Liu, David R

Publication with MATCHING institution:

Woolston BM, Roth T, Kohale I, ..., Stephanopoulos G (2017) Development of a formaldehyde biosensor with application to
synthetic methylotrophy. Biotechnology and Bioengineering. [IF=0.932, Cited=20, 28921510].
Pattanayak V, Guilinger JP, Liu DR (2014) Determining the specificities of TALENs, Cas9, and other genome-editing
enzymes. None. [IF=None, Cited=35, 25398335].
Krishnan Y, Rees HA, Rossitto CP, ..., Grodzinsky AJ (2018) Green fluorescent proteins engineered for cartilage-targeted
drug delivery: Insights for transport into highly charged avascular tissues. Biomaterials. [IF=1.871, Cited=29, 30173104].
Ham HO, Haller CA, Su G, ..., Chaikof EL (2021) A rechargeable anti-thrombotic coating for blood-contacting devices.
Biomaterials. [IF=1.871, Cited=3, 34303154].
Badran AH, Liu DR (2014) In vivo continuous directed evolution. Current Opinion in Chemical Biology. [IF=1.51,
Cited=43, 25461718].
Chan AI, McGregor LM, Liu DR (2015) Novel selection methods for DNA-encoded chemical libraries. Current Opinion in
Chemical Biology. [IF=1.51, Cited=28, 25723146].
Komor AC, Badran AH, Liu DR (2016) CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell.
[IF=8.479, Cited=438, 27866654].
Maji B, Gangopadhyay SA, Lee M, ..., Choudhary A (2019) A High-Throughput Platform to Identify Small-Molecule Inhibitors
of CRISPR-Cas9. Cell. [IF=8.479, Cited=77, 31051099].
Arbab M, Shen MW, Mok B, ..., Liu DR (2020) Determinants of Base Editing Outcomes from Target Library Analysis and
Machine Learning. Cell. [IF=8.479, Cited=113, 32533916].
Hanna RE, Hegde M, Fagre CR, ..., Doench JG (2021) Massively parallel assessment of human variants with base editor
screens. Cell. [IF=8.479, Cited=124, 33606977].
Chen PJ, Hussmann JA, Yan J, ..., Liu DR (2021) Enhanced prime editing systems by manipulating cellular determinants of
editing outcomes. Cell. [IF=8.479, Cited=237, 34653350].
Banskota S, Raguram A, Suh S, ..., Liu DR (2022) Engineered virus-like particles for efficient in vivo delivery of
therapeutic proteins. Cell. [IF=8.479, Cited=159, 35021064].
Raguram A, Banskota S, Liu DR (2022) Therapeutic in vivo delivery of gene editing agents. Cell. [IF=8.479, Cited=96, 35798006].
McAuley GE, Yiu G, Chang PC, ..., Kohn DB (2023) Human T cell generation is restored in CD3δ severe combined
immunodeficiency through adenine base editing. Cell. [IF=8.479, Cited=18, 36944331].
Martin-Rufino JD, Castano N, Pang M, ..., Sankaran VG (2023) Massively parallel base editing to map variant effects in
human hematopoiesis. Cell. [IF=8.479, Cited=20, 37137305].
Doman JL, Pandey S, Neugebauer ME, ..., Liu DR (2023) Phage-assisted evolution and protein engineering yield compact,
efficient prime editors. Cell. [IF=8.479, Cited=27, 37657419].
Davis JC, Alves TC, Helman A, ..., Melton DA (2020) Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited
by a Bottleneck in Glycolysis. Cell Reports. [IF=1.738, Cited=56, 32402282].
Liu JM, Bittker JA, Lonshteyn M, Liu DR (2005) Functional dissection of sRNA translational regulators by nonhomologous
random recombination and in vivo selection. None. [IF=None, Cited=8, 16039523].
Hu JH, Davis KM, Liu DR (2016) Chemical Biology Approaches to Genome Editing: Understanding, Controlling, and Delivering
Programmable Nucleases. Cell Chemical Biology. [IF=1.446, Cited=28, 26933736].
Aleem S, Georghiou G, Kleiner RE, ..., Seeliger MA (2016) Structural and Biochemical Basis for Intracellular Kinase
Inhibition by Src-specific Peptidic Macrocycles. Cell Chemical Biology. [IF=1.446, Cited=5, 27593110].
Osborn MJ, Newby GA, McElroy AN, ..., Tolar J (2019) Base Editor Correction of COL7A1 in Recessive Dystrophic
Epidermolysis Bullosa Patient-Derived Fibroblasts and iPSCs. None. [IF=None, Cited=43, 31437443].
Steinbeck BJ, Gao XD, McElroy AN, ..., Osborn MJ (2024) Twin prime editing mediated exon skipping/reinsertion for
restored collagen VII expression in recessive dystrophic epidermolysis bullosa. None. [IF=None, Cited=0, 38763174].
Pak CW, Kosno M, Holehouse AS, ..., Rosen MK (2016) Sequence Determinants of Intracellular Phase Separation by Complex
Coacervation of a Disordered Protein. Molecular Cell. [IF=2.773, Cited=343, 27392146].
Joynt AT, Kavanagh EW, Newby GA, ..., Cutting GR (2023) Protospacer modification improves base editing of a canonical
splice site variant and recovery of CFTR function in human airway epithelial cells. Molecular Therapy - Nucleic Acids.
[IF=1.318, Cited=1, 37547293].
Newby GA, Liu DR (2021) In vivo somatic cell base editing and prime editing. Molecular Therapy. [IF=1.72, Cited=56, 34509669].
Knipping F, Newby GA, Eide CR, ..., Osborn MJ (2021) Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human
T cells and hematopoietic stem and progenitor cells using base editing. Molecular Therapy. [IF=1.72, Cited=17, 34737067].
Peters CW, Hanlon KS, Ivanchenko MV, ..., Corey DP (2023) Rescue of hearing by adenine base editing in a humanized mouse
model of Usher syndrome type 1F. Molecular Therapy. [IF=1.72, Cited=4, 37312453].
Harmand TJ, Bousbaine D, Chan A, ..., Ploegh HL (2018) One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion
Proteins Through a Combination of Sortase A and Butelase 1. Bioconjugate Chemistry. [IF=0.921, Cited=37, 30231608].
Komor AC, Badran AH, Liu DR (2017) Editing the Genome Without Double-Stranded DNA Breaks. ACS Chemical Biology.
[IF=0.963, Cited=64, 28957631].
Roth TB, Woolston BM, Stephanopoulos G, Liu DR (2019) Phage-Assisted Evolution of Bacillus methanolicus Methanol
Dehydrogenase 2. ACS Synthetic Biology. [IF=0.96, Cited=31, 30856338].
Leconte AM, Dickinson BC, Yang DD, ..., Liu DR (2013) A population-based experimental model for protein evolution:
effects of mutation rate and selection stringency on evolutionary outcomes. Biochemistry. [IF=0.753, Cited=26, 23360105].
Luo M, Lin H, Fischbach MA, ..., Groves JT (2006) Enzymatic tailoring of enterobactin alters membrane partitioning and
iron acquisition. ACS Chemical Biology. [IF=0.963, Cited=29, 17163637].
Cronican JJ, Thompson DB, Beier KT, ..., Liu DR (2010) Potent delivery of functional proteins into Mammalian cells in
vitro and in vivo using a supercharged protein. ACS Chemical Biology. [IF=0.963, Cited=110, 20545362].
Gartner ZJ, Liu DR (2001) The generality of DNA-templated synthesis as a basis for evolving non-natural small molecules.
Journal of the American Chemical Society. [IF=2.573, Cited=132, 11448217].
Gartner ZJ, Kanan M, Kanan MW, Liu DR (2002) Multistep small-molecule synthesis programmed by DNA templates. Journal of
the American Chemical Society. [IF=2.573, Cited=65, 12197733].
Li X, Liu DR (2003) Stereoselectivity in DNA-templated organic synthesis and its origins. Journal of the American
Chemical Society. [IF=2.573, Cited=15, 12926938].
