Kool, Eric

Publication with MATCHING institution:

Kool E, Miller GP (2003) 5'-Iodination of solid-phase-linked oligodeoxyribonucleotides. Current Protocols in Nucleic
Acid Chemistry. [IF=0.313, Cited=0, 18428909].
Ji D, Mohsen MG, Harcourt EM, Kool E (2016) ATP-Releasing Nucleotides: Linking DNA Synthesis to Luciferase Signaling.
Angewandte Chemie - International Edition. [IF=2.456, Cited=4, 26836342].
Chan KM, Kölmel DK, Wang S, Kool E (2017) Color-Change Photoswitching of an Alkynylpyrene Excimer Dye. Angewandte Chemie
- International Edition. [IF=2.456, Cited=6, 28474388].
Kadina A, Kietrys AM, Kool E (2018) RNA Cloaking by Reversible Acylation. Angewandte Chemie - International Edition.
[IF=2.456, Cited=29, 29370460].
Wilson DL, Beharry AA, Srivastava A, ..., Kool E (2018) Fluorescence Probes for ALKBH2 Allow the Measurement of DNA
Alkylation Repair and Drug Resistance Responses. Angewandte Chemie - International Edition. [IF=2.456, Cited=11, 30098084].
Jun YW, Wilson DL, Kietrys AM, ..., Kool E (2020) An Excimer Clamp for Measuring Damaged-Base Excision by the DNA Repair
Enzyme NTH1. Angewandte Chemie - International Edition. [IF=2.456, Cited=5, 32109332].
Velema WA, Park HS, Kadina A, ..., Kool E (2020) Trapping Transient RNA Complexes by Chemically Reversible Acylation.
Angewandte Chemie - International Edition. [IF=2.456, Cited=10, 32845055].
Jun YW, Albarran E, Wilson DL, ..., Kool E (2021) Fluorescence Imaging of Mitochondrial DNA Base Excision Repair Reveals
Dynamics of Oxidative Stress Responses. Angewandte Chemie - International Edition. [IF=2.456, Cited=8, 34851014].
Xiao L, Jun YW, Kool E (2021) DNA Tiling Enables Precise Acylation-Based Labeling and Control of mRNA. Angewandte Chemie
- International Edition. [IF=2.456, Cited=9, 34624169].
Guo J, Chen S, Onishi Y, ..., Zhu RY (2024) RNA Control via Redox-Responsive Acylation. Angewandte Chemie -
International Edition. [IF=2.456, Cited=0, 38480851].
Chatterjee S, Xiao L, Zhong W, ..., Kool E (2024) Selective Arylation of RNA 2'-OH Groups via S_NAr Reaction
with Trialkylammonium Heterocycles. Angewandte Chemie - International Edition. [IF=2.456, Cited=0, 38625814].
Edwards SK, Ono T, Wang S, ..., Kool E (2015) In Vitro Fluorogenic Real-Time Assay of the Repair of Oxidative DNA
Damage. ChemBioChem. [IF=0.691, Cited=19, 26073452].
Spitale RC, Flynn RA, Torre EA, ..., Chang HY (2014) RNA structural analysis by evolving SHAPE chemistry. Wiley
interdisciplinary reviews. RNA. [IF=1.585, Cited=34, 25132067].
Jun YW, Kool E (2020) Small Substrate or Large? Debate Over the Mechanism of Glycation Adduct Repair by DJ-1. Cell
Chemical Biology. [IF=1.446, Cited=21, 32783963].
Xiao L, Fang L, Kool E (2022) Acylation probing of "generic" RNA libraries reveals critical influence of loop
constraints on reactivity. Cell Chemical Biology. [IF=1.446, Cited=6, 35662395].
Xiao L, Fang L, Kool E (2023) 2'-OH as a universal handle for studying intracellular RNAs. Cell Chemical Biology.
[IF=1.446, Cited=0, 37992716].
Venzon M, Das R, Luciano DJ, ..., Cadwell K (2022) Microbial byproducts determine reproductive fitness of free-living
and parasitic nematodes. None. [IF=None, Cited=6, 35413267].
Baskar R, Chen AF, Favaro P, ..., Bendall SC (2022) Integrating transcription-factor abundance with chromatin
accessibility in human erythroid lineage commitment. Cell Reports Methods. [IF=1.007, Cited=6, 35463156].
Xu L, Da L, Plouffe SW, ..., Wang D (2014) Molecular basis of transcriptional fidelity and DNA lesion-induced
transcriptional mutagenesis. None. [IF=None, Cited=26, 24767259].
McPherson LA, Troccoli CI, Ji D, ..., Ford JM (2019) Increased MTH1-specific 8-oxodGTPase activity is a hallmark of
cancer in colon, lung and pancreatic tissue. None. [IF=None, Cited=14, 31311767].
