000) Microscopic properties of elementary Ca2+ release sites in non-
excitable cells. Current Biology. [IF=1.81, Cited=61, 10660296].
Cubitt AB, Heim R, Adams SR, ..., Tsien RY (1995) Understanding, improving and using green fluorescent proteins. Trends
in Biochemical Sciences. [IF=2.462, Cited=637, 8578587].
Wu MM, Llopis J, Adams S, ..., Tsien RY (2000) Organelle pH studies using targeted avidin and fluorescein-biotin. None.
[IF=None, Cited=103, 10712929].
Scheenen WJ, Makings LR, Gross LR, ..., Tsien RY (1996) Photodegradation of indo-1 and its effect on apparent Ca2+
concentrations. None. [IF=None, Cited=34, 8939693].
González JE, Tsien RY (1997) Improved indicators of cell membrane potential that use fluorescence resonance energy
transfer. None. [IF=None, Cited=95, 9195864].
Adams SR, Lev-Ram V, Tsien RY (1997) A new caged Ca2+, azid-1, is far more photosensitive than nitrobenzyl-based
chelators. None. [IF=None, Cited=32, 9384535].
Tsien RY (1980) New calcium indicators and buffers with high selectivity against magnesium and protons: design,
synthesis, and properties of prototype structures. Biochemistry. [IF=0.753, Cited=1000, 6770893].
Woodford CR, Frady EP, Smith RS, ..., Tsien RY (2015) Improved PeT molecules for optically sensing voltage in neurons.
Journal of the American Chemical Society. [IF=2.573, Cited=58, 25584688].
Ortac I, Simberg D, Yeh Ys, ..., Esener S (2014) Dual-porosity hollow nanoparticles for the immunoprotection and
delivery of nonhuman enzymes. Nano Letters. [IF=1.873, Cited=16, 24471767].
Tsien RY (1999) Rosy dawn for fluorescent proteins. Nature Biotechnology. [IF=8.861, Cited=25, 10504692].
Rink TJ, Tsien RY, Warner AE (1980) Free calcium in Xenopus embryos measured with ion-selective microelectrodes. Nature.
[IF=11.591, Cited=73, 7354852].
Marban E, Rink TJ, Tsien RW, Tsien RY (1980) Free calcium in heart muscle at rest and during contraction measured with
Ca2+ -sensitive microelectrodes. Nature. [IF=11.591, Cited=146, 7412868].
Tsien RY (1981) A non-disruptive technique for loading calcium buffers and indicators into cells. Nature. [IF=11.591,
Cited=562, 7219539].
Tsien RY, Pozzan T, Rink TJ (1982) T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential
in lymphocytes. Nature. [IF=11.591, Cited=636, 6799829].
Lew VL, Tsien RY, Miner C, Bookchin RM (1982) Physiological [Ca2+]i level and pump-leak turnover in intact red cells
measured using an incorporated Ca chelator. Nature. [IF=11.591, Cited=126, 6283392].
Moolenaar WH, Tsien RY, van der Saag PT, de Laat SW (None) Na+/H+ exchange and cytoplasmic pH in the action of growth
factors in human fibroblasts. Nature. [IF=11.591, Cited=389, 6410286].
Poenie M, Alderton J, Tsien RY, Steinhardt RA (None) Changes of free calcium levels with stages of the cell division
cycle. Nature. [IF=11.591, Cited=316, 3838803].
Williams DA, Fogarty KE, Tsien RY, Fay FS (None) Calcium gradients in single smooth muscle cells revealed by the digital
imaging microscope using Fura-2. Nature. [IF=11.591, Cited=353, 3934562].
Li W, Llopis J, Whitney M, ..., Tsien RY (1998) Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can
optimize gene expression. Nature. [IF=11.591, Cited=523, 9582076].
Paradiso AM, Tsien RY, Machen TE (None) Digital image processing of intracellular pH in gastric oxyntic and chief cells.
Nature. [IF=11.591, Cited=51, 3808046].
