Lefkowitz, Robert J

Publication with MATCHING institution:

Lefkowitz RJ (2013) A brief history of G-protein coupled receptors (Nobel Lecture). Angewandte Chemie - International
Edition. [IF=2.456, Cited=113, 23650015].
Lefkowitz RJ, Lefkowitz RJ, Kobilka BK, ..., Caron MG (1989) The new biology of drug receptors. Biochemical
Pharmacology. [IF=1.155, Cited=17, 2551299].
Lefkowitz RJ, Hausdorff WP, Caron MG (1990) Role of phosphorylation in desensitization of the beta-adrenoceptor. Trends
in Pharmacological Sciences. [IF=2.377, Cited=160, 2188401].
Lefkowitz RJ, Cotecchia S, Samama P, Costa T (1993) Constitutive activity of receptors coupled to guanine nucleotide
regulatory proteins. Trends in Pharmacological Sciences. [IF=2.377, Cited=404, 8249148].
Lefkowitz RJ (1994) Rodbell and Gilman win 1994 Nobel Prize for Physiology and Medicine. Trends in Pharmacological
Sciences. [IF=2.377, Cited=4, 7886813].
Lefkowitz RJ (2013) Arrestins come of age: a personal historical perspective. None. [IF=None, Cited=42, 23764048].
Lefkowitz RJ (2006) Seven transmembrane receptors: a brief personal retrospective. None. [IF=None, Cited=29, 17173855].
Lefkowitz RJ, Whalen EJ (2004) beta-arrestins: traffic cops of cell signaling. Current Opinion in Cell Biology.
[IF=1.539, Cited=183, 15196559].
Wisler JW, Xiao K, Thomsen ARB, Lefkowitz RJ (2013) Recent developments in biased agonism. Current Opinion in Cell
Biology. [IF=1.539, Cited=176, 24680426].
Thomsen ARB, Plouffe B, Cahill TJ, ..., Lefkowitz RJ (2016) GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G
Protein Signaling. Cell. [IF=8.479, Cited=271, 27499021].
Wingler LM, Elgeti M, Hilger D, ..., Lefkowitz RJ (2019) Angiotensin Analogs with Divergent Bias Stabilize Distinct
Receptor Conformations. Cell. [IF=8.479, Cited=117, 30639099].
Wingler LM, McMahon C, Staus DP, ..., Kruse AC (2019) Distinctive Activation Mechanism for Angiotensin Receptor Revealed
by a Synthetic Nanobody. Cell. [IF=8.479, Cited=80, 30639100].
Ahn S, Shenoy SK, Luttrell LM, Lefkowitz RJ (2020) SnapShot: β-Arrestin Functions. Cell. [IF=8.479, Cited=25, 32888497].
Asher WB, Terry DS, Gregorio GGA, ..., Javitch JA (2022) GPCR-mediated β-arrestin activation deconvoluted with single-
molecule precision. Cell. [IF=8.479, Cited=29, 35483373].
Stoppel LJ, Auerbach BD, Senter RK, ..., Bear MF (2017) β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to
Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X. Cell Reports. [IF=1.738, Cited=33, 28329674].
Zang Y, Kahsai AW, Pakharukova N, ..., Lefkowitz RJ (2021) The GPCR-β-arrestin complex allosterically activates C-Raf by
binding its amino terminus. Journal of Biological Chemistry. [IF=1.122, Cited=5, 34757127].
Lefkowitz RJ, Rajagopal K, Whalen EJ (2006) New roles for beta-arrestins in cell signaling: not just for seven-
transmembrane receptors. Molecular Cell. [IF=2.773, Cited=199, 17157248].
Wingler LM, Lefkowitz RJ (2020) Conformational Basis of G Protein-Coupled Receptor Signaling Versatility. Trends in Cell
Biology. [IF=3.592, Cited=87, 32622699].
Lefkowitz RJ (2004) Historical review: a brief history and personal retrospective of seven-transmembrane receptors.
Trends in Pharmacological Sciences. [IF=2.377, Cited=221, 15276710].
Price DT, Schwinn DA, Lomasney JW, ..., Lefkowitz RJ (1993) Identification, quantification, and localization of mRNA for
three distinct alpha 1 adrenergic receptor subtypes in human prostate. Journal of Urology. [IF=2.411, Cited=181, 7686987].
Lefkowitz RJ, Pitcher J, Krueger K, Daaka Y (1998) Mechanisms of beta-adrenergic receptor desensitization and
resensitization. None. [IF=None, Cited=108, 9327928].
Freeman JLR, Gonzalo P, Pitcher JA, ..., Lefkowitz RJ (2002) Beta 2-adrenergic receptor stimulated, G protein-coupled
receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. Biochemistry. [IF=0.753, Cited=25, 12379128].
Lin FT, Chen W, Shenoy S, ..., Lefkowitz RJ (2002) Phosphorylation of beta-arrestin2 regulates its function in
internalization of beta(2)-adrenergic receptors. Biochemistry. [IF=0.753, Cited=55, 12186555].
Ménard L, Ferguson SS, Barak LS, ..., Caron MG (1996) Members of the G protein-coupled receptor kinase family that
phosphorylate the beta2-adrenergic receptor facilitate sequestration. Biochemistry. [IF=0.753, Cited=53, 8672451].
Garnovskaya MN, van Biesen T, Hawe B, ..., Raymond JR (1996) Ras-dependent activation of fibroblast mitogen-activated
protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway. Biochemistry. [IF=0.753,
Cited=72, 8901512].
Stoffel RH, Inglese J, Macrae AD, ..., Premont RT (1998) Palmitoylation increases the kinase activity of the G protein-
coupled receptor kinase, GRK6. Biochemistry. [IF=0.753, Cited=29, 9819198].
Aristotelous T, Ahn S, Shukla AK, ..., Navratilova I (2013) Discovery of β2 Adrenergic Receptor Ligands Using Biosensor
Fragment Screening of Tagged Wild-Type Receptor. ACS Medicinal Chemistry Letters. [IF=0.873, Cited=25, 24454993].
Lefkowitz RJ (2000) The superfamily of heptahelical receptors. Nature Cell Biology. [IF=3.908, Cited=117, 10878827].
Lefkowitz RJ (2016) Alfred Goodman Gilman (1941-2015). Nature. [IF=11.591, Cited=1, 26791713].
Heitzler D, Durand G, Gallay N, ..., Reiter E (2012) Competing G protein-coupled receptor kinases balance G protein and
β-arrestin signaling. Molecular Systems Biology. [IF=2.015, Cited=43, 22735336].
Shukla AK, Westfield GH, Xiao K, ..., Lefkowitz RJ (2014) Visualization of arrestin recruitment by a G-protein-coupled
receptor. Nature. [IF=11.591, Cited=291, 25043026].
Liu X, Ahn S, Kahsai AW, ..., Kobilka BK (2017) Mechanism of intracellular allosteric β₂AR antagonist
revealed by X-ray crystal structure. Nature. [IF=11.591, Cited=82, 28813418].
Lefkowitz RJ (1996) G protein-coupled receptors and receptor kinases: from molecular biology to potential therapeutic
applications. Nature Biotechnology. [IF=8.861, Cited=25, 9630887].
Kahsai AW, Wisler JW, Lee J, ..., Lefkowitz RJ (2016) Conformationally selective RNA aptamers allosterically modulate
the β2-adrenoceptor. Nature Chemical Biology. [IF=2.623, Cited=41, 27398998].
Smith JS, Lefkowitz RJ, Rajagopal S (2018) Biased signalling: from simple switches to allosteric microprocessors. Nature
Reviews Drug Discovery. [IF=18.471, Cited=298, 29302067].
Kahsai AW, Pani B, Lefkowitz RJ (2018) GPCR signaling: conformational activation of arrestins. Cell Research. [IF=3.826,
Cited=15, 30030517].
Lefkowitz RJ, Rockman HA, Shim PJ, ..., Packer M (2023) How carvedilol does not activate β₂-adrenoceptors.
Nature Communications. [IF=3.268, Cited=2, 38036531].
Staus DP, Hu H, Robertson MJ, ..., Skiniotis G (2020) Structure of the M2 muscarinic receptor-β-arrestin complex in a
lipid nanodisc. Nature. [IF=11.591, Cited=139, 31945772].
Nguyen AH, Thomsen ARB, Cahill TJ, ..., Lefkowitz RJ (2019) Structure of an endosomal signaling GPCR-G protein-β-
arrestin megacomplex. Nature Structural and Molecular Biology. [IF=2.542, Cited=84, 31740855].
Lefkowitz RJ (1995) G proteins in medicine. New England Journal of Medicine. [IF=17.194, Cited=11, 7800014].
Dinudom A, Fotia AB, Lefkowitz RJ, ..., Cook DI (2004) The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of
epithelial Na+ channels. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=59, 15284439].
Witherow DS, Garrison TR, Miller WE, Lefkowitz RJ (2004) beta-Arrestin inhibits NF-kappaB activity by means of its
interaction with the NF-kappaB inhibitor IkappaBalpha. Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=164, 15173580].
Kim J, Ahn S, Ren XR, ..., Lefkowitz RJ (2005) Functional antagonism of different G protein-coupled receptor kinases for
beta-arrestin-mediated angiotensin II receptor signaling. Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=214, 15671181].
Ren XR, Reiter E, Ahn S, ..., Lefkowitz RJ (2005) Different G protein-coupled receptor kinases govern G protein and
beta-arrestin-mediated signaling of V2 vasopressin receptor. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=200, 15671180].
Luttrell LM, Roudabush FL, Choy EW, ..., Lefkowitz RJ (2001) Activation and targeting of extracellular signal-regulated
kinases by beta-arrestin scaffolds. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=515, 11226259].
Rajagopal K, Whalen EJ, Violin JD, ..., Lefkowitz RJ (2006) Beta-arrestin2-mediated inotropic effects of the angiotensin
II type 1A receptor in isolated cardiac myocytes. Proceedings of the National Academy of Sciences of the United States
of America. [IF=2.765, Cited=155, 17060617].
Xiao K, McClatchy DB, Shukla AK, ..., Lefkowitz RJ (2007) Functional specialization of beta-arrestin interactions
revealed by proteomic analysis. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=258, 17620599].
Wisler JW, DeWire SM, Whalen EJ, ..., Lefkowitz RJ (2007) A unique mechanism of beta-blocker action: carvedilol
stimulates beta-arrestin signaling. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=359, 17925438].
Shukla AK, Violin JD, Whalen EJ, ..., Lefkowitz RJ (2008) Distinct conformational changes in beta-arrestin report biased
agonism at seven-transmembrane receptors. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=142, 18621717].
White DC, Hata JA, Shah AS, ..., Koch WJ (2000) Preservation of myocardial beta-adrenergic receptor signaling delays the
development of heart failure after myocardial infarction. Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=136, 10779554].
Zidar DA, Violin JD, Whalen EJ, Lefkowitz RJ (2009) Selective engagement of G protein coupled receptor kinases (GRKs)
encodes distinct functions of biased ligands. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=169, 19497875].
Harding VB, Jones LR, Lefkowitz RJ, ..., Rockman HA (2001) Cardiac beta ARK1 inhibition prolongs survival and augments
beta blocker therapy in a mouse model of severe heart failure. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=169, 11331748].
Rajagopal S, Kim J, Ahn S, ..., Lefkowitz RJ (2009) Beta-arrestin- but not G protein-mediated signaling by the "decoy"
receptor CXCR7. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=345, 20018651].
Xiao K, Sun J, Kim J, ..., Lefkowitz RJ (2010) Global phosphorylation analysis of beta-arrestin-mediated signaling
downstream of a seven transmembrane receptor (7TMR). Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=123, 20686112].
Fong AM, Premont RT, Richardson RM, ..., Patel DD (2002) Defective lymphocyte chemotaxis in beta-arrestin2- and
GRK6-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=199, 12032308].
Fereshteh M, Ito T, Kovacs JJ, ..., Reya T (2012) β-Arrestin2 mediates the initiation and progression of myeloid
leukemia. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=33, 22773819].
Ahn S, Kahsai AW, Pani B, ..., Lefkowitz RJ (2017) Allosteric "beta-blocker" isolated from a DNA-encoded small molecule
library. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=59, 28130548].
Cahill TJ, Thomsen ARB, Tarrasch JT, ..., Lefkowitz RJ (2017) Distinct conformations of GPCR-β-arrestin complexes
mediate desensitization, signaling, and endocytosis. Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=172, 28223524].
Staus DP, Wingler LM, Choi M, ..., Lefkowitz RJ (2018) Sortase ligation enables homogeneous GPCR phosphorylation to
reveal diversity in β-arrestin coupling. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=38, 29581292].
Wei H, Ahn S, Shenoy SK, ..., Lefkowitz RJ (2003) Independent beta-arrestin 2 and G protein-mediated pathways for
angiotensin II activation of extracellular signal-regulated kinases 1 and 2. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=426, 12949261].
Kim J, Grotegut CA, Wisler JW, ..., Lefkowitz RJ (2020) The β-arrestin-biased β-adrenergic receptor blocker carvedilol
enhances skeletal muscle contractility. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=13, 32414934].
McMahon C, Staus DP, Wingler LM, ..., Lefkowitz RJ (2020) Synthetic nanobodies as angiotensin receptor blockers.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=19, 32753386].
Baillie GS, Sood A, McPhee I, ..., Houslay MD (2003) beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment
regulates beta-adrenoceptor switching from Gs to Gi. Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=227, 12552097].
Ahn S, Nelson CD, Garrison TR, ..., Lefkowitz RJ (2003) Desensitization, internalization, and signaling functions of
beta-arrestins demonstrated by RNA interference. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=159, 12582207].
Caron MG, Srinivasan Y, Snyderman R, Lefkowitz RJ (1979) Antibodies raised against purified beta-adrenergic receptors
specifically bind beta-adrenergic ligands. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=5, 36615].
Regan JW, Barden N, Lefkowitz RJ, ..., Hieble JP (1982) Affinity chromatography of human platelet alpha 2-adrenergic
receptors. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=7, 6130523].
Frielle T, Collins S, Daniel KW, ..., Kobilka BK (1987) Cloning of the cDNA for the human beta 1-adrenergic receptor.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=292, 2825170].
Benovic JL, Kühn H, Weyand I, ..., Lefkowitz RJ (1987) Functional desensitization of the isolated beta-adrenergic
receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa
protein). Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=229, 2827157].
Regan JW, Kobilka TS, Yang-Feng TL, ..., Kobilka BK (1988) Cloning and expression of a human kidney cDNA for an alpha
2-adrenergic receptor subtype. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=185, 2842764].
Frielle T, Daniel KW, Caron MG, Lefkowitz RJ (1988) Structural basis of beta-adrenergic receptor subtype specificity
studied with chimeric beta 1/beta 2-adrenergic receptors. Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=60, 2849109].
Collins S, Bouvier M, Bolanowski MA, ..., Lefkowitz RJ (1989) cAMP stimulates transcription of the beta 2-adrenergic
receptor gene in response to short-term agonist exposure. Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=87, 2472635].
Lohse MJ, Lefkowitz RJ, Caron MG, Benovic JL (1989) Inhibition of beta-adrenergic receptor kinase prevents rapid
homologous desensitization of beta 2-adrenergic receptors. Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=56, 2541428].
Cotecchia S, Exum S, Caron MG, Lefkowitz RJ (1990) Regions of the alpha 1-adrenergic receptor involved in coupling to
phosphatidylinositol hydrolysis and enhanced sensitivity of biological function. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=157, 2158097].
Roth NS, Campbell PT, Caron MG, ..., Lohse MJ (1991) Comparative rates of desensitization of beta-adrenergic receptors
by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. Proceedings of the National Academy
of Sciences of the United States of America. [IF=2.765, Cited=65, 1648731].
Lorenz W, Inglese J, Palczewski K, ..., Lefkowitz RJ (1991) The receptor kinase family: primary structure of rhodopsin
kinase reveals similarities to the beta-adrenergic receptor kinase. Proceedings of the National Academy of Sciences of
the United States of America. [IF=2.765, Cited=73, 1656454].
Hausdorff WP, Campbell PT, Ostrowski J, ..., Lefkowitz RJ (1991) A small region of the beta-adrenergic receptor is
selectively involved in its rapid regulation. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=79, 1849641].
Hausdorff WP, Pitcher JA, Luttrell DK, ..., Lefkowitz RJ (1992) Tyrosine phosphorylation of G protein alpha subunits by
pp60c-src. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=48, 1378615].
Koch WJ, Hawes BE, Allen LF, Lefkowitz RJ (1994) Direct evidence that Gi-coupled receptor stimulation of mitogen-
activated protein kinase is mediated by G beta gamma activation of p21ras. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=212, 7809106].
Pei G, Samama P, Lohse M, ..., Lefkowitz RJ (1994) A constitutively active mutant beta 2-adrenergic receptor is
constitutively desensitized and phosphorylated. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=64, 7908440].
Pei G, Tiberi M, Caron MG, Lefkowitz RJ (1994) An approach to the study of G-protein-coupled receptor kinases: an in
vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=21, 8170959].
Inglese J, Luttrell LM, Iñiguez-Lluhi JA, ..., Lefkowitz RJ (1994) Functionally active targeting domain of the beta-
adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. Proceedings
of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=39, 8170960].
Touhara K, Hawes BE, van Biesen T, Lefkowitz RJ (1995) G protein beta gamma subunits stimulate phosphorylation of Shc
adapter protein. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=59, 7568118].
Jaber M, Koch WJ, Rockman H, ..., Giros B (1996) Essential role of beta-adrenergic receptor kinase 1 in cardiac
development and function. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=207, 8917529].
Samama P, Bond RA, Rockman HA, ..., Lefkowitz RJ (1997) Ligand-induced overexpression of a constitutively active
beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=41, 8990174].
Akhter SA, Skaer CA, Kypson AP, ..., Koch WJ (1997) Restoration of beta-adrenergic signaling in failing cardiac
ventricular myocytes via adenoviral-mediated gene transfer. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=118, 9342369].
Daaka Y, Pitcher JA, Richardson M, ..., Lefkowitz RJ (1997) Receptor and G betagamma isoform-specific interactions with
G protein-coupled receptor kinases. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=107, 9122168].
Rockman HA, Chien KR, Choi DJ, ..., Koch WJ (1998) Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents
the development of myocardial failure in gene-targeted mice. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=318, 9618528].
Hall RA, Ostedgaard LS, Premont RT, ..., Lefkowitz RJ (1998) A C-terminal motif found in the beta2-adrenergic receptor,
P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger
regulatory factor family of PDZ proteins. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=246, 9671706].
Premont RT, Claing A, Vitale N, ..., Lefkowitz RJ (1998) beta2-Adrenergic receptor regulation by GIT1, a G protein-
coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=187, 9826657].
Tang Y, Hu LA, Miller WE, ..., Lefkowitz RJ (1999) Identification of the endophilins (SH3p4/p8/p13) as novel binding
partners for the beta1-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=85, 10535961].
Iaccarino G, Smithwick LA, Lefkowitz RJ, Koch WJ (1999) Targeting Gbeta gamma signaling in arterial vascular smooth
muscle proliferation: a novel strategy to limit restenosis. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=54, 10097143].
Claing A, Perry SJ, Achiriloaie M, ..., Premont RT (2000) Multiple endocytic pathways of G protein-coupled receptors
delineated by GIT1 sensitivity. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=103, 10655494].
Pierce KL, Maudsley S, Daaka Y, ..., Lefkowitz RJ (2000) Role of endocytosis in the activation of the extracellular
signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. Proceedings of the
National Academy of Sciences of the United States of America. [IF=2.765, Cited=130, 10677489].
Kohout TA, Lin FS, Perry SJ, ..., Lefkowitz RJ (2001) beta-Arrestin 1 and 2 differentially regulate heptahelical
receptor signaling and trafficking. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=242, 11171997].
Zhu WZ, Zheng M, Koch WJ, ..., Xiao RP (2001) Dual modulation of cell survival and cell death by beta(2)-adrenergic
signaling in adult mouse cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=277, 11171998].
Lefkowitz RJ (1998) G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor
signaling and desensitization. Journal of Biological Chemistry. [IF=1.122, Cited=588, 9668034].
Staus DP, Wingler LM, Pichugin D, ..., Lefkowitz RJ (2019) Detergent- and phospholipid-based reconstitution systems have
differential effects on constitutive activity of G-protein-coupled receptors. Journal of Biological Chemistry.
[IF=1.122, Cited=17, 31362983].
Strachan RT, Sun Jp, Rominger DH, ..., Lefkowitz RJ (2014) Divergent transducer-specific molecular efficacies generate
biased agonism at a G protein-coupled receptor (GPCR). Journal of Biological Chemistry. [IF=1.122, Cited=79, 24668815].
Tang W, Strachan RT, Lefkowitz RJ, Rockman HA (2014) Allosteric modulation of β-arrestin-biased angiotensin II type 1
receptor signaling by membrane stretch. Journal of Biological Chemistry. [IF=1.122, Cited=41, 25170081].
Pakharukova N, Masoudi A, Pani B, ..., Lefkowitz RJ (2020) Allosteric activation of proto-oncogene kinase Src by GPCR-
beta-arrestin complexes. Journal of Biological Chemistry. [IF=1.122, Cited=16, 32978252].
Hall RA, Premont RT, Lefkowitz RJ (1999) Heptahelical receptor signaling: beyond the G protein paradigm. Journal of Cell
Biology. [IF=1.509, Cited=190, 10352011].
Premont RT, Inglese J, Lefkowitz RJ (1995) Protein kinases that phosphorylate activated G protein-coupled receptors.
FASEB Journal. [IF=1.029, Cited=270, 7781920].
Pakharukova N, Thomas BN, Bansia H, ..., Lefkowitz RJ (2024) Beta-arrestin 1 mediated Src activation via Src SH3 domain
revealed by cryo-electron microscopy. None. [IF=None, Cited=0, 39131402].
Lefkowitz RJ, Inglese J, Koch WJ, ..., Caron MG (1992) G-protein-coupled receptors: regulatory role of receptor kinases
and arrestin proteins. Cold Spring Harbor Symposia on Quantitative Biology. [IF=0.889, Cited=34, 1339651].
Nguyen AH, Lefkowitz RJ (2021) Signaling at the endosome: cryo-EM structure of a GPCR-G protein-beta-arrestin
megacomplex. None. [IF=None, Cited=15, 33605032].
