Shokat, Kevan M

Publication with MATCHING institution:

Blethrow J, Zhang C, Shokat KM, Weiss EL (2004) Design and use of analog-sensitive protein kinases. Current Protocols in
Molecular Biology. [IF=0.961, Cited=33, 18265343].
Hertz NT, Wang BT, Allen JJ, ..., Shokat KM (2010) Chemical genetic approach for kinase-substrate mapping by covalent
capture of thiophosphopeptides and analysis by mass spectrometry. Current protocols in chemical biology. [IF=0.71,
Cited=55, 23836541].
Zhang Z, Shokat KM (2019) Bifunctional Small-Molecule Ligands of K-Ras Induce Its Association with Immunophilin
Proteins. Angewandte Chemie - International Edition. [IF=2.456, Cited=20, 31557383].
Atreya CE, Sangale Z, Xu N, ..., Warren RS (2013) PTEN expression is consistent in colorectal cancer primaries and
metastases and associates with patient survival. Cancer Medicine. [IF=1.13, Cited=29, 24156022].
Floor SN, Barkovich KJ, Condon KJ, ..., Doudna JA (2015) Analog sensitive chemical inhibition of the DEAD-box protein
DDX3. Protein Science. [IF=1.97, Cited=6, 26650549].
Fowler ML, McPhail JA, Jenkins ML, ..., Burke JE (2016) Using hydrogen deuterium exchange mass spectrometry to engineer
optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11. Protein Science.
[IF=1.97, Cited=19, 26756197].
Wong AW, Urisman A, Burlingame AL, Shokat KM (2019) Chemically reprogramming the phospho-transfer reaction to crosslink
protein kinases to their substrates. Protein Science. [IF=1.97, Cited=1, 30636329].
Savitt J, Singh D, Zhang C, ..., Wright WW (2012) The in vivo response of stem and other undifferentiated spermatogonia
to the reversible inhibition of glial cell line-derived neurotrophic factor signaling in the adult. Stem Cells.
[IF=0.985, Cited=23, 22232066].
Lopez MS, Kliegman JI, Shokat KM (2014) The logic and design of analog-sensitive kinases and their small molecule
inhibitors. None. [IF=None, Cited=54, 25399647].
Lazarus MB, Shokat KM (2015) Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase
ULK1. Bioorganic and Medicinal Chemistry. [IF=0.86, Cited=29, 26275681].
Melnyk JE, Steri V, Nguyen HG, ..., Shokat KM (2020) The splicing modulator sulfonamide indisulam reduces AR-V7 in
prostate cancer cells. Bioorganic and Medicinal Chemistry. [IF=0.86, Cited=12, 33069070].
Lee JK, Phillips JW, Smith BA, ..., Witte ON (2016) N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human
Prostate Epithelial Cells. Cancer Cell. [IF=5.274, Cited=233, 27050099].
Fan Q, Aksoy O, Wong RA, ..., Weiss WA (2017) A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.
Cancer Cell. [IF=5.274, Cited=95, 28292440].
Coles GL, Cristea S, Webber JT, ..., Sage J (2020) Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis
in Small Cell Lung Cancer Stem Cells. Cancer Cell. [IF=5.274, Cited=43, 32531271].
Zhang Z, Rohweder PJ, Ongpipattanakul C, ..., Craik CS (2022) A covalent inhibitor of K-Ras(G12C) induces MHC class I
presentation of haptenated peptide neoepitopes targetable by immunotherapy. Cancer Cell. [IF=5.274, Cited=31, 36099883].
Gustafson WC, Meyerowitz JG, Nekritz EA, ..., Weiss WA (2014) Drugging MYCN through an allosteric transition in Aurora
kinase A. Cancer Cell. [IF=5.274, Cited=159, 25175806].
Shokat KM (2005) Chemicals call bacteria, and a new membrane protein machine answers. Cell. [IF=8.479, Cited=1, 15851024].
Hu Q, Shokat KM (2018) Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of GDP and GTP. Cell. [IF=8.479,
Cited=34, 29628140].
Bouhaddou M, Memon D, Meyer B, ..., Krogan NJ (2020) The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell.
[IF=8.479, Cited=540, 32645325].
Dai SA, Hu Q, Gao R, ..., Shokat KM (2022) State-selective modulation of heterotrimeric Gαs signaling with macrocyclic
peptides. Cell. [IF=8.479, Cited=10, 36170854].
Lazarus MB, Levin RS, Shokat KM (2016) Discovery of new substrates of the elongation factor-2 kinase suggests a broader
role in the cellular nutrient response. Cellular Signalling. [IF=0.941, Cited=12, 27760376].
Kliegman JI, Fiedler D, Ryan CJ, ..., Shokat KM (2013) Chemical genetics of rapamycin-insensitive TORC2 in S.
cerevisiae. Cell Reports. [IF=1.738, Cited=22, 24360963].
Sos ML, Levin RS, Gordan JD, ..., Shokat KM (2014) Oncogene mimicry as a mechanism of primary resistance to BRAF
inhibitors. Cell Reports. [IF=1.738, Cited=55, 25127139].
Shin S, Han MJ, Jedrychowski MP, ..., Yoon SO (2023) mTOR inhibition reprograms cellular proteostasis by regulating
eIF3D-mediated selective mRNA translation and promotes cell phenotype switching. Cell Reports. [IF=1.738, Cited=3, 37494188].
Riel-Mehan MM, Shokat KM (2014) A crosslinker based on a tethered electrophile for mapping kinase-substrate networks.
None. [IF=None, Cited=8, 24746561].
Gentile DR, Rathinaswamy MK, Jenkins ML, ..., Shokat KM (2017) Ras Binder Induces a Modified Switch-II Pocket in GTP and
GDP States. Cell Chemical Biology. [IF=1.446, Cited=50, 29033317].
Moss SM, Taylor IR, Ruggero D, ..., Mukherjee S (2019) A Legionella pneumophila Kinase Phosphorylates the Hsp70
Chaperone Family to Inhibit Eukaryotic Protein Synthesis. None. [IF=None, Cited=26, 30827827].
Schaffer BE, Levin RS, Hertz NT, ..., Brunet A (2015) Identification of AMPK Phosphorylation Sites Reveals a Network of
Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction. None. [IF=None, Cited=95, 26456332].
Zhang TT, Okkenhaug K, Nashed BF, ..., Marshall AJ (2008) Genetic or pharmaceutical blockade of p110delta
phosphoinositide 3-kinase enhances IgE production. Journal of Allergy and Clinical Immunology. [IF=2.533, Cited=41, 19014771].
Dugan MP, Ferguson LB, Hertz NT, ..., Messing RO (2023) Chemical Genetic Identification of PKC Epsilon Substrates in
Mouse Brain. Molecular and Cellular Proteomics. [IF=1.296, Cited=1, 36863607].
Shokat KM (2010) A drug-drug interaction crystallizes a new entry point into the UPR. Molecular Cell. [IF=2.773,
Cited=2, 20417596].
Orr AL, Rutaganira FU, de Roulet D, ..., Nakamura K (2017) Long-term oral kinetin does not protect against α-synuclein-
induced neurodegeneration in rodent models of Parkinson's disease. Neurochemistry International. [IF=0.797, Cited=18, 28434973].
Ultanir SK, Yadav S, Hertz NT, ..., Jan YN (2014) MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in
promoting spine synapse development. Neuron. [IF=3.346, Cited=40, 25456499].
Wu T, Hornsby M, Zhu L, ..., Gestwicki JE (2023) Protocol for performing and optimizing differential scanning
fluorimetry experiments. STAR Protocols. [IF=0.357, Cited=4, 37943662].
Malakoutikhah M, Mahran R, Gooran N, ..., Härmä H (2023) Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes.
Analytical Chemistry. [IF=1.41, Cited=1, 38060502].
Tabaei SR, Guo F, Rutaganira FU, ..., Cho NJ (2016) Multistep Compositional Remodeling of Supported Lipid Membranes by
Interfacially Active Phosphatidylinositol Kinases. Analytical Chemistry. [IF=1.41, Cited=3, 27118725].
McGregor LM, Jenkins ML, Kerwin C, ..., Shokat KM (2017) Expanding the Scope of Electrophiles Capable of Targeting K-Ras
Oncogenes. Biochemistry. [IF=0.753, Cited=28, 28621541].
Lou K, Gilbert LA, Shokat KM (2019) A Bounty of New Challenging Targets in Oncology for Chemical Discovery.
Biochemistry. [IF=0.753, Cited=5, 31343870].
Nnadi CI, Jenkins ML, Gentile DR, ..., London N (2018) Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and
Accelerate Nucleotide Exchange. Journal of Chemical Information and Modeling. [IF=1.379, Cited=26, 29320178].
Zheng Q, Peacock DM, Shokat KM (2022) Drugging the Next Undruggable KRAS Allele-Gly12Asp. Journal of Medicinal
Chemistry. [IF=1.655, Cited=14, 35167298].
Rutaganira FU, Fowler ML, McPhail JA, ..., Burke JE (2016) Design and Structural Characterization of Potent and
Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. Journal of Medicinal Chemistry. [IF=1.655, Cited=25, 26885694].
Rutaganira FU, Barks J, Dhason MS, ..., Sibley LD (2017) Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by
Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma
gondii. Journal of Medicinal Chemistry. [IF=1.655, Cited=23, 28933846].