Chen WS, Lazar CS, Poenie M, ..., Rosenfeld MG (None) Requirement for intrinsic protein tyrosine kinase in the immediate
and late actions of the EGF receptor. Nature. [IF=11.591, Cited=333, 3498122].
Adams SR, Harootunian AT, Buechler YJ, ..., Tsien RY (1991) Fluorescence ratio imaging of cyclic AMP in single cells.
Nature. [IF=11.591, Cited=324, 1847505].
Matsuyama S, Llopis J, Deveraux QL, ..., Reed JC (2000) Changes in intramitochondrial and cytosolic pH: early events
that modulate caspase activation during apoptosis. Nature Cell Biology. [IF=3.908, Cited=420, 10854321].
Randriamampita C, Tsien RY (1993) Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates
Ca2+ influx. Nature. [IF=11.591, Cited=532, 8355806].
Vajanaphanich M, Schultz C, Rudolf MT, ..., Traynor-Kaplan A (1994) Long-term uncoupling of chloride secretion from
intracellular calcium levels by Ins(3,4,5,6)P4. Nature. [IF=11.591, Cited=99, 7935818].
Heim R, Cubitt AB, Tsien RY (1995) Improved green fluorescence. Nature. [IF=11.591, Cited=932, 7854443].
Hempel CM, Vincent P, Adams SR, ..., Selverston AI (1996) Spatio-temporal dynamics of cyclic AMP signals in an intact
neural circuitm. Nature. [IF=11.591, Cited=100, 8906791].
Dickson RM, Cubitt AB, Tsien RY, ..., Moerner WE (1997) On/off blinking and switching behaviour of single molecules of
green fluorescent protein. Nature. [IF=11.591, Cited=508, 9237752].
Miyawaki A, Llopis J, Heim R, ..., Tsien RY (1997) Fluorescent indicators for Ca2+ based on green fluorescent proteins
and calmodulin. Nature. [IF=11.591, Cited=1000, 9278050].
Zaccolo M, De Giorgi F, Cho CY, ..., Pozzan T (2000) A genetically encoded, fluorescent indicator for cyclic AMP in
living cells. Nature Cell Biology. [IF=3.908, Cited=264, 10620803].
Gilman AG, Harris BA, Long R, ..., Sambrano GR (2002) Overview of the Alliance for Cellular Signaling. Nature.
[IF=11.591, Cited=71, 12478301].
Wang Y, Botvinick EL, Zhao Y, ..., Chien S (2005) Visualizing the mechanical activation of Src. Nature. [IF=11.591,
Cited=410, 15846350].
Zhang J, Hupfeld CJ, Taylor SS, ..., Tsien RY (2005) Insulin disrupts beta-adrenergic signalling to protein kinase A in
adipocytes. Nature. [IF=11.591, Cited=200, 16177793].
Whitney MA, Crisp JL, Nguyen LT, ..., Nguyen QT (2011) Fluorescent peptides highlight peripheral nerves during surgery
in mice. Nature Biotechnology. [IF=8.861, Cited=111, 21297616].
Shaner NC, Campbell RE, Steinbach PA, ..., Tsien RY (2004) Improved monomeric red, orange and yellow fluorescent
proteins derived from Discosoma sp. red fluorescent protein. Nature Biotechnology. [IF=8.861, Cited=1000, 15558047].
Martin BR, Giepmans BNG, Adams SR, Tsien RY (2005) Mammalian cell-based optimization of the biarsenical-binding
tetracysteine motif for improved fluorescence and affinity. Nature Biotechnology. [IF=8.861, Cited=256, 16155565].
Tour O, Meijer RM, Zacharias DA, ..., Tsien RY (2003) Genetically targeted chromophore-assisted light inactivation.
Nature Biotechnology. [IF=8.861, Cited=133, 14625562].
Tour O, Adams SR, Kerr RA, ..., Tsien RY (2007) Calcium Green FlAsH as a genetically targeted small-molecule calcium
indicator. Nature Chemical Biology. [IF=2.623, Cited=96, 17572670].