Lefkowitz RJ (2007) Seven transmembrane receptors: something old, something new. Acta Physiologica. [IF=1.288,
Cited=175, 17428228].
Barak LS, Salahpour A, Zhang X, ..., Gainetdinov RR (2008) Pharmacological characterization of membrane-expressed human
trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor. Molecular
Pharmacology. [IF=0.939, Cited=83, 18524885].
Ahn S, Pani B, Kahsai AW, ..., Lefkowitz RJ (2018) Small-Molecule Positive Allosteric Modulators of the
β₂-Adrenoceptor Isolated from DNA-Encoded Libraries. Molecular Pharmacology. [IF=0.939, Cited=34, 29769246].
Lefkowitz RJ, Pierce KL, Luttrell LM (2002) Dancing with different partners: protein kinase a phosphorylation of seven
membrane-spanning receptors regulates their G protein-coupling specificity. Molecular Pharmacology. [IF=0.939,
Cited=115, 12391258].
Wang J, Pani B, Gokhan I, ..., Rockman HA (2021) β-Arrestin-Biased Allosteric Modulator Potentiates Carvedilol-
Stimulated β Adrenergic Receptor Cardioprotection. Molecular Pharmacology. [IF=0.939, Cited=19, 34561298].
Pani B, Ahn S, Rambarat PK, ..., Lefkowitz RJ (2021) Unique Positive Cooperativity Between the β-Arrestin-Biased
β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor.
Molecular Pharmacology. [IF=0.939, Cited=13, 34580163].
Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ (2001) Regulation of receptor fate by ubiquitination of activated beta
2-adrenergic receptor and beta-arrestin. Science. [IF=7.729, Cited=514, 11588219].
Perry SJ, Baillie GS, Kohout TA, ..., Lefkowitz RJ (2002) Targeting of cyclic AMP degradation to beta 2-adrenergic
receptors by beta-arrestins. Science. [IF=7.729, Cited=301, 12399592].
Lodowski DT, Pitcher JA, Capel WD, ..., Tesmer JJG (2003) Keeping G proteins at bay: a complex between G protein-coupled
receptor kinase 2 and Gbetagamma. Science. [IF=7.729, Cited=255, 12764189].
Chen W, ten Berge D, Brown J, ..., Lefkowitz RJ (2003) Dishevelled 2 recruits beta-arrestin 2 to mediate
Wnt5A-stimulated endocytosis of Frizzled 4. Science. [IF=7.729, Cited=224, 12958364].
Chen W, Kirkbride KC, How T, ..., Blobe GC (2003) Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and
down-regulation of its signaling. Science. [IF=7.729, Cited=159, 12958365].
Wang Q, Zhao J, Brady AE, ..., Limbird LE (2004) Spinophilin blocks arrestin actions in vitro and in vivo at G protein-
coupled receptors. Science. [IF=7.729, Cited=96, 15218143].
Chen W, Ren XR, Nelson CD, ..., Lefkowitz RJ (2004) Activity-dependent internalization of smoothened mediated by beta-
arrestin 2 and GRK2. Science. [IF=7.729, Cited=168, 15618519].
Lefkowitz RJ, Shenoy SK (2005) Transduction of receptor signals by beta-arrestins. Science. [IF=7.729, Cited=1000, 15845844].
Nelson CD, Perry SJ, Regier DS, ..., Lefkowitz RJ (2007) Targeting of diacylglycerol degradation to M1 muscarinic
receptors by beta-arrestins. Science. [IF=7.729, Cited=86, 17272726].
Kovacs JJ, Whalen EJ, Liu R, ..., Lefkowitz RJ (2008) Beta-arrestin-mediated localization of smoothened to the primary
cilium. Science. [IF=7.729, Cited=178, 18497258].
Lohse MJ, Benovic JL, Codina J, ..., Lefkowitz RJ (1990) beta-Arrestin: a protein that regulates beta-adrenergic
receptor function. Science. [IF=7.729, Cited=628, 2163110].
King K, Dohlman HG, Thorner J, ..., Lefkowitz RJ (1990) Control of yeast mating signal transduction by a mammalian beta
2-adrenergic receptor and Gs alpha subunit. Science. [IF=7.729, Cited=128, 2171146].
Benovic JL, DeBlasi A, Stone WC, ..., Lefkowitz RJ (1989) Beta-adrenergic receptor kinase: primary structure delineates
a multigene family. Science. [IF=7.729, Cited=221, 2552582].
Akhter SA, Luttrell LM, Rockman HA, ..., Koch WJ (1998) Targeting the receptor-Gq interface to inhibit in vivo pressure
overload myocardial hypertrophy. Science. [IF=7.729, Cited=277, 9554846].
Ford CE, Skiba NP, Bae H, ..., Hamm HE (1998) Molecular basis for interactions of G protein betagamma subunits with
effectors. Science. [IF=7.729, Cited=264, 9596582].
Kobilka BK, Kobilka BK, Matsui H, ..., Regan JW (1987) Cloning, sequencing, and expression of the gene coding for the
human platelet alpha 2-adrenergic receptor. Science. [IF=7.729, Cited=394, 2823383].
Luttrell LM, Ferguson SS, Daaka Y, ..., Lefkowitz RJ (1999) Beta-arrestin-dependent formation of beta2 adrenergic
receptor-Src protein kinase complexes. Science. [IF=7.729, Cited=893, 9924018].
Kobilka BK, Kobilka BK, Kobilka TS, ..., Lefkowitz RJ (1988) Chimeric alpha 2-,beta 2-adrenergic receptors: delineation
of domains involved in effector coupling and ligand binding specificity. Science. [IF=7.729, Cited=373, 2836950].
Bohn LM, Lefkowitz RJ, Gainetdinov RR, ..., Lin FT (1999) Enhanced morphine analgesia in mice lacking beta-arrestin 2.
Science. [IF=7.729, Cited=626, 10617462].
McDonald PH, Chow CW, Miller WE, ..., Lefkowitz RJ (2000) Beta-arrestin 2: a receptor-regulated MAPK scaffold for the
activation of JNK3. Science. [IF=7.729, Cited=502, 11090355].
Strulovici B, Cerione RA, Kilpatrick BF, ..., Lefkowitz RJ (1984) Direct demonstration of impaired functionality of a
purified desensitized beta-adrenergic receptor in a reconstituted system. Science. [IF=7.729, Cited=33, 6089331].
Koch WJ, Rockman HA, Samama P, ..., Lefkowitz RJ (1995) Cardiac function in mice overexpressing the beta-adrenergic
receptor kinase or a beta ARK inhibitor. Science. [IF=7.729, Cited=450, 7761854].
Milano CA, Allen LF, Rockman HA, ..., Lefkowitz RJ (1994) Enhanced myocardial function in transgenic mice overexpressing
the beta 2-adrenergic receptor. Science. [IF=7.729, Cited=436, 8160017].
Dawson TM, Arriza JL, Jaworsky DE, ..., Ronnett GV (1993) Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as
mediators of odorant-induced desensitization. Science. [IF=7.729, Cited=104, 8381559].
Luttrell LM, Ostrowski J, Cotecchia S, ..., Lefkowitz RJ (1993) Antagonism of catecholamine receptor signaling by
expression of cytoplasmic domains of the receptors. Science. [IF=7.729, Cited=48, 8383880].
Liu X, Masoudi A, Kahsai AW, ..., Kobilka B (2019) Mechanism of β₂AR regulation by an intracellular positive
allosteric modulator. Science. [IF=7.729, Cited=57, 31249059].
Wingler LM, Skiba MA, McMahon C, ..., Kruse AC (2020) Angiotensin and biased analogs induce structurally distinct active
conformations within a GPCR. Science. [IF=7.729, Cited=94, 32079768].
Suomivuori CM, Latorraca NR, Wingler LM, ..., Dror RO (2020) Molecular mechanism of biased signaling in a prototypical G
protein-coupled receptor. Science. [IF=7.729, Cited=101, 32079767].
Xie L, Xiao K, Whalen EJ, ..., Stamler JS (2009) Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and
ubiquitylation by pVHL. Science Signaling. [IF=1.6, Cited=94, 19584355].
Nobles KN, Xiao K, Ahn S, ..., Lefkowitz RJ (2011) Distinct phosphorylation sites on the β(2)-adrenergic receptor
establish a barcode that encodes differential functions of β-arrestin. Science Signaling. [IF=1.6, Cited=360, 21868357].
Choi M, Staus DP, Wingler LM, ..., Lefkowitz RJ (2018) G protein-coupled receptor kinases (GRKs) orchestrate biased
agonism at the β₂-adrenergic receptor. Science Signaling. [IF=1.6, Cited=33, 30131371].
Luttrell LM, Wang J, Plouffe B, ..., Lefkowitz RJ (2018) Manifold roles of β-arrestins in GPCR signaling elucidated with
siRNA and CRISPR/Cas9. Science Signaling. [IF=1.6, Cited=94, 30254056].
Gesty-Palmer D, Flannery P, Yuan L, ..., Luttrell LM (2009) A beta-arrestin-biased agonist of the parathyroid hormone
receptor (PTH1R) promotes bone formation independent of G protein activation. Science Translational Medicine. [IF=2.778,
Cited=104, 20368153].
Lovgren AK, Kovacs JJ, Xie T, ..., Noble PW (2011) β-arrestin deficiency protects against pulmonary fibrosis in mice and
prevents fibroblast invasion of extracellular matrix. Science Translational Medicine. [IF=2.778, Cited=60, 21411739].
Miller WE, Lefkowitz RJ (2001) Arrestins as signaling molecules involved in apoptotic pathways: a real eye opener. None.
[IF=None, Cited=5, 11752639].
Shenoy SK, Lefkowitz RJ (2005) Seven-transmembrane receptor signaling through beta-arrestin. None. [IF=None, Cited=99, 16267056].
Shenoy SK, Lefkowitz RJ (2005) Angiotensin II-stimulated signaling through G proteins and beta-arrestin. None. [IF=None,
Cited=33, 16304060].
Meloni AR, Fralish GB, Kelly P, ..., Caron MG (2006) Smoothened signal transduction is promoted by G protein-coupled
receptor kinase 2. Molecular and Cellular Biology. [IF=1.026, Cited=71, 16908539].
Maudsley S, Zamah AM, Rahman N, ..., Hall RA (2000) Platelet-derived growth factor receptor association with Na(+)/H(+)
exchanger regulatory factor potentiates receptor activity. Molecular and Cellular Biology. [IF=1.026, Cited=131, 11046132].
Usui I, Imamura T, Huang J, ..., Olefsky JM (2004) beta-arrestin-1 competitively inhibits insulin-induced ubiquitination
and degradation of insulin receptor substrate 1. Molecular and Cellular Biology. [IF=1.026, Cited=39, 15456867].
Lefkowitz RJ (2017) A Serendipitous Scientist. Annual Review of Pharmacology and Toxicology. [IF=2.886, Cited=2, 28715979].
Pitcher JA, Freedman NJ, Lefkowitz RJ (1998) G protein-coupled receptor kinases. Annual Review of Biochemistry.
[IF=5.273, Cited=721, 9759500].
Gainetdinov RR, Premont RT, Bohn LM, ..., Caron MG (2004) Desensitization of G protein-coupled receptors and neuronal
functions. Annual Review of Neuroscience. [IF=3.679, Cited=543, 15217328].
Reiter E, Ahn S, Shukla AK, Lefkowitz RJ (2011) Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane
receptors. Annual Review of Pharmacology and Toxicology. [IF=2.886, Cited=369, 21942629].
Koch WJ, Lefkowitz RJ, Rockman HA (2000) Functional consequences of altering myocardial adrenergic receptor signaling.
Annual Review of Physiology. [IF=4.535, Cited=92, 10845091].
DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK (2007) Beta-arrestins and cell signaling. Annual Review of Physiology.
[IF=4.535, Cited=907, 17305471].
Wisler JW, Harris EM, Raisch M, ..., Lefkowitz RJ (2015) The role of β-arrestin2-dependent signaling in thoracic aortic
aneurysm formation in a murine model of Marfan syndrome. American Journal of Physiology - Heart and Circulatory
Physiology. [IF=1.161, Cited=14, 26371162].
Walker JK, Peppel K, Lefkowitz RJ, ..., Fisher JT (1999) Altered airway and cardiac responses in mice lacking G protein-
coupled receptor kinase 3. None. [IF=None, Cited=29, 10198406].
Tachibana H, Naga Prasad SV, Lefkowitz RJ, ..., Rockman HA (2005) Level of beta-adrenergic receptor kinase 1 inhibition
determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. Circulation. [IF=6.144,
Cited=45, 15668342].
Drake MT, Shenoy SK, Lefkowitz RJ (2006) Trafficking of G protein-coupled receptors. Circulation Research. [IF=3.534,
Cited=201, 16973913].
Akhter SA, Eckhart AD, Rockman HA, ..., Koch WJ (1999) In vivo inhibition of elevated myocardial beta-adrenergic
receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. Circulation.
[IF=6.144, Cited=58, 10441103].
Shah AS, Lilly RE, Kypson AP, ..., Koch WJ (2000) Intracoronary adenovirus-mediated delivery and overexpression of the
beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance. Circulation. [IF=6.144,
Cited=68, 10653833].
Shah AS, White DC, Emani S, ..., Koch WJ (2001) In vivo ventricular gene delivery of a beta-adrenergic receptor kinase
inhibitor to the failing heart reverses cardiac dysfunction. Circulation. [IF=6.144, Cited=115, 11238278].
Iaccarino G, Tomhave ED, Lefkowitz RJ, Koch WJ (1998) Reciprocal in vivo regulation of myocardial G protein-coupled
receptor kinase expression by beta-adrenergic receptor stimulation and blockade. Circulation. [IF=6.144, Cited=158, 9788834].
Hall RA, Lefkowitz RJ (2002) Regulation of G protein-coupled receptor signaling by scaffold proteins. Circulation
Research. [IF=3.534, Cited=134, 12386143].
Nair LA, Inglese J, Stoffel R, ..., Grant AO (1995) Cardiac muscarinic potassium channel activity is attenuated by
inhibitors of G beta gamma. Circulation Research. [IF=3.534, Cited=28, 7729000].
Koch WJ, Milano CA, Lefkowitz RJ (1996) Transgenic manipulation of myocardial G protein-coupled receptors and receptor
kinases. Circulation Research. [IF=3.534, Cited=17, 8635207].
Xiao RP, Avdonin P, Zhou YY, ..., Lakatta EG (None) Coupling of beta2-adrenoceptor to Gi proteins and its physiological
relevance in murine cardiac myocytes. Circulation Research. [IF=3.534, Cited=216, 9915773].
Cross HR, Steenbergen C, Lefkowitz RJ, ..., Murphy E (1999) Overexpression of the cardiac beta(2)-adrenergic receptor
and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but
have differential effects on susceptibility to ischemic injury. Circulation Research. [IF=3.534, Cited=34, 10571539].
Eckhart AD, Duncan SJ, Penn RB, ..., Koch WJ (None) Hybrid transgenic mice reveal in vivo specificity of G protein-
coupled receptor kinases in the heart. Circulation Research. [IF=3.534, Cited=61, 10625304].
Kim J, Zhang L, Peppel K, ..., Freedman NJ (2008) Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by
controlling smooth muscle cell proliferation and migration. Circulation Research. [IF=3.534, Cited=76, 18519945].
Rockman HA, Lefkowitz RJ (2011) Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor
signaling. Circulation Research. [IF=3.534, Cited=2, 21737815].
Liu S, Anderson PJ, Rajagopal S, ..., Rockman HA (2024) G Protein-Coupled Receptors: A Century of Research and
Discovery. Circulation Research. [IF=3.534, Cited=0, 38900852].
Wisler JW, Rockman HA, Lefkowitz RJ (2018) Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug
Discovery. Circulation. [IF=6.144, Cited=41, 29844068].
Manglik A, Wingler LM, Rockman HA, Lefkowitz RJ (2020) β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19.
Circulation. [IF=6.144, Cited=12, 32412788].
Kohout TA, Takaoka H, McDonald PH, ..., Rockman HA (2001) Augmentation of cardiac contractility mediated by the human
beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice. Circulation. [IF=6.144, Cited=51, 11705829].
Lefkowitz RJ (1988) The spirit of science. Presidential address to the American Society for Clinical Investigation,
Washington, DC, 30 April 1988. Journal of Clinical Investigation. [IF=2.423, Cited=6, 3403708].
Ahn S, Maarsingh H, Walker JK, ..., Lefkowitz RJ (2023) Allosteric modulator potentiates β2AR agonist-promoted
bronchoprotection in asthma models. Journal of Clinical Investigation. [IF=2.423, Cited=1, 37432742].
Rockman HA, Lefkowitz RJ (2024) G protein-coupled receptors: from radioligand binding to cellular signaling. Journal of
Clinical Investigation. [IF=2.423, Cited=0, 38426490].
Lefkowitz RJ (2008) The annual ASCI meeting: does nostalgia have a future? Journal of Clinical Investigation. [IF=2.423,
Cited=1, 18382732].
Lefkowitz RJ (2011) A tale of two callings. Journal of Clinical Investigation. [IF=2.423, Cited=1, 21965340].
Rein LA, Wisler JW, Kim J, ..., Lefkowitz RJ (2017) β-Arrestin2 mediates progression of murine primary myelofibrosis.
JCI insight. [IF=1.554, Cited=4, 29263312].
Kim J, Grotegut CA, Wisler JW, ..., Lefkowitz RJ (2018) β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal
muscle hypertrophy and contractility. Skeletal Muscle. [IF=1.171, Cited=26, 30591079].
Luttrell LM, Lefkowitz RJ (2002) The role of beta-arrestins in the termination and transduction of G-protein-coupled
receptor signals. Journal of Cell Science. [IF=0.99, Cited=575, 11861753].
Li A, Liu S, Huang R, ..., Lefkowitz RJ (2023) Loss of biased signaling at a G protein-coupled receptor in overexpressed
systems. PLoS ONE. [IF=1.253, Cited=3, 36961836].
Lefkowitz RJ (2005) Summary of Wenner-Gren international symposium receptor-receptor interactions among heptaspanning
membrane receptors: from structure to function. Journal of Molecular Neuroscience. [IF=0.76, Cited=2, 16012202].
Kavelaars A, Vroon A, Raatgever RP, ..., Heijnen CJ (2003) Increased acute inflammation, leukotriene B4-induced
chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. Journal of Immunology. [IF=0.939,
Cited=48, 14634128].
Lefkowitz RJ, Caron MG (1990) The adrenergic receptors. None. [IF=None, Cited=4, 1976327].
Lefkowitz RJ, Caron MG (None) Adrenergic receptors. None. [IF=None, Cited=0, 2152138].
Lefkowitz RJ, Caron MG (1988) Adrenergic receptors. None. [IF=None, Cited=4, 2843210].
Lefkowitz RJ, Caron MG (1988) Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide
regulatory proteins. Journal of Biological Chemistry. [IF=1.122, Cited=209, 3128532].
Lefkowitz RJ, Cotecchia S, Kjelsberg MA, ..., Caron MG (1993) Adrenergic receptors: recent insights into their mechanism
of activation and desensitization. None. [IF=None, Cited=26, 8398391].

Publication with MISSING institution:

Stadel JM, De Lean A, Lefkowitz RJ (1982) Molecular mechanisms of coupling in hormone receptor-adenylate cyclase
systems. None. [IF=None, Cited=44, 6277164].
Lefkowitz RJ, Limbird LE, Williams LT, Wessels M (1978) Beta-adrenergic receptors: regulatory role of agonists. None.
[IF=None, Cited=3, 31515].
Bittner HB, Chen EP, Milano CA, ..., Van Trigt P (1997) Functional analysis of myocardial performance in murine hearts
overexpressing the human beta 2-adrenergic receptor. Journal of Molecular and Cellular Cardiology. [IF=1.079, Cited=10, 9152857].
Gaballa MA, Peppel K, Lefkowitz RJ, ..., Goldman S (1998) Enhanced vasorelaxation by overexpression of beta 2-adrenergic
receptors in large arteries. Journal of Molecular and Cellular Cardiology. [IF=1.079, Cited=23, 9618244].
Eckhart AD, Fentzke RC, Lepore J, ..., Leiden JM (2002) Inhibition of betaARK1 restores impaired biochemical beta-
adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy. Journal of Molecular and
Cellular Cardiology. [IF=1.079, Cited=9, 12054854].
Kwatra MM, Schreurs J, Schwinn DA, ..., Lefkowitz RJ (1995) Immunoaffinity purification of epitope-tagged human beta
2-adrenergic receptor to homogeneity. Protein Expression and Purification. [IF=0.594, Cited=5, 8746622].
Roth NS, Lefkowitz RJ, Caron MG (1991) Structure and function of the adrenergic receptor family. Advances in
Experimental Medicine and Biology. [IF=0.945, Cited=5, 1801586].
Sibley DR, Benovic JL, Caron MG, Lefkowitz RJ (1987) Molecular mechanisms of beta-adrenergic receptor desensitization.
Advances in Experimental Medicine and Biology. [IF=0.945, Cited=18, 2829583].
Strasser RH, Benovic JL, Lefkowitz RJ, Caron MG (1988) The beta-adrenergic receptor kinase: role in homologous
desensitization in S49 lymphoma cells. Advances in Experimental Medicine and Biology. [IF=0.945, Cited=2, 2843012].
Lefkowitz RJ (1978) Identification and regulation of beta-adrenergic receptors. Advances in Experimental Medicine and
Biology. [IF=0.945, Cited=1, 24993].
Rockman HA, Koch WJ, Milano CA, Lefkowitz RJ (1996) Myocardial beta-adrenergic receptor signaling in vivo: insights from
transgenic mice. Journal of Molecular Medicine. [IF=1.051, Cited=18, 8892053].
Caron MG, Limbird LE, Lefkowitz RJ (1979) Biochemical characterization of the beta-adrenergic receptor of the frog
erythrocyte. Molecular and Cellular Biochemistry. [IF=0.788, Cited=8, 231201].
Kingsmore SF, Peppel K, Suh D, ..., Seldin MF (1995) Genetic mapping of the beta-arrestin 1 and 2 genes on mouse
chromosomes 7 and 11 respectively. Mammalian Genome. [IF=0.583, Cited=5, 7613043].