Doyon JB, Snyder TM, Liu DR (2003) Highly sensitive in vitro selections for DNA-linked synthetic small molecules with
protein binding affinity and specificity. Journal of the American Chemical Society. [IF=2.573, Cited=33, 14531656].
Rosenbaum DM, Liu DR (2003) Efficient and sequence-specific DNA-templated polymerization of peptide nucleic acid
aldehydes. Journal of the American Chemical Society. [IF=2.573, Cited=64, 14611205].
Sakurai K, Snyder TM, Liu DR (2005) DNA-templated functional group transformations enable sequence-programmed synthesis
using small-molecule reagents. Journal of the American Chemical Society. [IF=2.573, Cited=18, 15700999].
Li X, Gartner ZJ, Tse BN, Liu DR (2004) Translation of DNA into synthetic N-acyloxazolidines. Journal of the American
Chemical Society. [IF=2.573, Cited=22, 15099091].
Lin H, Fischbach MA, Liu DR, Walsh CT (2005) In vitro characterization of salmochelin and enterobactin trilactone
hydrolases IroD, IroE, and Fes. Journal of the American Chemical Society. [IF=2.573, Cited=108, 16076215].
Doyon JB, Pattanayak V, Meyer CB, Liu DR (2006) Directed evolution and substrate specificity profile of homing
endonuclease I-SceI. Journal of the American Chemical Society. [IF=2.573, Cited=79, 16478204].
Yuen CM, Rodda SJ, Vokes SA, ..., Liu DR (2006) Control of transcription factor activity and osteoblast differentiation
in mammalian cells using an evolved small-molecule-dependent intein. Journal of the American Chemical Society.
[IF=2.573, Cited=31, 16819890].
Lin H, Fischbach MA, Gatto GJ, ..., Walsh CT (2006) Bromoenterobactins as potent inhibitors of a pathogen-associated,
siderophore-modifying C-glycosyltransferase. Journal of the American Chemical Society. [IF=2.573, Cited=5, 16848455].
Lai JR, Fischbach MA, Liu DR, Walsh CT (2006) Localized protein interaction surfaces on the EntB carrier protein
revealed by combinatorial mutagenesis and selection. Journal of the American Chemical Society. [IF=2.573, Cited=30, 16925399].
Phillips KJ, Rosenbaum DM, Liu DR (2006) Binding and stability determinants of the PPARgamma nuclear receptor-
coactivator interface as revealed by shotgun alanine scanning and in vivo selection. Journal of the American Chemical
Society. [IF=2.573, Cited=4, 16925449].
Momiyama N, Kanan M, Kanan MW, Liu DR (2007) Synthesis of acyclic alpha,beta-unsaturated ketones via Pd(II)-catalyzed
intermolecular reaction of alkynamides and alkenes. Journal of the American Chemical Society. [IF=2.573, Cited=17, 17279758].
Lawrence MS, Phillips KJ, Liu DR (2007) Supercharging proteins can impart unusual resilience. Journal of the American
Chemical Society. [IF=2.573, Cited=263, 17665911].
Rozenman MM, Kanan M, Kanan MW, Liu DR (2007) Development and initial application of a hybridization-independent, DNA-
encoded reaction discovery system compatible with organic solvents. Journal of the American Chemical Society. [IF=2.573,
Cited=39, 17994738].
Kleiner RE, Brudno Y, Birnbaum ME, Liu DR (2008) DNA-templated polymerization of side-chain-functionalized peptide
nucleic acid aldehydes. Journal of the American Chemical Society. [IF=2.573, Cited=58, 18341334].
Snyder TM, Tse BN, Liu DR (2008) Effects of template sequence and secondary structure on DNA-templated reactivity.
Journal of the American Chemical Society. [IF=2.573, Cited=18, 18179216].
Ruff KM, Snyder TM, Liu DR (2010) Enhanced functional potential of nucleic acid aptamer libraries patterned to increase
secondary structure. Journal of the American Chemical Society. [IF=2.573, Cited=32, 20565094].
Kleiner RE, Dumelin CE, Tiu GC, ..., Liu DR (2010) In vitro selection of a DNA-templated small-molecule library reveals
a class of macrocyclic kinase inhibitors. Journal of the American Chemical Society. [IF=2.573, Cited=69, 20681606].
McGregor LM, Gorin DJ, Dumelin CE, Liu DR (2010) Interaction-dependent PCR: identification of ligand-target pairs from
libraries of ligands and libraries of targets in a single solution-phase experiment. Journal of the American Chemical
Society. [IF=2.573, Cited=49, 20949943].
He Y, Liu DR (2011) A sequential strand-displacement strategy enables efficient six-step DNA-templated synthesis.
Journal of the American Chemical Society. [IF=2.573, Cited=33, 21657248].
Hili R, Niu J, Liu DR (2012) DNA ligase-mediated translation of DNA into densely functionalized nucleic acid polymers.
Journal of the American Chemical Society. [IF=2.573, Cited=25, 23256841].
McGregor LM, Jain T, Liu DR (2014) Identification of ligand-target pairs from combined libraries of small molecules and
unpurified protein targets in cell lysates. Journal of the American Chemical Society. [IF=2.573, Cited=33, 24495225].
Tse BN, Snyder TM, Shen Y, Liu DR (2008) Translation of DNA into a library of 13,000 synthetic small-molecule
macrocycles suitable for in vitro selection. Journal of the American Chemical Society. [IF=2.573, Cited=73, 18956864].
Gorin DJ, Kamlet AS, Liu DR (2009) Reactivity-dependent PCR: direct, solution-phase in vitro selection for bond
formation. Journal of the American Chemical Society. [IF=2.573, Cited=19, 19522494].
Dempsey GT, Bates M, Kowtoniuk WE, ..., Zhuang X (2009) Photoswitching mechanism of cyanine dyes. Journal of the
American Chemical Society. [IF=2.573, Cited=154, 19961226].
Heemstra JM, Liu DR (2009) Templated synthesis of peptide nucleic acids via sequence-selective base-filling reactions.
Journal of the American Chemical Society. [IF=2.573, Cited=23, 19722647].
Li M, Tao Y, Shu Y, ..., Liu DR (2015) Discovery and characterization of a peptide that enhances endosomal escape of
delivered proteins in vitro and in vivo. Journal of the American Chemical Society. [IF=2.573, Cited=45, 26465072].
Chan AI, McGregor LM, Jain T, Liu DR (2017) Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule
Library × Protein Library Selection. Journal of the American Chemical Society. [IF=2.573, Cited=32, 28689404].
Fan JA, He Y, Bao K, ..., Capasso F (2011) DNA-enabled self-assembly of plasmonic nanoclusters. Nano Letters. [IF=1.873,
Cited=34, 22007607].
Maianti JP, McFedries A, Foda ZH, ..., Liu DR (2014) Anti-diabetic activity of insulin-degrading enzyme inhibitors
mediated by multiple hormones. Nature. [IF=11.591, Cited=113, 24847884].
Badran AH, Guzov VM, Huai Q, ..., Liu DR (2016) Continuous evolution of Bacillus thuringiensis toxins overcomes insect
resistance. Nature. [IF=11.591, Cited=102, 27120167].
Komor AC, Kim YB, Packer MS, ..., Liu DR (2016) Programmable editing of a target base in genomic DNA without double-
stranded DNA cleavage. Nature. [IF=11.591, Cited=1000, 27096365].
Gaudelli NM, Komor AC, Rees HA, ..., Liu DR (2017) Programmable base editing of A•T to G•C in genomic DNA without DNA
cleavage. Nature. [IF=11.591, Cited=1000, 29160308].
Gao X, Tao Y, Lamas V, ..., Liu DR (2017) Treatment of autosomal dominant hearing loss by in vivo delivery of genome
editing agents. Nature. [IF=11.591, Cited=258, 29258297].
Hu JH, Miller SM, Geurts MH, ..., Liu DR (2018) Evolved Cas9 variants with broad PAM compatibility and high DNA
specificity. Nature. [IF=11.591, Cited=714, 29512652].
Guilinger JP, Thompson DB, Liu DR (2014) Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity
of genome modification. Nature Biotechnology. [IF=8.861, Cited=474, 24770324].