Ando H, Furuta T, Tsien RY, Okamoto H (2001) Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos.
Nature Genetics. [IF=6.89, Cited=191, 11479592].
Shaner NC, Lin MZ, McKeown MR, ..., Tsien RY (2008) Improving the photostability of bright monomeric orange and red
fluorescent proteins. Nature Methods. [IF=10.009, Cited=586, 18454154].
Wallace DJ, Meyer zum Alten Borgloh S, Astori S, ..., Hasan MT (2008) Single-spike detection in vitro and in vivo with a
genetic Ca2+ sensor. Nature Methods. [IF=10.009, Cited=106, 19160514].
Lam AJ, St-Pierre F, Gong Y, ..., Lin MZ (2012) Improving FRET dynamic range with bright green and red fluorescent
proteins. Nature Methods. [IF=10.009, Cited=452, 22961245].
Hoffmann C, Gaietta G, Bünemann M, ..., Lohse MJ (2005) A FlAsH-based FRET approach to determine G protein-coupled
receptor activation in living cells. Nature Methods. [IF=10.009, Cited=288, 15782185].
Shaner NC, Steinbach PA, Tsien RY (2005) A guide to choosing fluorescent proteins. Nature Methods. [IF=10.009,
Cited=1000, 16299475].
Butko MT, Yang J, Geng Y, ..., Lin MZ (2012) Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light
and electron microscopy. Nature Neuroscience. [IF=4.893, Cited=45, 23103964].
Lin JY, Knutsen PM, Muller A, ..., Tsien RY (2013) ReaChR: a red-shifted variant of channelrhodopsin enables deep
transcranial optogenetic excitation. Nature Neuroscience. [IF=4.893, Cited=418, 23995068].
Ju W, Morishita W, Tsui J, ..., Malenka RC (2004) Activity-dependent regulation of dendritic synthesis and trafficking
of AMPA receptors. Nature Neuroscience. [IF=4.893, Cited=364, 14770185].
Tsien RY (2006) Measuring calcium signaling using genetically targetable fluorescent indicators. None. [IF=None,
Cited=269, 17406387].
Wang L, Tsien RY (2006) Evolving proteins in mammalian cells using somatic hypermutation. None. [IF=None, Cited=20, 17406421].
Adams SR, Tsien RY (2008) Preparation of the membrane-permeant biarsenicals FlAsH-EDT2 and ReAsH-EDT2 for fluorescent
labeling of tetracysteine-tagged proteins. None. [IF=None, Cited=59, 18772880].
Hoffmann C, Gaietta G, Zürn A, ..., Lohse MJ (2010) Fluorescent labeling of tetracysteine-tagged proteins in intact
cells. None. [IF=None, Cited=103, 20885379].
Nguyen QT, Tsien RY (2013) Fluorescence-guided surgery with live molecular navigation--a new cutting edge. Nature
Reviews Cancer. [IF=10.357, Cited=260, 23924645].
Zhang J, Campbell RE, Ting A, ..., Tsien RY (2002) Creating new fluorescent probes for cell biology. Nature Reviews
Molecular Cell Biology. [IF=19.213, Cited=933, 12461557].
Goldstein JC, Muñoz-Pinedo C, Ricci JE, ..., Green DR (2005) Cytochrome c is released in a single step during apoptosis.
Cell Death and Differentiation. [IF=2.211, Cited=130, 15933725].
Shu X, Lev-Ram V, Olson ES, ..., Tsien RY (2011) Spiers Memorial Lecture. Breeding and building molecular spies. None.
[IF=None, Cited=2, 21413170].
Rink TJ, Tsien RY (1982) Cytoplasmic free [Ca2+] in very small intact cells. Biochemical Society Transactions.
[IF=0.925, Cited=8, 6982838].