Zhang Z, Gao R, Hu Q, ..., Suga H (2020) GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction
with Raf. ACS Central Science. [IF=2.363, Cited=43, 33145412].
Peacock DM, Kelly MJS, Shokat KM (2022) Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy. ACS Chemical
Biology. [IF=0.963, Cited=1, 36166818].
Morstein J, Shrestha R, Van QN, ..., Shokat KM (2023) Direct Modulators of K-Ras-Membrane Interactions. ACS Chemical
Biology. [IF=0.963, Cited=5, 37579045].
Novotny CJ, Hamilton GL, McCormick F, Shokat KM (2017) Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor
Overcomes Alternative Prenylation to Mislocalize K-Ras. ACS Chemical Biology. [IF=0.963, Cited=22, 28530791].
Ocasio CA, Warkentin AA, McIntyre PJ, ..., Bayliss R (2018) Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases
Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases. ACS Chemical Biology. [IF=0.963, Cited=6, 30239186].
Ulrich SM, Kenski DM, Shokat KM (2003) Engineering a "methionine clamp" into Src family kinases enhances specificity
toward unnatural ATP analogues. Biochemistry. [IF=0.753, Cited=11, 12834343].
Zhang C, Lopez MS, Dar AC, ..., Shokat KM (2013) Structure-guided inhibitor design expands the scope of analog-sensitive
kinase technology. ACS Chemical Biology. [IF=0.963, Cited=36, 23841803].
Lazarus MB, Novotny CJ, Shokat KM (2015) Structure of the human autophagy initiating kinase ULK1 in complex with potent
inhibitors. ACS Chemical Biology. [IF=0.963, Cited=80, 25551253].
Allen JJ, Shokat KM (2006) Chemical genomics: dialed in transcriptional network control with non-steroidal
glucocorticoid receptor modulators. ACS Chemical Biology. [IF=0.963, Cited=1, 17163659].
Simon MD, Feldman ME, Rauh D, ..., Shokat KM (2006) Structure and properties of a re-engineered homeodomain protein-DNA
interface. ACS Chemical Biology. [IF=0.963, Cited=1, 17240973].
Kraybill BC, Elkin LL, Blethrow JD, ..., Shokat KM (2002) Inhibitor scaffolds as new allele specific kinase substrates.
Journal of the American Chemical Society. [IF=2.573, Cited=27, 12371851].
Simon MD, Shokat KM (2004) Adaptability at a protein-DNA interface: re-engineering the engrailed homeodomain to
recognize an unnatural nucleotide. Journal of the American Chemical Society. [IF=2.573, Cited=6, 15225024].
Maly DJ, Allen JA, Shokat KM (2004) A mechanism-based cross-linker for the identification of kinase-substrate pairs.
Journal of the American Chemical Society. [IF=2.573, Cited=44, 15281787].
Allen JJ, Lazerwith SE, Shokat KM (2005) Bio-orthogonal affinity purification of direct kinase substrates. Journal of
the American Chemical Society. [IF=2.573, Cited=62, 15826144].
Knight ZA, Garrison JL, Chan K, ..., Shokat KM (2007) A remodelled protease that cleaves phosphotyrosine substrates.
Journal of the American Chemical Society. [IF=2.573, Cited=13, 17803306].
Lopez MS, Choy JW, Peters U, ..., Shokat KM (2013) Staurosporine-derived inhibitors broaden the scope of analog-
sensitive kinase technology. Journal of the American Chemical Society. [IF=2.573, Cited=10, 24171479].
Zhang Z, Morstein J, Ecker AK, ..., Shokat KM (2022) Chemoselective Covalent Modification of K-Ras(G12R) with a Small
Molecule Electrophile. Journal of the American Chemical Society. [IF=2.573, Cited=33, 36001446].
Rodrik-Outmezguine VS, Okaniwa M, Yao Z, ..., Shokat KM (2016) Overcoming mTOR resistance mutations with a new-
generation mTOR inhibitor. Nature. [IF=11.591, Cited=229, 27279227].
Novotny CJ, Pollari S, Park JH, ..., Shokat KM (2016) Overcoming resistance to HER2 inhibitors through state-specific
kinase binding. Nature Chemical Biology. [IF=2.623, Cited=22, 27595329].
Hoppmann C, Wong A, Yang B, ..., Wang L (2017) Site-specific incorporation of phosphotyrosine using an expanded genetic
code. Nature Chemical Biology. [IF=2.623, Cited=53, 28604697].
Tan YX, Manz BN, Freedman TS, ..., Weiss A (2013) Inhibition of the kinase Csk in thymocytes reveals a requirement for
actin remodeling in the initiation of full TCR signaling. Nature Immunology. [IF=4.23, Cited=62, 24317039].
Au-Yeung BB, Melichar HJ, Ross JO, ..., Weiss A (2014) Quantitative and temporal requirements revealed for Zap70
catalytic activity during T cell development. Nature Immunology. [IF=4.23, Cited=44, 24908390].
Dang CV, Reddy EP, Shokat KM, Soucek L (2017) Drugging the 'undruggable' cancer targets. Nature Reviews Cancer.
[IF=10.357, Cited=353, 28643779].
Ostrem JML, Shokat KM (2016) Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based
design. Nature Reviews Drug Discovery. [IF=18.471, Cited=279, 27469033].
Lipp JJ, Marvin MC, Shokat KM, Guthrie C (2015) SR protein kinases promote splicing of nonconsensus introns. Nature
Structural and Molecular Biology. [IF=2.542, Cited=29, 26167880].
Ducker GS, Atreya CE, Simko JP, ..., Warren RS (2013) Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism
of primary resistance to ATP-competitive mTOR inhibitors. Oncogene. [IF=1.523, Cited=59, 23542178].
Hernández-Ortega S, Sánchez-Botet A, Quandt E, ..., Clotet J (2019) Phosphoregulation of the oncogenic protein regulator
of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex. Experimental and Molecular Medicine. [IF=2.341, Cited=16, 30992425].
Leyte-Vidal A, DeFilippis R, Outhwaite IR, ..., Shah NP (2024) Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1
destabilizes the autoinhibited kinase conformation and confers resistance to asciminib. Leukemia. [IF=2.198, Cited=0, 39085402].
Melnyk JE, Steri V, Nguyen HG, ..., Shokat KM (2022) Targeting a splicing-mediated drug resistance mechanism in prostate
cancer by inhibiting transcriptional regulation by PKCβ1. Oncogene. [IF=1.523, Cited=5, 35087237].
Ehinger Y, Zhang Z, Phamluong K, ..., Ron D (2021) Brain-specific inhibition of mTORC1 eliminates side effects resulting
from mTORC1 blockade in the periphery and reduces alcohol intake in mice. Nature Communications. [IF=3.268, Cited=5, 34315870].
Haas KM, McGregor MJ, Bouhaddou M, ..., Krogan NJ (2023) Proteomic and genetic analyses of influenza A viruses identify
pan-viral host targets. Nature Communications. [IF=3.268, Cited=3, 37758692].
Gordon DE, Jang GM, Bouhaddou M, ..., Krogan NJ (2020) A SARS-CoV-2 protein interaction map reveals targets for drug
repurposing. Nature. [IF=11.591, Cited=1000, 32353859].
Zhang Z, Fan Q, Luo X, ..., Shokat KM (2022) Brain-restricted mTOR inhibition with binary pharmacology. Nature.
[IF=11.591, Cited=19, 36104566].
Zhulyn O, Rosenblatt HD, Shokat L, ..., Barna M (2023) Evolutionarily divergent mTOR remodels translatome for tissue
regeneration. Nature. [IF=11.591, Cited=7, 37495694].
Donnella HJ, Webber JT, Levin RS, ..., Bandyopadhyay S (2018) Kinome rewiring reveals AURKA limits PI3K-pathway
inhibitor efficacy in breast cancer. Nature Chemical Biology. [IF=2.623, Cited=43, 29942081].
Vasta JD, Peacock DM, Zheng Q, ..., Shokat KM (2022) KRAS is vulnerable to reversible switch-II pocket engagement in
cells. Nature Chemical Biology. [IF=2.623, Cited=34, 35314814].
Zhang Z, Guiley KZ, Shokat KM (2022) Chemical acylation of an acquired serine suppresses oncogenic signaling of
K-Ras(G12S). Nature Chemical Biology. [IF=2.623, Cited=34, 35864332].
Zheng Q, Zhang Z, Guiley KZ, Shokat KM (2024) Strain-release alkylation of Asp12 enables mutant selective targeting of
K-Ras-G12D. Nature Chemical Biology. [IF=2.623, Cited=3, 38443470].
Ostrem JML, Peters U, Shokat KM (2024) Direct RAS inhibitors turn 10. Nature Chemical Biology. [IF=2.623, Cited=0, 39060392].
Torbett NE, Luna-Moran A, Knight ZA, ..., Stokoe D (2008) A chemical screen in diverse breast cancer cell lines reveals
genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. Biochemical Journal. [IF=0.852,
Cited=80, 18498248].
Knight ZA, Shokat KM (2007) Chemically targeting the PI3K family. Biochemical Society Transactions. [IF=0.925,
Cited=74, 17371250].