Zuris JA, Thompson DB, Shu Y, ..., Liu DR (2014) Cationic lipid-mediated delivery of proteins enables efficient protein-
based genome editing in vitro and in vivo. Nature Biotechnology. [IF=8.861, Cited=693, 25357182].
Kim YB, Komor AC, Levy JM, ..., Liu DR (2017) Increasing the genome-targeting scope and precision of base editing with
engineered Cas9-cytidine deaminase fusions. Nature Biotechnology. [IF=8.861, Cited=400, 28191901].
Koblan LW, Doman JL, Wilson C, ..., Liu DR (2018) Improving cytidine and adenine base editors by expression optimization
and ancestral reconstruction. Nature Biotechnology. [IF=8.861, Cited=431, 29813047].
Carlson JC, Badran AH, Guggiana-Nilo DA, Liu DR (2014) Negative selection and stringency modulation in phage-assisted
continuous evolution. Nature Chemical Biology. [IF=2.623, Cited=85, 24487694].
McDonald RI, Guilinger JP, Mukherji S, ..., Liu DR (2014) Electrophilic activity-based RNA probes reveal a self-
alkylating RNA for RNA labeling. Nature Chemical Biology. [IF=2.623, Cited=15, 25306441].
Davis KM, Pattanayak V, Thompson DB, ..., Liu DR (2015) Small molecule-triggered Cas9 protein with improved genome-
editing specificity. Nature Chemical Biology. [IF=2.623, Cited=211, 25848930].
Bryson DI, Fan C, Guo LT, ..., Liu DR (2017) Continuous directed evolution of aminoacyl-tRNA synthetases. Nature
Chemical Biology. [IF=2.623, Cited=132, 29035361].
Suzuki T, Miller C, Guo LT, ..., Söll D (2017) Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA
synthetase. Nature Chemical Biology. [IF=2.623, Cited=54, 29035363].
Ham HO, Qu Z, Haller CA, ..., Chaikof EL (2016) In situ regeneration of bioactive coatings enabled by an evolved
Staphylococcus aureus sortase A. Nature Communications. [IF=3.268, Cited=18, 27073027].
Rees HA, Komor AC, Yeh WH, ..., Liu DR (2017) Improving the DNA specificity and applicability of base editing through
protein engineering and protein delivery. Nature Communications. [IF=3.268, Cited=223, 28585549].
Tang W, Hu JH, Liu DR (2017) Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional
activation. Nature Communications. [IF=3.268, Cited=76, 28656978].
Dickinson BC, Packer MS, Badran AH, Liu DR (2014) A system for the continuous directed evolution of proteases rapidly
reveals drug-resistance mutations. Nature Communications. [IF=3.268, Cited=50, 25355134].
Badran AH, Liu DR (2015) Development of potent in vivo mutagenesis plasmids with broad mutational spectra. Nature
Communications. [IF=3.268, Cited=99, 26443021].
Guilinger JP, Pattanayak V, Reyon D, ..., Liu DR (2014) Broad specificity profiling of TALENs results in engineered
nucleases with improved DNA-cleavage specificity. Nature Methods. [IF=10.009, Cited=119, 24531420].
Blakely BL, Dumelin CE, Trappmann B, ..., Chen CS (2014) A DNA-based molecular probe for optically reporting cellular
traction forces. Nature Methods. [IF=10.009, Cited=97, 25306545].
Hubbard BP, Badran AH, Zuris JA, ..., Liu DR (2015) Continuous directed evolution of DNA-binding proteins to improve
TALEN specificity. Nature Methods. [IF=10.009, Cited=60, 26258293].
Packer MS, Liu DR (2015) Methods for the directed evolution of proteins. Nature Reviews Genetics. [IF=8.261, Cited=337, 26055155].
Packer MS, Rees HA, Liu DR (2017) Phage-assisted continuous evolution of proteases with altered substrate specificity.
Nature Communications. [IF=3.268, Cited=45, 29038472].
Yeh WH, Chiang H, Rees HA, ..., Liu DR (2018) In vivo base editing of post-mitotic sensory cells. Nature Communications.
[IF=3.268, Cited=121, 29872041].
Lee HK, Willi M, Miller SM, ..., Hennighausen L (2018) Targeting fidelity of adenine and cytosine base editors in mouse
embryos. Nature Communications. [IF=3.268, Cited=49, 30442934].
Rees HA, Yeh WH, Liu DR (2019) Development of hRad51-Cas9 nickase fusions that mediate HDR without double-stranded
breaks. Nature Communications. [IF=3.268, Cited=52, 31101808].
Bessen JL, Afeyan LK, Dančík V, ..., Liu DR (2019) High-resolution specificity profiling and off-target prediction for
site-specific DNA recombinases. Nature Communications. [IF=3.268, Cited=17, 31028261].
Kim YB, Zhao KT, Thompson DB, Liu DR (2019) An anionic human protein mediates cationic liposome delivery of genome
editing proteins into mammalian cells. Nature Communications. [IF=3.268, Cited=10, 31266953].
Bessen JL, Afeyan LK, Dančík V, ..., Liu DR (2019) Addendum: High-resolution specificity profiling and off-target
prediction for site-specific DNA recombinases. Nature Communications. [IF=3.268, Cited=0, 31266947].
Jiang T, Henderson JM, Coote K, ..., Xue W (2020) Chemical modifications of adenine base editor mRNA and guide RNA
expand its application scope. Nature Communications. [IF=3.268, Cited=52, 32332735].
Hsu JY, Grünewald J, Szalay R, ..., Pinello L (2021) PrimeDesign software for rapid and simplified design of prime
editing guide RNAs. Nature Communications. [IF=3.268, Cited=74, 33589617].
Morrison MS, Wang T, Raguram A, ..., Liu DR (2021) Disulfide-compatible phage-assisted continuous evolution in the
periplasmic space. Nature Communications. [IF=3.268, Cited=7, 34645844].
Morrison MS, Wang T, Raguram A, ..., Liu DR (2021) Author Correction: Disulfide-compatible phage-assisted continuous
evolution in the periplasmic space. Nature Communications. [IF=3.268, Cited=0, 34789771].
Choi EH, Suh S, Foik AT, ..., Palczewski K (2022) In vivo base editing rescues cone photoreceptors in a mouse model of
early-onset inherited retinal degeneration. Nature Communications. [IF=3.268, Cited=31, 35383196].
Chen JC, Chen JP, Shen MW, ..., Liu DR (2022) Generating experimentally unrelated target molecule-binding highly
functionalized nucleic-acid polymers using machine learning. Nature Communications. [IF=3.268, Cited=2, 35927274].
Willis JCW, Silva-Pinheiro P, Widdup L, ..., Liu DR (2022) Compact zinc finger base editors that edit mitochondrial or
nuclear DNA in vitro and in vivo. Nature Communications. [IF=3.268, Cited=17, 36418298].
Tao Y, Lamas V, Du W, ..., Chen ZY (2023) Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-
Cas9 ribonucleoprotein delivery in vivo. Nature Communications. [IF=3.268, Cited=4, 37582836].
Kulhankova K, Traore S, Cheng X, ..., McCray PB (2023) Shuttle peptide delivers base editor RNPs to rhesus monkey airway
epithelial cells in vivo. Nature Communications. [IF=3.268, Cited=2, 38052872].
Zhang E, Neugebauer ME, Krasnow NA, Liu DR (2024) Phage-assisted evolution of highly active cytosine base editors with
enhanced selectivity and minimal sequence context preference. Nature Communications. [IF=3.268, Cited=2, 38402281].
Song CQ, Jiang T, Richter M, ..., Xue W (2019) Adenine base editing in an adult mouse model of tyrosinaemia. Nature
Biomedical Engineering. [IF=3.79, Cited=94, 31740768].
Levy JM, Yeh WH, Pendse N, ..., Liu DR (2020) Cytosine and adenine base editing of the brain, liver, retina, heart and
skeletal muscle of mice via adeno-associated viruses. Nature Biomedical Engineering. [IF=3.79, Cited=218, 31937940].
Kim HK, Lee S, Kim Y, ..., Kim HH (2020) High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at
matched and mismatched target sequences in human cells. Nature Biomedical Engineering. [IF=3.79, Cited=58, 31937939].