Allen GJ, Kwak JM, Chu SP, ..., Schroeder JI (1999) Cameleon calcium indicator reports cytoplasmic calcium dynamics in
Arabidopsis guard cells. Plant Journal. [IF=1.71, Cited=179, 10571859].
Meldolesi J, Huttner WB, Tsien RY, Pozzan T (1984) Free cytoplasmic Ca2+ and neurotransmitter release: studies on PC12
cells and synaptosomes exposed to alpha-latrotoxin. Proceedings of the National Academy of Sciences of the United States
of America. [IF=2.765, Cited=75, 6141561].
Paradiso AM, Tsien RY, Machen TE (1984) Na+-H+ exchange in gastric glands as measured with a cytoplasmic-trapped,
fluorescent pH indicator. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=79, 6095295].
Vergara J, Tsien RY, Delay M (1985) Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction
coupling in muscle. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=166, 2994073].
Gurney AM, Tsien RY, Lester HA (1987) Activation of a potassium current by rapid photochemically generated step
increases of intracellular calcium in rat sympathetic neurons. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=40, 2437582].
Randriamampita C, Tsien RY (1995) Degradation of a calcium influx factor (CIF) can be blocked by phosphatase inhibitors
or chelation of Ca2+. Journal of Biological Chemistry. [IF=1.122, Cited=67, 7814389].
Jiang T, Sweeney G, Rudolf MT, ..., Tsien RY (1998) Membrane-permeant esters of phosphatidylinositol
3,4,5-trisphosphate. Journal of Biological Chemistry. [IF=1.122, Cited=84, 9556583].
Kapahi P, Takahashi T, Natoli G, ..., Karin M (2000) Inhibition of NF-kappa B activation by arsenite through reaction
with a critical cysteine in the activation loop of Ikappa B kinase. Journal of Biological Chemistry. [IF=1.122,
Cited=223, 10967126].
Griesbeck O, Baird GS, Campbell RE, ..., Tsien RY (2001) Reducing the environmental sensitivity of yellow fluorescent
protein. Mechanism and applications. Journal of Biological Chemistry. [IF=1.122, Cited=619, 11387331].
Wu MM, Grabe M, Adams S, ..., Machen TE (2001) Mechanisms of pH regulation in the regulated secretory pathway. Journal
of Biological Chemistry. [IF=1.122, Cited=159, 11402049].
Whitney M, Crisp JL, Olson ES, ..., Tsien RY (2010) Parallel in vivo and in vitro selection using phage display
identifies protease-dependent tumor-targeting peptides. Journal of Biological Chemistry. [IF=1.122, Cited=45, 20460372].
De Jaco A, Lin MZ, Dubi N, ..., Taylor P (2010) Neuroligin trafficking deficiencies arising from mutations in the
alpha/beta-hydrolase fold protein family. Journal of Biological Chemistry. [IF=1.122, Cited=26, 20615874].
Hanson GT, Aggeler R, Oglesbee D, ..., Remington SJ (2004) Investigating mitochondrial redox potential with redox-
sensitive green fluorescent protein indicators. Journal of Biological Chemistry. [IF=1.122, Cited=581, 14722062].
Dooley CT, Dore TM, Hanson GT, ..., Tsien RY (2004) Imaging dynamic redox changes in mammalian cells with green
fluorescent protein indicators. Journal of Biological Chemistry. [IF=1.122, Cited=480, 14985369].
Kunkel MT, Ni Q, Tsien RY, ..., Newton AC (2004) Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by
a genetically encoded fluorescent reporter. Journal of Biological Chemistry. [IF=1.122, Cited=145, 15583002].
Sun M, Oakes JL, Ananthanarayanan SK, ..., Yengo CM (2005) Dynamics of the upper 50-kDa domain of myosin V examined with
fluorescence resonance energy transfer. Journal of Biological Chemistry. [IF=1.122, Cited=25, 16377637].
Kunkel MT, Toker A, Tsien RY, Newton AC (2006) Calcium-dependent regulation of protein kinase D revealed by a
genetically encoded kinase activity reporter. Journal of Biological Chemistry. [IF=1.122, Cited=75, 17189263].