Provance DW, Gourley CR, Silan CM, ..., Mercer JA (2004) Chemical-genetic inhibition of a sensitized mutant myosin Vb
demonstrates a role in peripheral-pericentriolar membrane traffic. Proceedings of the National Academy of Sciences of
the United States of America. [IF=2.765, Cited=26, 14766983].
Wong S, McLaughlin J, Cheng D, ..., Witte ON (2004) Sole BCR-ABL inhibition is insufficient to eliminate all
myeloproliferative disorder cell populations. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=47, 15505216].
Kung C, Kenski DM, Dickerson SH, ..., Shokat KM (2005) Chemical genomic profiling to identify intracellular targets of a
multiplex kinase inhibitor. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=33, 15738404].
Dephoure N, Howson RW, Blethrow JD, ..., O'Shea EK (2005) Combining chemical genetics and proteomics to identify protein
kinase substrates. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=70, 16330754].
Kanin EI, Kipp RT, Kung C, ..., Ansari AZ (2007) Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not
impair global mRNA synthesis. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=76, 17392431].
Wang H, Shimizu E, Tang YP, ..., Tsien JZ (2003) Inducible protein knockout reveals temporal requirement of CaMKII
reactivation for memory consolidation in the brain. Proceedings of the National Academy of Sciences of the United States
of America. [IF=2.765, Cited=104, 12646704].
Burkard ME, Randall CL, Larochelle S, ..., Jallepalli PV (2007) Chemical genetics reveals the requirement for Polo-like
kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=162, 17360533].
Das M, Jiang F, Sluss HK, ..., Davis RJ (2007) Suppression of p53-dependent senescence by the JNK signal transduction
pathway. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=98, 17893331].
Blethrow JD, Glavy JS, Morgan DO, Shokat KM (2008) Covalent capture of kinase-specific phosphopeptides reveals
Cdk1-cyclin B substrates. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=209, 18234856].
Sauer S, Bruno L, Hertweck A, ..., Merkenschlager M (2008) T cell receptor signaling controls Foxp3 expression via PI3K,
Akt, and mTOR. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=587, 18509048].
Morgan DJ, Weisenhaus M, Shum S, ..., McKnight GS (2008) Tissue-specific PKA inhibition using a chemical genetic
approach and its application to studies on sperm capacitation. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=37, 19074277].
Sos ML, Fischer S, Ullrich R, ..., Thomas RK (2009) Identifying genotype-dependent efficacy of single and combined PI3K-
and MAPK-pathway inhibition in cancer. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=167, 19805051].
Wang BT, Ducker GS, Barczak AJ, ..., Shokat KM (2011) The mammalian target of rapamycin regulates cholesterol
biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=68, 21876130].
Garske AL, Peters U, Cortesi AT, ..., Shokat KM (2011) Chemical genetic strategy for targeting protein kinases based on
covalent complementarity. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=43, 21852571].
Cheng CK, Gustafson WC, Charron E, ..., Fan QW (2012) Dual blockade of lipid and cyclin-dependent kinases induces
synthetic lethality in malignant glioma. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=25, 22802621].
Pourdehnad M, Truitt ML, Siddiqi IN, ..., Ruggero D (2013) Myc and mTOR converge on a common node in protein synthesis
control that confers synthetic lethality in Myc-driven cancers. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=170, 23803853].
Chen L, Shu Y, Liang X, ..., Giacomini KM (2014) OCT1 is a high-capacity thiamine transporter that regulates hepatic
steatosis and is a target of metformin. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=126, 24961373].
Au-Yeung BB, Zikherman J, Mueller JL, ..., Weiss A (2014) A sharp T-cell antigen receptor signaling threshold for T-cell
proliferation. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=95, 25136127].
Reed DE, Shokat KM (2014) Targeting osteosarcoma. Proceedings of the National Academy of Sciences of the United States
of America. [IF=2.765, Cited=10, 25512494].
Costa HA, Leitner MG, Sos ML, ..., Bustamante CD (2015) Discovery and functional characterization of a neomorphic PTEN
mutation. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=28, 26504226].
Levin RS, Hertz NT, Burlingame AL, ..., Mukherjee S (2016) Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot
for posttranslational modifications by host and pathogen. Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=26, 27482120].
Carroll AS, Bishop AC, DeRisi JL, ..., O'Shea EK (2001) Chemical inhibition of the Pho85 cyclin-dependent kinase reveals
a role in the environmental stress response. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=82, 11675494].
Wassarman DR, Bankapalli K, Pallanck LJ, Shokat KM (2022) Tissue-restricted inhibition of mTOR using chemical genetics.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=1, 36095197].
Chorba JS, Shokat KM (2014) The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence
differentially regulate protein secretion from proteolysis. Journal of Biological Chemistry. [IF=1.122, Cited=18, 25210046].
Rubenstein EM, McCartney RR, Zhang C, ..., Schmidt MC (2007) Access denied: Snf1 activation loop phosphorylation is
controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. Journal of Biological Chemistry.
[IF=1.122, Cited=83, 17991748].
Chorba JS, Galvan AM, Shokat KM (2017) Stepwise processing analyses of the single-turnover PCSK9 protease reveal its
substrate sequence specificity and link clinical genotype to lipid phenotype. Journal of Biological Chemistry.
[IF=1.122, Cited=8, 29259136].
Urisman A, Levin RS, Gordan JD, ..., Burlingame AL (2016) An Optimized Chromatographic Strategy for Multiplexing In
Parallel Reaction Monitoring Mass Spectrometry: Insights from Quantitation of Activated Kinases. Molecular and Cellular
Proteomics. [IF=1.296, Cited=23, 27940637].
Sekiya-Kawasaki M, Groen AC, Cope MJTV, ..., Drubin DG (2003) Dynamic phosphoregulation of the cortical actin
cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. Journal of Cell Biology.
[IF=1.509, Cited=69, 12952930].
Van Keymeulen A, Wong K, Knight ZA, ..., Bourne HR (2006) To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA
activity at the back as well as signals at the front. Journal of Cell Biology. [IF=1.509, Cited=110, 16864657].
Maciejowski J, George KA, Terret ME, ..., Jallepalli PV (2010) Mps1 directs the assembly of Cdc20 inhibitory complexes
during interphase and mitosis to control M phase timing and spindle checkpoint signaling. Journal of Cell Biology.
[IF=1.509, Cited=125, 20624902].
Kunkel EJ, Plavec I, Nguyen D, ..., Berg EL (2004) Rapid structure-activity and selectivity analysis of kinase
inhibitors by BioMAP analysis in complex human primary cell-based models. Assay and Drug Development Technologies.
[IF=0.651, Cited=39, 15357924].
Jo A, Choi TG, Jo YH, ..., Kim SS (2016) Inhibition of Carbonyl Reductase 1 Safely Improves the Efficacy of Doxorubicin
in Breast Cancer Treatment. Antioxidants and Redox Signaling. [IF=1.479, Cited=15, 27357096].
Sun Y, Miao Y, Yamane Y, ..., Drubin DG (2012) Orm protein phosphoregulation mediates transient sphingolipid
biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. Molecular Biology of the Cell. [IF=0.848,
Cited=97, 22535525].
Abeliovich H, Zhang C, Dunn WA, ..., Klionsky DJ (2003) Chemical genetic analysis of Apg1 reveals a non-kinase role in
the induction of autophagy. Molecular Biology of the Cell. [IF=0.848, Cited=104, 12589048].
Balla A, Kim YJ, Varnai P, ..., Balla T (2007) Maintenance of hormone-sensitive phosphoinositide pools in the plasma
membrane requires phosphatidylinositol 4-kinase IIIalpha. Molecular Biology of the Cell. [IF=0.848, Cited=129, 18077555].
Kurischko C, Kuravi VK, Wannissorn N, ..., Luca FC (2008) The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-
dependent glycosylation and secretion. Molecular Biology of the Cell. [IF=0.848, Cited=29, 18843045].
Barkovich KJ, Moore MK, Hu Q, Shokat KM (2018) Chemical genetic inhibition of DEAD-box proteins using covalent
complementarity. Nucleic Acids Research. [IF=4.663, Cited=5, 30102385].
Fan Q, An Z, Wong RA, ..., Weiss WA (2020) Betacellulin drives therapy resistance in glioblastoma. Neuro-Oncology.
[IF=4.329, Cited=7, 31678994].
Parker N, Falk H, Singh D, ..., Wright WW (2014) Responses to glial cell line-derived neurotrophic factor change in mice
as spermatogonial stem cells form progenitor spermatogonia which replicate and give rise to more differentiated progeny.
Biology of Reproduction. [IF=0.959, Cited=13, 25165119].
Loonat AA, Martin ED, Sarafraz-Shekary N, ..., Clark JE (2019) p38γ MAPK contributes to left ventricular remodeling
after pathologic stress and disinhibits calpain through phosphorylation of calpastatin. FASEB Journal. [IF=1.029,
Cited=5, 31638431].
Alaimo PJ, Shogren-Knaak MA, Shokat KM (2002) Chemical Genetic Analysis of Protein Kinase Cascades. The Scientific World
Journal. [IF=1.142, Cited=0, 29973826].
Reuschl AK, Thorne LG, Zuliani-Alvarez L, ..., Krogan NJ (2021) Host-directed therapies against early-lineage SARS-CoV-2
retain efficacy against B.1.1.7 variant. None. [IF=None, Cited=5, 33501437].