Zhang L, Misiara L, Samaranayake GJ, ..., Rai P (2021) OGG1 co-inhibition antagonizes the tumor-inhibitory effects of
targeting MTH1. Redox Biology. [IF=2.133, Cited=4, 33450725].
Fang L, Kool E (2023) Reactivity-based RNA profiling for analyzing transcriptome interactions of small molecules in
human cells. STAR Protocols. [IF=0.357, Cited=0, 37917579].
Kool E (2000) Synthetically modified DNAs as substrates for polymerases. Current Opinion in Chemical Biology. [IF=1.51,
Cited=34, 11102863].
Jun YW, Kool E (2022) Chemical Tools for the Study of DNA Repair. Accounts of Chemical Research. [IF=3.533, Cited=1, 36355579].
Mohsen MG, Kool E (2016) The Discovery of Rolling Circle Amplification and Rolling Circle Transcription. Accounts of
Chemical Research. [IF=3.533, Cited=83, 27797171].
Shioi R, Xiao L, Kool E (2023) Aqueous Activation of RNA 2'-OH for Conjugation with Amines and Thiols. Bioconjugate
Chemistry. [IF=0.921, Cited=0, 38150592].
Clark SA, Singh V, Vega Mendoza D, ..., Kool E (2016) Light-Up "Channel Dyes" for Haloalkane-Based Protein Labeling in
Vitro and in Bacterial Cells. Bioconjugate Chemistry. [IF=0.921, Cited=12, 27998074].
Ji D, Kietrys AM, Lee Y, Kool E (2018) ATP-Linked Chimeric Nucleotide as a Specific Luminescence Reporter of
Deoxyuridine Triphosphatase. Bioconjugate Chemistry. [IF=0.921, Cited=1, 29578692].
Kölmel DK, Kool E (2017) Oximes and Hydrazones in Bioconjugation: Mechanism and Catalysis. Chemical Reviews. [IF=11.712,
Cited=184, 28640998].
Shioi R, Chatterjee S, Xiao L, ..., Kool E (2024) Second-Generation Chiral Amino Acid Derivatives Afford High
Stereoselectivity and Stability in Aqueous RNA Acylation. Journal of Organic Chemistry. [IF=0.885, Cited=0, 38809698].
Velema WA, Kool E (2018) Water-Soluble Leaving Group Enables Hydrophobic Functionalization of RNA. Organic Letters.
[IF=1.091, Cited=5, 30299958].
Habibian M, Velema WA, Kietrys AM, ..., Kool E (2019) Polyacetate and Polycarbonate RNA: Acylating Reagents and
Properties. Organic Letters. [IF=1.091, Cited=9, 31268332].
Zhu RY, Majumdar C, Khuu C, ..., Kool E (2020) Designer Fluorescent Adenines Enable Real-Time Monitoring of MUTYH
Activity. ACS Central Science. [IF=2.363, Cited=6, 33145410].
Chatterjee S, Shioi R, Kool E (2023) Sulfonylation of RNA 2'-OH groups. ACS Central Science. [IF=2.363, Cited=4, 36968531].
Jun YW, Kant M, Coskun E, ..., Kool E (2023) Possible Genetic Risks from Heat-Damaged DNA in Food. ACS Central Science.
[IF=2.363, Cited=2, 37396864].
Kant M, Tahara YK, Jaruga P, ..., Dizdaroglu M (2020) Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the
Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products of Oxidatively induced DNA Base Lesions. ACS
Chemical Biology. [IF=0.963, Cited=1, 33331782].
Lee Y, Onishi Y, McPherson L, ..., Kool E (2022) Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators
of MTH1. ACS Chemical Biology. [IF=0.963, Cited=3, 35830623].
Pandit B, Fang L, Kool E, Royzen M (2024) Reversible RNA Acylation Using Bio-Orthogonal Chemistry Enables Temporal
Control of CRISPR-Cas9 Nuclease Activity. ACS Chemical Biology. [IF=0.963, Cited=0, 39051564].
Yuen LH, Saxena NS, Park HS, ..., Kool E (2016) Dark Hydrazone Fluorescence Labeling Agents Enable Imaging of Cellular
Aldehydic Load. ACS Chemical Biology. [IF=0.963, Cited=23, 27326450].
Wilson DL, Kool E (2017) Fluorescent Probes of DNA Repair. ACS Chemical Biology. [IF=0.963, Cited=14, 29156135].
Tahara YK, Kietrys AM, Hebenbrock M, ..., Kool E (2019) Dual Inhibitors of 8-Oxoguanine Surveillance by OGG1 and NUDT1.
ACS Chemical Biology. [IF=0.963, Cited=10, 31622553].
Kool E (2002) Replacing the nucleobases in DNA with designer molecules. Accounts of Chemical Research. [IF=3.533,
Cited=152, 12437318].
Krueger AT, Lu H, Lee AHF, Kool E (2007) Synthesis and properties of size-expanded DNAs: toward designed, functional
genetic systems. Accounts of Chemical Research. [IF=3.533, Cited=64, 17309194].