Sosinsky GE, Gaietta GM, Hand G, ..., Ellisman MH (2003) Tetracysteine genetic tags complexed with biarsenical ligands
as a tool for investigating gap junction structure and dynamics. None. [IF=None, Cited=18, 14681013].
Tsien RY, Pozzan T, Rink TJ (1982) Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a
new, intracellularly trapped fluorescent indicator. Journal of Cell Biology. [IF=1.509, Cited=1000, 6980885].
Pozzan T, Arslan P, Tsien RY, Rink TJ (1982) Anti-immunoglobulin, cytoplasmic free calcium, and capping in B
lymphocytes. Journal of Cell Biology. [IF=1.509, Cited=136, 6809769].
Rink TJ, Tsien RY, Pozzan T (1982) Cytoplasmic pH and free Mg2+ in lymphocytes. Journal of Cell Biology. [IF=1.509,
Cited=556, 6815204].
Wilson HA, Greenblatt D, Poenie M, ..., Tsien RY (1987) Crosslinkage of B lymphocyte surface immunoglobulin by anti-Ig
or antigen induces prolonged oscillation of intracellular ionized calcium. Journal of Experimental Medicine. [IF=2.235,
Cited=45, 3496421].
Tsien RY, Green DP, Levinson SR, ..., Sanders JK (1975) A pharmacologically active derivative of tetrodotoxin. None.
[IF=None, Cited=3, 1784].
Lev-Ram V, Lemieux SP, Deerinck TJ, ..., Tsien RY (2023) Do perineuronal nets stabilize the engram of a synaptic
circuit? None. [IF=None, Cited=0, 37066274].
Lev-Ram V, Nebyelul Z, Ellisman MH, ..., Tsien RY (1997) Absence of cerebellar long-term depression in mice lacking
neuronal nitric oxide synthase. Learning and Memory. [IF=0.754, Cited=39, 10456061].
Tsien RY (2009) Indicators based on fluorescence resonance energy transfer (FRET). Cold Spring Harbor Protocols.
[IF=0.733, Cited=10, 20147227].
Harootunian AT, Kao JP, Tsien RY (1988) Agonist-induced calcium oscillations in depolarized fibroblasts and their
manipulation by photoreleased Ins(1,4,5)P3, Ca++, and Ca++ buffer. Cold Spring Harbor Symposia on Quantitative Biology.
[IF=0.889, Cited=30, 3267115].
Orosco RK, Tsien RY, Nguyen QT (2013) Fluorescence imaging in surgery. IEEE Reviews in Biomedical Engineering.
[IF=3.956, Cited=39, 23335674].
Alvarez-Leefmans FJ, Rink TJ, Tsien RY (1981) Free calcium ions in neurones of Helix aspersa measured with ion-selective
micro-electrodes. Journal of Physiology. [IF=1.417, Cited=87, 6273543].
Pozzan T, Lew DP, Wollheim CB, Tsien RY (1983) Is cytosolic ionized calcium regulating neutrophil activation? Science.
[IF=7.729, Cited=252, 6310757].
Tsien RY (1983) Intracellular measurements of ion activities. None. [IF=None, Cited=98, 6347046].
Adams SR, Tsien RY (1993) Controlling cell chemistry with caged compounds. Annual Review of Physiology. [IF=4.535,
Cited=246, 8466191].
Paradiso AM, Tsien RY, Demarest JR, Machen TE (1987) Na-H and Cl-HCO3 exchange in rabbit oxyntic cells using
fluorescence microscopy. None. [IF=None, Cited=34, 3037913].
Vajanaphanich M, Schultz C, Tsien RY, ..., Barrett KE (1995) Cross-talk between calcium and cAMP-dependent intracellular
signaling pathways. Implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic acinar
cells. Journal of Clinical Investigation. [IF=2.423, Cited=32, 7542282].