Liccardo F, Morstein J, Lin TY, ..., Irannejad R (2023) Selective activation of intracellular β1AR using a spatially
restricted antagonist. None. [IF=None, Cited=0, 38045405].
Sansó M, Levin RS, Lipp JJ, ..., Fisher RP (2016) P-TEFb regulation of transcription termination factor Xrn2 revealed by
a chemical genetic screen for Cdk9 substrates. Genes and Development. [IF=1.985, Cited=80, 26728557].
Morisot N, Novotny CJ, Shokat KM, Ron D (2017) A new generation of mTORC1 inhibitor attenuates alcohol intake and reward
in mice. Addiction Biology. [IF=0.941, Cited=9, 28681511].
Uchida Y, Rutaganira FU, Jullié D, ..., von Zastrow M (2016) Endosomal Phosphatidylinositol 3-Kinase Is Essential for
Canonical GPCR Signaling. Molecular Pharmacology. [IF=0.939, Cited=7, 27821547].
Lin JH, Li H, Yasumura D, ..., Walter P (2007) IRE1 signaling affects cell fate during the unfolded protein response.
Science. [IF=7.729, Cited=895, 17991856].
Justman QA, Serber Z, Ferrell JE, ..., Shokat KM (2009) Tuning the activation threshold of a kinase network by nested
feedback loops. Science. [IF=7.729, Cited=33, 19390045].
Herbert SP, Huisken J, Kim TN, ..., Stainier DYR (2009) Arterial-venous segregation by selective cell sprouting: an
alternative mode of blood vessel formation. Science. [IF=7.729, Cited=196, 19815777].
Miller S, Tavshanjian B, Oleksy A, ..., Williams RL (2010) Shaping development of autophagy inhibitors with the
structure of the lipid kinase Vps34. Science. [IF=7.729, Cited=118, 20339072].
Bandyopadhyay S, Mehta M, Kuo D, ..., Ideker T (2010) Rewiring of genetic networks in response to DNA damage. Science.
[IF=7.729, Cited=276, 21127252].
Burke JE, Inglis AJ, Perisic O, ..., Williams RL (2014) Structures of PI4KIIIβ complexes show simultaneous recruitment
of Rab11 and its effectors. Science. [IF=7.729, Cited=69, 24876499].
Guiley KZ, Stevenson JW, Lou K, ..., Rubin SM (2019) p27 allosterically activates cyclin-dependent kinase 4 and
antagonizes palbociclib inhibition. Science. [IF=7.729, Cited=96, 31831640].
Gordon DE, Hiatt J, Bouhaddou M, ..., Krogan NJ (2020) Comparative host-coronavirus protein interaction networks reveal
pan-viral disease mechanisms. Science. [IF=7.729, Cited=381, 33060197].
White KM, Rosales R, Yildiz S, ..., García-Sastre A (2021) Plitidepsin has potent preclinical efficacy against SARS-
CoV-2 by targeting the host protein eEF1A. Science. [IF=7.729, Cited=174, 33495306].
Lou K, Wassarman DR, Yang T, ..., Shokat KM (2022) IFITM proteins assist cellular uptake of diverse linked chemotypes.
Science. [IF=7.729, Cited=7, 36480603].
Cohen MS, Zhang C, Shokat KM, Taunton J (2005) Structural bioinformatics-based design of selective, irreversible kinase
inhibitors. Science. [IF=7.729, Cited=280, 15919995].
Fan QW, Cheng C, Knight ZA, ..., Weiss WA (2009) EGFR signals to mTOR through PKC and independently of Akt in glioma.
Science Signaling. [IF=1.6, Cited=115, 19176518].
Fan QW, Cheng C, Hackett C, ..., Weiss WA (2010) Akt and autophagy cooperate to promote survival of drug-resistant
glioma. Science Signaling. [IF=1.6, Cited=191, 21062993].
Bodenmiller B, Wanka S, Kraft C, ..., Aebersold R (2010) Phosphoproteomic analysis reveals interconnected system-wide
responses to perturbations of kinases and phosphatases in yeast. Science Signaling. [IF=1.6, Cited=205, 21177495].
Schoenborn JR, Tan YX, Zhang C, ..., Weiss A (2011) Feedback circuits monitor and adjust basal Lck-dependent events in T
cell receptor signaling. Science Signaling. [IF=1.6, Cited=55, 21917715].
Friedel P, Kahle KT, Zhang J, ..., Medina I (2015) WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter
maintains the depolarizing action of GABA in immature neurons. Science Signaling. [IF=1.6, Cited=73, 26126716].
Katsuno Y, Meyer DS, Zhang Z, ..., Derynck R (2019) Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and
cancer drug resistance with vulnerability to bitopic mTOR inhibition. Science Signaling. [IF=1.6, Cited=111, 30808819].
Lou K, Steri V, Ge AY, ..., Gilbert LA (2019) KRAS^G12C inhibition produces a driver-limited state revealing
collateral dependencies. Science Signaling. [IF=1.6, Cited=81, 31138768].
Yang G, Francis D, Krycer JR, ..., James DE (2021) Dissecting the biology of mTORC1 beyond rapamycin. Science Signaling.
[IF=1.6, Cited=8, 34546793].
Amin DN, Sergina N, Ahuja D, ..., Moasser MM (2010) Resiliency and vulnerability in the HER2-HER3 tumorigenic driver.
Science Translational Medicine. [IF=2.778, Cited=90, 20371474].
Plenker D, Riedel M, Brägelmann J, ..., Sos ML (2017) Drugging the catalytically inactive state of RET kinase in RET-
rearranged tumors. Science Translational Medicine. [IF=2.778, Cited=33, 28615362].
Smith GA, Padmanabhan A, Lau BH, ..., Chorba JS (2022) Cold shock domain-containing protein E1 is a posttranscriptional
regulator of the LDL receptor. Science Translational Medicine. [IF=2.778, Cited=6, 36103516].
Kuhlenschmidt TB, Rutaganira FU, Long S, ..., Sibley LD (2015) Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1)
In Vitro by Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell
Culture. Antimicrobial Agents and Chemotherapy. [IF=1.175, Cited=26, 26552986].
Liu Y, Warfield L, Zhang C, ..., Hahn S (2009) Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1
kinase stimulates recruitment of the PAF complex. Molecular and Cellular Biology. [IF=1.026, Cited=130, 19581288].
St Amour CV, Sansó M, Bösken CA, ..., Fisher RP (2012) Separate domains of fission yeast Cdk9 (P-TEFb) are required for
capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.
Molecular and Cellular Biology. [IF=1.026, Cited=28, 22508988].
Sreenivasan A, Bishop AC, Shokat KM, Kellogg DR (2003) Specific inhibition of Elm1 kinase activity reveals functions
required for early G1 events. Molecular and Cellular Biology. [IF=1.026, Cited=30, 12917352].
Liu Y, Kung C, Fishburn J, ..., Hahn S (2004) Two cyclin-dependent kinases promote RNA polymerase II transcription and
formation of the scaffold complex. Molecular and Cellular Biology. [IF=1.026, Cited=130, 14749387].
Dar AC, Shokat KM (2011) The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling.
Annual Review of Biochemistry. [IF=5.273, Cited=168, 21548788].
Shogren-Knaak MA, Alaimo PJ, Shokat KM (2001) Recent advances in chemical approaches to the study of biological systems.
Annual Review of Cell and Developmental Biology. [IF=2.757, Cited=58, 11687495].
Mantilla CB, Stowe JM, Sieck DC, ..., Sieck GC (2014) TrkB kinase activity maintains synaptic function and structural
integrity at adult neuromuscular junctions. Journal of Applied Physiology. [IF=1.164, Cited=40, 25170066].
Fan QW, Cheng CK, Nicolaides TP, ..., Weiss WA (2007) A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates
with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Research. [IF=1.624, Cited=129, 17804702].
Oda K, Okada J, Timmerman L, ..., McCormick F (2008) PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway
mutations to effect oncogenic transformation. Cancer Research. [IF=1.624, Cited=119, 18829572].
Chaisuparat R, Hu J, Jham BC, ..., Montaner S (2008) Dual inhibition of PI3Kalpha and mTOR as an alternative treatment
for Kaposi's sarcoma. Cancer Research. [IF=1.624, Cited=34, 18922908].
Jang M, Kim Y, Won H, ..., Kim SS (2012) Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia
treatment by arsenic trioxide. Cancer Research. [IF=1.624, Cited=18, 22719067].
Wong RA, Luo X, Lu M, ..., Fan QW (2019) Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma. Cancer
Research. [IF=1.624, Cited=9, 31806641].
Wolpaw AJ, Bayliss R, Büchel G, ..., Mossé YP (2021) Drugging the "Undruggable" MYCN Oncogenic Transcription Factor:
Overcoming Previous Obstacles to Impact Childhood Cancers. Cancer Research. [IF=1.624, Cited=21, 33509943].
Sturgeon CM, Knight ZA, Shokat KM, Roberge M (2006) Effect of combined DNA repair inhibition and G2 checkpoint
inhibition on cell cycle progression after DNA damage. Molecular Cancer Therapeutics. [IF=1.04, Cited=24, 16648558].
Li N, Maly DJ, Chanthery YH, ..., Persson AI (2014) Radiotherapy followed by aurora kinase inhibition targets tumor-
propagating cells in human glioblastoma. Molecular Cancer Therapeutics. [IF=1.04, Cited=17, 25522764].