Lefkowitz RJ, Cerione RA, Codina J, ..., Caron MG (1985) Reconstitution of the beta-adrenergic receptor. Journal of
Membrane Biology. [IF=0.733, Cited=8, 2865370].
Sibley DR, Lefkowitz RJ (1987) Beta-adrenergic receptor-coupled adenylate cyclase. Biochemical mechanisms of regulation.
Molecular Neurobiology. [IF=1.132, Cited=22, 2855789].
Stoffel RH, Pitcher JA, Lefkowitz RJ (1997) Targeting G protein-coupled receptor kinases to their receptor substrates.
Journal of Membrane Biology. [IF=0.733, Cited=23, 9141353].
Stiles GL, Lefkowitz RJ (1982) A reconstitution assay for the guanine nucleotide regulatory protein of the adenylate
cyclase system using turkey erythrocyte membranes as the acceptor preparation. Archives of Biochemistry and Biophysics.
[IF=0.874, Cited=2, 6127058].
Briggs MM, Stadel JM, Iyengar R, Lefkowitz RJ (1983) Functional modification of the guanine nucleotide regulatory
protein after desensitization of turkey erythrocytes by catecholamines. Archives of Biochemistry and Biophysics.
[IF=0.874, Cited=17, 6307146].
Sibley DR, Jeffs RA, Daniel K, ..., Lefkowitz RJ (1986) Phorbol diester treatment promotes enhanced adenylate cyclase
activity in frog erythrocytes. Archives of Biochemistry and Biophysics. [IF=0.874, Cited=38, 3484932].
Sibley DR, Daniel K, Strader CD, Lefkowitz RJ (1987) Phosphorylation of the beta-adrenergic receptor in intact cells:
relationship to heterologous and homologous mechanisms of adenylate cyclase desensitization. Archives of Biochemistry
and Biophysics. [IF=0.874, Cited=12, 2444163].
Aprille JR, Lefkowitz RJ, Warshaw JB (1974) (3H)norepinephrine binding and lipolysis by isolated fat cells. None.
[IF=None, Cited=6, 4433592].
Limbird LE, Lefkowitz RJ (1975) Myocardial guanylate cyclase: properties of the enzyme and effects of cholinergic
agonists in vitro. None. [IF=None, Cited=20, 235292].
Lefkowitz RJ, Mukherjee C, Coverstone M, Caron MG (1974) Stereospecific (3H)(minus)-alprenolol binding sites, beta-
adrenergic receptors and adenylate cyclase. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=95, 4370935].
Limbird LE, Meyts PD, Lefkowitz RJ (1975) Beta-adrenergic receptors: evidence for negative cooperativity. Biochemical
and Biophysical Research Communications. [IF=0.643, Cited=99, 1137592].
Caron MG, Lefkowitz RJ (1976) Beta-Adrenergic receptors: solubilization of (-)(3H)alprenolol binding sites from frog
erythrocyte membranes. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=9, 1082747].
Glaubiger G, Lefkowitz RJ (1977) Elevated beta-adrenergic receptor number after chronic propranolol treatment.
Biochemical and Biophysical Research Communications. [IF=0.643, Cited=143, 199185].
Wood CL, Caron MG, Lefkowitz RJ (1979) Separation of solubilized alpha and beta adrenergic receptors by affinity
chromatography. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=10, 222278].
Michel T, Hoffman BB, Lefkowitz RJ, Caron MG (1981) Different sedimentation properties of agonist- and antagonist-
labelled platelet alpha 2 adrenergic receptors. Biochemical and Biophysical Research Communications. [IF=0.643,
Cited=21, 6268079].
Koo C, Lefkowitz RJ, Snyderman R (1982) The oligopeptide chemotactic factor receptor on human polymorphonuclear
leukocyte membranes exists in two affinity states. Biochemical and Biophysical Research Communications. [IF=0.643,
Cited=83, 6285921].
Benovic JL, Stiles GL, Lefkowitz RJ, Caron MG (1983) Photoaffinity labelling of mammalian beta-adrenergic receptors:
metal-dependent proteolysis explains apparent heterogeneity. Biochemical and Biophysical Research Communications.
[IF=0.643, Cited=36, 6301455].
Sibley DR, Nambi P, Peters JR, Lefkowitz RJ (1984) Phorbol diesters promote beta-adrenergic receptor phosphorylation and
adenylate cyclase desensitization in duck erythrocytes. Biochemical and Biophysical Research Communications. [IF=0.643,
Cited=133, 6331437].
Regan JW, Raymond JR, Lefkowitz RJ, DeMarinis RM (1986) Photoaffinity labeling of human platelet and rabbit kidney alpha
2-adrenoceptors with [3H]SKF 102229. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=3, 3015124].
Liggett SB, Bouvier M, O'Dowd BF, ..., DeBlasi A (1989) Substitution of an extracellular cysteine in the beta
2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization. Biochemical and
Biophysical Research Communications. [IF=0.643, Cited=10, 2556136].
Yang SD, Benovic JL, Fong YL, ..., Lefkowitz RJ (1991) Cyclic phosphorylation-dephosphorylation of rhodopsin in retina
by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase). Biochemical and Biophysical Research
Communications. [IF=0.643, Cited=10, 1651717].
Lefkowitz RJ (1974) Commentary. Molecular pharmacology of beta-adrenergic receptors--a status report. Biochemical
Pharmacology. [IF=1.155, Cited=12, 4153299].
Lefkowitz RJ (1975) Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-
adrenergic antagonists. Biochemical Pharmacology. [IF=1.155, Cited=20, 11].
Lefkowitz RJ (1975) Heterogeneity of adenylate cyclase-coupled beta-adrenergic receptors. Biochemical Pharmacology.
[IF=1.155, Cited=51, 235928].
Wood CL, Arnett CD, Clarke WR, ..., Lefkowitz RJ (1979) Subclassification of alpha-adrenergic receptors by direct
binding studies. Biochemical Pharmacology. [IF=1.155, Cited=96, 36095].
Hoffman BB, Lefkowitz RJ (1980) An assay for alpha-adrenergic receptor subtypes using [3H]dihydroergocryptine.
Biochemical Pharmacology. [IF=1.155, Cited=18, 6244840].
Hoffman BB, Lefkowitz RJ (1980) [3H]WB4101--caution about its role as an alpha-adrenergic subtype selective radioligand.
Biochemical Pharmacology. [IF=1.155, Cited=44, 6249320].
Wikberg JE, Lefkowitz RJ, Caron MG (1983) Solubilization of rat liver alpha 1-adrenergic receptors. Agonist specific
alteration in receptor binding affinity. Biochemical Pharmacology. [IF=1.155, Cited=14, 6139112].
Stiles GL, Hoffman BB, Hubbard M, ..., Lefkowitz RJ (1983) Guanine nucleotides and alpha 1 adrenergic receptors in the
heart. Biochemical Pharmacology. [IF=1.155, Cited=12, 6299299].
Nambi P, Sibley DR, Caron MG, Lefkowitz RJ (1984) Photoaffinity labeling of beta-adrenergic receptors in mammalian
tissues. Biochemical Pharmacology. [IF=1.155, Cited=9, 6095862].
Regan JW, DeMarinis RM, Lefkowitz RJ (1985) Arylazide photoaffinity probe for alpha 2-adrenoceptors. Biochemical
Pharmacology. [IF=1.155, Cited=2, 2864929].
Nakata H, Regan JW, Lefkowitz RJ (1986) Chemical modification of alpha 2-adrenoceptors. Possible role for tyrosine in
the ligand binding site. Biochemical Pharmacology. [IF=1.155, Cited=6, 3022750].
Davis JN, Lefkowitz RJ (1976) Beta-adrenergic receptor binding: synaptic localization in rat brain. Brain Research.
[IF=0.766, Cited=16, 953730].
Peters JR, Nambi P, Sibley DR, Lefkowitz RJ (1984) Enhanced adenylate cyclase activity of turkey erythrocytes following
treatment with beta-adrenergic receptor antagonists. European Journal of Pharmacology. [IF=1.015, Cited=4, 6151904].
Willingham MC, Strader CD, Lefkowitz RJ, Pastan I (1984) Morphologic demonstration of clathrin-coated pits in frog and
turkey erythrocytes. Experimental Cell Research. [IF=0.736, Cited=2, 6142826].
García-Sáinz JA, Boyer JL, Michel T, ..., Lefkowitz RJ (1984) Effect of pertussis toxin on alpha 2-adrenoceptors:
decreased formation of the high-affinity state for agonists. FEBS Letters. [IF=0.871, Cited=12, 6329826].
Collins S, Quarmby VE, French FS, ..., Caron MG (1988) Regulation of the beta 2-adrenergic receptor and its mRNA in the
rat ventral prostate by testosterone. FEBS Letters. [IF=0.871, Cited=24, 2838324].
Benovic JL, Stone WC, Huebner K, ..., Lefkowitz RJ (1991) cDNA cloning and chromosomal localization of the human beta-
adrenergic receptor kinase. FEBS Letters. [IF=0.871, Cited=16, 2037065].
Lefkowitz RJ (1975) Catecholamine stimulated myocardial adenylate cyclase: effects of phospholipase digestion and the
role of membrane lipids. Journal of Molecular and Cellular Cardiology. [IF=1.079, Cited=17, 1121031].
Lefkowitz RJ (1975) Catecholamine stimulated myocardial adenylate cyclase: effects of nucleotides. Journal of Molecular
and Cellular Cardiology. [IF=1.079, Cited=5, 1127710].
Lefkowitz RJ, Levey GS (1972) Norepinephrine: dissociation of -receptor binding from adenylate cyclase activation in
solubilized myocardium. None. [IF=None, Cited=11, 4144316].
Mukherjee C, Lefkowitz RJ (1976) Direct studies of beta-adrenergic receptors intact frog erythrocytes. Life Sciences.
[IF=1.121, Cited=9, 187891].
Lefkowitz RJ (1976) The beta-adrenergic receptor. Life Sciences. [IF=1.121, Cited=29, 3712].
Hoffman BB, De Lean A, Wood CL, ..., Lefkowitz RJ (1979) Alpha-adrenergic receptor subtypes: quantitative assessment by
ligand binding. Life Sciences. [IF=1.121, Cited=162, 222980].
García-Sínz JA, Hoffman BB, Li SY, ..., Fain JN (1980) Role of alpha 1 adrenoceptors in the turnover of
phosphatidylinositol and of alpha 2 adrenoceptors in the regulation of cyclic AMP accumulation in hamster adipocytes.
Life Sciences. [IF=1.121, Cited=58, 6107811].
Pitha J, Zjawiony J, Nasrin N, ..., Caron MG (1980) Potent beta-adrenergic antagonist possessing chemically reactive
group. Life Sciences. [IF=1.121, Cited=27, 6110155].
Stiles GL, Lefkowitz RJ (1981) Thyroid hormone modulation of agonist--beta-adrenergic receptor interactions in the rat
heart. Life Sciences. [IF=1.121, Cited=35, 6114379].
Hoffman BB, Dukes DF, Lefkowitz RJ (1981) Alpha-adrenergic receptors in liver membranes: delineation with subtype
selective radioligands. Life Sciences. [IF=1.121, Cited=72, 6261059].
Wikberg JE, Lefkowitz RJ (1982) Alpha 2 adrenergic receptors are located prejunctionally in the Auerbach's plexus of the
guinea pig small intestine: direct demonstration by radioligand binding. Life Sciences. [IF=1.121, Cited=23, 6298533].
De Lean A, Rouleau D, Lefkowitz RJ (1983) Activation of adenylate cyclase by beta-adrenergic receptors: investigation of
rate limiting steps by simultaneous assay of high affinity agonist binding and GDP release. Life Sciences. [IF=1.121,
Cited=3, 6310288].
Stiles GL, Taylor S, Lefkowitz RJ (1983) Human cardiac beta-adrenergic receptors: subtype heterogeneity delineated by
direct radioligand binding. Life Sciences. [IF=1.121, Cited=92, 6135968].
Strader CD, Sibley DR, Lefkowitz RJ (1984) Association of sequestered beta-adrenergic receptors with the plasma
membrane: a novel mechanism for receptor down regulation. Life Sciences. [IF=1.121, Cited=26, 6090842].
Cotecchia S, Leeb-Lundberg LM, Hagen PO, ..., Caron MG (1985) Phorbol ester effects on alpha 1-adrenoceptor binding and
phosphatidylinositol metabolism in cultured vascular smooth muscle cells. Life Sciences. [IF=1.121, Cited=25, 3001461].
Palacios JM, O'Dowd BF, Cotecchia S, ..., Lefkowitz RJ (1989) Adrenergic receptor homologies in vertebrate and
invertebrate species examined by DNA hybridization. Life Sciences. [IF=1.121, Cited=9, 2545987].
Caron MG, Shorr RG, Lavin TN, Lefkowitz RJ (1982) Molecular characterization of the beta-adrenergic receptor of frog
erythrocytes. Metabolism: Clinical and Experimental. [IF=2.576, Cited=1, 6283304].
Lefkowitz RJ, Limbird LE (1976) Techniques for the study of the biochemical basis of drug action. Progress in
Cardiovascular Diseases. [IF=1.781, Cited=1, 737].
Kao KJ, Tsai BS, McKee PA, ..., Pizzo SV (1983) Inhibitory effect of ristocetin and factor VIII/von Willebrand factor
protein on human platelet adenylate cyclase activity. Thrombosis Research. [IF=1.413, Cited=1, 6408756].
Bishopric NH, Cohen HJ, Lefkowitz RJ (1980) Beta adrenergic receptors in lymphocyte subpopulations. Journal of Allergy
and Clinical Immunology. [IF=2.533, Cited=100, 6243144].
Sibley DR, Benovic JL, Caron MG, Lefkowitz RJ (1987) Regulation of transmembrane signaling by receptor phosphorylation.
Cell. [IF=8.479, Cited=381, 3030559].
Frielle T, Kobilka B, Lefkowitz RJ, Caron MG (1988) Human beta 1- and beta 2-adrenergic receptors: structurally and
functionally related receptors derived from distinct genes. Trends in Neurosciences. [IF=3.343, Cited=18, 2465637].
Collins S, Ostrowski J, Lefkowitz RJ (1993) Cloning and sequence analysis of the human beta 1-adrenergic receptor
5'-flanking promoter region. None. [IF=None, Cited=31, 8382527].
Lomasney JW, Cotecchia S, Lefkowitz RJ, Caron MG (1991) Molecular biology of alpha-adrenergic receptors: implications
for receptor classification and for structure-function relationships. None. [IF=None, Cited=104, 1657194].
Scheinin M, Lomasney JW, Hayden-Hixson DM, ..., Fremeau RT (1994) Distribution of alpha 2-adrenergic receptor subtype
gene expression in rat brain. None. [IF=None, Cited=252, 8164514].
Lefkowitz RJ, Limbird LE, Mukherjee C, Caron MG (1976) The beta-adrenergic receptor and adenylate cyclase. None.
[IF=None, Cited=74, 769837].
Caron MG, Lefkowitz RJ (1976) Biological activity of agarose-immobilized catecholamines. None. [IF=None, Cited=1, 9146].
Limbird LE, DeLean A, Hickey AR, ..., Lefkowitz RJ (1979) Differential effects of GTP on the coupling of beta-adrenergic
receptors to adenylate cyclase from frog and turkey erythrocytes. Application of new methods for the analysis of
receptor-effector coupling. None. [IF=None, Cited=4, 224939].
Tsai BS, Lefkowitz RJ (1979) Multiple effects of guanine nucleotides on human platelet adenylated cyclase. None.
[IF=None, Cited=9, 486544].
Voeikov VL, Lefkowitz RJ (1980) Effects of local anesthetics on guanyl nucleotide modulation of the catecholamine-
sensitive adenylate cyclase system and on beta-adrenergic receptors. None. [IF=None, Cited=21, 6248119].
Pike LJ, Lefkowitz RJ (1980) Use of cell fusion techniques to probe the mechanism of catecholamine-induced
desensitization of adenylate cyclase in frog erythrocytes. None. [IF=None, Cited=10, 6251915].
Garćia-Sáinz JA, Litosch I, Hoffman BB, ..., Fain JN (1981) Effect of thyroid status on alpha- and beta-catecholamine
responsiveness of hamster adipocytes. None. [IF=None, Cited=6, 6274417].
Stiles GL, Strasser RH, Kilpatrick BF, ..., Lefkowitz RJ (1984) Endogenous proteinases modulate the function of the
beta-adrenergic receptor-adenylate cyclase system. None. [IF=None, Cited=10, 6095918].
Oakey RJ, Caron MG, Lefkowitz RJ, Seldin MF (1991) Genomic organization of adrenergic and serotonin receptors in the
mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution.
Genomics. [IF=1.012, Cited=42, 1676978].
Fargin A, Yamamoto K, Cotecchia S, ..., Lefkowitz RJ (1991) Dual coupling of the cloned 5-HT1A receptor to both adenylyl
cyclase and phospholipase C is mediated via the same Gi protein. Cellular Signalling. [IF=0.941, Cited=42, 1786205].
Luttrell DK, Hausdorff WP, Moyers JE, ..., Lefkowitz RJ (1992) Overexpression of pp60c-src is associated with altered
regulation of adenylyl cyclase. Cellular Signalling. [IF=0.941, Cited=10, 1384635].
Collins S, Caron MG, Lefkowitz RJ (1992) From ligand binding to gene expression: new insights into the regulation of
G-protein-coupled receptors. Trends in Biochemical Sciences. [IF=2.462, Cited=65, 1316650].
Kypson AP, Peppel K, Akhter SA, ..., Koch WJ (1998) Ex vivo adenovirus-mediated gene transfer to the adult rat heart.
Journal of Thoracic and Cardiovascular Surgery. [IF=2.274, Cited=30, 9535450].
Peppel K, Koch WJ, Lefkowitz RJ (1997) Gene transfer strategies for augmenting cardiac function. Trends in
Cardiovascular Medicine. [IF=2.356, Cited=4, 21235878].
Lefkowitz RJ, Wessels MR, Stadel JM (1980) Hormones, receptors, and cyclic AMP: their role in target cell
refractoriness. None. [IF=None, Cited=36, 6254729].
Lefkowitz RJ, Caron MG (1986) Regulation of adrenergic receptor function by phosphorylation. None. [IF=None, Cited=23, 3024910].
Lefkowitz RJ, Mukherjee C, Limbird LE, ..., Tate R (1976) Regulation of adenylate cyclase coupled beta-adrenergic
receptors. None. [IF=None, Cited=12, 785560].
Birnbaumer L, Codina J, Mattera R, ..., Iyengar R (1985) Regulation of hormone receptors and adenylyl cyclases by
guanine nucleotide binding N proteins. None. [IF=None, Cited=59, 2996090].
Lefkowitz RJ, Caron MG (1987) Molecular and regulatory properties of adrenergic receptors. None. [IF=None, Cited=14, 2819998].
Caron MG, Lefkowitz RJ (1993) Catecholamine receptors: structure, function, and regulation. None. [IF=None, Cited=32, 8441851].
Beaulieu JM, Sotnikova TD, Marion S, ..., Caron MG (2005) An Akt/beta-arrestin 2/PP2A signaling complex mediates
dopaminergic neurotransmission and behavior. Cell. [IF=8.479, Cited=664, 16051150].
Whalen EJ, Foster MW, Matsumoto A, ..., Stamler JS (2007) Regulation of beta-adrenergic receptor signaling by
S-nitrosylation of G-protein-coupled receptor kinase 2. Cell. [IF=8.479, Cited=201, 17482545].
Beaulieu JM, Marion S, Rodriguiz RM, ..., Caron MG (2008) A beta-arrestin 2 signaling complex mediates lithium action on
behavior. Cell. [IF=8.479, Cited=241, 18191226].
Martin NP, Whalen EJ, Zamah MA, ..., Lefkowitz RJ (2004) PKA-mediated phosphorylation of the beta1-adrenergic receptor
promotes Gs/Gi switching. Cellular Signalling. [IF=0.941, Cited=77, 15381255].
Cech TR, Charpentier E, Ciechanover A, ..., Wüthrich K (2024) Reflections from Nobel laureates in chemistry. Cell
Chemical Biology. [IF=1.446, Cited=0, 39151404].
Tarrant TK, Rampersad RR, Esserman D, ..., Patel DD (2008) Granulocyte chemotaxis and disease expression are
differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). Clinical Immunology.
[IF=1.324, Cited=25, 18662895].
Kovacs JJ, Hara MR, Davenport CL, ..., Lefkowitz RJ (2009) Arrestin development: emerging roles for beta-arrestins in
developmental signaling pathways. Developmental Cell. [IF=2.256, Cited=136, 19853559].
Ozawa K, Whalen EJ, Nelson CD, ..., Stamler JS (2008) S-nitrosylation of beta-arrestin regulates beta-adrenergic
receptor trafficking. Molecular Cell. [IF=2.773, Cited=122, 18691971].
Whalen EJ, Rajagopal S, Lefkowitz RJ (2010) Therapeutic potential of β-arrestin- and G protein-biased agonists. Trends
in Molecular Medicine. [IF=2.376, Cited=318, 21183406].
Reiter E, Lefkowitz RJ (2006) GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends in
Endocrinology and Metabolism. [IF=2.064, Cited=389, 16595179].
Shukla AK, Xiao K, Lefkowitz RJ (2011) Emerging paradigms of β-arrestin-dependent seven transmembrane receptor
signaling. Trends in Biochemical Sciences. [IF=2.462, Cited=274, 21764321].
Violin JD, Lefkowitz RJ (2007) Beta-arrestin-biased ligands at seven-transmembrane receptors. Trends in Pharmacological
Sciences. [IF=2.377, Cited=377, 17644195].
Shenoy SK, Lefkowitz RJ (2011) β-Arrestin-mediated receptor trafficking and signal transduction. Trends in
Pharmacological Sciences. [IF=2.377, Cited=414, 21680031].
Lefkowitz RJ (2012) An interview with Robert J. Lefkowitz. Trends in Pharmacological Sciences. [IF=2.377, Cited=1, 22403833].
Lefkowitz RJ (1974) (3H)norepinephrine binding: unrelated to catechol-O-methyl transferase. Biochemical and Biophysical
Research Communications. [IF=0.643, Cited=10, 4365564].