Suh S, Choi EH, Leinonen H, ..., Palczewski K (2020) Restoration of visual function in adult mice with an inherited
retinal disease via adenine base editing. Nature Biomedical Engineering. [IF=3.79, Cited=68, 33077938].
Suh S, Choi EH, Leinonen H, ..., Palczewski K (2020) Publisher Correction: Restoration of visual function in adult mice
with an inherited retinal disease via adenine base editing. Nature Biomedical Engineering. [IF=3.79, Cited=2, 33122854].
Davis JR, Wang X, Witte IP, ..., Liu DR (2022) Efficient in vivo base editing via single adeno-associated viruses with
size-optimized genomes encoding compact adenine base editors. Nature Biomedical Engineering. [IF=3.79, Cited=59, 35902773].
Davis JR, Wang X, Witte IP, ..., Liu DR (2022) Publisher Correction: Efficient in vivo base editing via single
adenoassociated viruses with size-optimized genomes encoding compact adenine base editors. Nature Biomedical
Engineering. [IF=3.79, Cited=1, 35931809].
Everette KA, Newby GA, Levine RM, ..., Liu DR (2023) Ex vivo prime editing of patient haematopoietic stem cells rescues
sickle-cell disease phenotypes after engraftment in mice. Nature Biomedical Engineering. [IF=3.79, Cited=25, 37069266].
Pandey S, Gao XD, Krasnow NA, ..., Liu DR (2024) Efficient site-specific integration of large genes in mammalian cells
via continuously evolved recombinases and prime editing. Nature Biomedical Engineering. [IF=3.79, Cited=0, 38858586].
Sousa AA, Hemez C, Lei L, ..., Liu DR (2024) Systematic optimization of prime editing for the efficient functional
correction of CFTR F508del in human airway epithelial cells. Nature Biomedical Engineering. [IF=3.79, Cited=0, 38987629].
Chen Z, Lichtor PA, Berliner AP, ..., Liu DR (2018) Evolution of sequence-defined highly functionalized nucleic acid
polymers. Nature Chemistry. [IF=3.667, Cited=38, 29507367].
Usanov DL, Chan AI, Maianti JP, Liu DR (2018) Second-generation DNA-templated macrocycle libraries for the discovery of
bioactive small molecules. Nature Chemistry. [IF=3.667, Cited=65, 29610462].
Usanov DL, Chan AI, Maianti JP, Liu DR (2019) Author Correction: Second-generation DNA-templated macrocycle libraries
for the discovery of bioactive small molecules. Nature Chemistry. [IF=3.667, Cited=1, 31576016].
Nguyen TM, Sreekanth V, Deb A, ..., Choudhary A (2023) Proteolysis-targeting chimeras with reduced off-targets. Nature
Chemistry. [IF=3.667, Cited=3, 38110475].
Lian X, Chatterjee S, Sun Y, ..., Siegwart DJ (2024) Bone-marrow-homing lipid nanoparticles for genome editing in
diseased and malignant haematopoietic stem cells. Nature Nanotechnology. [IF=6.001, Cited=1, 38783058].
Peterson AA, Liu DR (2023) Small-molecule discovery through DNA-encoded libraries. Nature Reviews Drug Discovery.
[IF=18.471, Cited=10, 37328653].
Rees HA, Liu DR (2018) Base editing: precision chemistry on the genome and transcriptome of living cells. Nature Reviews
Genetics. [IF=8.261, Cited=667, 30323312].
Rees HA, Liu DR (2018) Publisher Correction: Base editing: precision chemistry on the genome and transcriptome of living
cells. Nature Reviews Genetics. [IF=8.261, Cited=25, 30341440].
Chen PJ, Liu DR (2022) Prime editing for precise and highly versatile genome manipulation. Nature Reviews Genetics.
[IF=8.261, Cited=91, 36344749].
Gaudelli NM, Komor AC, Rees HA, ..., Liu DR (2018) Publisher Correction: Programmable base editing of A•T to G•C in
genomic DNA without DNA cleavage. Nature. [IF=11.591, Cited=13, 29720650].
Shen MW, Arbab M, Hsu JY, ..., Sherwood RI (2018) Predictable and precise template-free CRISPR editing of pathogenic
variants. Nature. [IF=11.591, Cited=266, 30405244].
Shen MW, Arbab M, Hsu JY, ..., Sherwood RI (2019) Author Correction: Predictable and precise template-free CRISPR
editing of pathogenic variants. Nature. [IF=11.591, Cited=4, 30765887].
Anzalone AV, Randolph PB, Davis JR, ..., Liu DR (2019) Search-and-replace genome editing without double-strand breaks or
donor DNA. Nature. [IF=11.591, Cited=1000, 31634902].
Koblan LW, Erdos MR, Wilson C, ..., Liu DR (2021) In vivo base editing rescues Hutchinson-Gilford progeria syndrome in
mice. Nature. [IF=11.591, Cited=190, 33408413].
Mok BY, de Moraes MH, Zeng J, ..., Liu DR (2020) A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial
base editing. Nature. [IF=11.591, Cited=275, 32641830].
Saha K, Sontheimer EJ, Brooks PJ, ..., Zhou J (2021) The NIH Somatic Cell Genome Editing program. Nature. [IF=11.591,
Cited=51, 33828315].
Newby GA, Yen JS, Woodard KJ, ..., Liu DR (2021) Base editing of haematopoietic stem cells rescues sickle cell disease
in mice. Nature. [IF=11.591, Cited=137, 34079130].
Clement K, Rees H, Canver MC, ..., Pinello L (2019) CRISPResso2 provides accurate and rapid genome editing sequence
analysis. Nature Biotechnology. [IF=8.861, Cited=603, 30809026].
Huang TP, Zhao KT, Miller SM, ..., Liu DR (2019) Circularly permuted and PAM-modified Cas9 variants broaden the
targeting scope of base editors. Nature Biotechnology. [IF=8.861, Cited=129, 31110355].
Huang TP, Zhao KT, Miller SM, ..., Liu DR (2019) Author Correction: Circularly permuted and PAM-modified Cas9 variants
broaden the targeting scope of base editors. Nature Biotechnology. [IF=8.861, Cited=3, 31182863].
Thuronyi BW, Koblan LW, Levy JM, ..., Liu DR (2019) Continuous evolution of base editors with expanded target
compatibility and improved activity. Nature Biotechnology. [IF=8.861, Cited=146, 31332326].
Thuronyi BW, Koblan LW, Levy JM, ..., Liu DR (2019) Publisher Correction: Continuous evolution of base editors with
expanded target compatibility and improved activity. Nature Biotechnology. [IF=8.861, Cited=6, 31406330].
Miller SM, Wang T, Randolph PB, ..., Liu DR (2020) Continuous evolution of SpCas9 variants compatible with non-G PAMs.
Nature Biotechnology. [IF=8.861, Cited=148, 32042170].
Doman JL, Raguram A, Newby GA, Liu DR (2020) Evaluation and minimization of Cas9-independent off-target DNA editing by
cytosine base editors. Nature Biotechnology. [IF=8.861, Cited=197, 32042165].
Richter MF, Zhao KT, Eton E, ..., Liu DR (2020) Phage-assisted evolution of an adenine base editor with improved Cas
domain compatibility and activity. Nature Biotechnology. [IF=8.861, Cited=357, 32433547].
Lin Q, Zong Y, Xue C, ..., Gao C (2020) Prime genome editing in rice and wheat. Nature Biotechnology. [IF=8.861,
Cited=283, 32393904].
Anzalone AV, Koblan LW, Liu DR (2020) Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime
editors. Nature Biotechnology. [IF=8.861, Cited=800, 32572269].
Richter MF, Zhao KT, Eton E, ..., Liu DR (2020) Author Correction: Phage-assisted evolution of an adenine base editor
with improved Cas domain compatibility and activity. Nature Biotechnology. [IF=8.861, Cited=9, 32433548].
Wilson C, Chen PJ, Miao Z, Liu DR (2020) Programmable m⁶A modification of cellular RNAs with a Cas13-directed
methyltransferase. Nature Biotechnology. [IF=8.861, Cited=117, 32601430].