Miller RE, Brough R, Bajrami I, ..., Ashworth A (2016) Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell
Tumors with Dasatinib. Molecular Cancer Therapeutics. [IF=1.04, Cited=52, 27364904].
Chamberlain CE, German MS, Yang K, ..., Nakakura EK (2018) A Patient-derived Xenograft Model of Pancreatic
Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors. Molecular
Cancer Therapeutics. [IF=1.04, Cited=23, 30254185].
Werr L, Plenker D, Dammert MA, ..., Thomas RK (2022) CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically
Tractable ERBB2:ERBB3 Heterodimerization. Molecular Cancer Therapeutics. [IF=1.04, Cited=4, 35247925].
Reed DE, Shokat KM (2017) INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC. Molecular
Cancer Research. [IF=1.012, Cited=14, 28196852].
Barkovich KJ, Hariono S, Garske AL, ..., Weiss WA (2012) Kinetics of inhibitor cycling underlie therapeutic disparities
between EGFR-driven lung and brain cancers. Cancer Discovery. [IF=3.608, Cited=34, 22588882].
Martins MM, Zhou AY, Corella A, ..., Bandyopadhyay S (2014) Linking tumor mutations to drug responses via a quantitative
chemical-genetic interaction map. Cancer Discovery. [IF=3.608, Cited=39, 25501949].
Saha SK, Gordan JD, Kleinstiver BP, ..., Bardeesy N (2016) Isocitrate Dehydrogenase Mutations Confer Dasatinib
Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. Cancer Discovery. [IF=3.608, Cited=80, 27231123].
Guiley KZ, Shokat KM (2023) A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal
Stability. Cancer Discovery. [IF=3.608, Cited=25, 36197521].
Niedermeier M, Hennessy BT, Knight ZA, ..., Burger JA (2009) Isoform-selective phosphoinositide 3'-kinase inhibitors
inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel
therapeutic approach. Blood. [IF=2.983, Cited=99, 19318683].
Sly LM, Hamilton MJ, Kuroda E, ..., Krystal G (2009) SHIP prevents lipopolysaccharide from triggering an antiviral
response in mice. Blood. [IF=2.983, Cited=29, 19139077].
Wei F, Wang GD, Zhang C, ..., Zhuo M (2006) Forebrain overexpression of CaMKII abolishes cingulate long term depression
and reduces mechanical allodynia and thermal hyperalgesia. Molecular Pain. [IF=0.866, Cited=15, 16776832].
Ksionda O, Mues M, Wandler AM, ..., Roose JP (2018) Comprehensive analysis of T cell leukemia signals reveals
heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy. PLoS ONE.
[IF=1.253, Cited=12, 29799846].
Martin H, Shales M, Fernandez-Piñar P, ..., Krogan NJ (2015) Differential genetic interactions of yeast stress response
MAPK pathways. Molecular Systems Biology. [IF=2.015, Cited=30, 25888283].
Wan L, Zhang C, Shokat KM, Hollingsworth NM (2006) Chemical inactivation of cdc7 kinase in budding yeast results in a
reversible arrest that allows efficient cell synchronization prior to meiotic recombination. Genetics. [IF=1.102,
Cited=38, 17057233].
Chorba JS, Galvan AM, Shokat KM (2018) A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover
Protease PCSK9. Journal of Visualized Experiments. [IF=0.398, Cited=1, 30222160].
Miller AL, Zhang C, Shokat KM, Lowell CA (2009) Generation of a novel system for studying spleen tyrosine kinase
function in macrophages and B cells. Journal of Immunology. [IF=0.939, Cited=4, 19124742].
Guo T, Marmol P, Moliner A, ..., Ibanez CF (2014) Adipocyte ALK7 links nutrient overload to catecholamine resistance in
obesity. eLife. [IF=1.743, Cited=42, 25161195].
Warkentin AA, Lopez MS, Lasater EA, ..., Shokat KM (2014) Overcoming myelosuppression due to synthetic lethal toxicity
for FLT3-targeted acute myeloid leukemia therapy. eLife. [IF=1.743, Cited=17, 25531068].
Mendez AS, Alfaro J, Morales-Soto MA, ..., Walter P (2015) Endoplasmic reticulum stress-independent activation of
unfolded protein response kinases by a small molecule ATP-mimic. eLife. [IF=1.743, Cited=31, 25986605].
Manz BN, Tan YX, Courtney AH, ..., Weiss A (2015) Small molecule inhibition of Csk alters affinity recognition by T
cells. eLife. [IF=1.743, Cited=28, 26302204].

Publication with MISSING institution:

Ting AY, Ting A, Witte K, ..., Schultz PG (2001) Phage-display evolution of tyrosine kinases with altered nucleotide
specificity. Biopolymers. [IF=0.522, Cited=10, 11774228].
Kung C, Shokat KM (2005) Small-molecule kinase-inhibitor target assessment. ChemBioChem. [IF=0.691, Cited=14, 15696508].
Yang F, Liu Y, Bixby SD, ..., Shokat KM (1999) Highly efficient green fluorescent protein-based kinase substrates.
Analytical Biochemistry. [IF=0.706, Cited=15, 9888972].
Feldman ME, Shokat KM (2010) New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new
generation of Tor Kinase Domain Inhibitors (TORKinibs). None. [IF=None, Cited=38, 20549474].
Salomon D, Zhang C, Shokat KM, Sessa G (2011) Sensitizing plant protein kinases to specific inhibition by ATP-
competitive molecules. Methods in Molecular Biology. [IF=0.413, Cited=1, 21837567].
Statsuk AV, Shokat KM (2012) Covalent cross-linking of kinases with their corresponding peptide substrates. Methods in
Molecular Biology. [IF=0.413, Cited=3, 21960223].
Atreya CE, Ducker GS, Feldman ME, ..., Shokat KM (2012) Combination of ATP-competitive mammalian target of rapamycin
inhibitors with standard chemotherapy for colorectal cancer. Investigational New Drugs. [IF=0.78, Cited=15, 22270257].
Shokat KM, Shokat KM, Schultz PG, Schultz PG (1991) Catalytic antibodies. None. [IF=None, Cited=5, 1762563].
Simon MD, Shokat KM (2012) A method to site-specifically incorporate methyl-lysine analogues into recombinant proteins.
None. [IF=None, Cited=9, 22910202].
Shokat KM (2014) Methods in Enzymology. Protein kinase inhibitors in research and medicine. Preface. None. [IF=None,
Cited=1, 25399648].
Carlson HK, Plate L, Price MS, ..., Marletta MA (2009) Use of a semisynthetic epitope to probe histidine kinase activity
and regulation. Analytical Biochemistry. [IF=0.706, Cited=20, 19819215].
Knight ZA, Chiang GG, Alaimo PJ, ..., Shokat KM (2004) Isoform-specific phosphoinositide 3-kinase inhibitors from an
arylmorpholine scaffold. Bioorganic and Medicinal Chemistry. [IF=0.86, Cited=72, 15358300].
Alaimo PJ, Knight ZA, Shokat KM (2005) Targeting the gatekeeper residue in phosphoinositide 3-kinases. Bioorganic and
Medicinal Chemistry. [IF=0.86, Cited=30, 15781393].
Fan QW, Knight ZA, Goldenberg DD, ..., Weiss WA (2006) A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in
glioma. Cancer Cell. [IF=5.274, Cited=369, 16697955].
Zunder ER, Knight ZA, Houseman BT, ..., Shokat KM (2008) Discovery of drug-resistant and drug-sensitizing mutations in
the oncogenic PI3K isoform p110 alpha. Cancer Cell. [IF=5.274, Cited=63, 18691552].
Hsieh AC, Costa M, Zollo O, ..., Ruggero D (2010) Genetic dissection of the oncogenic mTOR pathway reveals druggable
addiction to translational control via 4EBP-eIF4E. Cancer Cell. [IF=5.274, Cited=310, 20227039].
Fan QW, Cheng CK, Gustafson WC, ..., Weiss WA (2013) EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and
progression in glioblastoma. Cancer Cell. [IF=5.274, Cited=168, 24135280].
Muratani M, Kung C, Shokat KM, Tansey WP (2005) The F box protein Dsg1/Mdm30 is a transcriptional coactivator that
stimulates Gal4 turnover and cotranscriptional mRNA processing. Cell. [IF=8.479, Cited=119, 15797387].
Knight ZA, Gonzalez B, Feldman ME, ..., Shokat KM (2006) A pharmacological map of the PI3-K family defines a role for
p110alpha in insulin signaling. Cell. [IF=8.479, Cited=691, 16647110].
Simon MD, Chu F, Racki LR, ..., Shokat KM (2007) The site-specific installation of methyl-lysine analogs into
recombinant histones. Cell. [IF=8.479, Cited=313, 17350582].
Knight ZA, Shokat KM (2007) Chemical genetics: where genetics and pharmacology meet. Cell. [IF=8.479, Cited=149, 17289560].
Li S, Makovets S, Matsuguchi T, ..., Blackburn EH (2009) Cdk1-dependent phosphorylation of Cdc13 coordinates telomere
elongation during cell-cycle progression. Cell. [IF=8.479, Cited=99, 19135888].