Hoffman BB, Yim S, Tsai BS, Lefkowitz RJ (1981) Preferential uncoupling by manganese of alpha adrenergic receptor
mediated inhibition of adenylate cyclase in human platelets. Biochemical and Biophysical Research Communications.
[IF=0.643, Cited=32, 6268073].
Leeb-Lundberg LM, Dickinson KE, Heald SL, ..., Caron MG (1983) Covalent labeling of the cerebral cortex alpha
1-adrenergic receptor with a new high affinity radioiodinated photoaffinity probe. Biochemical and Biophysical Research
Communications. [IF=0.643, Cited=7, 6313003].
Sibley DR, Peters JR, Nambi P, ..., Lefkowitz RJ (1984) Photoaffinity labeling of turkey erythrocyte beta-adrenergic
receptors: degradation of the Mr = 49,000 protein explains apparent heterogeneity. Biochemical and Biophysical Research
Communications. [IF=0.643, Cited=8, 6324763].
Freeman JL, Pitcher JA, Li X, ..., Lefkowitz RJ (2000) alpha-Actinin is a potent regulator of G protein-coupled receptor
kinase activity and substrate specificity in vitro. FEBS Letters. [IF=0.871, Cited=27, 10818226].
Lefkowitz RJ, Caron MG (1986) Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by
phosphorylation. Journal of Molecular and Cellular Cardiology. [IF=1.079, Cited=19, 3023644].
Milano CA, Allen LF, Dolber PC, ..., Lefkowitz RJ (1995) Marked enhancement in myocardial function resulting from
overexpression of a human beta-adrenergic receptor gene. Journal of Thoracic and Cardiovascular Surgery. [IF=2.274,
Cited=11, 7853876].
O'Hara DS, Lefkowitz RJ (1974) Affinity chromatography of adrenergic receptors and binding proteins. None. [IF=None,
Cited=3, 4449483].
Collins S, Lohse MJ, O'Dowd B, ..., Lefkowitz RJ (1991) Structure and regulation of G protein-coupled receptors: the
beta 2-adrenergic receptor as a model. None. [IF=None, Cited=21, 1660639].
Macrae AD, Premont RT, Jaber M, ..., Lefkowitz RJ (1996) Cloning, characterization, and chromosomal localization of
rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. None. [IF=None, Cited=23, 9013780].
Claing A, Laporte SA, Caron MG, Lefkowitz RJ (2002) Endocytosis of G protein-coupled receptors: roles of G protein-
coupled receptor kinases and beta-arrestin proteins. Progress in Neurobiology. [IF=1.947, Cited=318, 11900882].
Iaccarino G, Keys JR, Rapacciuolo A, ..., Koch WJ (2001) Regulation of myocardial betaARK1 expression in catecholamine-
induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors. Journal of the American
College of Cardiology. [IF=6.424, Cited=35, 11499749].
Diverse-Pierluissi M, Inglese J, Stoffel RH, ..., Dunlap K (1996) G protein-coupled receptor kinase mediates
desensitization of norepinephrine-induced Ca2+ channel inhibition. Neuron. [IF=3.346, Cited=38, 8785055].
Gainetdinov RR, Bohn LM, Walker JK, ..., Premont RT (1999) Muscarinic supersensitivity and impaired receptor
desensitization in G protein-coupled receptor kinase 5-deficient mice. Neuron. [IF=3.346, Cited=139, 10624964].
Gainetdinov RR, Bohn LM, Sotnikova TD, ..., Premont RT (2003) Dopaminergic supersensitivity in G protein-coupled
receptor kinase 6-deficient mice. Neuron. [IF=3.346, Cited=159, 12718862].
Fukuto HS, Ferkey DM, Apicella AJ, ..., Hart AC (2004) G protein-coupled receptor kinase function is essential for
chemosensation in C. elegans. Neuron. [IF=3.346, Cited=62, 15157420].
McDonald PH, Lefkowitz RJ (2001) Beta-Arrestins: new roles in regulating heptahelical receptors' functions. Cellular
Signalling. [IF=0.941, Cited=73, 11602178].
Miller WE, Lefkowitz RJ (2001) Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and
trafficking. Current Opinion in Cell Biology. [IF=1.539, Cited=180, 11248546].
Luttrell LM, Daaka Y, Lefkowitz RJ (1999) Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Current
Opinion in Cell Biology. [IF=1.539, Cited=417, 10209148].
Fraser ID, Cong M, Kim J, ..., Scott JD (2000) Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor
complex facilitates receptor phosphorylation and signaling. Current Biology. [IF=1.81, Cited=146, 10753752].
Perry SJ, Lefkowitz RJ (2002) Arresting developments in heptahelical receptor signaling and regulation. Trends in Cell
Biology. [IF=3.592, Cited=123, 11859025].
Inglese J, Koch WJ, Touhara K, Lefkowitz RJ (1995) G beta gamma interactions with PH domains and Ras-MAPK signaling
pathways. Trends in Biochemical Sciences. [IF=2.462, Cited=94, 7770915].
Luttrell LM, van Biesen T, Hawes BE, ..., Lefkowitz RJ (1998) Regulation of mitogen-activated protein kinase pathways by
catecholamine receptors. None. [IF=None, Cited=2, 9327940].
Koch WJ, Lefkowitz RJ, Milano CA, ..., Rockman HA (1998) Myocardial overexpression of adrenergic receptors and receptor
kinases. None. [IF=None, Cited=9, 9327950].
Pitcher J, Lohse MJ, Codina J, ..., Lefkowitz RJ (1992) Desensitization of the isolated beta 2-adrenergic receptor by
beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular
mechanisms. Biochemistry. [IF=0.753, Cited=111, 1348186].
Kurose H, Regan JW, Caron MG, Lefkowitz RJ (1991) Functional interactions of recombinant alpha 2 adrenergic receptor
subtypes and G proteins in reconstituted phospholipid vesicles. Biochemistry. [IF=0.753, Cited=53, 1849000].
Onorato JJ, Palczewski K, Regan JW, ..., Benovic JL (1991) Role of acidic amino acids in peptide substrates of the beta-
adrenergic receptor kinase and rhodopsin kinase. Biochemistry. [IF=0.753, Cited=98, 1645191].
Benovic JL, Shorr RG, Caron MG, Lefkowitz RJ (1984) The mammalian beta 2-adrenergic receptor: purification and
characterization. Biochemistry. [IF=0.753, Cited=86, 6093858].
Cerione RA, Codina J, Benovic JL, ..., Caron MG (1984) The mammalian beta 2-adrenergic receptor: reconstitution of
functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase
system. Biochemistry. [IF=0.753, Cited=105, 6149763].
Cerione RA, Codina J, Kilpatrick BF, ..., Lefkowitz RJ (1985) Transducin and the inhibitory nucleotide regulatory
protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid
vesicle systems. Biochemistry. [IF=0.753, Cited=14, 3933556].
Strasser RH, Sibley DR, Lefkowitz RJ (1986) A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent
pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous
desensitization of adenylate cyclase. Biochemistry. [IF=0.753, Cited=54, 3008828].
Cerione RA, Gierschik P, Staniszewski C, ..., Caron MG (1987) Functional differences in the beta gamma complexes of
transducin and the inhibitory guanine nucleotide regulatory protein. Biochemistry. [IF=0.753, Cited=30, 3032251].
Dohlman HG, Caron MG, Lefkowitz RJ (1987) A family of receptors coupled to guanine nucleotide regulatory proteins.
Biochemistry. [IF=0.753, Cited=293, 3038163].
Dohlman HG, Caron MG, Strader CD, ..., Lefkowitz RJ (1988) Identification and sequence of a binding site peptide of the
beta 2-adrenergic receptor. Biochemistry. [IF=0.753, Cited=57, 2837273].
Matsui H, Lefkowitz RJ, Caron MG, Regan JW (1989) Localization of the fourth membrane spanning domain as a ligand
binding site in the human platelet alpha 2-adrenergic receptor. Biochemistry. [IF=0.753, Cited=16, 2546589].
Kwatra MM, Benovic JL, Caron MG, ..., Hosey MM (1989) Phosphorylation of chick heart muscarinic cholinergic receptors by
the beta-adrenergic receptor kinase. Biochemistry. [IF=0.753, Cited=61, 2765501].
Dohlman HG, Caron MG, DeBlasi A, ..., Lefkowitz RJ (1990) Role of extracellular disulfide-bonded cysteines in the ligand
binding function of the beta 2-adrenergic receptor. Biochemistry. [IF=0.753, Cited=126, 2159799].
Briggs MM, Lefkowitz RJ (1980) Parallel modulation of catecholamine activation of adenylate cyclase and formation of the
high-affinity agonist.receptor complex in turkey erythrocyte membranes by temperature and cis-vaccenic acid.
Biochemistry. [IF=0.753, Cited=33, 6250586].
Weiss DR, Ahn S, Sassano MF, ..., Shoichet BK (2013) Conformation guides molecular efficacy in docking screens of
activated β-2 adrenergic G protein coupled receptor. ACS Chemical Biology. [IF=0.963, Cited=55, 23485065].
Randall MH, Altman LJ, Lefkowitz RJ (1977) Structure and biological activity of (-)-[3H]dihydroalprenolol, a radioligand
for studies of beta-adrenergic receptors. Journal of Medicinal Chemistry. [IF=1.655, Cited=5, 197238].
Rauckman EJ, Rosen GM, Lefkowitz RJ (1976) Pharmacological activity of nitroxide analogues of dichloroisoproterenol and
propranolol. Journal of Medicinal Chemistry. [IF=1.655, Cited=2, 11346].
Heald SL, Jeffs PW, Lavin TN, ..., Caron MG (1983) Synthesis of iodine-125 labeled (+/-)-15-(4-azidobenzyl)carazolol: a
potent beta-adrenergic photoaffinity probe. Journal of Medicinal Chemistry. [IF=1.655, Cited=9, 6304313].
DeMarinis RM, Krog AJ, Shah DH, ..., Caron MG (1984) Development of an affinity ligand for purification of alpha
2-adrenoceptors from human platelet membranes. Journal of Medicinal Chemistry. [IF=1.655, Cited=7, 6330361].
Lefkowitz RJ, Roth J, Pastan I (1970) Effects of calcium on ACTH stimulation of the adrenal: separation of hormone
binding from adenyl cyclase activation. Nature. [IF=11.591, Cited=69, 4320054].
Caron MG, Lefkowitz RJ (1974) Temperature immutability of adenyl cyclase-coupled beta adrenergic receptors. Nature.
[IF=11.591, Cited=12, 4151464].
Alexander RW, Davis JN, Lefkowitz RJ (1975) Direct identification and characterisation of beta-adrenergic receptors in
rat brain. Nature. [IF=11.591, Cited=177, 620].
Lefkowitz RJ, Hamp M (1977) Comparison of specificity of agonist and antagonist radioligand binding to beta adrenergic
receptors. Nature. [IF=11.591, Cited=8, 19707].
Glaubiger G, Tsai BS, Lefkowitz RJ, ..., Johnson EM (1978) Chronic guanethidine treatment increases cardiac beta-
adrenergic receptors. Nature. [IF=11.591, Cited=50, 205804].
Pike LJ, Limbird LE, Lefkowitz RJ (1979) Beta-adrenoreceptors determine affinity but not intrinsic activity of adenylate
cyclase stimulants. Nature. [IF=11.591, Cited=10, 37448].
DeLean A, Lefkowitz RJ (1980) Dihydroergocryptine binding and alpha-adrenoreceptors in smooth muscle. Nature.
[IF=11.591, Cited=5, 6243175].
Michel T, Hoffman BB, Lefkowitz RJ (1980) Differential regulation of the alpha 2-adrenergic receptor by Na+ and guanine
nucleotides. Nature. [IF=11.591, Cited=70, 6256638].
Cerione RA, Strulovici B, Benovic JL, ..., Caron MG (None) Pure beta-adrenergic receptor: the single polypeptide confers
catecholamine responsiveness to adenylate cyclase. Nature. [IF=11.591, Cited=49, 6316161].
Sibley DR, Lefkowitz RJ (None) Molecular mechanisms of receptor desensitization using the beta-adrenergic receptor-
coupled adenylate cyclase system as a model. Nature. [IF=11.591, Cited=400, 2993919].
Cerione RA, Staniszewski C, Caron MG, ..., Birnbaumer L (None) A role for Ni in the hormonal stimulation of adenylate
cyclase. Nature. [IF=11.591, Cited=50, 2999605].
Dixon RA, Kobilka BK, Kobilka BK, ..., Strader CD (None) Cloning of the gene and cDNA for mammalian beta-adrenergic
receptor and homology with rhodopsin. Nature. [IF=11.591, Cited=615, 3010132].
Benovic JL, Mayor F, Somers RL, ..., Lefkowitz RJ (None) Light-dependent phosphorylation of rhodopsin by beta-adrenergic
receptor kinase. Nature. [IF=11.591, Cited=78, 3014340].
Yoshimasa T, Sibley DR, Bouvier M, ..., Caron MG (None) Cross-talk between cellular signalling pathways suggested by
phorbol-ester-induced adenylate cyclase phosphorylation. Nature. [IF=11.591, Cited=304, 3033513].
Kobilka BK, Kobilka BK, Frielle T, ..., Caron MG (None) An intronless gene encoding a potential member of the family of
receptors coupled to guanine nucleotide regulatory proteins. Nature. [IF=11.591, Cited=270, 3041227].
Bouvier M, Hausdorff WP, De Blasi A, ..., Lefkowitz RJ (1988) Removal of phosphorylation sites from the beta
2-adrenergic receptor delays onset of agonist-promoted desensitization. Nature. [IF=11.591, Cited=221, 2836733].
Hall RA, Premont RT, Chow CW, ..., Lefkowitz RJ (1998) The beta2-adrenergic receptor interacts with the Na+/H+-exchanger
regulatory factor to control Na+/H+ exchange. Nature. [IF=11.591, Cited=332, 9560162].
Fargin A, Raymond JR, Lohse MJ, ..., Lefkowitz RJ (1988) The genomic clone G-21 which resembles a beta-adrenergic
receptor sequence encodes the 5-HT1A receptor. Nature. [IF=11.591, Cited=322, 3138543].
Bohn LM, Gainetdinov RR, Lin FT, ..., Caron MG (2000) Mu-opioid receptor desensitization by beta-arrestin-2 determines
morphine tolerance but not dependence. Nature. [IF=11.591, Cited=582, 11130073].
Pierce KL, Lefkowitz RJ (2001) Classical and new roles of beta-arrestins in the regulation of G-protein-coupled
receptors. Nature Reviews Neuroscience. [IF=4.332, Cited=268, 11584310].
Lefkowitz RJ (1991) Thrombin receptor. Variations on a theme. Nature. [IF=11.591, Cited=10, 1851963].
Lefkowitz RJ (1992) G proteins. The subunit story thickens. Nature. [IF=11.591, Cited=14, 1322498].
Inglese J, Koch WJ, Caron MG, Lefkowitz RJ (1992) Isoprenylation in regulation of signal transduction by G-protein-
coupled receptor kinases. Nature. [IF=11.591, Cited=151, 1522899].
Daaka Y, Luttrell LM, Lefkowitz RJ (1997) Switching of the coupling of the beta2-adrenergic receptor to different G
proteins by protein kinase A. Nature. [IF=11.591, Cited=773, 9363896].
Lefkowitz RJ (1993) G-protein-coupled receptors. Turned on to ill effect. Nature. [IF=11.591, Cited=40, 8413622].
Reuveny E, Slesinger PA, Inglese J, ..., Jan LY (1994) Activation of the cloned muscarinic potassium channel by G
protein beta gamma subunits. Nature. [IF=11.591, Cited=307, 8022483].
van Biesen T, Hawes BE, Luttrell DK, ..., Lefkowitz RJ (1995) Receptor-tyrosine-kinase- and G beta gamma-mediated MAP
kinase activation by a common signalling pathway. Nature. [IF=11.591, Cited=297, 7651538].
Rockman HA, Koch WJ, Lefkowitz RJ (2002) Seven-transmembrane-spanning receptors and heart function. Nature. [IF=11.591,
Cited=597, 11805844].
Gilman AG, Harris BA, Long R, ..., Sambrano GR (2002) Overview of the Alliance for Cellular Signaling. Nature.
[IF=11.591, Cited=71, 12478301].
Hara MR, Kovacs JJ, Whalen EJ, ..., Lefkowitz RJ (2011) A stress response pathway regulates DNA damage through
β2-adrenoreceptors and β-arrestin-1. Nature. [IF=11.591, Cited=234, 21857681].
Shukla AK, Manglik A, Kruse AC, ..., Lefkowitz RJ (2013) Structure of active β-arrestin-1 bound to a G-protein-coupled
receptor phosphopeptide. Nature. [IF=11.591, Cited=265, 23604254].
Staus DP, Strachan RT, Manglik A, ..., Lefkowitz RJ (2016) Allosteric nanobodies reveal the dynamic range and diverse
mechanisms of G-protein-coupled receptor activation. Nature. [IF=11.591, Cited=169, 27409812].
Lefkowitz RJ, Sun JP, Shukla AK (2008) A crystal clear view of the beta2-adrenergic receptor. Nature Biotechnology.
[IF=8.861, Cited=15, 18259173].
Shenoy SK, Lefkowitz RJ (2005) Receptor regulation: beta-arrestin moves up a notch. Nature Cell Biology. [IF=3.908,
Cited=20, 16319967].
Kahsai AW, Xiao K, Rajagopal S, ..., Lefkowitz RJ (2011) Multiple ligand-specific conformations of the β2-adrenergic
receptor. Nature Chemical Biology. [IF=2.623, Cited=161, 21857662].
Lefkowitz RJ, O'Hara DS, Warshaw J (1973) Binding of catecholamines to receptors in cultured myocardial cells. None.
[IF=None, Cited=13, 4516145].
Shenoy SK, Lefkowitz RJ (2004) Resonating to the music of ubiquitination. Nature Methods. [IF=10.009, Cited=1, 15782194].
Rajagopal S, Rajagopal K, Lefkowitz RJ (2010) Teaching old receptors new tricks: biasing seven-transmembrane receptors.
Nature Reviews Drug Discovery. [IF=18.471, Cited=502, 20431569].
Pierce KL, Premont RT, Lefkowitz RJ (2002) Seven-transmembrane receptors. Nature Reviews Molecular Cell Biology.
[IF=19.213, Cited=1000, 12209124].
Terman GW, Jin W, Cheong YP, ..., Chavkin C (2003) G-protein receptor kinase 3 (GRK3) influences opioid analgesic
tolerance but not opioid withdrawal. British Journal of Pharmacology. [IF=1.816, Cited=72, 14662727].
Pierce KL, Luttrell LM, Lefkowitz RJ (2001) New mechanisms in heptahelical receptor signaling to mitogen activated
protein kinase cascades. Oncogene. [IF=1.523, Cited=253, 11313899].
Shenoy SK, Lefkowitz RJ (2003) Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning
receptor trafficking and signalling. Biochemical Journal. [IF=0.852, Cited=237, 12959637].
Milasta S, Evans NA, Ormiston L, ..., Milligan G (2005) The sustainability of interactions between the orexin-1 receptor
and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK
MAPK regulation. Biochemical Journal. [IF=0.852, Cited=49, 15683363].
Collins S, Bouvier M, Lohse MJ, ..., Lefkowitz RJ (1990) Mechanisms involved in adrenergic receptor desensitization.
Biochemical Society Transactions. [IF=0.925, Cited=15, 2177406].
Lefkowitz RJ (1973) Isolated hormone receptors: physiologic and clinical implications. New England Journal of Medicine.
[IF=17.194, Cited=9, 4144513].
Lefkowitz RJ (1976) Beta-adrenergic receptors: recognition and regulation. New England Journal of Medicine. [IF=17.194,
Cited=31, 6910].
Lefkowitz RJ (1976) Editorial: Smoking, catecholamines, and the heart. New England Journal of Medicine. [IF=17.194,
Cited=5, 950975].
Hoffman BB, Lefkowitz RJ (1980) Alpha-adrenergic receptor subtypes. New England Journal of Medicine. [IF=17.194,
Cited=124, 6246426].
Lefkowitz RJ, Caron MG, Stiles GL (1984) Mechanisms of membrane-receptor regulation. Biochemical, physiological, and
clinical insights derived from studies of the adrenergic receptors. New England Journal of Medicine. [IF=17.194,
Cited=148, 6145093].
Shah AS, White DC, Tai O, ..., Koch WJ (2000) Adenovirus-mediated genetic manipulation of the myocardial beta-adrenergic
signaling system in transplanted hearts. Journal of Thoracic and Cardiovascular Surgery. [IF=2.274, Cited=15, 10962422].
Alexander RW, Williams LT, Lefkowitz RJ (1975) Identification of cardiac beta-adrenergic receptors by (minus)
[3H]alprenolol binding. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=72, 1055427].
Mukherjee C, Caron MG, Lefkowitz RJ (1975) Catecholamine-induced subsensitivity of adenylate cyclase associated with
loss of beta-adrenergic receptor binding sites. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=140, 1057183].
Mukherjee C, Lefkowitz RJ (1976) Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free
system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides. Proceedings of the
National Academy of Sciences of the United States of America. [IF=2.765, Cited=39, 5723].
Lefkowitz RJ, Williams LT (1977) Catecholamine binding to the beta-adrenergic receptor. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=48, 15249].
Williams LT, Snyderman R, Pike MC, Lefkowitz RJ (1977) Specific receptor sites for chemotactic peptides on human
polymorphonuclear leukocytes. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=266, 265563].
Limbird LE, Gill DM, Lefkowitz RJ (1980) Agonist-promoted coupling of the beta-adrenergic receptor with the guanine
nucleotide regulatory protein of the adenylate cyclase system. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=77, 6244585].
Pitha J, Zjawiony J, Lefkowitz RJ, Caron MG (1980) Macromolecular beta-adrenergic antagonists discriminating between
receptor and antibody. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=3, 6154947].
Hoffman BB, Michel T, Kilpatrick DM, ..., Fain JN (1980) Agonist versus antagonist binding to alpha-adrenergic
receptors. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=37, 6107908].
Burgisser E, De Lean A, Lefkowitz RJ (1982) Reciprocal modulation of agonist and antagonist binding to muscarinic
cholinergic receptor by guanine nucleotide. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=54, 6979043].