Koblan LW, Arbab M, Shen MW, ..., Liu DR (2021) Efficient C•G-to-G•C base editors developed using CRISPRi screens,
target-library analysis, and machine learning. Nature Biotechnology. [IF=8.861, Cited=83, 34183861].
Nelson JW, Randolph PB, Shen SP, ..., Liu DR (2021) Engineered pegRNAs improve prime editing efficiency. Nature
Biotechnology. [IF=8.861, Cited=204, 34608327].
Anzalone AV, Gao XD, Podracky CJ, ..., Liu DR (2021) Programmable deletion, replacement, integration and inversion of
large DNA sequences with twin prime editing. Nature Biotechnology. [IF=8.861, Cited=158, 34887556].
Nelson JW, Randolph PB, Shen SP, ..., Liu DR (2022) Author Correction: Engineered pegRNAs improve prime editing
efficiency. Nature Biotechnology. [IF=8.861, Cited=0, 34880468].
Mok BY, Kotrys AV, Raguram A, ..., Liu DR (2022) CRISPR-free base editors with enhanced activity and expanded targeting
scope in mitochondrial and nuclear DNA. Nature Biotechnology. [IF=8.861, Cited=64, 35379961].
Huang TP, Heins ZJ, Miller SM, ..., Liu DR (2022) High-throughput continuous evolution of compact Cas9 variants
targeting single-nucleotide-pyrimidine PAMs. Nature Biotechnology. [IF=8.861, Cited=31, 36076084].
Neugebauer ME, Hsu A, Arbab M, ..., Liu DR (2022) Evolution of an adenine base editor into a small, efficient cytosine
base editor with low off-target activity. Nature Biotechnology. [IF=8.861, Cited=48, 36357719].
Davis JR, Banskota S, Levy JM, ..., Liu DR (2023) Efficient prime editing in mouse brain, liver and heart with dual
AAVs. Nature Biotechnology. [IF=8.861, Cited=24, 37142705].
Ely ZA, Mathey-Andrews N, Naranjo S, ..., Jacks T (2023) A prime editor mouse to model a broad spectrum of somatic
mutations in vivo. Nature Biotechnology. [IF=8.861, Cited=12, 37169967].
Chen L, Hong M, Luan C, ..., Li D (2023) Adenine transversion editors enable precise, efficient A•T-to-C•G base editing
in mammalian cells and embryos. Nature Biotechnology. [IF=8.861, Cited=19, 37322276].
Koblan LW, Arbab M, Shen MW, ..., Liu DR (2023) Author Correction: Efficient C•G-to-G•C base editors developed using
CRISPRi screens, target-library analysis, and machine learning. Nature Biotechnology. [IF=8.861, Cited=3, 37853259].
An M, Raguram A, Du SW, ..., Liu DR (2024) Engineered virus-like particles for transient delivery of prime editor
ribonucleoprotein complexes in vivo. Nature Biotechnology. [IF=8.861, Cited=6, 38191664].
Kim-Yip RP, McNulty R, Joyce B, ..., Adamson B (2024) Efficient prime editing in two-cell mouse embryos using PEmbryo.
Nature Biotechnology. [IF=8.861, Cited=1, 38321114].
Gould SI, Wuest AN, Dong K, ..., Sánchez Rivera FJ (2024) High-throughput evaluation of genetic variants with prime
editing sensor libraries. Nature Biotechnology. [IF=8.861, Cited=3, 38472508].
Chen H, Liu D, Guo J, ..., Wang X (2024) Branched chemically modified poly(A) tails enhance the translation capacity of
mRNA. Nature Biotechnology. [IF=8.861, Cited=0, 38519719].
Chen L, Hong M, Luan C, ..., Li D (2024) Author Correction: Adenine transversion editors enable precise, efficient
A•T-to-C•G base editing in mammalian cells and embryos. Nature Biotechnology. [IF=8.861, Cited=0, 38658732].
Mouri K, Guo MH, de Boer CG, ..., Ray JP (2022) Prioritization of autoimmune disease-associated genetic variants that
perturb regulatory element activity in T cells. Nature Genetics. [IF=6.89, Cited=14, 35513721].
Mayuranathan T, Newby GA, Feng R, ..., Yen JS (2023) Potent and uniform fetal hemoglobin induction via base editing.
Nature Genetics. [IF=6.89, Cited=7, 37400614].
Wang T, Badran AH, Huang TP, Liu DR (2018) Continuous directed evolution of proteins with improved soluble expression.
Nature Chemical Biology. [IF=2.623, Cited=41, 30127387].
Lichtor PA, Chen Z, Elowe NH, ..., Liu DR (2019) Side chain determinants of biopolymer function during selection and
replication. Nature Chemical Biology. [IF=2.623, Cited=9, 30742124].
Lichtor PA, Chen Z, Elowe NH, ..., Liu DR (2019) Publisher Correction: Side chain determinants of biopolymer function
during selection and replication. Nature Chemical Biology. [IF=2.623, Cited=0, 30858597].
Maianti JP, Tan GA, Vetere A, ..., Liu DR (2019) Substrate-selective inhibitors that reprogram the activity of insulin-
degrading enzyme. Nature Chemical Biology. [IF=2.623, Cited=22, 31086331].
Podracky CJ, An C, DeSousa A, ..., Liu DR (2021) Laboratory evolution of a sortase enzyme that modifies amyloid-β
protein. Nature Chemical Biology. [IF=2.623, Cited=17, 33432237].
Morrison MS, Podracky CJ, Liu DR (2020) The developing toolkit of continuous directed evolution. Nature Chemical
Biology. [IF=2.623, Cited=47, 32444838].
Shen MW, Zhao KT, Liu DR (2021) Reconstruction of evolving gene variants and fitness from short sequencing reads. Nature
Chemical Biology. [IF=2.623, Cited=5, 34635842].
Peterson AA, Rangwala AM, Thakur MK, ..., Liu DR (2022) Discovery and molecular basis of subtype-selective cyclophilin
inhibitors. Nature Chemical Biology. [IF=2.623, Cited=8, 36163383].
Li H, Ma T, Remsberg JR, ..., Cravatt BF (2023) Assigning functionality to cysteines by base editing of cancer
dependency genes. Nature Chemical Biology. [IF=2.623, Cited=6, 37783940].
Reichart D, Newby GA, Wakimoto H, ..., Seidman C (2023) Efficient in vivo genome editing prevents hypertrophic
cardiomyopathy in mice. Nature Medicine. [IF=11.877, Cited=31, 36797483].
Kennedy PH, Alborzian Deh Sheikh A, Balakar M, ..., Myers SA (2024) Post-translational modification-centric base editor
screens to assess phosphorylation site functionality in high throughput. Nature Methods. [IF=10.009, Cited=0, 38684783].
Miller SM, Wang T, Liu DR (2020) Phage-assisted continuous and non-continuous evolution. None. [IF=None, Cited=30, 33199872].
Huang TP, Newby GA, Liu DR (2021) Precision genome editing using cytosine and adenine base editors in mammalian cells.
None. [IF=None, Cited=67, 33462442].
Huang TP, Newby GA, Liu DR (2021) Publisher Correction: Precision genome editing using cytosine and adenine base editors
in mammalian cells. None. [IF=None, Cited=3, 34789924].
Doman JL, Sousa AA, Randolph PB, ..., Liu DR (2022) Designing and executing prime editing experiments in mammalian
cells. None. [IF=None, Cited=28, 35941224].
Lee HK, Willi M, Smith HE, ..., Hennighausen L (2019) Simultaneous targeting of linked loci in mouse embryos using base
editing. Scientific Reports. [IF=1.312, Cited=12, 30733567].
Sheriff A, Guri I, Zebrowska P, ..., Jacków J (2022) ABE8e adenine base editor precisely and efficiently corrects a
recurrent COL7A1 nonsense mutation. Scientific Reports. [IF=1.312, Cited=7, 36385635].
Bittker JA, Le BV, Liu JM, Liu DR (2004) Directed evolution of protein enzymes using nonhomologous random recombination.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=29, 15118093].