Fiedler D, Braberg H, Mehta M, ..., Krogan NJ (2009) Functional organization of the S. cerevisiae phosphorylation
network. Cell. [IF=8.479, Cited=193, 19269370].
Hertz NT, Berthet A, Sos ML, ..., Shokat KM (2013) A neo-substrate that amplifies catalytic activity of
parkinson's-disease-related kinase PINK1. Cell. [IF=8.479, Cited=152, 23953109].
Sato K, Simon MD, Levin AM, ..., Weiss GA (2004) Dissecting the Engrailed homeodomain-DNA interaction by phage-displayed
shotgun scanning. None. [IF=None, Cited=15, 15271360].
Knight ZA, Shokat KM (2005) Features of selective kinase inhibitors. None. [IF=None, Cited=351, 15975507].
Kung C, Kenski DM, Krukenberg K, ..., Shokat KM (2006) Selective kinase inhibition by exploiting differential pathway
sensitivity. None. [IF=None, Cited=13, 16632252].
Snead JL, Sullivan M, Lowery DM, ..., Shokat KM (2007) A coupled chemical-genetic and bioinformatic approach to Polo-
like kinase pathway exploration. None. [IF=None, Cited=67, 18022565].
Dar AC, Lopez MS, Shokat KM (2008) Small molecule recognition of c-Src via the Imatinib-binding conformation. None.
[IF=None, Cited=57, 18940662].
Williams O, Houseman BT, Kunkel EJ, ..., Shokat KM (2010) Discovery of dual inhibitors of the immune cell PI3Ks
p110delta and p110gamma: a prototype for new anti-inflammatory drugs. None. [IF=None, Cited=44, 20189103].
Hung CH, Thomas L, Ruby CE, ..., Thomas G (2007) HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to
downregulate cell-surface MHC-I. None. [IF=None, Cited=68, 18005690].
Kaasik K, Kivimäe S, Allen JJ, ..., Fu YH (2013) Glucose sensor O-GlcNAcylation coordinates with phosphorylation to
regulate circadian clock. None. [IF=None, Cited=152, 23395175].
Tak E, Lee S, Lee J, ..., Kim SS (2010) Human carbonyl reductase 1 upregulated by hypoxia renders resistance to
apoptosis in hepatocellular carcinoma cells. Journal of Hepatology. [IF=5.444, Cited=48, 21056497].
Sordet O, Larochelle S, Nicolas E, ..., Pommier Y (2008) Hyperphosphorylation of RNA polymerase II in response to
topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of
topoisomerase I. Journal of Molecular Biology. [IF=1.281, Cited=39, 18588899].
D'Aquino KE, Monje-Casas F, Paulson J, ..., Amon A (2005) The protein kinase Kin4 inhibits exit from mitosis in response
to spindle position defects. Molecular Cell. [IF=2.773, Cited=106, 16039591].
Ventura JJ, Hübner A, Zhang C, ..., Davis RJ (2006) Chemical genetic analysis of the time course of signal transduction
by JNK. Molecular Cell. [IF=2.773, Cited=210, 16507367].
Jaeschke A, Karasarides M, Ventura JJ, ..., Davis RJ (2006) JNK2 is a positive regulator of the cJun transcription
factor. Molecular Cell. [IF=2.773, Cited=115, 16973441].
Larochelle S, Merrick KA, Terret ME, ..., Fisher RP (2007) Requirements for Cdk7 in the assembly of Cdk1/cyclin B and
activation of Cdk2 revealed by chemical genetics in human cells. Molecular Cell. [IF=2.773, Cited=160, 17386261].
Kang J, Yang M, Li B, ..., Yu H (2008) Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.
Molecular Cell. [IF=2.773, Cited=72, 18995837].
Merrick KA, Larochelle S, Zhang C, ..., Fisher RP (2008) Distinct activation pathways confer cyclin-binding specificity
on Cdk1 and Cdk2 in human cells. Molecular Cell. [IF=2.773, Cited=58, 19061641].
Viladevall L, St Amour CV, Rosebrock A, ..., Fisher RP (2009) TFIIH and P-TEFb coordinate transcription with capping
enzyme recruitment at specific genes in fission yeast. Molecular Cell. [IF=2.773, Cited=81, 19328067].
Niu H, Wan L, Busygina V, ..., Hollingsworth NM (2009) Regulation of meiotic recombination via Mek1-mediated Rad54
phosphorylation. Molecular Cell. [IF=2.773, Cited=115, 19917248].
Merrick KA, Wohlbold L, Zhang C, ..., Fisher RP (2011) Switching Cdk2 on or off with small molecules to reveal
requirements in human cell proliferation. Molecular Cell. [IF=2.773, Cited=60, 21658603].
Banko MR, Allen JJ, Schaffer BE, ..., Brunet A (2011) Chemical genetic screen for AMPKα2 substrates uncovers a network
of proteins involved in mitosis. Molecular Cell. [IF=2.773, Cited=158, 22137581].
Ryan CJ, Roguev A, Patrick K, ..., Krogan NJ (2012) Hierarchical modularity and the evolution of genetic interactomes
across species. Molecular Cell. [IF=2.773, Cited=131, 22681890].
Schachter MM, Merrick KA, Larochelle S, ..., Fisher RP (2013) A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1
progression. Molecular Cell. [IF=2.773, Cited=80, 23622515].
Chen X, Ye H, Kuruvilla R, ..., Ginty DD (2005) A chemical-genetic approach to studying neurotrophin signaling. Neuron.
[IF=3.346, Cited=173, 15820690].
Ultanir SK, Hertz NT, Li G, ..., Jan YN (2012) Chemical genetic identification of NDR1/2 kinase substrates AAK1 and
Rabin8 Uncovers their roles in dendrite arborization and spine development. Neuron. [IF=3.346, Cited=90, 22445341].
Hindley AD, Park S, Wang L, ..., Yeung KC (2004) Engineering the serine/threonine protein kinase Raf-1 to utilise an
orthogonal analogue of ATP substituted at the N6 position. FEBS Letters. [IF=0.871, Cited=14, 14706820].
Holt JR, Gillespie SKH, Provance DW, ..., Gillespie PG (2002) A chemical-genetic strategy implicates myosin-1c in
adaptation by hair cells. Cell. [IF=8.479, Cited=209, 11853671].
Bishop AC, Shokat KM (1999) Acquisition of inhibitor-sensitive protein kinases through protein design. Pharmacology and
Therapeutics. [IF=2.796, Cited=34, 10454210].
Specht KM, Shokat KM (2002) The emerging power of chemical genetics. Current Opinion in Cell Biology. [IF=1.539,
Cited=77, 11891113].
Ulrich SM, Sallee NA, Shokat KM (2002) Conformational restraint is a critical determinant of unnatural nucleotide
recognition by protein kinases. Bioorganic and Medicinal Chemistry Letters. [IF=0.704, Cited=1, 12372539].
Fan QW, Zhang C, Shokat KM, Weiss WA (2002) Chemical genetic blockade of transformation reveals dependence on aberrant
oncogenic signaling. Current Biology. [IF=1.81, Cited=21, 12194819].
Bishop AC, Shah K, Liu Y, ..., Shokat KM (1998) Design of allele-specific inhibitors to probe protein kinase signaling.
Current Biology. [IF=1.81, Cited=149, 9501066].
Bishop AC, Buzko O, Shokat KM (2001) Magic bullets for protein kinases. Trends in Cell Biology. [IF=3.592, Cited=155, 11306297].
Liu Y, Shah K, Yang F, ..., Shokat KM (1998) A molecular gate which controls unnatural ATP analogue recognition by the
tyrosine kinase v-Src. Bioorganic and Medicinal Chemistry. [IF=0.86, Cited=74, 9784863].
Shah K, Shokat KM (2002) A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde
signaling pathway. None. [IF=None, Cited=88, 11841937].
Witucki LA, Huang X, Shah K, ..., Shokat KM (2002) Mutant tyrosine kinases with unnatural nucleotide specificity retain
the structure and phospho-acceptor specificity of the wild-type enzyme. None. [IF=None, Cited=37, 11841936].
Liu Y, Shah K, Yang F, ..., Shokat KM (1998) Engineering Src family protein kinases with unnatural nucleotide
specificity. None. [IF=None, Cited=105, 9495830].
Liu Y, Bishop A, Witucki L, ..., Shokat KM (1999) Structural basis for selective inhibition of Src family kinases by
PP1. None. [IF=None, Cited=152, 10467133].
Alaimo PJ, Shogren-Knaak MA, Shokat KM (2001) Chemical genetic approaches for the elucidation of signaling pathways.
Current Opinion in Chemical Biology. [IF=1.51, Cited=79, 11470597].
McClard RW, Shokat KM (1987) Does the bifunctional uridylate synthase channel orotidine 5'-phosphate? Kinetics of
orotate phosphoribosyltransferase and orotidylate decarboxylase activities fit a noninteracting sites model.
Biochemistry. [IF=0.753, Cited=4, 3651388].
Statsuk AV, Maly DJ, Seeliger MA, ..., Shokat KM (2008) Tuning a three-component reaction for trapping kinase substrate
complexes. Journal of the American Chemical Society. [IF=2.573, Cited=39, 19053485].
Buzko OV, Bishop AC, Shokat KM (2002) Modified AutoDock for accurate docking of protein kinase inhibitors. Journal of
Computer-Aided Molecular Design. [IF=0.881, Cited=25, 12188021].