Shorr RG, Heald SL, Jeffs PW, ..., Caron MG (1982) The beta-adrenergic receptor: rapid purification and covalent
labeling by photoaffinity crosslinking. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=28, 6283543].
Stadel JM, Nambi P, Shorr RG, ..., Lefkowitz RJ (1983) Catecholamine-induced desensitization of turkey erythrocyte
adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=93, 6304694].
Cerione RA, Strulovici B, Benovic JL, ..., Lefkowitz RJ (1983) Reconstitution of beta-adrenergic receptors in lipid
vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate
cyclase system. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=17, 6308659].
Strader CD, Pickel VM, Joh TH, ..., Caron MG (1983) Antibodies to the beta-adrenergic receptor: attenuation of
catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain. Proceedings
of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=27, 6300875].
Leeb-Lundberg LM, Cotecchia S, Lomasney JW, ..., Caron MG (1985) Phorbol esters promote alpha 1-adrenergic receptor
phosphorylation and receptor uncoupling from inositol phospholipid metabolism. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=155, 2994039].
Strasser RH, Benovic JL, Caron MG, Lefkowitz RJ (1986) Beta-agonist- and prostaglandin E1-induced translocation of the
beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=55, 3018728].
Sibley DR, Strasser RH, Benovic JL, ..., Lefkowitz RJ (1986) Phosphorylation/dephosphorylation of the beta-adrenergic
receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. Proceedings of the
National Academy of Sciences of the United States of America. [IF=2.765, Cited=93, 3025843].
Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ (1986) Beta-adrenergic receptor kinase: identification of a novel
protein kinase that phosphorylates the agonist-occupied form of the receptor. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=256, 2871555].
Kobilka BK, Kobilka BK, Dixon RA, ..., Lefkowitz RJ (1987) cDNA for the human beta 2-adrenergic receptor: a protein with
multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor
for platelet-derived growth factor. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=330, 3025863].
Pitcher JA, Touhara K, Payne ES, Lefkowitz RJ (1995) Pleckstrin homology domain-mediated membrane association and
activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid.
Journal of Biological Chemistry. [IF=1.122, Cited=191, 7744811].
Luttrell LM, Hawes BE, Touhara K, ..., Lefkowitz RJ (1995) Effect of cellular expression of pleckstrin homology domains
on Gi-coupled receptor signaling. Journal of Biological Chemistry. [IF=1.122, Cited=33, 7768889].
Luttrell LM, van Biesen T, Hawes BE, ..., Lefkowitz RJ (1995) G beta gamma subunits mediate mitogen-activated protein
kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. Journal of Biological Chemistry.
[IF=1.122, Cited=110, 7622449].
Touhara K, Koch WJ, Hawes BE, Lefkowitz RJ (1995) Mutational analysis of the pleckstrin homology domain of the beta-
adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding.
Journal of Biological Chemistry. [IF=1.122, Cited=54, 7622521].
Hawes BE, van Biesen T, Koch WJ, ..., Lefkowitz RJ (1995) Distinct pathways of Gi- and Gq-mediated mitogen-activated
protein kinase activation. Journal of Biological Chemistry. [IF=1.122, Cited=230, 7615510].
Freedman NJ, Liggett SB, Drachman DE, ..., Lefkowitz RJ (1995) Phosphorylation and desensitization of the human beta
1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. Journal of
Biological Chemistry. [IF=1.122, Cited=180, 7629102].
Chen CK, Inglese J, Lefkowitz RJ, Hurley JB (1995) Ca(2+)-dependent interaction of recoverin with rhodopsin kinase.
Journal of Biological Chemistry. [IF=1.122, Cited=168, 7629115].
Premont RT, Macrae AD, Stoffel RH, ..., Lefkowitz RJ (1996) Characterization of the G protein-coupled receptor kinase
GRK4. Identification of four splice variants. Journal of Biological Chemistry. [IF=1.122, Cited=110, 8626439].
Hawes BE, Luttrell LM, van Biesen T, Lefkowitz RJ (1996) Phosphatidylinositol 3-kinase is an early intermediate in the G
beta gamma-mediated mitogen-activated protein kinase signaling pathway. Journal of Biological Chemistry. [IF=1.122,
Cited=210, 8647803].
Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ (1996) Phosphorylation of the type 1A angiotensin II receptor by G
protein-coupled receptor kinases and protein kinase C. Journal of Biological Chemistry. [IF=1.122, Cited=126, 8662816].
Fredericks ZL, Pitcher JA, Lefkowitz RJ (1996) Identification of the G protein-coupled receptor kinase phosphorylation
sites in the human beta2-adrenergic receptor. Journal of Biological Chemistry. [IF=1.122, Cited=122, 8662852].
van Biesen T, Hawes BE, Raymond JR, ..., Lefkowitz RJ (1996) G(o)-protein alpha-subunits activate mitogen-activated
protein kinase via a novel protein kinase C-dependent mechanism. Journal of Biological Chemistry. [IF=1.122, Cited=109, 8576109].
Luttrell LM, Hawes BE, van Biesen T, ..., Lefkowitz RJ (1996) Role of c-Src tyrosine kinase in G protein-coupled
receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases. Journal of Biological
Chemistry. [IF=1.122, Cited=303, 8702633].
Pitcher JA, Fredericks ZL, Stone WC, ..., Lefkowitz RJ (1996) Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G
protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site
distinguishes the GRK subfamilies. Journal of Biological Chemistry. [IF=1.122, Cited=104, 8798768].
Tiberi M, Nash SR, Bertrand L, ..., Caron MG (1996) Differential regulation of dopamine D1A receptor responsiveness by
various G protein-coupled receptor kinases. Journal of Biological Chemistry. [IF=1.122, Cited=112, 8631993].
Krueger KM, Daaka Y, Pitcher JA, Lefkowitz RJ (1997) The role of sequestration in G protein-coupled receptor
resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification. Journal of
Biological Chemistry. [IF=1.122, Cited=172, 8995214].
Freedman NJ, Ament AS, Oppermann M, ..., Lefkowitz RJ (1997) Phosphorylation and desensitization of human endothelin A
and B receptors. Evidence for G protein-coupled receptor kinase specificity. Journal of Biological Chemistry. [IF=1.122,
Cited=116, 9211925].
Della Rocca GJ, van Biesen T, Daaka Y, ..., Lefkowitz RJ (1997) Ras-dependent mitogen-activated protein kinase
activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and
Src kinase. Journal of Biological Chemistry. [IF=1.122, Cited=269, 9235901].
Akhter SA, Milano CA, Shotwell KF, ..., Koch WJ (1997) Transgenic mice with cardiac overexpression of alpha1B-adrenergic
receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. Journal of Biological
Chemistry. [IF=1.122, Cited=92, 9261135].
Peppel K, Boekhoff I, McDonald P, ..., Lefkowitz RJ (1997) G protein-coupled receptor kinase 3 (GRK3) gene disruption
leads to loss of odorant receptor desensitization. Journal of Biological Chemistry. [IF=1.122, Cited=101, 9325250].
Lin FT, Krueger KM, Kendall HE, ..., Lefkowitz RJ (1997) Clathrin-mediated endocytosis of the beta-adrenergic receptor
is regulated by phosphorylation/dephosphorylation of beta-arrestin1. Journal of Biological Chemistry. [IF=1.122,
Cited=138, 9388255].
Luttrell LM, Daaka Y, Della Rocca GJ, Lefkowitz RJ (1997) G protein-coupled receptors mediate two functionally distinct
pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with
activation of Erk kinases. Journal of Biological Chemistry. [IF=1.122, Cited=114, 9395506].
Ishizaka N, Alexander RW, Laursen JB, ..., Griendling KK (1997) G protein-coupled receptor kinase 5 in cultured vascular
smooth muscle cells and rat aorta. Regulation by angiotensin II and hypertension. Journal of Biological Chemistry.
[IF=1.122, Cited=46, 9405459].
Boekhoff I, Touhara K, Danner S, ..., Lefkowitz RJ (1997) Phosducin, potential role in modulation of olfactory
signaling. Journal of Biological Chemistry. [IF=1.122, Cited=27, 9020189].
Luttrell LM, Della Rocca GJ, van Biesen T, ..., Lefkowitz RJ (1997) Gbetagamma subunits mediate Src-dependent
phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras
activation. Journal of Biological Chemistry. [IF=1.122, Cited=270, 9020193].
Daaka Y, Luttrell LM, Ahn S, ..., Lefkowitz RJ (1998) Essential role for G protein-coupled receptor endocytosis in the
activation of mitogen-activated protein kinase. Journal of Biological Chemistry. [IF=1.122, Cited=301, 9422717].
Pitcher JA, Hall RA, Daaka Y, ..., Barak LS (1998) The G protein-coupled receptor kinase 2 is a microtubule-associated
protein kinase that phosphorylates tubulin. Journal of Biological Chemistry. [IF=1.122, Cited=89, 9575184].
Snow BE, Hall RA, Krumins AM, ..., Siderovski DP (1998) GTPase activating specificity of RGS12 and binding specificity
of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. Journal of Biological Chemistry. [IF=1.122, Cited=139, 9651375].
Rockman HA, Choi DJ, Akhter SA, ..., Koch WJ (1998) Control of myocardial contractile function by the level of beta-
adrenergic receptor kinase 1 in gene-targeted mice. Journal of Biological Chemistry. [IF=1.122, Cited=105, 9660778].
Freeman JL, De La Cruz EM, Pollard TD, ..., Pitcher JA (1998) Regulation of G protein-coupled receptor kinase 5 (GRK5)
by actin. Journal of Biological Chemistry. [IF=1.122, Cited=28, 9685424].
Lin FT, Daaka Y, Lefkowitz RJ (1998) beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of
the insulin-like growth factor I receptor. Journal of Biological Chemistry. [IF=1.122, Cited=107, 9822622].
McDonald PH, Cote NL, Lin FT, ..., Lefkowitz RJ (1999) Identification of NSF as a beta-arrestin1-binding protein.
Implications for beta2-adrenergic receptor regulation. Journal of Biological Chemistry. [IF=1.122, Cited=87, 10196135].
Della Rocca GJ, Maudsley S, Daaka Y, ..., Luttrell LM (1999) Pleiotropic coupling of G protein-coupled receptors to the
mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases. Journal of Biological
Chemistry. [IF=1.122, Cited=161, 10318809].
Lin FT, Miller WE, Luttrell LM, Lefkowitz RJ (1999) Feedback regulation of beta-arrestin1 function by extracellular
signal-regulated kinases. Journal of Biological Chemistry. [IF=1.122, Cited=87, 10347142].
Ahn S, Maudsley S, Luttrell LM, ..., Daaka Y (1999) Src-mediated tyrosine phosphorylation of dynamin is required for
beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. Journal of Biological
Chemistry. [IF=1.122, Cited=155, 9880482].
Hall RA, Spurney RF, Premont RT, ..., Lefkowitz RJ (1999) G protein-coupled receptor kinase 6A phosphorylates the
Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. Journal of Biological Chemistry.
[IF=1.122, Cited=96, 10446210].
Premont RT, Macrae AD, Aparicio SA, ..., Lefkowitz RJ (1999) The GRK4 subfamily of G protein-coupled receptor kinases.
Alternative splicing, gene organization, and sequence conservation. Journal of Biological Chemistry. [IF=1.122,
Cited=54, 10506199].
Pitcher JA, Tesmer JJ, Freeman JL, ..., Lefkowitz RJ (1999) Feedback inhibition of G protein-coupled receptor kinase 2
(GRK2) activity by extracellular signal-regulated kinases. Journal of Biological Chemistry. [IF=1.122, Cited=116, 10574913].
Della Rocca GJ, Mukhin YV, Garnovskaya MN, ..., Raymond JR (1999) Serotonin 5-HT1A receptor-mediated Erk activation
requires calcium/calmodulin-dependent receptor endocytosis. Journal of Biological Chemistry. [IF=1.122, Cited=99, 9988712].
Maudsley S, Pierce KL, Zamah AM, ..., Luttrell LM (2000) The beta(2)-adrenergic receptor mediates extracellular signal-
regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. Journal
of Biological Chemistry. [IF=1.122, Cited=258, 10734107].
Miller WE, Maudsley S, Ahn S, ..., Lefkowitz RJ (2000) beta-arrestin1 interacts with the catalytic domain of the
tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. Journal of
Biological Chemistry. [IF=1.122, Cited=125, 10753943].
Vitale N, Patton WA, Moss J, ..., Premont RT (2000) GIT proteins, A novel family of phosphatidylinositol 3,4,
5-trisphosphate-stimulated GTPase-activating proteins for ARF6. Journal of Biological Chemistry. [IF=1.122, Cited=99, 10788515].
Premont RT, Claing A, Vitale N, ..., Lefkowitz RJ (2000) The GIT family of ADP-ribosylation factor GTPase-activating
proteins. Functional diversity of GIT2 through alternative splicing. Journal of Biological Chemistry. [IF=1.122,
Cited=84, 10896954].
Cao W, Luttrell LM, Medvedev AV, ..., Collins S (2000) Direct binding of activated c-Src to the beta 3-adrenergic
receptor is required for MAP kinase activation. Journal of Biological Chemistry. [IF=1.122, Cited=123, 11013230].
Vines CM, Revankar CM, Maestas DC, ..., Prossnitz ER (2003) N-formyl peptide receptors internalize but do not recycle in
the absence of arrestins. Journal of Biological Chemistry. [IF=1.122, Cited=67, 12947104].
Ahn S, Wei H, Garrison TR, Lefkowitz RJ (2004) Reciprocal regulation of angiotensin receptor-activated extracellular
signal-regulated kinases by beta-arrestins 1 and 2. Journal of Biological Chemistry. [IF=1.122, Cited=130, 14711824].
Hu LA, Tang Y, Miller WE, ..., Hall RA (2000) beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor
internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. Journal
of Biological Chemistry. [IF=1.122, Cited=105, 10995758].
Cong M, Perry SJ, Lin FT, ..., Lefkowitz RJ (2001) Regulation of membrane targeting of the G protein-coupled receptor
kinase 2 by protein kinase A and its anchoring protein AKAP79. Journal of Biological Chemistry. [IF=1.122, Cited=109, 11278469].
Pierce KL, Tohgo A, Ahn S, ..., Lefkowitz RJ (2001) Epidermal growth factor (EGF) receptor-dependent ERK activation by G
protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding
EGF shedding. Journal of Biological Chemistry. [IF=1.122, Cited=141, 11290747].
Miller WE, McDonald PH, Cai SF, ..., Lefkowitz RJ (2001) Identification of a motif in the carboxyl terminus of beta
-arrestin2 responsible for activation of JNK3. Journal of Biological Chemistry. [IF=1.122, Cited=88, 11356842].
Imamura T, Huang J, Dalle S, ..., Olefsky JM (2001) beta -Arrestin-mediated recruitment of the Src family kinase Yes
mediates endothelin-1-stimulated glucose transport. Journal of Biological Chemistry. [IF=1.122, Cited=80, 11546805].
Cong M, Perry SJ, Hu LA, ..., Lefkowitz RJ (2001) Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive
factor regulates receptor recycling. Journal of Biological Chemistry. [IF=1.122, Cited=89, 11577089].
Tohgo A, Pierce KL, Choy EW, ..., Luttrell LM (2002) beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK
activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. Journal of Biological
Chemistry. [IF=1.122, Cited=240, 11777902].
Hu LA, Chen W, Premont RT, ..., Lefkowitz RJ (2001) G protein-coupled receptor kinase 5 regulates beta 1-adrenergic
receptor association with PSD-95. Journal of Biological Chemistry. [IF=1.122, Cited=30, 11700307].
Claing A, Chen W, Miller WE, ..., Lefkowitz RJ (2001) beta-Arrestin-mediated ADP-ribosylation factor 6 activation and
beta 2-adrenergic receptor endocytosis. Journal of Biological Chemistry. [IF=1.122, Cited=135, 11533043].
Chen M, Philipp M, Wang J, ..., Chen W (2009) G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.
Journal of Biological Chemistry. [IF=1.122, Cited=40, 19801552].
Paing MM, Stutts AB, Kohout TA, ..., Trejo J (2001) beta -Arrestins regulate protease-activated receptor-1
desensitization but not internalization or Down-regulation. Journal of Biological Chemistry. [IF=1.122, Cited=134, 11694535].
Shukla AK, Kim J, Ahn S, ..., Lefkowitz RJ (2010) Arresting a transient receptor potential (TRP) channel: beta-arrestin
1 mediates ubiquitination and functional down-regulation of TRPV4. Journal of Biological Chemistry. [IF=1.122,
Cited=65, 20650893].
Ahn S, Kim J, Lucaveche CL, ..., Daaka Y (2002) Src-dependent tyrosine phosphorylation regulates dynamin self-assembly
and ligand-induced endocytosis of the epidermal growth factor receptor. Journal of Biological Chemistry. [IF=1.122,
Cited=88, 12011079].
Zamah AM, Delahunty M, Luttrell LM, Lefkowitz RJ (2002) Protein kinase A-mediated phosphorylation of the beta
2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. Journal of
Biological Chemistry. [IF=1.122, Cited=117, 12063255].
Hanyaloglu AC, Seeber RM, Kohout TA, ..., Eidne KA (2002) Homo- and hetero-oligomerization of thyrotropin-releasing
hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2. Journal of Biological Chemistry.
[IF=1.122, Cited=46, 12393857].
Shenoy SK, Lefkowitz RJ (2003) Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the
kinetics of beta-arrestin deubiquitination. Journal of Biological Chemistry. [IF=1.122, Cited=147, 12574160].
Tohgo A, Choy EW, Gesty-Palmer D, ..., Luttrell LM (2002) The stability of the G protein-coupled receptor-beta-arrestin
interaction determines the mechanism and functional consequence of ERK activation. Journal of Biological Chemistry.
[IF=1.122, Cited=217, 12473660].
Hu LA, Chen W, Martin NP, ..., Lefkowitz RJ (2003) GIPC interacts with the beta1-adrenergic receptor and regulates
beta1-adrenergic receptor-mediated ERK activation. Journal of Biological Chemistry. [IF=1.122, Cited=69, 12724327].
Miller WE, Houtz DA, Nelson CD, ..., Lefkowitz RJ (2003) G-protein-coupled receptor (GPCR) kinase phosphorylation and
beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR. Journal
of Biological Chemistry. [IF=1.122, Cited=71, 12668664].
Rapacciuolo A, Suvarna S, Barki-Harrington L, ..., Rockman HA (2003) Protein kinase A and G protein-coupled receptor
kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways. Journal of Biological
Chemistry. [IF=1.122, Cited=102, 12821660].
McLaughlin JP, Myers LC, Zarek PE, ..., Chavkin C (2003) Prolonged kappa opioid receptor phosphorylation mediated by
G-protein receptor kinase underlies sustained analgesic tolerance. Journal of Biological Chemistry. [IF=1.122,
Cited=80, 14597630].
Martin NP, Lefkowitz RJ, Shenoy SK (2003) Regulation of V2 vasopressin receptor degradation by agonist-promoted
ubiquitination. Journal of Biological Chemistry. [IF=1.122, Cited=88, 12960162].
Povsic TJ, Kohout TA, Lefkowitz RJ (2003) Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of
phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis. Journal of Biological Chemistry. [IF=1.122, Cited=110, 14534298].
Galliera E, Jala VR, Trent JO, ..., Haribabu B (2004) beta-Arrestin-dependent constitutive internalization of the human
chemokine decoy receptor D6. Journal of Biological Chemistry. [IF=1.122, Cited=96, 15084596].
Ahn S, Shenoy SK, Wei H, Lefkowitz RJ (2004) Differential kinetic and spatial patterns of beta-arrestin and G protein-
mediated ERK activation by the angiotensin II receptor. Journal of Biological Chemistry. [IF=1.122, Cited=334, 15205453].
Wei H, Ahn S, Barnes WG, Lefkowitz RJ (2004) Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor
is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. Journal of
Biological Chemistry. [IF=1.122, Cited=57, 15355986].
Xiao K, Shenoy SK, Nobles K, Lefkowitz RJ (2004) Activation-dependent conformational changes in {beta}-arrestin 2.
Journal of Biological Chemistry. [IF=1.122, Cited=92, 15501822].
Ge L, Shenoy SK, Lefkowitz RJ, DeFea K (2004) Constitutive protease-activated receptor-2-mediated migration of MDA
MB-231 breast cancer cells requires both beta-arrestin-1 and -2. Journal of Biological Chemistry. [IF=1.122, Cited=112, 15489220].
Shenoy SK, Lefkowitz RJ (2005) Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of
seven-transmembrane receptor signalosomes. Journal of Biological Chemistry. [IF=1.122, Cited=101, 15699045].
Barnes WG, Reiter E, Violin JD, ..., Lefkowitz RJ (2004) beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and
stress fiber formation following receptor stimulation. Journal of Biological Chemistry. [IF=1.122, Cited=135, 15611106].
Girnita L, Shenoy SK, Sehat B, ..., Larsson O (2005) {beta}-Arrestin is crucial for ubiquitination and down-regulation
of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. Journal of Biological
Chemistry. [IF=1.122, Cited=104, 15878855].
Shenoy SK, Drake MT, Nelson CD, ..., Lefkowitz RJ (2005) beta-arrestin-dependent, G protein-independent ERK1/2
activation by the beta2 adrenergic receptor. Journal of Biological Chemistry. [IF=1.122, Cited=492, 16280323].
Gesty-Palmer D, Chen M, Reiter E, ..., Lefkowitz RJ (2006) Distinct beta-arrestin- and G protein-dependent pathways for
parathyroid hormone receptor-stimulated ERK1/2 activation. Journal of Biological Chemistry. [IF=1.122, Cited=293, 16492667].
Violin JD, Ren XR, Lefkowitz RJ (2006) G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to
the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. Journal of Biological Chemistry.
[IF=1.122, Cited=89, 16687412].
Violin JD, Dewire SM, Barnes WG, Lefkowitz RJ (2006) G protein-coupled receptor kinase and beta-arrestin-mediated
desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics. Journal of Biological
Chemistry. [IF=1.122, Cited=44, 17008309].
Nobles KN, Guan Z, Xiao K, ..., Lefkowitz RJ (2007) The active conformation of beta-arrestin1: direct evidence for the
phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2. Journal
of Biological Chemistry. [IF=1.122, Cited=78, 17513300].