Metildi CA, Felsen CN, Savariar EN, ..., Bouvet M (2014) Ratiometric activatable cell-penetrating peptides label
pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse
models. Annals of Surgical Oncology. [IF=1.172, Cited=25, 25319581].
Babendure JR, Babendure JL, Ding JH, Tsien RY (2006) Control of mammalian translation by mRNA structure near caps. RNA.
[IF=0.956, Cited=193, 16540693].
Hasan MT, Friedrich RW, Euler T, ..., Denk W (2004) Functional fluorescent Ca2+ indicator proteins in transgenic mice
under TET control. PLoS Biology. [IF=2.285, Cited=146, 15208716].
Shu X, Lev-Ram V, Deerinck TJ, ..., Tsien RY (2011) A genetically encoded tag for correlated light and electron
microscopy of intact cells, tissues, and organisms. PLoS Biology. [IF=2.285, Cited=416, 21483721].
Chen B, Friedman B, Whitney MA, ..., Lyden PD (2012) Thrombin activity associated with neuronal damage during acute
focal ischemia. Journal of Neuroscience. [IF=1.471, Cited=70, 22649241].
Ratto GM, Payne R, Owen WG, Tsien RY (1988) The concentration of cytosolic free calcium in vertebrate rod outer segments
measured with fura-2. Journal of Neuroscience. [IF=1.471, Cited=119, 2459322].
Gurantz D, Harootunian AT, Tsien RY, ..., Margiotta JF (1994) VIP modulates neuronal nicotinic acetylcholine receptor
function by a cyclic AMP-dependent mechanism. Journal of Neuroscience. [IF=1.471, Cited=23, 8207470].
Yu D, Baird GS, Tsien RY, Davis RL (2003) Detection of calcium transients in Drosophila mushroom body neurons with
camgaroo reporters. Journal of Neuroscience. [IF=1.471, Cited=57, 12514202].
Dunn TA, Wang CT, Colicos MA, ..., Feller MB (2006) Imaging of cAMP levels and protein kinase A activity reveals that
retinal waves drive oscillations in second-messenger cascades. Journal of Neuroscience. [IF=1.471, Cited=100, 17151284].
Li H, Foss SM, Dobryy YL, ..., Voglmaier SM (2011) Concurrent imaging of synaptic vesicle recycling and calcium
dynamics. Frontiers in Molecular Neuroscience. [IF=1.151, Cited=40, 22065946].
Tsien RY (2010) The 2009 Lindau Nobel Laureate Meeting: Roger Y. Tsien, Chemistry 2008. Journal of Visualized
Experiments. [IF=0.398, Cited=7, 20072108].
Zacharias DA, Tsien RY (2006) Molecular biology and mutation of green fluorescent protein. None. [IF=None, Cited=0, 16335711].
LaBaer J, Tsien RY, Fahey KA, DeFranco AL (1986) Stimulation of the antigen receptor on WEHI-231 B lymphoma cells
results in a voltage-independent increase in cytoplasmic calcium. Journal of Immunology. [IF=0.939, Cited=0, 2427581].
Kawanishi T, Blank LM, Harootunian AT, ..., Tsien RY (1989) Ca2+ oscillations induced by hormonal stimulation of
individual fura-2-loaded hepatocytes. Journal of Biological Chemistry. [IF=1.122, Cited=0, 2473983].
Harootunian AT, Kao JP, Eckert BK, Tsien RY (1989) Fluorescence ratio imaging of cytosolic free Na+ in individual
fibroblasts and lymphocytes. Journal of Biological Chemistry. [IF=1.122, Cited=0, 2478559].
Minta A, Kao JP, Tsien RY (1989) Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein
chromophores. Journal of Biological Chemistry. [IF=1.122, Cited=0, 2498308].
Kao JP, Harootunian AT, Tsien RY (1989) Photochemically generated cytosolic calcium pulses and their detection by
fluo-3. Journal of Biological Chemistry. [IF=1.122, Cited=0, 2498309].