Buzko OV, Shokat KM (1999) Blocking HIV entry. None. [IF=None, Cited=5, 10504719].
Bishop AC, Ubersax JA, Petsch DT, ..., Shokat KM (2000) A chemical switch for inhibitor-sensitive alleles of any protein
kinase. Nature. [IF=11.591, Cited=728, 11014197].
Weiss EL, Bishop AC, Shokat KM, Drubin DG (2000) Chemical genetic analysis of the budding-yeast p21-activated kinase
Cla4p. Nature Cell Biology. [IF=3.908, Cited=102, 11025657].
Habelhah H, Shah K, Huang L, ..., Ronai Z (2001) ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and
inhibition of mRNA translation. Nature Cell Biology. [IF=3.908, Cited=206, 11231586].
Park S, Chapuis N, Bardet V, ..., Bouscary D (2008) PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase
and mTOR, has antileukemic activity in AML. Leukemia. [IF=2.198, Cited=102, 18548104].
Ubersax JA, Woodbury EL, Quang PN, ..., Morgan DO (2003) Targets of the cyclin-dependent kinase Cdk1. Nature.
[IF=11.591, Cited=620, 14574415].
Sergina NV, Rausch M, Wang D, ..., Moasser MM (2007) Escape from HER-family tyrosine kinase inhibitor therapy by the
kinase-inactive HER3. Nature. [IF=11.591, Cited=599, 17206155].
Korennykh AV, Egea PF, Korostelev AA, ..., Walter P (2008) The unfolded protein response signals through high-order
assembly of Ire1. Nature. [IF=11.591, Cited=412, 19079236].
Poulikakos PI, Zhang C, Bollag G, ..., Rosen N (2010) RAF inhibitors transactivate RAF dimers and ERK signalling in
cells with wild-type BRAF. Nature. [IF=11.591, Cited=1000, 20179705].
Lourido S, Shuman J, Zhang C, ..., Sibley LD (2010) Calcium-dependent protein kinase 1 is an essential regulator of
exocytosis in Toxoplasma. Nature. [IF=11.591, Cited=217, 20485436].
Brennan DF, Dar AC, Hertz NT, ..., Barford D (2011) A Raf-induced allosteric transition of KSR stimulates
phosphorylation of MEK. Nature. [IF=11.591, Cited=167, 21441910].
Hsieh AC, Liu Y, Edlind MP, ..., Ruggero D (2012) The translational landscape of mTOR signalling steers cancer
initiation and metastasis. Nature. [IF=11.591, Cited=834, 22367541].
Dar AC, Das TK, Shokat KM, Cagan RL (2012) Chemical genetic discovery of targets and anti-targets for cancer
polypharmacology. Nature. [IF=11.591, Cited=194, 22678283].
Ostrem JM, Peters U, Sos ML, ..., Shokat KM (2013) K-Ras(G12C) inhibitors allosterically control GTP affinity and
effector interactions. Nature. [IF=11.591, Cited=1000, 24256730].
Knight ZA, Schilling B, Row RH, ..., Shokat KM (2003) Phosphospecific proteolysis for mapping sites of protein
phosphorylation. Nature Biotechnology. [IF=8.861, Cited=129, 12923550].
Pinsky BA, Kung C, Shokat KM, Biggins S (2005) The Ipl1-Aurora protein kinase activates the spindle checkpoint by
creating unattached kinetochores. Nature Cell Biology. [IF=3.908, Cited=191, 16327780].
Su T, Bryant DM, Luton F, ..., Mostov KE (2010) A kinase cascade leading to Rab11-FIP5 controls transcytosis of the
polymeric immunoglobulin receptor. Nature Cell Biology. [IF=3.908, Cited=57, 21037565].
Hoon S, Smith AM, Wallace IM, ..., Nislow C (2008) An integrated platform of genomic assays reveals small-molecule
bioactivities. Nature Chemical Biology. [IF=2.623, Cited=127, 18622389].
Apsel B, Blair JA, Gonzalez B, ..., Knight ZA (2008) Targeted polypharmacology: discovery of dual inhibitors of tyrosine
and phosphoinositide kinases. Nature Chemical Biology. [IF=2.623, Cited=240, 18849971].
Okuzumi T, Fiedler D, Zhang C, ..., Shokat KM (2009) Inhibitor hijacking of Akt activation. Nature Chemical Biology.
[IF=2.623, Cited=185, 19465931].
Berndt A, Miller S, Williams O, ..., Williams RL (2010) The p110 delta structure: mechanisms for selectivity and potency
of new PI(3)K inhibitors. Nature Chemical Biology. [IF=2.623, Cited=110, 20081827].
Berndt A, Miller S, Williams O, ..., Williams RL (2010) The p110delta structure: mechanisms for selectivity and potency
of new PI(3)K inhibitors. Nature Chemical Biology. [IF=2.623, Cited=22, 20154668].
Weiss WA, Taylor SS, Shokat KM (2007) Recognizing and exploiting differences between RNAi and small-molecule inhibitors.
Nature Chemical Biology. [IF=2.623, Cited=175, 18007642].
Blair JA, Rauh D, Kung C, ..., Shokat KM (2007) Structure-guided development of affinity probes for tyrosine kinases
using chemical genetics. Nature Chemical Biology. [IF=2.623, Cited=94, 17334377].
Au-Yeung BB, Levin SE, Zhang C, ..., Weiss A (2010) A genetically selective inhibitor demonstrates a function for the
kinase Zap70 in regulatory T cells independent of its catalytic activity. Nature Immunology. [IF=4.23, Cited=76, 21037577].
Allen JJ, Li M, Brinkworth CS, ..., Shokat KM (2007) A semisynthetic epitope for kinase substrates. Nature Methods.
[IF=10.009, Cited=216, 17486086].
Zhang C, Kenski DM, Paulson JL, ..., Shokat KM (2005) A second-site suppressor strategy for chemical genetic analysis of
diverse protein kinases. Nature Methods. [IF=10.009, Cited=80, 15908922].
Soskis MJ, Ho HYH, Bloodgood BL, ..., Greenberg ME (2012) A chemical genetic approach reveals distinct EphB signaling
mechanisms during brain development. Nature Neuroscience. [IF=4.893, Cited=23, 23143520].
Knight ZA, Feldman ME, Balla A, ..., Shokat KM (2007) A membrane capture assay for lipid kinase activity. None.
[IF=None, Cited=34, 17947987].
Gregan J, Zhang C, Rumpf C, ..., Shokat KM (2007) Construction of conditional analog-sensitive kinase alleles in the
fission yeast Schizosaccharomyces pombe. None. [IF=None, Cited=29, 18007635].
Knight ZA, Lin H, Shokat KM (2010) Targeting the cancer kinome through polypharmacology. Nature Reviews Cancer.
[IF=10.357, Cited=379, 20094047].
Lu X, Simon MD, Chodaparambil JV, ..., Luger K (2008) The effect of H3K79 dimethylation and H4K20 trimethylation on
nucleosome and chromatin structure. Nature Structural and Molecular Biology. [IF=2.542, Cited=151, 18794842].
Larochelle S, Amat R, Glover-Cutter K, ..., Fisher RP (2012) Cyclin-dependent kinase control of the initiation-to-
elongation switch of RNA polymerase II. Nature Structural and Molecular Biology. [IF=2.542, Cited=233, 23064645].
Larochelle S, Batliner J, Gamble MJ, ..., Fisher RP (2005) Dichotomous but stringent substrate selection by the dual-
function Cdk7 complex revealed by chemical genetics. Nature Structural and Molecular Biology. [IF=2.542, Cited=61, 16327805].
Bateman R, Rauh D, Shokat KM (2007) Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct.
Organic and Biomolecular Chemistry. [IF=0.77, Cited=17, 17912391].
Okuzumi T, Ducker GS, Zhang C, ..., Shokat KM (2010) Synthesis and evaluation of indazole based analog sensitive Akt
inhibitors. None. [IF=None, Cited=14, 20582381].
Gillespie PG, Gillespie SK, Mercer JA, ..., Shokat KM (1999) Engineering of the myosin-ibeta nucleotide-binding pocket
to create selective sensitivity to N(6)-modified ADP analogs. Journal of Biological Chemistry. [IF=1.122, Cited=35, 10531338].
Chorba JS, Galvan AM, Shokat KM (2018) Stepwise processing analyses of the single-turnover PCSK9 protease reveal its
substrate sequence specificity and link clinical genotype to lipid phenotype. Journal of Biological Chemistry.
[IF=1.122, Cited=0, 29728531].
Habelhah H, Shah K, Huang L, ..., Ronai Z (2001) Identification of new JNK substrate using ATP pocket mutant JNK and a
corresponding ATP analogue. Journal of Biological Chemistry. [IF=1.122, Cited=89, 11259409].
Roux J, Carles M, Koh H, ..., Pittet JF (2009) Transforming growth factor beta1 inhibits cystic fibrosis transmembrane
conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-
dependent mechanism. Journal of Biological Chemistry. [IF=1.122, Cited=28, 19996317].
An S, Kyoung M, Allen JJ, ..., Benkovic SJ (2010) Dynamic regulation of a metabolic multi-enzyme complex by protein
kinase CK2. Journal of Biological Chemistry. [IF=1.122, Cited=49, 20157113].