Buskirk AR, Ong YC, Gartner ZJ, Liu DR (2004) Directed evolution of ligand dependence: small-molecule-activated protein
splicing. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=107, 15247421].
Fischbach MA, Lin H, Liu DR, Walsh CT (2004) In vitro characterization of IroB, a pathogen-associated
C-glycosyltransferase. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=96, 15598734].
Lai JR, Fischbach MA, Liu DR, Walsh CT (2006) A protein interaction surface in nonribosomal peptide synthesis mapped by
combinatorial mutagenesis and selection. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=45, 16567620].
Fischbach MA, Lin H, Zhou L, ..., Smith KD (2006) The pathogen-associated iroA gene cluster mediates bacterial evasion
of lipocalin 2. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=190, 17060628].
Fischbach MA, Lai JR, Roche ED, ..., Liu DR (2007) Directed evolution can rapidly improve the activity of chimeric
assembly-line enzymes. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=76, 17620609].
McNaughton BR, Cronican JJ, Thompson DB, Liu DR (2009) Mammalian cell penetration, siRNA transfection, and DNA
transfection by supercharged proteins. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=139, 19307578].
Kowtoniuk WE, Shen Y, Heemstra JM, ..., Liu DR (2009) A chemical screen for biological small molecule-RNA conjugates
reveals CoA-linked RNA. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=68, 19416889].
Chen I, Dorr BM, Liu DR (2011) A general strategy for the evolution of bond-forming enzymes using yeast display.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=256, 21697512].
Dorr BM, Ham HO, An C, ..., Liu DR (2014) Reprogramming the specificity of sortase enzymes. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=84, 25187567].
Wang M, Zuris JA, Meng F, ..., Xu Q (2016) Efficient delivery of genome-editing proteins using bioreducible lipid
nanoparticles. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=254, 26929348].
Suh S, Choi EH, Raguram A, ..., Palczewski K (2022) Precision genome editing in the eye. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=13, 36122230].
Reidenbach AG, Mesleh MF, Casalena D, ..., Minikel EV (2020) Multimodal small-molecule screening for human prion protein
binders. Journal of Biological Chemistry. [IF=1.122, Cited=7, 32723867].
Brooks IR, Alrokh Y, Kazemizadeh A, ..., Jacków-Malinowska J (2024) Highly efficient biallelic correction of homozygous
COL7A1 mutation using ABE8e adenine base editor. British Journal of Dermatology. [IF=2.564, Cited=0, 38149684].
Krishnamurthy S, Traore S, Cooney AL, ..., McCray PB (2021) Functional correction of CFTR mutations in human airway
epithelial cells using adenine base editors. Nucleic Acids Research. [IF=4.663, Cited=22, 34520545].
Zhang H, Kelly K, Lee J, ..., Sontheimer EJ (2024) Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery
and genome editing in vivo. Nucleic Acids Research. [IF=4.663, Cited=1, 38033325].
Liu JM, Liu DR (2007) Discovery of a mRNA mitochondrial localization element in Saccharomyces cerevisiae by
nonhomologous random recombination and in vivo selection. Nucleic Acids Research. [IF=4.663, Cited=8, 17916575].
Chaikind B, Bessen JL, Thompson DB, ..., Liu DR (2016) A programmable Cas9-serine recombinase fusion protein that
operates on DNA sequences in mammalian cells. Nucleic Acids Research. [IF=4.663, Cited=33, 27515511].
Sreekanth V, Jan M, Zhao KT, ..., Choudhary A (2023) A molecular glue approach to control the half-life of CRISPR-based
technologies. None. [IF=None, Cited=0, 36945568].
Zhang H, Kelly K, Lee J, ..., Sontheimer EJ (2023) Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing
in vivo. None. [IF=None, Cited=0, 36993169].
Gete YG, Koblan LW, Mao X, ..., Cao K (2021) Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via
downregulation of endothelial NOS. Aging Cell. [IF=1.58, Cited=11, 34086398].
Komor AC, Zhao KT, Packer MS, ..., Liu DR (2017) Improved base excision repair inhibition and bacteriophage Mu Gam
protein yields C:G-to-T:A base editors with higher efficiency and product purity. Science advances. [IF=2.861,
Cited=389, 28875174].
Rees HA, Wilson C, Doman JL, Liu DR (2019) Analysis and minimization of cellular RNA editing by DNA adenine base
editors. Science advances. [IF=2.861, Cited=128, 31086823].
Gartner ZJ, Tse BN, Grubina R, ..., Liu DR (2004) DNA-templated organic synthesis and selection of a library of
macrocycles. Science. [IF=7.729, Cited=221, 15319493].
Tahiliani M, Koh KP, Shen Y, ..., Rao A (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian
DNA by MLL partner TET1. Science. [IF=7.729, Cited=1000, 19372391].
Lutz JF, Ouchi M, Liu DR, Sawamoto M (2013) Sequence-controlled polymers. Science. [IF=7.729, Cited=257, 23929982].
Tang W, Liu DR (2018) Rewritable multi-event analog recording in bacterial and mammalian cells. Science. [IF=7.729,
Cited=89, 29449507].
Lapinaite A, Knott GJ, Palumbo CM, ..., Doudna JA (2020) DNA capture by a CRISPR-Cas9-guided adenine base editor.
Science. [IF=7.729, Cited=74, 32732424].
Blum TR, Liu H, Packer MS, ..., Liu DR (2021) Phage-assisted evolution of botulinum neurotoxin proteases with
reprogrammed specificity. Science. [IF=7.729, Cited=24, 33602850].
Arbab M, Matuszek Z, Kray KM, ..., Liu DR (2023) Base editing rescue of spinal muscular atrophy in cells and in mice.
Science. [IF=7.729, Cited=30, 36996170].
Mercer JAM, DeCarlo SJ, Roy Burman SS, ..., Liu DR (2024) Continuous evolution of compact protein degradation tags
regulated by selective molecular glues. Science. [IF=7.729, Cited=2, 38484051].
Yeh WH, Shubina-Oleinik O, Levy JM, ..., Liu DR (2020) In vivo base editing restores sensory transduction and
transiently improves auditory function in a mouse model of recessive deafness. Science Translational Medicine.
[IF=2.778, Cited=84, 32493795].
Chicca J, Cazeault NR, Rus F, ..., Aroian RV (2022) Efficient and Scalable Process to Produce Novel and Highly Bioactive
Purified Cytosolic Crystals from Bacillus thuringiensis. Microbiology spectrum. [IF=1.045, Cited=0, 35946940].
Kabra M, Shahi PK, Wang Y, ..., Pattnaik BR (2023) Nonviral base editing of KCNJ13 mutation preserves vision in a model
of inherited retinal channelopathy. Journal of Clinical Investigation. [IF=2.423, Cited=1, 37561581].
Li C, Georgakopoulou A, Newby GA, ..., Lieber A (2022) In vivo base editing by a single i.v. vector injection for
treatment of hemoglobinopathies. JCI insight. [IF=1.554, Cited=12, 36006707].
Li C, Georgakopoulou A, Newby GA, ..., Lieber A (2023) In vivo HSC prime editing rescues sickle cell disease in a mouse
model. Blood. [IF=2.983, Cited=24, 36800642].
Gao P, Lyu Q, Ghanam AR, ..., Miano JM (2021) Prime editing in mice reveals the essentiality of a single base in driving
tissue-specific gene expression. None. [IF=None, Cited=45, 33722289].
Liu DR (2004) Translating DNA into synthetic molecules. PLoS Biology. [IF=2.285, Cited=3, 15252462].
Cooney AL, Brommel CM, Traore S, ..., Sinn PL (2023) Reciprocal mutations of lung-tropic AAV capsids lead to improved
transduction properties. None. [IF=None, Cited=0, 38077224].
Curtis EA, Liu DR (2014) A naturally occurring, noncanonical GTP aptamer made of simple tandem repeats. RNA Biology.
[IF=0.745, Cited=7, 24824832].
Zhang Z, Liang WG, Bailey LJ, ..., Tang WJ (2018) Ensemble cryoEM elucidates the mechanism of insulin capture and
degradation by human insulin degrading enzyme. eLife. [IF=1.743, Cited=26, 29596046].