Girnita L, Shenoy SK, Sehat B, ..., Larsson O (2007) Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK
activation and cell cycle progression. Journal of Biological Chemistry. [IF=1.122, Cited=88, 17303558].
Shenoy SK, Barak LS, Xiao K, ..., Lefkowitz RJ (2007) Ubiquitination of beta-arrestin links seven-transmembrane receptor
endocytosis and ERK activation. Journal of Biological Chemistry. [IF=1.122, Cited=82, 17666399].
Violin JD, DiPilato LM, Yildirim N, ..., Lefkowitz RJ (2007) beta2-adrenergic receptor signaling and desensitization
elucidated by quantitative modeling of real time cAMP dynamics. Journal of Biological Chemistry. [IF=1.122, Cited=162, 18045878].
Drake MT, Violin JD, Whalen EJ, ..., Lefkowitz RJ (2007) beta-arrestin-biased agonism at the beta2-adrenergic receptor.
Journal of Biological Chemistry. [IF=1.122, Cited=170, 18086673].
DeWire SM, Kim J, Whalen EJ, ..., Lefkowitz RJ (2008) Beta-arrestin-mediated signaling regulates protein synthesis.
Journal of Biological Chemistry. [IF=1.122, Cited=57, 18276584].
Nelson CD, Kovacs JJ, Nobles KN, ..., Lefkowitz RJ (2008) Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate
5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. Journal of Biological
Chemistry. [IF=1.122, Cited=26, 18534983].
Kim J, Ahn S, Rajagopal K, Lefkowitz RJ (2009) Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK
stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal
growth factor receptor. Journal of Biological Chemistry. [IF=1.122, Cited=79, 19254952].
Ahn S, Kim J, Hara MR, ..., Lefkowitz RJ (2009) {beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation
of BAD Phosphorylation. Journal of Biological Chemistry. [IF=1.122, Cited=102, 19171933].
Zhang SJ, Cheng H, Zhou YY, ..., Xiao RP (2000) Inhibition of spontaneous beta 2-adrenergic activation rescues beta
1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor. Journal of Biological Chemistry.
[IF=1.122, Cited=18, 10787424].
Heinsimer JA, Lefkowitz RJ (1983) The beta-adrenergic receptor in heart failure. None. [IF=None, Cited=6, 6138306].
Lefkowitz RJ (2003) An interview with Professor Robert J. Lefkowitz, M.D. Interview by Vicki Glaser. Assay and Drug
Development Technologies. [IF=0.651, Cited=0, 15090188].
O'Keefe DD, Lefkowitz RJ, Grantham RN, ..., Daggett WM (1975) Absence of effect of cardiac denervation and induced right
ventricular failure on canine myocardial norepinephrine binding sites. Cardiovascular Research. [IF=1.982, Cited=0, 45648].
Williams RS, Lefkowitz RJ (1979) Thyroid hormone regulation of alpha-adrenergic receptors: studies in rat myocardium.
Journal of Cardiovascular Pharmacology. [IF=0.686, Cited=34, 94388].
McConnaughey MM, Jones LR, Watanabe AM, ..., Lefkowitz RJ (1979) Thyroxine and propylthiouracil effects on alpha- and
beta-adrenergic receptor number, ATPase activities, and sialic acid content of rat cardiac membrane vesicles. Journal of
Cardiovascular Pharmacology. [IF=0.686, Cited=40, 94627].
Williams RS, Dukes DF, Lefkowitz RJ (1981) Subtype specificity of alpha-adrenergic receptors in rat heart. Journal of
Cardiovascular Pharmacology. [IF=0.686, Cited=24, 6168833].
Hoffman BB, Lefkowitz RJ (1982) Agonist interactions with alpha-adrenergic receptors. Journal of Cardiovascular
Pharmacology. [IF=0.686, Cited=19, 6175829].
Casiraghi M, Wang H, Brennan P, ..., Kobilka BK (2024) Structure and dynamics determine G protein coupling specificity
at a class A GPCR. None. [IF=None, Cited=0, 38586060].
Lodowski DT, Barnhill JF, Pitcher JA, ..., Tesmer JJG (2003) Purification, crystallization and preliminary X-ray
diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2. None. [IF=None,
Cited=15, 12777817].
Fräki JE, Jakoi L, Davies AO, ..., Lazarus GS (1983) Polymorphonuclear leukocyte function in psoriasis: chemotaxis,
chemokinesis, beta-adrenergic receptors, and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood
from psoriatic patients. Journal of Investigative Dermatology. [IF=1.265, Cited=32, 6309987].
Benovic JL, Onorato J, Lohse MJ, ..., Lefkowitz RJ (1990) Synthetic peptides of the hamster beta 2-adrenoceptor as
substrates and inhibitors of the beta-adrenoceptor kinase. British Journal of Clinical Pharmacology. [IF=1.22,
Cited=33, 2176526].
An R, Heath BM, Higgins JP, ..., Kass RS (1999) Beta2-adrenergic receptor overexpression in the developing mouse heart:
evidence for targeted modulation of ion channels. Journal of Physiology. [IF=1.417, Cited=14, 10066919].
Dickinson KE, Leeb-Lundberg LM, Strasser RH, ..., Lefkowitz RJ (1986) Identification of the subunit structure of rat
pineal adrenergic receptors by photoaffinity labeling. Journal of Neurochemistry. [IF=1.089, Cited=9, 3005506].
Heinsimer JA, Lefkowitz RJ (1985) The impact of aging on adrenergic receptor function: clinical and biochemical aspects.
Journal of the American Geriatrics Society. [IF=2.072, Cited=35, 2857740].
Lefkowitz RJ, Roth J, Pastan I (1971) ACTH-receptor interaction in the adrenal: a model for the initial step in the
action of hormones that stimulate adenyl cyclase. Annals of the New York Academy of Sciences. [IF=1.878, Cited=36, 4330491].
Lefkowitz RJ (2009) Focus on the research journey. An interview with Robert J. Lefkowitz, MD, scientist, mentor, and
recipient of the 2007 National Medal of Science by Elaine Musgrave. Clinical and Translational Science. [IF=1.108,
Cited=0, 20443860].
Iaccarino G, Lefkowitz RJ, Koch WJ (1999) Myocardial G protein-coupled receptor kinases: implications for heart failure
therapy. None. [IF=None, Cited=18, 10519160].
Hunton DL, Barnes WG, Kim J, ..., Lefkowitz RJ (2005) Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated
pathway of chemotaxis. Molecular Pharmacology. [IF=0.939, Cited=88, 15635042].
Shukla AK, Sun JP, Lefkowitz RJ (2008) Crystallizing thinking about the beta2-adrenergic receptor. Molecular
Pharmacology. [IF=0.939, Cited=16, 18239031].
Rajagopal S, Ahn S, Rominger DH, ..., Lefkowitz RJ (2011) Quantifying ligand bias at seven-transmembrane receptors.
Molecular Pharmacology. [IF=0.939, Cited=225, 21610196].
Staus DP, Wingler LM, Strachan RT, ..., Lefkowitz RJ (2013) Regulation of β2-adrenergic receptor function by
conformationally selective single-domain intrabodies. Molecular Pharmacology. [IF=0.939, Cited=77, 24319111].
Kohout TA, Lefkowitz RJ (2003) Regulation of G protein-coupled receptor kinases and arrestins during receptor
desensitization. Molecular Pharmacology. [IF=0.939, Cited=269, 12488531].
Bohn LM, Dykstra LA, Lefkowitz RJ, ..., Barak LS (2004) Relative opioid efficacy is determined by the complements of the
G protein-coupled receptor desensitization machinery. Molecular Pharmacology. [IF=0.939, Cited=110, 15213301].
Butcher RW, Crofford OB, Gammeltoff S, ..., Marinetti GV (1973) Letter: Insulin activity: the solid matrix. Science.
[IF=7.729, Cited=11, 4356902].
Nambi P, Sibley DR, Lefkowitz RJ (1985) Sensitization of frog erythrocyte adenylate cyclase system by tumor-promoting
phorbol diesters. Canadian Journal of Physiology and Pharmacology. [IF=0.544, Cited=10, 3878225].
Lefkowitz RJ, Stadel JM, Caron MG (1983) Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms
of activation and desensitization. Annual Review of Biochemistry. [IF=5.273, Cited=226, 6137187].
Dohlman HG, Thorner J, Caron MG, Lefkowitz RJ (1991) Model systems for the study of seven-transmembrane-segment
receptors. Annual Review of Biochemistry. [IF=5.273, Cited=649, 1652922].
Benovic JL, Bouvier M, Caron MG, Lefkowitz RJ (1988) Regulation of adenylyl cyclase-coupled beta-adrenergic receptors.
None. [IF=None, Cited=170, 2848553].
Stiles GL, Lefkowitz RJ (1984) Cardiac adrenergic receptors. Annual Review of Medicine. [IF=3.155, Cited=26, 6144285].
O'Dowd BF, Lefkowitz RJ, Caron MG (1989) Structure of the adrenergic and related receptors. Annual Review of
Neuroscience. [IF=3.679, Cited=150, 2648960].
Hoffman BB, Lefkowitz RJ (1980) Radioligand binding studies of adrenergic receptors: new insights into molecular and
physiological regulation. Annual Review of Pharmacology and Toxicology. [IF=2.886, Cited=155, 6247962].
Ostrowski J, Kjelsberg MA, Caron MG, Lefkowitz RJ (1992) Mutagenesis of the beta 2-adrenergic receptor: how structure
elucidates function. Annual Review of Pharmacology and Toxicology. [IF=2.886, Cited=84, 1318669].
Hoffman BB, Lefkowitz RJ (1982) Adrenergic receptors in the heart. Annual Review of Physiology. [IF=4.535, Cited=23, 6280590].
Davies AO, Lefkowitz RJ (1984) Regulation of beta-adrenergic receptors by steroid hormones. Annual Review of Physiology.
[IF=4.535, Cited=131, 6324653].
Collins S, Bolanowski MA, Caron MG, Lefkowitz RJ (1989) Genetic regulation of beta-adrenergic receptors. Annual Review
of Physiology. [IF=4.535, Cited=26, 2540696].
Collins S, Caron MG, Lefkowitz RJ (1991) Regulation of adrenergic receptor responsiveness through modulation of receptor
gene expression. Annual Review of Physiology. [IF=4.535, Cited=80, 2042970].
Lefkowitz RJ (1982) Clinical physiology of adrenergic receptor regulation. None. [IF=None, Cited=20, 6124130].
Walker JKL, Gainetdinov RR, Feldman DS, ..., Fisher JT (2003) G protein-coupled receptor kinase 5 regulates airway
responses induced by muscarinic receptor activation. American Journal of Physiology - Lung Cellular and Molecular
Physiology. [IF=0.96, Cited=37, 14565944].
Stiles GL, Caron MG, Lefkowitz RJ (1984) Beta-adrenergic receptors: biochemical mechanisms of physiological regulation.
Physiological Reviews. [IF=11.448, Cited=371, 6143332].
Lefkowitz RJ (1974) Editorial: Selectivity in beta-adrenergic responses: clinical implications. Circulation. [IF=6.144,
Cited=8, 4151328].
Iaccarino G, Dolber PC, Lefkowitz RJ, Koch WJ (1999) Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced
myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. Hypertension. [IF=2.252, Cited=49, 9931136].
Caron MG, Leeb-Lundberg LM, Strader CD, ..., Lefkowitz RJ (1984) Molecular biology of adrenergic receptors in the rat
and frog central nervous system. Hypertension. [IF=2.252, Cited=0, 6094345].
Williams RS, Lefkowitz RJ (1978) Alpha-adrenergic receptors in rat myocardium. Identification by binding of
[3H]dihydroergocryptine. Circulation Research. [IF=3.534, Cited=56, 213201].
Williams LT, Snyderman R, Lefkowitz RJ (1976) Identification of beta-adrenergic receptors in human lymphocytes by (-)
(3H) alprenolol binding. Journal of Clinical Investigation. [IF=2.423, Cited=240, 1245597].
Williams LT, Gore TB, Lefkowitz RJ (1977) Ectopic beta-adrenergic receptor binding sites. possible molecular basis of
aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase. Journal of Clinical Investigation.
[IF=2.423, Cited=13, 13086].
Williams LT, Lefkowitz RJ (1977) Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and
progesterone. Journal of Clinical Investigation. [IF=2.423, Cited=75, 197125].
Newman KD, Williams LT, Bishopric NH, Lefkowitz RJ (1978) Identification of alpha-adrenergic receptors in human
platelets by [3H]dihydroergocryptine binding. Journal of Clinical Investigation. [IF=2.423, Cited=108, 23392].
Mukherjee A, Wong TM, Buja LM, ..., Willerson JT (1979) Beta adrenergic and muscarinic cholinergic receptors in canine
myocardium. Effects of ischemia. Journal of Clinical Investigation. [IF=2.423, Cited=83, 227935].
Burns TW, Langley PE, Terry BE, ..., Fain JN (1981) Pharmacological characterizations of adrenergic receptors in human
adipocytes. Journal of Clinical Investigation. [IF=2.423, Cited=62, 6257762].
Koo C, Lefkowitz RJ, Snyderman R (1983) Guanine nucleotides modulate the binding affinity of the oligopeptide
chemoattractant receptor on human polymorphonuclear leukocytes. Journal of Clinical Investigation. [IF=2.423,
Cited=105, 6309908].
Lefkowitz RJ, Michel T (1983) Plasma membrane receptors. Journal of Clinical Investigation. [IF=2.423, Cited=21, 6313753].
Heinsimer JA, Davies AO, Downs RW, ..., Lefkowitz RJ (1984) Impaired formation of beta-adrenergic receptor-nucleotide
regulatory protein complexes in pseudohypoparathyroidism. Journal of Clinical Investigation. [IF=2.423, Cited=10, 6325502].
Rockman HA, Hamilton RA, Jones LR, ..., Lefkowitz RJ (1996) Enhanced myocardial relaxation in vivo in transgenic mice
overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein. Journal of Clinical
Investigation. [IF=2.423, Cited=44, 8601626].
Drazner MH, Peppel KC, Dyer S, ..., Lefkowitz RJ (1997) Potentiation of beta-adrenergic signaling by adenoviral-mediated
gene transfer in adult rabbit ventricular myocytes. Journal of Clinical Investigation. [IF=2.423, Cited=71, 9005997].
Freeman K, Lerman I, Kranias EG, ..., Leinwand LA (2001) Alterations in cardiac adrenergic signaling and calcium cycling
differentially affect the progression of cardiomyopathy. Journal of Clinical Investigation. [IF=2.423, Cited=123, 11306600].
Walker JKL, Fong AM, Lawson BL, ..., Lefkowitz RJ (2003) Beta-arrestin-2 regulates the development of allergic asthma.
Journal of Clinical Investigation. [IF=2.423, Cited=130, 12925697].
Freedman NJ, Lefkowitz RJ (2004) Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just
correlation. Journal of Clinical Investigation. [IF=2.423, Cited=69, 15146232].
Rajagopal K, Lefkowitz RJ, Rockman HA (2005) When 7 transmembrane receptors are not G protein-coupled receptors. Journal
of Clinical Investigation. [IF=2.423, Cited=60, 16276410].
Noma T, Lemaire A, Naga Prasad SV, ..., Rockman HA (2007) Beta-arrestin-mediated beta1-adrenergic receptor
transactivation of the EGFR confers cardioprotection. Journal of Clinical Investigation. [IF=2.423, Cited=294, 17786238].
Walters RW, Shukla AK, Kovacs JJ, ..., Lefkowitz RJ (2009) beta-Arrestin1 mediates nicotinic acid-induced flushing, but
not its antilipolytic effect, in mice. Journal of Clinical Investigation. [IF=2.423, Cited=143, 19349687].
Maurice JP, Hata JA, Shah AS, ..., Koch WJ (1999) Enhancement of cardiac function after adenoviral-mediated in vivo
intracoronary beta2-adrenergic receptor gene delivery. Journal of Clinical Investigation. [IF=2.423, Cited=117, 10393695].
Lefkowitz RJ (2015) Inspiring the next generation of physician-scientists. Journal of Clinical Investigation. [IF=2.423,
Cited=5, 26237039].
Stiles GL, Stadel JM, De Lean A, Lefkowitz RJ (1981) Hypothyroidism modulates beta adrenergic receptor adenylate cyclase
interactions in rat reticulocytes. Journal of Clinical Investigation. [IF=2.423, Cited=25, 6274909].
Davies AO, Lefkowitz RJ (1983) In vitro desensitization of beta adrenergic receptors in human neutrophils. Attenuation
by corticosteroids. Journal of Clinical Investigation. [IF=2.423, Cited=48, 6298279].
van Biesen T, Luttrell LM, Hawes BE, Lefkowitz RJ (1996) Mitogenic signaling via G protein-coupled receptors. Endocrine
Reviews. [IF=7.592, Cited=190, 8969974].
Sibley DR, Benovic JL, Caron MG, Lefkowitz RJ (1988) Phosphorylation of cell surface receptors: a mechanism for
regulating signal transduction pathways. Endocrine Reviews. [IF=7.592, Cited=55, 2836188].
Davies AO, De Lean A, Lefkowitz RJ (1981) Myocardial beta-adrenergic receptors from adrenalectomized rats: impaired
formation of high-affinity agonist-receptor complexes. Endocrinology. [IF=1.146, Cited=29, 6256161].
Hoffman BB, Michel T, Brenneman TB, Lefkowitz RJ (1982) Interactions of agonists with platelet alpha 2-adrenergic
receptors. Endocrinology. [IF=1.146, Cited=59, 6120077].
Strasser RH, Stiles GL, Lefkowitz RJ (1984) Translocation and uncoupling of the beta-adrenergic receptor in rat lung
after catecholamine promoted desensitization in vivo. Endocrinology. [IF=1.146, Cited=30, 6090100].
Mukherjee C, Caron MG, Lefkowitz RJ (1976) Regulation of adenylate cyclase coupled beta-adrenergic receptors by beta-
adrenergic catecholamines. Endocrinology. [IF=1.146, Cited=59, 954636].
Williams RS, Guthrow CE, Lefkowitz RJ (1979) Beta-Adrenergic receptors of human lymphocytes are unaltered by
hyperthyroidism. Journal of Clinical Endocrinology and Metabolism. [IF=1.766, Cited=28, 218998].
Schocken DD, Caron MG, Lefkowitz RJ (1980) The human placenta--a rich source of beta-adrenergic receptors:
characterization of the receptors in particulate and solubilized preparations. Journal of Clinical Endocrinology and
Metabolism. [IF=1.766, Cited=23, 6103009].
Davies AO, Lefkowitz RJ (1980) Corticosteroid-induced differential regulation of beta-adrenergic receptors in
circulating human polymorphonuclear leukocytes and mononuclear leukocytes. Journal of Clinical Endocrinology and
Metabolism. [IF=1.766, Cited=126, 6251106].
Tharp MD, Hoffman BB, Lefkowitz RJ (1981) alpha-Adrenergic receptors in human adipocyte membranes: direct determination
by [3H]yohimbine binding. Journal of Clinical Endocrinology and Metabolism. [IF=1.766, Cited=29, 6110673].
Davies AO, Lefkowitz RJ (1981) Agonist-promoted high affinity state of the beta-adrenergic receptor in human
neutrophils: modulation by corticosteroids. Journal of Clinical Endocrinology and Metabolism. [IF=1.766, Cited=58, 6116722].
Simard E, Kovacs JJ, Miller WE, ..., Lefkowitz RJ (2013) β-Arrestin regulation of myosin light chain phosphorylation
promotes AT1aR-mediated cell contraction and migration. PLoS ONE. [IF=1.253, Cited=14, 24255721].
Arriza JL, Dawson TM, Simerly RB, ..., Lefkowitz RJ (1992) The G-protein-coupled receptor kinases beta ARK1 and beta
ARK2 are widely distributed at synapses in rat brain. Journal of Neuroscience. [IF=1.471, Cited=114, 1403099].
Bohn LM, Lefkowitz RJ, Caron MG (2002) Differential mechanisms of morphine antinociceptive tolerance revealed in
(beta)arrestin-2 knock-out mice. Journal of Neuroscience. [IF=1.471, Cited=172, 12451149].
Bohn LM, Gainetdinov RR, Sotnikova TD, ..., Caron MG (2003) Enhanced rewarding properties of morphine, but not cocaine,
in beta(arrestin)-2 knock-out mice. Journal of Neuroscience. [IF=1.471, Cited=139, 14614085].
Xu M, Petraschka M, McLaughlin JP, ..., Chavkin C (2004) Neuropathic pain activates the endogenous kappa opioid system
in mouse spinal cord and induces opioid receptor tolerance. Journal of Neuroscience. [IF=1.471, Cited=99, 15140929].
Benovic JL, Staniszewski C, Cerione RA, ..., Caron MG (1987) The mammalian beta-adrenergic receptor: structural and
functional characterization of the carbohydrate moiety. None. [IF=None, Cited=10, 2887651].
Caron MG, Kobilka BK, Kobilka BK, ..., Lefkowitz RJ (1988) Cloning of the cDNA and genes for the hamster and human beta
2-adrenergic receptors. None. [IF=None, Cited=4, 2838630].
Hara MR, Sachs BD, Caron MG, Lefkowitz RJ (2012) Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade
prevents the accumulation of DNA damage in a behavioral stress model. Cell Cycle. [IF=0.792, Cited=49, 23287463].
Lefkowitz RJ (1979) Direct binding studies of adrenergic receptors: biochemical, physiologic, and clinical implications.
Annals of Internal Medicine. [IF=5.157, Cited=66, 38720].
Lefkowitz RJ (1975) Guanosine triphosphate binding sites in solubilized myocardium. Relation to adenylate cyclase
activity. Journal of Biological Chemistry. [IF=1.122, Cited=0, 1120774].
Cotecchia S, Ostrowski J, Kjelsberg MA, ..., Lefkowitz RJ (1992) Discrete amino acid sequences of the alpha 1-adrenergic
receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. Journal of Biological Chemistry.
[IF=1.122, Cited=60, 1309789].
Liggett SB, Ostrowski J, Chesnut LC, ..., Lefkowitz RJ (1992) Sites in the third intracellular loop of the alpha
2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated
mechanism. Journal of Biological Chemistry. [IF=1.122, Cited=57, 1311318].