Young ET, Zhang C, Shokat KM, ..., Braun KA (2012) The AMP-activated protein kinase Snf1 regulates transcription factor
binding, RNA polymerase II activity, and mRNA stability of glucose-repressed genes in Saccharomyces cerevisiae. Journal
of Biological Chemistry. [IF=1.122, Cited=26, 22761425].
Niswender CM, Ishihara RW, Judge LM, ..., McKnight GS (2002) Protein engineering of protein kinase A catalytic subunits
results in the acquisition of novel inhibitor sensitivity. Journal of Biological Chemistry. [IF=1.122, Cited=20, 12034735].
Eblen ST, Kumar NV, Shah K, ..., Weber MJ (2003) Identification of novel ERK2 substrates through use of an engineered
kinase and ATP analogs. Journal of Biological Chemistry. [IF=1.122, Cited=79, 12594221].
Kenski DM, Zhang C, von Zastrow M, Shokat KM (2005) Chemical genetic engineering of G protein-coupled receptor kinase 2.
Journal of Biological Chemistry. [IF=1.122, Cited=18, 16081410].
Tóth B, Balla A, Ma H, ..., Balla T (2006) Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide
between the endoplasmic reticulum and Golgi. Journal of Biological Chemistry. [IF=1.122, Cited=84, 17003043].
Qi ZH, Song M, Wallace MJ, ..., Messing RO (2007) Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor
sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. Journal of Biological Chemistry.
[IF=1.122, Cited=73, 17875639].
Levin SE, Zhang C, Kadlecek TA, ..., Weiss A (2008) Inhibition of ZAP-70 kinase activity via an analog-sensitive allele
blocks T cell receptor and CD28 superagonist signaling. Journal of Biological Chemistry. [IF=1.122, Cited=37, 18378687].
Shirra MK, McCartney RR, Zhang C, ..., Arndt KM (2008) A chemical genomics study identifies Snf1 as a repressor of GCN4
translation. Journal of Biological Chemistry. [IF=1.122, Cited=36, 18955495].
Bateman RL, Rauh D, Tavshanjian B, Shokat KM (2008) Human carbonyl reductase 1 is an S-nitrosoglutathione reductase.
Journal of Biological Chemistry. [IF=1.122, Cited=86, 18826943].
Salomon D, Bonshtien A, Mayrose M, ..., Sessa G (2009) Bypassing kinase activity of the tomato Pto resistance protein
with small molecule ligands. Journal of Biological Chemistry. [IF=1.122, Cited=6, 19332544].
Hengeveld RCC, Hertz NT, Vromans MJM, ..., Lens SMA (2012) Development of a chemical genetic approach for human aurora B
kinase identifies novel substrates of the chromosomal passenger complex. Molecular and Cellular Proteomics. [IF=1.296,
Cited=31, 22267324].
Wang H, Kakaradov B, Collins SR, ..., Koller D (2009) A complex-based reconstruction of the Saccharomyces cerevisiae
interactome. Molecular and Cellular Proteomics. [IF=1.296, Cited=54, 19176519].
Buzko O, Shokat KM (2002) A kinase sequence database: sequence alignments and family assignment. Bioinformatics.
[IF=1.954, Cited=34, 12217924].
Simon MD, Sato K, Weiss GA, Shokat KM (2004) A phage display selection of engrailed homeodomain mutants and the
importance of residue Q50. Nucleic Acids Research. [IF=4.663, Cited=10, 15247345].
Benjamin KR, Zhang C, Shokat KM, Herskowitz I (2003) Control of landmark events in meiosis by the CDK Cdc28 and the
meiosis-specific kinase Ime2. Genes and Development. [IF=1.985, Cited=207, 12783856].
Wan L, Niu H, Futcher B, ..., Hollingsworth NM (2008) Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate
meiotic recombination in yeast. Genes and Development. [IF=1.985, Cited=99, 18245450].
Kim HH, Abdelmohsen K, Lal A, ..., Gorospe M (2008) Nuclear HuR accumulation through phosphorylation by Cdk1. Genes and
Development. [IF=1.985, Cited=149, 18593881].
Chuluunbaatar U, Roller R, Feldman ME, ..., Mohr I (2010) Constitutive mTORC1 activation by a herpesvirus Akt surrogate
stimulates mRNA translation and viral replication. Genes and Development. [IF=1.985, Cited=98, 21123650].
Brodersen P, Petersen M, Bjørn Nielsen H, ..., Mundy J (2006) Arabidopsis MAP kinase 4 regulates salicylic acid- and
jasmonic acid/ethylene-dependent responses via EDS1 and PAD4. Plant Journal. [IF=1.71, Cited=193, 16813576].
Johnson AW, Chen X, Crombag HS, ..., Ginty DD (2008) The brain-derived neurotrophic factor receptor TrkB is critical for
the acquisition but not expression of conditioned incentive value. European Journal of Neuroscience. [IF=0.891,
Cited=17, 18671735].
Wang J, Knight ZA, Fiedler D, ..., Pearce D (2008) Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase
is required for activation of epithelial sodium transport. American Journal of Physiology - Renal Physiology. [IF=1.073,
Cited=16, 18653476].
Kharas MG, Janes MR, Scarfone VM, ..., Fruman DA (2008) Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a
dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. Journal of Clinical Investigation.
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Chen C, Kudo M, Rutaganira F, ..., Sheppard D (2012) Integrin α9β1 in airway smooth muscle suppresses exaggerated airway
narrowing. Journal of Clinical Investigation. [IF=2.423, Cited=34, 22772469].
Kharas MG, Janes MR, Scarfone VM, ..., Fruman DA (2017) Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a
dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. Journal of Clinical Investigation.
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Korennykh AV, Korostelev AA, Egea PF, ..., Walter P (2011) Structural and functional basis for RNA cleavage by Ire1. BMC
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Korennykh AV, Egea PF, Korostelev AA, ..., Walter P (2011) Cofactor-mediated conformational control in the bifunctional
kinase/RNase Ire1. BMC Biology. [IF=1.461, Cited=48, 21729334].
Kim JSM, Lilley BN, Zhang C, ..., Zhen M (2008) A chemical-genetic strategy reveals distinct temporal requirements for
SAD-1 kinase in neuronal polarization and synapse formation. Neural Development. [IF=0.89, Cited=25, 18808695].
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small molecules. PLoS Biology. [IF=2.285, Cited=128, 15799708].
Feldman ME, Apsel B, Uotila A, ..., Shokat KM (2009) Active-site inhibitors of mTOR target rapamycin-resistant outputs
of mTORC1 and mTORC2. PLoS Biology. [IF=2.285, Cited=712, 19209957].
Burkard ME, Maciejowski J, Rodriguez-Bravo V, ..., Jallepalli PV (2009) Plk1 self-organization and priming
phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biology.
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Beltrao P, Trinidad JC, Fiedler D, ..., Krogan NJ (2009) Evolution of phosphoregulation: comparison of phosphorylation
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Sansó M, Lee KM, Viladevall L, ..., Tanny JC (2012) A positive feedback loop links opposing functions of P-TEFb/Cdk9 and
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Wohlbold L, Merrick KA, De S, ..., Fisher RP (2012) Chemical genetics reveals a specific requirement for Cdk2 activity
in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells. PLoS Genetics. [IF=1.236, Cited=40, 22927831].
Sliedrecht T, Zhang C, Shokat KM, Kops GJPL (2010) Chemical genetic inhibition of Mps1 in stable human cell lines
reveals novel aspects of Mps1 function in mitosis. PLoS ONE. [IF=1.253, Cited=63, 20422024].
Cibrián Uhalte E, Kirchner M, Hellwig N, ..., Abdelilah-Seyfried S (2012) In vivo conditions to identify Prkci
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Shah K, Shokat KM (2003) A chemical genetic approach for the identification of direct substrates of protein kinases.
Methods in Molecular Biology. [IF=0.413, Cited=28, 12840513].
Chou WH, Wang D, McMahon T, ..., Messing RO (2010) GABAA receptor trafficking is regulated by protein kinase C(epsilon)
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Yoshii A, Murata Y, Kim J, ..., Constantine-Paton M (2011) TrkB and protein kinase Mζ regulate synaptic localization of
PSD-95 in developing cortex. Journal of Neuroscience. [IF=1.471, Cited=51, 21849550].
Choi DS, Wei W, Deitchman JK, ..., Messing RO (2008) Protein kinase Cdelta regulates ethanol intoxication and
enhancement of GABA-stimulated tonic current. Journal of Neuroscience. [IF=1.471, Cited=65, 19005054].
Lu M, Wang J, Jones KT, ..., Pearce D (2010) mTOR complex-2 activates ENaC by phosphorylating SGK1. Journal of the
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Cipak L, Zhang C, Kovacikova I, ..., Gregan J (2011) Generation of a set of conditional analog-sensitive alleles of
essential protein kinases in the fission yeast Schizosaccharomyces pombe. Cell Cycle. [IF=0.792, Cited=28, 22030861].
Wohlbold L, Larochelle S, Liao JCF, ..., Fisher RP (2006) The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK
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Fan QW, Specht KM, Zhang C, ..., Weiss WA (2003) Combinatorial efficacy achieved through two-point blockade within a
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Shokat, Kevan M

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