Publication with MISSING institution:

Gartner ZJ, Kanan M, Kanan MW, Liu DR (2002) Expanding the reaction scope of DNA-templated synthesis. Angewandte Chemie
- International Edition. [IF=2.456, Cited=51, 19750721].
Calderone CT, Puckett JW, Gartner ZJ, Liu DR (2002) Directing otherwise incompatible reactions in a single solution by
using DNA-templated organic synthesis. Angewandte Chemie - International Edition. [IF=2.456, Cited=18, 12412096].
Qu Z, Krishnamurthy V, Haller CA, ..., Chaikof EL (2013) Immobilization of actively thromboresistant assemblies on
sterile blood-contacting surfaces. Advanced healthcare materials. [IF=1.452, Cited=15, 23788402].
Gartner ZJ, Grubina R, Calderone CT, Liu DR (2003) Two enabling architectures for DNA-templated organic synthesis.
Angewandte Chemie - International Edition. [IF=2.456, Cited=38, 12671971].
Li X, Liu DR (2004) DNA-templated organic synthesis: nature's strategy for controlling chemical reactivity applied to
synthetic molecules. Angewandte Chemie - International Edition. [IF=2.456, Cited=199, 15372570].
Snyder TM, Liu DR (2005) Ordered multistep synthesis in a single solution directed by DNA templates. Angewandte Chemie -
International Edition. [IF=2.456, Cited=24, 16217825].
Calderone CT, Liu DR (2005) Small-molecule diversification from iterated branching reaction pathways enabled by DNA-
templated synthesis. Angewandte Chemie - International Edition. [IF=2.456, Cited=8, 16240310].
Kim W, Haller C, Dai E, ..., Chaikof EL (2014) Targeted antithrombotic protein micelles. Angewandte Chemie -
International Edition. [IF=2.456, Cited=15, 25504546].
Rozenman MM, Liu DR (2006) DNA-templated synthesis in organic solvents. ChemBioChem. [IF=0.691, Cited=30, 16381048].
Baker CH, Matsuda SP, Liu DR, ..., Corey EJ (1995) Molecular cloning of the human gene encoding lanosterol synthase from
a liver cDNA library. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=37, 7639730].
Li N, Parsons BL, Liu DR, Mattoo AK (1992) Accumulation of wound-inducible ACC synthase transcript in tomato fruit is
inhibited by salicylic acid and polyamines. Plant Molecular Biology. [IF=1.274, Cited=51, 1371404].
Thompson DB, Cronican JJ, Liu DR (2012) Engineering and identifying supercharged proteins for macromolecule delivery
into mammalian cells. None. [IF=None, Cited=58, 22230574].
Calderone CT, Liu DR (2004) Nucleic-acid-templated synthesis as a model system for ancient translation. Current Opinion
in Chemical Biology. [IF=1.51, Cited=10, 15556410].
Rozenman MM, McNaughton BR, Liu DR (2007) Solving chemical problems through the application of evolutionary principles.
Current Opinion in Chemical Biology. [IF=1.51, Cited=20, 17548235].
Komor AC, Badran AH, Liu DR (2017) CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell.
[IF=8.479, Cited=104, 28431253].
Buskirk AR, Landrigan A, Liu DR (2004) Engineering a ligand-dependent RNA transcriptional activator. None. [IF=None,
Cited=59, 15324817].
Buskirk AR, Liu DR (2005) Creating small-molecule-dependent switches to modulate biological functions. None. [IF=None,
Cited=47, 15734643].
Kehayova PD, Liu DR (2007) In vivo evolution of an RNA-based transcriptional silencing domain in S. cerevisiae. None.
[IF=None, Cited=6, 17254953].
Brudno Y, Liu DR (2009) Recent progress toward the templated synthesis and directed evolution of sequence-defined
synthetic polymers. None. [IF=None, Cited=38, 19318208].
Peck SH, Chen I, Liu DR (2011) Directed evolution of a small-molecule-triggered intein with improved splicing properties
in mammalian cells. None. [IF=None, Cited=38, 21609843].
Cronican JJ, Beier KT, Davis TN, ..., Liu DR (2011) A class of human proteins that deliver functional proteins into
mammalian cells in vitro and in vivo. None. [IF=None, Cited=67, 21802004].
Thompson DB, Villaseñor R, Dorr BM, ..., Liu DR (2012) Cellular uptake mechanisms and endosomal trafficking of
supercharged proteins. None. [IF=None, Cited=50, 22840771].
Curtis EA, Liu DR (2013) Discovery of widespread GTP-binding motifs in genomic DNA and RNA. None. [IF=None, Cited=20, 23601641].
Karanicolas J, Corn JE, Chen I, ..., Baker D (2011) A de novo protein binding pair by computational design and directed
evolution. Molecular Cell. [IF=2.773, Cited=111, 21458342].
Ichida JK, Blanchard J, Lam K, ..., Eggan K (2009) A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in
reprogramming by inducing nanog. None. [IF=None, Cited=497, 19818703].
Buskirk AR, Kehayova PD, Landrigan A, Liu DR (2003) In vivo evolution of an RNA-based transcriptional activator. None.
[IF=None, Cited=41, 12837386].
Cload ST, Liu DR, Liu DR, ..., Schultz PG (1996) Development of improved tRNAs for in vitro biosynthesis of proteins
containing unnatural amino acids. None. [IF=None, Cited=37, 9000011].
Bittker JA, Phillips KJ, Liu DR (2002) Recent advances in the in vitro evolution of nucleic acids. Current Opinion in
Chemical Biology. [IF=1.51, Cited=30, 12023118].
Koblan LW, Erdos MR, Gordon LB, ..., Liu DR (2021) Base editor treats progeria in mice. Nature. [IF=11.591, Cited=3, 34285403].
Kanan M, Kanan MW, Rozenman MM, ..., Liu DR (2004) Reaction discovery enabled by DNA-templated synthesis and in vitro
selection. Nature. [IF=11.591, Cited=134, 15457254].
Esvelt KM, Carlson JC, Liu DR (2011) A system for the continuous directed evolution of biomolecules. Nature. [IF=11.591,
Cited=306, 21478873].
Pattanayak V, Lin S, Guilinger JP, ..., Liu DR (2013) High-throughput profiling of off-target DNA cleavage reveals RNA-
programmed Cas9 nuclease specificity. Nature Biotechnology. [IF=8.861, Cited=852, 23934178].
Bittker JA, Le BV, Liu DR (2002) Nucleic acid evolution and minimization by nonhomologous random recombination. Nature
Biotechnology. [IF=8.861, Cited=39, 12219078].
Yi F, Pereira L, Hoffman JA, ..., Merrill BJ (2011) Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of
embryonic stem cell self-renewal. Nature Cell Biology. [IF=3.908, Cited=210, 21685894].
Niu J, Hili R, Liu DR (2013) Enzyme-free translation of DNA into sequence-defined synthetic polymers structurally
unrelated to nucleic acids. Nature Chemistry. [IF=3.667, Cited=68, 23511416].
Chen Y, Kamlet AS, Steinman JB, Liu DR (2011) A biomolecule-compatible visible-light-induced azide reduction from a DNA-
encoded reaction-discovery system. Nature Chemistry. [IF=3.667, Cited=105, 21258388].
Dumelin CE, Chen Y, Leconte AM, ..., Liu DR (2012) Discovery and biological characterization of geranylated RNA in
bacteria. Nature Chemical Biology. [IF=2.623, Cited=60, 22983156].
Chen YG, Kowtoniuk WE, Agarwal I, ..., Liu DR (2009) LC/MS analysis of cellular RNA reveals NAD-linked RNA. Nature
Chemical Biology. [IF=2.623, Cited=109, 19820715].
Brudno Y, Birnbaum ME, Kleiner RE, Liu DR (2009) An in vitro translation, selection and amplification system for peptide
nucleic acids. Nature Chemical Biology. [IF=2.623, Cited=44, 20081830].