Kjelsberg MA, Cotecchia S, Ostrowski J, ..., Lefkowitz RJ (1992) Constitutive activation of the alpha 1B-adrenergic
receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.
Journal of Biological Chemistry. [IF=1.122, Cited=259, 1346134].
Lohse MJ, Andexinger S, Pitcher J, ..., Lefkowitz RJ (1992) Receptor-specific desensitization with purified proteins.
Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin
systems. Journal of Biological Chemistry. [IF=1.122, Cited=171, 1349018].
Bylund DB, Blaxall HS, Iversen LJ, ..., Lomasney JW (1992) Pharmacological characteristics of alpha 2-adrenergic
receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Molecular
Pharmacology. [IF=0.939, Cited=126, 1353247].
Attramadal H, Arriza JL, Aoki C, ..., Lefkowitz RJ (1992) Beta-arrestin2, a novel member of the arrestin/beta-arrestin
gene family. Journal of Biological Chemistry. [IF=1.122, Cited=296, 1517224].
Williams LT, Lefkowitz RJ, Watanabe AM, ..., Besch HR (1977) Thyroid hormone regulation of beta-adrenergic receptor
number. Journal of Biological Chemistry. [IF=1.122, Cited=288, 15999].
Mukherjee C, Lefkowitz RJ (1977) Regulation of beta adrenergic receptors in isolated frog erythrocyte plasma membranes.
Molecular Pharmacology. [IF=0.939, Cited=19, 16207].
Schwinn DA, Page SO, Middleton JP, ..., Cotecchia S (1991) The alpha 1C-adrenergic receptor: characterization of signal
transduction pathways and mammalian tissue heterogeneity. Molecular Pharmacology. [IF=0.939, Cited=88, 1658600].
Liggett SB, Ostrowski J, Chesnut LC, ..., Lefkowitz RJ (1991) Role of the beta-adrenergic receptor kinase in
desensitization of the alpha 2-adrenergic receptor. None. [IF=None, Cited=1, 1668989].
Lefkowitz RJ, Caron MG (1975) Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase. Journal of
Biological Chemistry. [IF=1.122, Cited=24, 166994].
Mickey J, Tate R, Lefkowitz RJ (1975) Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding
after chronic exposure to (minus)-isoproterenol in vitro. Journal of Biological Chemistry. [IF=1.122, Cited=103, 167023].
Lomasney JW, Cotecchia S, Lorenz W, ..., Caron MG (1991) Molecular cloning and expression of the cDNA for the alpha
1A-adrenergic receptor. The gene for which is located on human chromosome 5. Journal of Biological Chemistry. [IF=1.122,
Cited=250, 1706716].
Inglese J, Glickman JF, Lorenz W, ..., Lefkowitz RJ (1992) Isoprenylation of a protein kinase. Requirement of
farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. Journal of Biological
Chemistry. [IF=1.122, Cited=81, 1730692].
Raymond JR, Albers FJ, Middleton JP, ..., Dennis VW (1991) 5-HT1A and histamine H1 receptors in HeLa cells stimulate
phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. Journal of Biological Chemistry.
[IF=1.122, Cited=41, 1845968].
Campbell PT, Hnatowich M, O'Dowd BF, ..., Hausdorff WP (1991) Mutations of the human beta 2-adrenergic receptor that
impair coupling to Gs interfere with receptor down-regulation but not sequestration. Molecular Pharmacology. [IF=0.939,
Cited=58, 1847493].
Liggett SB, Caron MG, Lefkowitz RJ, Hnatowich M (1991) Coupling of a mutated form of the human beta 2-adrenergic
receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process. Journal of Biological
Chemistry. [IF=1.122, Cited=61, 1848226].
Benovic JL, Onorato JJ, Arriza JL, ..., Lefkowitz RJ (1991) Cloning, expression, and chromosomal localization of beta-
adrenergic receptor kinase 2. A new member of the receptor kinase family. Journal of Biological Chemistry. [IF=1.122,
Cited=96, 1869533].
Williams LT, Lefkowitz RJ (1977) Molecular pharmacology of alpha adrenergic receptors: utilization of
[3H]dihydroergocryptine binding in the study of pharmacological receptor alterations. Molecular Pharmacology. [IF=0.939,
Cited=18, 192992].
Lefkowitz RJ, Mullikin D, Wood CL, ..., Mukherjee C (1977) Regulation of prostaglandin receptors by prostaglandins and
guanine nucleotides in frog erythrocytes. Journal of Biological Chemistry. [IF=1.122, Cited=75, 195945].
Strittmatter WJ, Davis JN, Lefkowitz RJ (1977) alpha-Adrenergic receptors in rat parotid cells. I. Correlation of
[3H]dihydroergocryptine binding and catecholamine-stimulated potassium efflux. Journal of Biological Chemistry.
[IF=1.122, Cited=35, 195950].
Strittmatter WJ, Davis JN, Lefkowitz RJ (1977) alpha-Adrenergic receptors in rat parotid cells. II. Desensitization of
receptor binding sites and potassium release. Journal of Biological Chemistry. [IF=1.122, Cited=42, 195951].
Schwinn DA, Cotecchia S, Lorenz W, ..., Lefkowitz RJ (1990) The alpha 1C-adrenergic receptor: a new member in the alpha
1-adrenergic receptor family. None. [IF=None, Cited=4, 1966743].
Schwinn DA, Lomasney JW, Lorenz W, ..., Cotecchia S (1990) Molecular cloning and expression of the cDNA for a novel
alpha 1-adrenergic receptor subtype. Journal of Biological Chemistry. [IF=1.122, Cited=233, 1970822].
Benovic JL, Onorato JJ, Caron MG, Lefkowitz RJ (1990) Regulation of G protein-coupled receptors by agonist-dependent
phosphorylation. None. [IF=None, Cited=5, 1974087].
Hausdorff WP, Lohse MJ, Bouvier M, ..., Lefkowitz RJ (1990) Two kinases mediate agonist-dependent phosphorylation and
desensitization of the beta 2-adrenergic receptor. None. [IF=None, Cited=24, 1983369].
Williams LT, Lefkowitz RJ (1977) Slowly reversible binding of catecholamine to a nucleotide-sensitive state of the beta-
adrenergic receptor. Journal of Biological Chemistry. [IF=1.122, Cited=96, 198405].
Lefkowitz RJ (1978) Identification and regulation of alpha- and beta-adrenergic receptors. None. [IF=None, Cited=24, 203489].
Pike LJ, Lefkowitz RJ (1978) Multiple effects of N, N' dicyclohexyl carbodiimide on the beta-adrenergic receptor--
adenylate cyclase system in frog erythrocytes. None. [IF=None, Cited=4, 205559].
Lefkowitz RJ, Williams LT (1978) Molecular mechanisms of activation and desensitization of adenylate cyclase coupled
beta-adrenergic receptors. None. [IF=None, Cited=21, 208372].
Clarke WR, Jones LR, Lefkowitz RJ (1978) Hepatic alpha-adrenergic receptors. Identification and subcellular localization
using [3H]dihydroergocryptine. Journal of Biological Chemistry. [IF=1.122, Cited=34, 210164].
Tsai BS, Lefkowitz RJ (1978) Agonist-specific effects of monovalent and divalent cations on adenylate cyclase-coupled
alpha adrenergic receptors in rabbit platelets. Molecular Pharmacology. [IF=0.939, Cited=86, 210368].
Cotecchia S, Kobilka BK, Kobilka BK, ..., Regan JW (1990) Multiple second messenger pathways of alpha-adrenergic
receptor subtypes expressed in eukaryotic cells. Journal of Biological Chemistry. [IF=1.122, Cited=137, 2152928].
Hausdorff WP, Hnatowich M, O'Dowd BF, ..., Lefkowitz RJ (1990) A mutation of the beta 2-adrenergic receptor impairs
agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants
of the receptor are involved in physical coupling to and functional activation of Gs. Journal of Biological Chemistry.
[IF=1.122, Cited=60, 2153131].
Lohse MJ, Benovic JL, Caron MG, Lefkowitz RJ (1990) Multiple pathways of rapid beta 2-adrenergic receptor
desensitization. Delineation with specific inhibitors. Journal of Biological Chemistry. [IF=1.122, Cited=179, 2154473].
Hausdorff WP, Caron MG, Lefkowitz RJ (1990) Turning off the signal: desensitization of beta-adrenergic receptor
function. FASEB Journal. [IF=1.029, Cited=628, 2165947].
Collins S, Altschmied J, Herbsman O, ..., Lefkowitz RJ (1990) A cAMP response element in the beta 2-adrenergic receptor
gene confers transcriptional autoregulation by cAMP. Journal of Biological Chemistry. [IF=1.122, Cited=66, 2172252].
Lorenz W, Lomasney JW, Collins S, ..., Lefkowitz RJ (1990) Expression of three alpha 2-adrenergic receptor subtypes in
rat tissues: implications for alpha 2 receptor classification. Molecular Pharmacology. [IF=0.939, Cited=77, 2172770].
Caron MG, Srinivasan Y, Pitha J, ..., Lefkowitz RJ (1979) Affinity chromatography of the beta-adrenergic receptor.
Journal of Biological Chemistry. [IF=1.122, Cited=54, 218957].
Hoffman BB, Mullikin-Kilpatrick D, Lefkowitz RJ (1979) Desensitization of beta-adrenergic stimulated adenylate cyclase
in turkey erythrocytes. None. [IF=None, Cited=24, 230209].
Stadel JM, Lefkowitz RJ (1979) Multiple reactive sulfhydryl groups modulate the function of adenylate cyclase coupled
beta-adrenergic receptors. Molecular Pharmacology. [IF=0.939, Cited=41, 231192].
Mukherjee C, Caron MG, Coverstone M, Lefkowitz RJ (1975) Identification of adenylate cyclase-coupled beta-adrenergic
receptors in frog erythrocytes with (minus)-[3-H] alprenolol. Journal of Biological Chemistry. [IF=1.122, Cited=108, 238972].
Benovic JL, Stone WC, Caron MG, Lefkowitz RJ (1989) Inhibition of the beta-adrenergic receptor kinase by polyanions.
Journal of Biological Chemistry. [IF=1.122, Cited=38, 2468660].
Tsai BS, Lefkowitz RJ (1978) [3H]Dihydroergocryptine binding to alpha adrenergic receptors in canine aortic membranes.
Journal of Pharmacology and Experimental Therapeutics. [IF=0.906, Cited=11, 24730].
Bouvier M, Collins S, O'Dowd BF, ..., Lefkowitz RJ (1989) Two distinct pathways for cAMP-mediated down-regulation of the
beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. Journal of Biological
Chemistry. [IF=1.122, Cited=133, 2476447].
Raymond JR, Fargin A, Lohse MJ, ..., Caron MG (1989) Identification of the ligand-binding subunit of the human
5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated
photoaffinity probe. Molecular Pharmacology. [IF=0.939, Cited=9, 2526292].
Williams LT, Mullikin D, Lefkowitz RJ (1978) Magnesium dependence of agonist binding to adenylate cyclase-coupled
hormone receptors. Journal of Biological Chemistry. [IF=1.122, Cited=90, 25276].
Pike LJ, Lefkowitz RJ (1978) Agonist-specific alterations in receptor binding affinity associated with solubilization of
turkey erythrocyte membrane beta adrenergic receptors. Molecular Pharmacology. [IF=0.939, Cited=25, 25377].
Lefkowitz RJ, Mullikin D, Williams LT (1978) A desensitized state of the beta adrenergic receptor not associated with
high-affinity agonist occupancy. Molecular Pharmacology. [IF=0.939, Cited=13, 25378].
O'Dowd BF, Hnatowich M, Caron MG, ..., Bouvier M (1989) Palmitoylation of the human beta 2-adrenergic receptor. Mutation
of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. Journal of Biological
Chemistry. [IF=1.122, Cited=310, 2540197].
Frielle T, Caron MG, Lefkowitz RJ (1989) Properties of the beta 1- and beta 2-adrenergic receptor subtypes revealed by
molecular cloning. Clinical Chemistry. [IF=1.432, Cited=8, 2541947].
Hausdorff WP, Bouvier M, O'Dowd BF, ..., Lefkowitz RJ (1989) Phosphorylation sites on two domains of the beta
2-adrenergic receptor are involved in distinct pathways of receptor desensitization. Journal of Biological Chemistry.
[IF=1.122, Cited=179, 2545714].
Fargin A, Raymond JR, Regan JW, ..., Caron MG (1989) Effector coupling mechanisms of the cloned 5-HT1A receptor. Journal
of Biological Chemistry. [IF=1.122, Cited=129, 2549039].
Liggett SB, Bouvier M, Hausdorff WP, ..., Lefkowitz RJ (1989) Altered patterns of agonist-stimulated cAMP accumulation
in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites. Molecular Pharmacology. [IF=0.939,
Cited=43, 2554115].
Raymond JR, Fargin A, Middleton JP, ..., Dennis VW (1989) The human 5-HT1A receptor expressed in HeLa cells stimulates
sodium-dependent phosphate uptake via protein kinase C. Journal of Biological Chemistry. [IF=1.122, Cited=25, 2557347].
Wessels MR, Mullikin D, Lefkowitz RJ (1978) Differences between agonist and antagonist binding following beta-adrenergic
receptor desensitization. Journal of Biological Chemistry. [IF=1.122, Cited=34, 25886].
Frielle T, Caron MG, Lefkowitz RJ (1989) The mammalian beta-adrenergic receptors. None. [IF=None, Cited=0, 2698631].
Dohlman HG, Bouvier M, Benovic JL, ..., Lefkowitz RJ (1987) The multiple membrane spanning topography of the beta
2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited
proteolysis. Journal of Biological Chemistry. [IF=1.122, Cited=75, 2821000].
Kobilka BK, Kobilka BK, MacGregor C, ..., Lefkowitz RJ (1987) Functional activity and regulation of human beta
2-adrenergic receptors expressed in Xenopus oocytes. Journal of Biological Chemistry. [IF=1.122, Cited=61, 2824467].
Benovic JL, Regan JW, Matsui H, ..., Lefkowitz RJ (1987) Agonist-dependent phosphorylation of the alpha 2-adrenergic
receptor by the beta-adrenergic receptor kinase. Journal of Biological Chemistry. [IF=1.122, Cited=64, 2826414].
Bouvier M, Hnatowich M, Collins S, ..., Caron MG (1988) Expression of a human cDNA encoding the beta 2-adrenergic
receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors. Molecular
Pharmacology. [IF=0.939, Cited=41, 2828911].
Benovic JL, Staniszewski C, Mayor F, ..., Lefkowitz RJ (1988) beta-Adrenergic receptor kinase. Activity of partial
agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation. Journal of
Biological Chemistry. [IF=1.122, Cited=62, 2831211].
Dohlman HG, Caron MG, Lefkowitz RJ (1987) Structure and function of the beta 2-adrenergic receptor--homology with
rhodopsin. None. [IF=None, Cited=2, 2831423].
Yang SD, Fong YL, Benovic JL, ..., Lefkowitz RJ (1988) Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin
by latent phosphatase 2. Journal of Biological Chemistry. [IF=1.122, Cited=15, 2837466].
Collins S, Caron MG, Lefkowitz RJ (1988) Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally
regulated by glucocorticoids. Journal of Biological Chemistry. [IF=1.122, Cited=126, 2837475].
O'Dowd BF, Hnatowich M, Regan JW, ..., Lefkowitz RJ (1988) Site-directed mutagenesis of the cytoplasmic domains of the
human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling. Journal of Biological
Chemistry. [IF=1.122, Cited=164, 2846532].
Sibley DR, Strasser RH, Caron MG, Lefkowitz RJ (1985) Homologous desensitization of adenylate cyclase is associated with
phosphorylation of the beta-adrenergic receptor. Journal of Biological Chemistry. [IF=1.122, Cited=58, 2858484].
Mayor F, Benovic JL, Caron MG, Lefkowitz RJ (1987) Somatostatin induces translocation of the beta-adrenergic receptor
kinase and desensitizes somatostatin receptors in S49 lymphoma cells. Journal of Biological Chemistry. [IF=1.122,
Cited=42, 2883186].
Cerione RA, Staniszewski C, Benovic JL, ..., Birnbaumer L (1985) Specificity of the functional interactions of the beta-
adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.
Journal of Biological Chemistry. [IF=1.122, Cited=92, 2981858].
Nambi P, Peters JR, Sibley DR, Lefkowitz RJ (1985) Desensitization of the turkey erythrocyte beta-adrenergic receptor in
a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor. Journal of
Biological Chemistry. [IF=1.122, Cited=41, 2982811].
Strasser RH, Lefkowitz RJ (1985) Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase.
Resensitization by polyethylene glycol treatment. Journal of Biological Chemistry. [IF=1.122, Cited=18, 2985555].
Dickinson KE, Heald SL, Jeffs PW, ..., Caron MG (1985) Covalent labeling of the beta-adrenergic ligand-binding site with
para-(bromoacetamidyl)benzylcarazolol. A highly potent beta-adrenergic affinity label. Molecular Pharmacology.
[IF=0.939, Cited=15, 2985948].
Benovic JL, Pike LJ, Cerione RA, ..., Lefkowitz RJ (1985) Phosphorylation of the mammalian beta-adrenergic receptor by
cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist
occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein. Journal of
Biological Chemistry. [IF=1.122, Cited=139, 2987243].
Caron MG, Cerione RA, Benovic JL, ..., Birnbaumer L (1985) Biochemical characterization of the adrenergic receptors:
affinity labeling, purification, and reconstitution studies. None. [IF=None, Cited=4, 2988293].
Strasser RH, Cerione RA, Codina J, ..., Lefkowitz RJ (1985) Homologous desensitization of the beta-adrenergic receptor.
Functional integrity of the desensitized receptor from mammalian lung. Molecular Pharmacology. [IF=0.939, Cited=14, 2993846].
Lefkowitz RJ, Caron MG (1985) Adrenergic receptors: molecular mechanisms of clinically relevant regulation. None.
[IF=None, Cited=18, 2994939].
Regan JW, Nakata H, DeMarinis RM, ..., Lefkowitz RJ (1986) Purification and characterization of the human platelet alpha
2-adrenergic receptor. Journal of Biological Chemistry. [IF=1.122, Cited=39, 3005306].
Cerione RA, Regan JW, Nakata H, ..., Lefkowitz RJ (1986) Functional reconstitution of the alpha 2-adrenergic receptor
with guanine nucleotide regulatory proteins in phospholipid vesicles. Journal of Biological Chemistry. [IF=1.122,
Cited=87, 3005307].
Lomasney JW, Leeb-Lundberg LM, Cotecchia S, ..., Lefkowitz RJ (1986) Mammalian alpha 1-adrenergic receptor. Purification
and characterization of the native receptor ligand binding subunit. Journal of Biological Chemistry. [IF=1.122,
Cited=38, 3011796].
Cerione RA, Staniszewski C, Gierschik P, ..., Lefkowitz RJ (1986) Mechanism of guanine nucleotide regulatory protein-
mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.
Journal of Biological Chemistry. [IF=1.122, Cited=27, 3013893].
Leeb-Lundberg LM, Cotecchia S, DeBlasi A, ..., Lefkowitz RJ (1987) Regulation of adrenergic receptor function by
phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to
inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells. Journal of Biological Chemistry. [IF=1.122,
Cited=102, 3029100].
Bouvier M, Leeb-Lundberg LM, Benovic JL, ..., Lefkowitz RJ (1987) Regulation of adrenergic receptor function by
phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by
protein kinase C and the cyclic AMP-dependent protein kinase. Journal of Biological Chemistry. [IF=1.122, Cited=115, 3029101].
Sibley DR, Lefkowitz RJ (1986) Adenylate cyclase coupled beta-adrenergic receptors: biochemical mechanisms of
desensitization. Clinical Neuropharmacology. [IF=0.503, Cited=0, 3032428].
Kobilka BK, Kobilka BK, Frielle T, ..., Lefkowitz RJ (1987) Delineation of the intronless nature of the genes for the
human and hamster beta 2-adrenergic receptor and their putative promoter regions. Journal of Biological Chemistry.
[IF=1.122, Cited=121, 3034889].
Benovic JL, Mayor F, Staniszewski C, ..., Caron MG (1987) Purification and characterization of the beta-adrenergic
receptor kinase. Journal of Biological Chemistry. [IF=1.122, Cited=98, 3036840].
Mukherjee C, Caron MG, Mullikin D, Lefkowitz RJ (1976) Structure-activity relationships of adenylate cyclase-coupled
beta adrenergic receptors: determination by direct binding studies. Molecular Pharmacology. [IF=0.939, Cited=36, 3725].
Hancock AA, DeLean AL, Lefkowitz RJ (1979) Quantitative resolution of beta-adrenergic receptor subtypes by selective
ligand binding: application of a computerized model fitting technique. Molecular Pharmacology. [IF=0.939, Cited=122, 39239].
Wessels MR, Mullikin D, Lefkowitz RJ (1979) Selective alteration in high affinity agonist binding: a mechanism of beta-
adrenergic receptor desensitization. Molecular Pharmacology. [IF=0.939, Cited=35, 39240].
Tsai BS, Lefkowitz RJ (1979) Agonist-specific effects of guanine nucleotides on alpha-adrenergic receptors in human
platelets. Molecular Pharmacology. [IF=0.939, Cited=80, 39249].
Lefkowitz RJ, Sharp GW, Haber E (1973) Specific binding of -adrenergic catecholamines to a subcellular fraction from
cardiac muscle. Journal of Biological Chemistry. [IF=1.122, Cited=49, 4144255].
Lefkowitz RJ (1973) Isolated beta-adrenergic binding sites: a potential assay vehicle for catecholamines.
Pharmacological Reviews. [IF=4.608, Cited=1, 4150174].
Caron MG, Beaulieu M, Raymond V, ..., Labrie F (1978) Dopaminergic receptors in the anterior pituitary gland.
Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release. Journal of Biological
Chemistry. [IF=1.122, Cited=205, 416027].
Limbird LE, Hickey AR, Lefkowitz RJ (1979) Unique uncoupling of the frog erythrocyte adenylate cyclase system by
manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high
affinity agonist binding. Journal of Biological Chemistry. [IF=1.122, Cited=59, 429310].