Havran WL, Poenie M, Tigelaar RE, ..., Allison JP (1989) Phenotypic and functional analysis of gamma delta T cell
receptor-positive murine dendritic epidermal clones. Journal of Immunology. [IF=0.939, Cited=0, 2783942].
Minta A, Tsien RY (1989) Fluorescent indicators for cytosolic sodium. Journal of Biological Chemistry. [IF=1.122,
Cited=0, 2808435].
Ambler SK, Poenie M, Tsien RY, Taylor P (1988) Agonist-stimulated oscillations and cycling of intracellular free calcium
in individual cultured muscle cells. Journal of Biological Chemistry. [IF=1.122, Cited=0, 2892835].
Wilson HA, Greenblatt D, Taylor CW, ..., Chused TM (1987) The B lymphocyte calcium response to anti-Ig is diminished by
membrane immunoglobulin cross-linkage to the Fc gamma receptor. Journal of Immunology. [IF=0.939, Cited=0, 2950170].
Tsien RY (1986) New tetracarboxylate chelators for fluorescence measurement and photochemical manipulation of cytosolic
free calcium concentrations. None. [IF=None, Cited=0, 3520839].
Grynkiewicz G, Poenie M, Tsien RY (1985) A new generation of Ca2+ indicators with greatly improved fluorescence
properties. Journal of Biological Chemistry. [IF=1.122, Cited=0, 3838314].
Arslan P, Di Virgilio F, Beltrame M, ..., Pozzan T (1985) Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas.
A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free
Ca2+. Journal of Biological Chemistry. [IF=1.122, Cited=0, 3919006].
Tsien RY, Pozzan T, Rink TJ (1984) Calcium activities and fluxes inside small intact cells as measured with
intracellularly trapped chelators. None. [IF=None, Cited=0, 6328935].
Tsien RY (1984) Measuring and manipulating cytosolic Ca2+ with trapped indicators. None. [IF=None, Cited=0, 6439833].
Ashley CC, Rink TJ, Tsien RY (1978) Changes in free Ca during muscle contraction, measured with an intracellular Ca-
selective electrode [proceedings]. Journal of Physiology. [IF=1.417, Cited=0, 690875].
Wen W, Harootunian AT, Adams SR, ..., Taylor SS (1994) Heat-stable inhibitors of cAMP-dependent protein kinase carry a
nuclear export signal. Journal of Biological Chemistry. [IF=1.122, Cited=0, 7798221].
Schultz C, Vajanaphanich M, Genieser HG, ..., Tsien RY (1994) Membrane-permeant derivatives of cyclic AMP optimized for
high potency, prolonged activity, or rapid reversibility. Molecular Pharmacology. [IF=0.939, Cited=0, 7969049].
Makings LR, Tsien RY (1994) Caged nitric oxide. Stable organic molecules from which nitric oxide can be photoreleased.
Journal of Biological Chemistry. [IF=1.122, Cited=0, 8119976].
Adams SR, Bacskai BJ, Hochner B, ..., Tsien RY (1993) Confocal imaging of cAMP signals in Aplysia neurons. None.
[IF=None, Cited=0, 8271521].
Fantozzi DA, Harootunian AT, Wen W, ..., Meinkoth JL (1994) Thermostable inhibitor of cAMP-dependent protein kinase
enhances the rate of export of the kinase catalytic subunit from the nucleus. Journal of Biological Chemistry.
[IF=1.122, Cited=0, 8300597].
Schultz C, Vajanaphanich M, Harootunian AT, ..., Tsien RY (1993) Acetoxymethyl esters of phosphates, enhancement of the
permeability and potency of cAMP. Journal of Biological Chemistry. [IF=1.122, Cited=0, 8384207].
Adams S, Bacskai B, Harootunian AT, ..., Tsien RY (1993) Imaging of cAMP signals and A-kinase translocation in single
living cells. None. [IF=None, Cited=0, 8398399].

Tsien, Roger Y

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