Georghiou G, Kleiner RE, Pulkoski-Gross M, ..., Seeliger MA (2012) Highly specific, bisubstrate-competitive Src
inhibitors from DNA-templated macrocycles. Nature Chemical Biology. [IF=2.623, Cited=30, 22344177].
Bryson DI, Fan C, Guo LT, ..., Liu DR (2018) Errata: Continuous directed evolution of aminoacyl-tRNA synthetases. Nature
Chemical Biology. [IF=2.623, Cited=1, 29337967].
Fischbach MA, Lin H, Liu DR, Walsh CT (2006) How pathogenic bacteria evade mammalian sabotage in the battle for iron.
Nature Chemical Biology. [IF=2.623, Cited=189, 16485005].
Pattanayak V, Ramirez CL, Joung JK, Liu DR (2011) Revealing off-target cleavage specificities of zinc-finger nucleases
by in vitro selection. Nature Methods. [IF=10.009, Cited=273, 21822273].
Yuen CM, Liu DR (2007) Dissecting protein structure and function using directed evolution. Nature Methods. [IF=10.009,
Cited=31, 18049466].
He Y, Liu DR (2010) Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker.
Nature Nanotechnology. [IF=6.001, Cited=93, 20935654].
Kleiner RE, Dumelin CE, Liu DR (2011) Small-molecule discovery from DNA-encoded chemical libraries. Chemical Society
Reviews. [IF=8.116, Cited=104, 21674077].
Angrist M, Barrangou R, Baylis F, ..., Davies K (2020) Reactions to the National Academies/Royal Society Report on
Heritable Human Genome Editing. CRISPR Journal. [IF=0.697, Cited=7, 33095048].
Gruen M, Chang K, Serbanescu I, Liu DR (2002) An in vivo selection system for homing endonuclease activity. Nucleic
Acids Research. [IF=4.663, Cited=20, 11917035].
Doyon JB, Liu DR (2007) Identification of eukaryotic promoter regulatory elements using nonhomologous random
recombination. Nucleic Acids Research. [IF=4.663, Cited=5, 17720707].
Sander JD, Ramirez CL, Linder SJ, ..., Joung JK (2013) In silico abstraction of zinc finger nuclease cleavage profiles
reveals an expanded landscape of off-target sites. Nucleic Acids Research. [IF=4.663, Cited=32, 23945932].
Borot F, Humbert O, Newby GA, ..., Kiem HP (2023) Multiplex Base Editing to Protect from CD33-Directed Therapy:
Implications for Immune and Gene Therapy. None. [IF=None, Cited=0, 36865281].
Lee GR, Pellock SJ, Norn C, ..., Baker D (2023) Small-molecule binding and sensing with a designed protein family. None.
[IF=None, Cited=0, 37961294].
Kennedy PH, Deh Sheikh AA, Balakar M, ..., Myers SA (2023) Proteome-wide base editor screens to assess phosphorylation
site functionality in high-throughput. None. [IF=None, Cited=0, 38014346].
Boyages SC, Bloot AM, Maberly GF, ..., Drexhage HA (1989) Thyroid autoimmunity in endemic goitre caused by excessive
iodine intake. Clinical Endocrinology. [IF=1.216, Cited=21, 2576398].
Cho WH, Lee CT, Yu CC, ..., Lee CC (2011) Microstructure and optical properties of Al2O3 prepared by oblique deposition
using microsphere shell templates. None. [IF=None, Cited=2, 21460946].
Tsema BB, Tsema YB, Shcherbakov MR, ..., Tsai DP (2012) Handedness-sensitive emission of surface plasmon polaritons by
elliptical nanohole ensembles. Optics Express. [IF=1.434, Cited=2, 22565679].
Liu DR, Wu KS, Shih MF, Chern MY (2002) Giant nonlinear optical properties of bismuth thin films grown by pulsed laser
deposition. Optics Letters. [IF=1.297, Cited=1, 18026502].
Huang Y, Pastor WA, Shen Y, ..., Rao A (2010) The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS
ONE. [IF=1.253, Cited=447, 20126651].
Lin A, Jimenez J, Derr J, ..., Chen IA (2011) Inhibition of bacterial conjugation by phage M13 and its protein g3p:
quantitative analysis and model. PLoS ONE. [IF=1.253, Cited=48, 21637841].
Zhang Xp, Liu DR, Shi Y (2007) Study progress in therapeutic effects of traditional Chinese medicine monomer in severe
acute pancreatitis. Journal of Zhejiang University: Science B. [IF=1.025, Cited=11, 17266191].
Ding GP, Cao LP, Liu DR, Que RS (2012) Saline conducted electric coagulation (SCEC): original experience in experimental
hepatectomy. None. [IF=None, Cited=0, 22374610].
Ye Ly, Liu DR, Li C, ..., Chen L (2013) Systematic review of laparoscopy-assisted versus open gastrectomy for advanced
gastric cancer. None. [IF=None, Cited=7, 23733423].
Li C, Liu DR, Ye Ly, ..., Chen L (2014) HER-2 overexpression and survival in colorectal cancer: a meta-analysis. None.
[IF=None, Cited=10, 24903996].
Zhang Wd, Liu DR, Feng Cc, ..., Chen L (2014) Management of differentiated thyroid carcinoma with bone metastasis: a
case report and review of the Chinese literature. None. [IF=None, Cited=4, 25471838].
Li GG, Li L, Li C, ..., Chen J (2013) Influence of up-regulation of Notch ligand DLL4 on biological behaviors of human
gastric cancer cells. None. [IF=None, Cited=15, 23901223].
Fan JQ, Liu DR, Li C, Chen G (2013) Phlegmonous gastritis after esophagectomy: a case report. None. [IF=None, Cited=6, 23482416].
Peng ZX, Zou MY, Xu J, ..., Li FQ (2018) [Antimicrobial susceptibility and drug-resistance genes of Yersinia spp.
of retailed poultry in 4 provinces of China]. None. [IF=None, Cited=3, 29614601].
Zhou QH, Liu DR, Wang Y, ..., Wang XC (2016) [Laboratory diagnosis of chronic granulomatous disease]. None. [IF=None,
Cited=1, 27143074].
Yu G, Yu G, Wang WJ, ..., Wang XC (2018) [Clinical characteristics of human recombination activating gene 1 mutations in
8 immunodeficiency patients with diverse phenotypes]. None. [IF=None, Cited=0, 29518828].
Ye LY, Wang JJ, Liu DR, ..., Cao LP (2012) Management of giant ovarian teratoma: A case series and review of the
literature. Oncology Letters. [IF=0.671, Cited=7, 23205081].
Liu DR (1993) [[The cause of health care established by overseas Chinese of Fujian Province in modern age] (Chi)]. None.
[IF=None, Cited=0, 11613072].
Liu DR (1992) [[On the introduction of western medicine into Fujian Province] (Chi)]. None. [IF=None, Cited=0, 11623276].
Xin YL, Liu DR, Meng X (2001) [Clinical observation on effect of electroacupuncture therapy in treating superficial
tumor]. None. [IF=None, Cited=0, 12577330].
Zhang XP, Li ZJ, Liu DR (2006) Progress in research into the mechanism of Radix salviae miltiorrhizae in treatment of
acute pancreatitis. Hepatobiliary and Pancreatic Diseases International. [IF=1.028, Cited=0, 17085332].
Ding GP, Cao LP, Liu J, ..., Hu JA (2011) Assessment of ¹⁸⁸Re marked anti MHC class II antibody by peripheral blood
mononuclear cells stimulated by donor alloantigen. Chinese Medical Journal. [IF=0.786, Cited=0, 21933597].
Li M, Liu DR, Qu CY, ..., Boyages SC (1987) Endemic goitre in central China caused by excessive iodine intake. The
Lancet. [IF=25.787, Cited=0, 2886725].
Liu DR (1986) [Survey of resources of medicinal plants in the mountainous region of Yixing and Liyang]. None. [IF=None,
Cited=0, 2948687].
Liu DR, Guan RY (1984) The relationship between the count of fungiform papillae of tongue and differentiation of
syndromes. A clinical analysis of 114 cases. Journal of Traditional Chinese Medicine. [IF=0.47, Cited=0, 6565885].

Liu, David R

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