Lefkowitz RJ, Haber E (1973) Physiological receptors as physicochemical entities. Circulation Research. [IF=3.534,
Cited=0, 4351359].
Lefkowitz RJ (1974) Stimulation of catecholamine-sensitive adenylate cyclase by 5'-guanylyl-imidodiphosphate. Journal of
Biological Chemistry. [IF=1.122, Cited=62, 4425095].
Caron MG, Lefkowitz RJ (1976) Solubilization and characterization of the beta-adrenergic receptor binding sites of frog
erythrocytes. Journal of Biological Chemistry. [IF=1.122, Cited=92, 4447].
Zatz M, Kebabian JW, Romero JA, ..., Axelrod J (1976) Pineal beta adrenergic receptor: correlation of binding of 3H-l-
alprenolol with stimulation of adenylate cyclase. Journal of Pharmacology and Experimental Therapeutics. [IF=0.906,
Cited=32, 4608].
Vatner DE, Lefkowitz RJ (1974) (3H)-Propranolol binding sites in myocardial membranes: nonidentity with beta adrenergic
receptors. Molecular Pharmacology. [IF=0.939, Cited=14, 4847937].
Limbird LE, Hickey AR, Lefkowitz RJ (1979) The molecular size of adenylate cyclase in the absence and presence of
nucleotide and hormone effectors. None. [IF=None, Cited=4, 573291].
Sibley DR, Peters JR, Nambi P, ..., Lefkowitz RJ (1984) Desensitization of turkey erythrocyte adenylate cyclase. Beta-
adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity. Journal of Biological
Chemistry. [IF=1.122, Cited=65, 6086645].
Cerione RA, Sibley DR, Codina J, ..., Lefkowitz RJ (1984) Reconstitution of a hormone-sensitive adenylate cyclase
system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the
resolved catalytic unit. Journal of Biological Chemistry. [IF=1.122, Cited=46, 6088509].
Dickinson KE, Leeb-Lundberg LM, Heald SL, ..., Lefkowitz RJ (1984) Photoaffinity cross-linking of a radioiodinated
probe, 125I-A55453, into alpha 1-adrenergic receptors. Molecular Pharmacology. [IF=0.939, Cited=5, 6090880].
Stadel JM, Nambi P, Shorr RG, ..., Lefkowitz RJ (1983) Phosphorylation of the beta-adrenergic receptor accompanies
catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. None. [IF=None, Cited=2, 6093309].
Caron MG, Srinivasan Y, Lefkowitz RJ (1980) Affinity chromatography of the beta-adrenergic receptor and characterization
of antibodies raised against purified receptor preparations. None. [IF=None, Cited=0, 6103643].
Kent RS, De Lean A, Lefkowitz RJ (1980) A quantitative analysis of beta-adrenergic receptor interactions: resolution of
high and low affinity states of the receptor by computer modeling of ligand binding data. Molecular Pharmacology.
[IF=0.939, Cited=266, 6104284].
Pike LJ, Lefkowitz RJ (1980) Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate
cyclase of frog and turkey erythrocyte membranes. Journal of Biological Chemistry. [IF=1.122, Cited=19, 6104667].
Lavin TN, Hoffman BB, Lefkowitz RJ (1981) Determination of subtype selectivity of alpha-adrenergic antagonists:
comparison of selective and nonselective radioligands. Molecular Pharmacology. [IF=0.939, Cited=21, 6117003].
Lefkowitz RJ, Caron MG, Michel T, Stadel JM (1982) Mechanisms of hormone receptor-effector coupling: the beta-adrenergic
receptor and adenylate cyclase. None. [IF=None, Cited=22, 6125416].
Stadel JM, Nambi P, Lavin TN, ..., Lefkowitz RJ (1982) Catecholamine-induced desensitization of turkey erythrocyte
adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling. Journal of
Biological Chemistry. [IF=1.122, Cited=30, 6125504].
Stadel JM, Lefkowitz RJ (1981) Differential effects of cholera toxin on guanine nucleotide regulation of beta-adrenergic
agonist high affinity binding and adenylate cyclase activation in frog erythrocyte membranes. None. [IF=None, Cited=9, 6125532].
Heinsimer JA, Lefkowitz RJ (1982) Adrenergic receptors: biochemistry, regulation, molecular mechanism, and clinical
implications. None. [IF=None, Cited=20, 6127370].
Lefkowitz RJ (1983) The Gordon Wilson lecture. Adrenergic receptors: regulation at the biochemical, physiological and
clinical levels. None. [IF=None, Cited=0, 6137097].
Lefkowitz RJ, Stadel JM, Cerione RA, ..., Caron MG (1984) Structure and function of beta-adrenergic receptors:
regulation at the molecular level. None. [IF=None, Cited=1, 6145320].
Stadel JM, DeLean A, Lefkowitz RJ (1980) A high affinity agonist . beta-adrenergic receptor complex is an intermediate
for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes. Journal of Biological
Chemistry. [IF=1.122, Cited=78, 6243637].
Limbird LE, Gill DM, Stadel JM, ..., Lefkowitz RJ (1980) Loss of beta-adrenergic receptor-guanine nucleotide regulatory
protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat
erythrocytes. Journal of Biological Chemistry. [IF=1.122, Cited=53, 6243651].
Hoffman BB, Mullikin-Kilpatrick D, Lefkowitz RJ (1980) Heterogeneity of radioligand binding to alpha-adrenergic
receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes. Journal of
Biological Chemistry. [IF=1.122, Cited=121, 6246079].
De Lean A, Stadel JM, Lefkowitz RJ (1980) A ternary complex model explains the agonist-specific binding properties of
the adenylate cyclase-coupled beta-adrenergic receptor. Journal of Biological Chemistry. [IF=1.122, Cited=825, 6248546].
Stadel JM, Lefkowitz RJ (1980) Molecular mechanisms of beta-adrenergic receptor desensitization. None. [IF=None,
Cited=2, 6250160].
Hoffman BB, Lefkowitz RJ (1980) Peripheral alpha-adrenergic receptor subtypes. Psychopharmacology Bulletin. [IF=0.27,
Cited=0, 6250184].
Lefkowitz RJ, Hoffman BB (1980) Adrenergic receptors. None. [IF=None, Cited=11, 6250368].
Pike LJ, Lefkowitz RJ (1981) Correlation of beta-adrenergic receptor-stimulated [3H]GDP release and adenylate cyclase
activation. Differences between frog and turkey erythrocyte membranes. Journal of Biological Chemistry. [IF=1.122,
Cited=25, 6257708].
Bürgisser E, Hancock AA, Lefkowitz RJ, De Lean A (1981) Anomalous equilibrium binding properties of high-affinity
racemic radioligands. Molecular Pharmacology. [IF=0.939, Cited=30, 6262614].
Shorr RG, Lefkowitz RJ, Caron MG (1981) Purification of the beta-adrenergic receptor. Identification of the hormone
binding subunit. Journal of Biological Chemistry. [IF=1.122, Cited=63, 6263890].
Stadel JM, De Lean A, Mullikin-Kilpatrick D, ..., Lefkowitz RJ (1981) Catecholamine-induced desensitization in turkey
erythrocytes: cAMP mediated impairment of high affinity agonist binding without alteration in receptor number. None.
[IF=None, Cited=26, 6265513].
Stadel JM, Shorr RG, Limbird LE, Lefkowitz RJ (1981) Evidence that a beta-adrenergic receptor-associated guanine
nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity. Journal
of Biological Chemistry. [IF=1.122, Cited=28, 6267049].
Bürgisser E, Lefkowitz RJ, DeLean A (1981) Alternative explanation for the apparent "two-step" binding kinetics of high-
affinity racemic antagonist radioligands. Molecular Pharmacology. [IF=0.939, Cited=15, 6267448].
Caron MG, Shorr RG, Lefkowitz RJ, ..., Pitha J (1981) Isolation and characterization of the beta-adrenergic receptor of
frog erythrocytes and development of potential affinity ligands. None. [IF=None, Cited=0, 6269375].
Lefkowitz RJ, De Lean A, Hoffman BB, ..., Limbird L (1981) Molecular pharmacology of adenylate cyclase-coupled alpha-
and beta-adrenergic receptors. None. [IF=None, Cited=13, 6269377].
Hoffman BB, Lavin TN, Lefkowitz RJ, Ruffolo RR (1981) Alpha adrenergic receptor subtypes in rabbit uterus: mediation of
myometrial contraction and regulation by estrogens. Journal of Pharmacology and Experimental Therapeutics. [IF=0.906,
Cited=49, 6270302].
Lavin TN, Heald SL, Jeffs PW, ..., Caron MG (1981) Photoaffinity labeling of the beta-adrenergic receptor. Journal of
Biological Chemistry. [IF=1.122, Cited=23, 6271767].
Stiles GL, Lefkowitz RJ (1982) Hormone-sensitive adenylate cyclase. Delineation of a trypsin-sensitive site in the
pathway of receptor-mediated inhibition. Journal of Biological Chemistry. [IF=1.122, Cited=25, 6281265].
Lefkowitz RJ (1982) Biochemical mechanisms of hormone receptor-effector coupling. Introduction. None. [IF=None,
Cited=1, 6286368].
Lavin TN, Nambi P, Heald SL, ..., Caron MG (1982) 125I-labeled p-azidobenzylcarazolol, a photoaffinity label for the
beta-adrenergic receptor. Characterization of the ligand and photoaffinity labeling of beta 1- and beta 2-adrenergic
receptors. Journal of Biological Chemistry. [IF=1.122, Cited=38, 6288716].
Shorr RG, Strohsacker MW, Lavin TN, ..., Caron MG (1982) The beta 1-adrenergic receptor of the turkey erythrocyte.
Molecular heterogeneity revealed by purification and photoaffinity labeling. Journal of Biological Chemistry. [IF=1.122,
Cited=46, 6288717].
Michel T, Lefkowitz RJ (1982) Hormonal inhibition of adenylate cyclase. alpha 2 Adrenergic receptors promote release of
[3H]guanylylimidodiphosphate from platelet membranes. Journal of Biological Chemistry. [IF=1.122, Cited=34, 6292195].
Stadel JM, Strulovici B, Nambi P, ..., Lefkowitz RJ (1983) Desensitization of the beta-adrenergic receptor of frog
erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles. Journal of
Biological Chemistry. [IF=1.122, Cited=102, 6298219].
Strulovici B, Stadel JM, Lefkowitz RJ (1983) Functional integrity of desensitized beta-adrenergic receptors. Journal of
Biological Chemistry. [IF=1.122, Cited=30, 6304039].
Stiles GL, Lefkowitz RJ (1982) Human platelet adenylate cyclase: delineation of distinct stimulatory and inhibitory
guanine nucleotide regulatory pathways. None. [IF=None, Cited=0, 6304976].
Stiles GL, Strasser RH, Lavin TN, ..., Lefkowitz RJ (1983) The cardiac beta-adrenergic receptor. Structural similarities
of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling. Journal of Biological Chemistry.
[IF=1.122, Cited=39, 6305985].
Stiles GL, Strasser RH, Caron MG, Lefkowitz RJ (1983) Mammalian beta-adrenergic receptors. Structural differences in
beta 1 and beta 2 subtypes revealed by peptide maps. Journal of Biological Chemistry. [IF=1.122, Cited=22, 6309811].
Leeb-Lundberg LM, Dickinson KE, Heald SL, ..., Caron MG (1984) Photoaffinity labeling of mammalian alpha 1-adrenergic
receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe. Journal of Biological
Chemistry. [IF=1.122, Cited=41, 6321475].
Strulovici B, Lefkowitz RJ (1984) Activation, desensitization, and recycling of frog erythrocyte beta-adrenergic
receptors. Differential perturbation by in situ trypsinization. Journal of Biological Chemistry. [IF=1.122, Cited=9, 6323469].
Nambi P, Sibley DR, Stadel JM, ..., Lefkowitz RJ (1984) Cell-free desensitization of catecholamine-sensitive adenylate
cyclase. Agonist- and cAMP-promoted alterations in turkey erythrocyte beta-adrenergic receptors. Journal of Biological
Chemistry. [IF=1.122, Cited=15, 6323481].
Regan JW, DeMarinis RM, Caron MG, Lefkowitz RJ (1984) Identification of the subunit-binding site of alpha 2-adrenergic
receptors using [3H]phenoxybenzamine. Journal of Biological Chemistry. [IF=1.122, Cited=13, 6330087].
Stiles GL, Benovic JL, Caron MG, Lefkowitz RJ (1984) Mammalian beta-adrenergic receptors. Distinct glycoprotein
populations containing high mannose or complex type carbohydrate chains. Journal of Biological Chemistry. [IF=1.122,
Cited=54, 6330118].
Vale RD, De Lean A, Lefkowitz RJ, Stadel JM (1982) Regulation of insulin receptors in frog erythrocytes by insulin and
concanavalin A. Evidence for discrete classes of insulin binding sites. Molecular Pharmacology. [IF=0.939, Cited=1, 6759916].
De Lean A, Hancock AA, Lefkowitz RJ (1982) Validation and statistical analysis of a computer modeling method for
quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes. Molecular
Pharmacology. [IF=0.939, Cited=345, 6982395].
Barak LS, Tiberi M, Freedman NJ, ..., Caron MG (1994) A highly conserved tyrosine residue in G protein-coupled receptors
is required for agonist-mediated beta 2-adrenergic receptor sequestration. Journal of Biological Chemistry. [IF=1.122,
Cited=176, 7507928].
Hieble JP, Bylund DB, Clarke DE, ..., Ruffolo RR (1995) International Union of Pharmacology. X. Recommendation for
nomenclature of alpha 1-adrenoceptors: consensus update. Pharmacological Reviews. [IF=4.608, Cited=436, 7568329].
Pei G, Kieffer BL, Lefkowitz RJ, Freedman NJ (1995) Agonist-dependent phosphorylation of the mouse delta-opioid
receptor: involvement of G protein-coupled receptor kinases but not protein kinase C. Molecular Pharmacology. [IF=0.939,
Cited=121, 7651349].
Kwatra MM, Schwinn DA, Schreurs J, ..., Lefkowitz RJ (1993) The substance P receptor, which couples to Gq/11, is a
substrate of beta-adrenergic receptor kinase 1 and 2. Journal of Biological Chemistry. [IF=1.122, Cited=84, 7683643].
Kurose H, Lefkowitz RJ (1994) Differential desensitization and phosphorylation of three cloned and transfected alpha
2-adrenergic receptor subtypes. Journal of Biological Chemistry. [IF=1.122, Cited=46, 7908287].
Samama P, Pei G, Costa T, ..., Lefkowitz RJ (1994) Negative antagonists promote an inactive conformation of the beta
2-adrenergic receptor. Molecular Pharmacology. [IF=0.939, Cited=120, 7908404].
Bylund DB, Eikenberg DC, Hieble JP, ..., Trendelenburg U (1994) International Union of Pharmacology nomenclature of
adrenoceptors. Pharmacological Reviews. [IF=4.608, Cited=703, 7938162].
Stoffel RH, Randall RR, Premont RT, ..., Inglese J (1994) Palmitoylation of G protein-coupled receptor kinase, GRK6.
Lipid modification diversity in the GRK family. Journal of Biological Chemistry. [IF=1.122, Cited=71, 7961702].
Hawes BE, Touhara K, Kurose H, ..., Inglese J (1994) Determination of the G beta gamma-binding domain of phosducin. A
regulatable modulator of G beta gamma signaling. Journal of Biological Chemistry. [IF=1.122, Cited=36, 7961975].
Samama P, Cotecchia S, Costa T, Lefkowitz RJ (1993) A mutation-induced activated state of the beta 2-adrenergic
receptor. Extending the ternary complex model. Journal of Biological Chemistry. [IF=1.122, Cited=619, 8095262].
Kurose H, Arriza JL, Lefkowitz RJ (1993) Characterization of alpha 2-adrenergic receptor subtype-specific antibodies.
Molecular Pharmacology. [IF=0.939, Cited=31, 8095696].
Price DT, Lefkowitz RJ, Caron MG, ..., Schwinn DA (1994) Localization of mRNA for three distinct alpha 1-adrenergic
receptor subtypes in human tissues: implications for human alpha-adrenergic physiology. Molecular Pharmacology.
[IF=0.939, Cited=108, 8114668].
Koch WJ, Hawes BE, Inglese J, ..., Lefkowitz RJ (1994) Cellular expression of the carboxyl terminus of a G protein-
coupled receptor kinase attenuates G beta gamma-mediated signaling. Journal of Biological Chemistry. [IF=1.122,
Cited=237, 8119963].
Premont RT, Koch WJ, Inglese J, Lefkowitz RJ (1994) Identification, purification, and characterization of GRK5, a member
of the family of G protein-coupled receptor kinases. Journal of Biological Chemistry. [IF=1.122, Cited=105, 8120045].
Touhara K, Inglese J, Pitcher JA, ..., Lefkowitz RJ (1994) Binding of G protein beta gamma-subunits to pleckstrin
homology domains. Journal of Biological Chemistry. [IF=1.122, Cited=238, 8144601].
Hawes BE, Luttrell LM, Exum ST, Lefkowitz RJ (1994) Inhibition of G protein-coupled receptor signaling by expression of
cytoplasmic domains of the receptor. Journal of Biological Chemistry. [IF=1.122, Cited=32, 8195232].
Inglese J, Freedman NJ, Koch WJ, Lefkowitz RJ (1993) Structure and mechanism of the G protein-coupled receptor kinases.
Journal of Biological Chemistry. [IF=1.122, Cited=191, 8226899].
Williams LT, Mullikin D, Lefkowitz RJ (1976) Identification of alpha-adrenergic receptors in uterine smooth muscle
membranes by [3H]dihydroergocryptine binding. Journal of Biological Chemistry. [IF=1.122, Cited=107, 825511].
Boekhoff I, Inglese J, Schleicher S, ..., Breer H (1994) Olfactory desensitization requires membrane targeting of
receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins. Journal of Biological Chemistry.
[IF=1.122, Cited=53, 8276821].
Ishii K, Chen J, Ishii M, ..., Coughlin SR (1994) Inhibition of thrombin receptor signaling by a G-protein coupled
receptor kinase. Functional specificity among G-protein coupled receptor kinases. Journal of Biological Chemistry.
[IF=1.122, Cited=101, 8288570].
Limbird LE, Lefkowitz RJ (1977) Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel
exclusion chromatography. Journal of Biological Chemistry. [IF=1.122, Cited=46, 833154].
Yu SS, Lefkowitz RJ, Hausdorff WP (1993) Beta-adrenergic receptor sequestration. A potential mechanism of receptor
resensitization. Journal of Biological Chemistry. [IF=1.122, Cited=180, 8380158].
Pippig S, Andexinger S, Daniel K, ..., Lohse MJ (1993) Overexpression of beta-arrestin and beta-adrenergic receptor
kinase augment desensitization of beta 2-adrenergic receptors. Journal of Biological Chemistry. [IF=1.122, Cited=100, 8381421].
Blitzer RD, Omri G, De Vivo M, ..., Lefkowitz RJ (1993) Coupling of the expressed alpha 1B-adrenergic receptor to the
phospholipase C pathway in Xenopus oocytes. The role of Go. Journal of Biological Chemistry. [IF=1.122, Cited=28, 8385110].
Ren Q, Kurose H, Lefkowitz RJ, Cotecchia S (1993) Constitutively active mutants of the alpha 2-adrenergic receptor.
Journal of Biological Chemistry. [IF=1.122, Cited=119, 8393865].
Koch WJ, Inglese J, Stone WC, Lefkowitz RJ (1993) The binding site for the beta gamma subunits of heterotrimeric G
proteins on the beta-adrenergic receptor kinase. Journal of Biological Chemistry. [IF=1.122, Cited=245, 8463335].
Walensky LD, Roskams AJ, Lefkowitz RJ, ..., Ronnett GV (1995) Odorant receptors and desensitization proteins colocalize
in mammalian sperm. Molecular Medicine. [IF=1.026, Cited=52, 8529092].
Freedman NJ, Lefkowitz RJ (1996) Desensitization of G protein-coupled receptors. None. [IF=None, Cited=253, 8701085].
Sizmann D, Kuusinen H, Keränen S, ..., Keinänen K (1996) Production of adrenergic receptors in yeast. None. [IF=None,
Cited=9, 9014242].
Ménard L, Ferguson SS, Zhang J, ..., Barak LS (1997) Synergistic regulation of beta2-adrenergic receptor sequestration:
intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization.
Molecular Pharmacology. [IF=0.939, Cited=119, 9145918].
Drazner MH, Koch WJ, Lefkowitz RJ (1997) Potentiation of beta-adrenergic signaling by gene transfer. None. [IF=None,
Cited=6, 9154638].
Mickey JV, Tate R, Mullikin D, Lefkowitz RJ (1976) Regulation of adenylate cyclase-coupled beta adrenergic receptor
binding sites by beta adrenergic catecholamines in vitro. Molecular Pharmacology. [IF=0.939, Cited=48, 934056].
Luttrell LM, van Biesen T, Hawes BE, ..., Lefkowitz RJ (1997) G-protein-coupled receptors and their regulation:
activation of the MAP kinase signaling pathway by G-protein-coupled receptors. None. [IF=None, Cited=41, 9344257].
Williams LT, Jarett L, Lefkowitz RJ (1976) Adipocyte beta-adrenergic receptors. Identification and subcellular
localization by (-)-[3H]dihydroalprenolol binding. Journal of Biological Chemistry. [IF=1.122, Cited=78, 942608].
Lefkowitz RJ, Mullikin D, Caron MG (1976) Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and
other purine nucleotides. Journal of Biological Chemistry. [IF=1.122, Cited=125, 947904].
Limbird LE, Lefkowitz RJ (1976) Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes.
Journal of Biological Chemistry. [IF=1.122, Cited=66, 956174].
Limbird LE, Lefkowitz RJ (1976) Adenylate cyclase-coupled beta adrenergic receptors effect of membrane lipid-perturbing
agents on receptor binding and enzyme stimulation by catecholamines. Molecular Pharmacology. [IF=0.939, Cited=40, 958206].
Zhang J, Ferguson SS, Barak LS, ..., Caron MG (1997) Molecular mechanisms of G protein-coupled receptor signaling: role
of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization. None. [IF=None,
Cited=69, 9606723].

Lefkowitz, Robert J

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