Cuppoletti A, Cho Y, Park JS, ..., Kool E (2005) Oligomeric fluorescent labels for DNA. Bioconjugate Chemistry.
[IF=0.921, Cited=30, 15898718].
Kleinbaum DJ, Miller GP, Kool E (2010) Double displacement: An improved bioorthogonal reaction strategy for templated
nucleic acid detection. Bioconjugate Chemistry. [IF=0.921, Cited=7, 20509625].
Franzini RM, Kool E (2011) Improved templated fluorogenic probes enhance the analysis of closely related pathogenic
bacteria by microscopy and flow cytometry. Bioconjugate Chemistry. [IF=0.921, Cited=17, 21870777].
Crisalli P, Kool E (2011) Multi-path quenchers: efficient quenching of common fluorophores. Bioconjugate Chemistry.
[IF=0.921, Cited=18, 22034828].
Crisalli P, Hernández AR, Kool E (2012) Fluorescence quenchers for hydrazone and oxime orthogonal bioconjugation.
Bioconjugate Chemistry. [IF=0.921, Cited=16, 22913527].
Teo YN, Kool E (2009) Polyfluorophore excimers and exciplexes as FRET donors in DNA. Bioconjugate Chemistry. [IF=0.921,
Cited=19, 19916519].
Sun L, Wang M, Kool E, Taylor JS (2000) Pyrene nucleotide as a mechanistic probe: evidence for a transient abasic site-
like intermediate in the bypass of dipyrimidine photoproducts by T7 DNA polymerase. Biochemistry. [IF=0.753, Cited=22, 11087416].
Morales JC, Kool E (2000) Functional hydrogen-bonding map of the minor groove binding tracks of six DNA polymerases.
Biochemistry. [IF=0.753, Cited=69, 11041863].
Dzantiev L, Alekseyev YO, Morales JC, ..., Romano LJ (2001) Significance of nucleobase shape complementarity and
hydrogen bonding in the formation and stability of the closed polymerase-DNA complex. Biochemistry. [IF=0.753,
Cited=21, 11258938].
Sun L, Zhang K, Zhou L, ..., Taylor JS (2003) Yeast pol eta holds a cis-syn thymine dimer loosely in the active site
during elongation opposite the 3'-T of the dimer, but tightly opposite the 5'-T. Biochemistry. [IF=0.753, Cited=10, 12899630].
Maki AS, Kim T, Kool E (2004) Direct comparison of A- and T-strand minor groove interactions in DNA curvature at A
tracts. Biochemistry. [IF=0.753, Cited=14, 14744156].
Hariharan C, Bloom LB, Helquist SA, ..., Reha-Krantz LJ (2006) Dynamics of nucleotide incorporation: snapshots revealed
by 2-aminopurine fluorescence studies. Biochemistry. [IF=0.753, Cited=27, 16503638].
Potapova O, Chan C, DeLucia AM, ..., Joyce CM (2006) DNA polymerase catalysis in the absence of Watson-Crick hydrogen
bonds: analysis by single-turnover kinetics. Biochemistry. [IF=0.753, Cited=29, 16411765].
Mizukami S, Kim TW, Helquist SA, Kool E (2006) Varying DNA base-pair size in subangstrom increments: evidence for a
loose, not large, active site in low-fidelity Dpo4 polymerase. Biochemistry. [IF=0.753, Cited=53, 16503632].
Killelea T, Ghosh S, Tan SS, ..., Connolly BA (2010) Probing the interaction of archaeal DNA polymerases with deaminated
bases using X-ray crystallography and non-hydrogen bonding isosteric base analogues. Biochemistry. [IF=0.753, Cited=23, 20527806].
Ulrich S, Kool E (2011) Importance of steric effects on the efficiency and fidelity of transcription by T7 RNA
polymerase. Biochemistry. [IF=0.753, Cited=9, 22044042].
Silverman AP, Jiang Q, Goodman MF, Kool E (2007) Steric and electrostatic effects in DNA synthesis by the SOS-induced
DNA polymerases II and IV of Escherichia coli. Biochemistry. [IF=0.753, Cited=5, 17988102].
Silverman AP, Garforth SJ, Prasad VR, Kool E (2008) Probing the active site steric flexibility of HIV-1 reverse
transcriptase: different constraints for DNA- versus RNA-templated synthesis. Biochemistry. [IF=0.753, Cited=10, 18366188].
Hernández AR, Peterson LW, Kool E (2012) Steric restrictions of RISC in RNA interference identified with size-expanded
RNA nucleobases. ACS Chemical Biology. [IF=0.963, Cited=14, 22646660].
Silverman AP, Kool E (2006) Detecting RNA and DNA with templated chemical reactions. Chemical Reviews. [IF=11.712,
Cited=127, 16967920].
Teo YN, Kool E (2012) DNA-multichromophore systems. Chemical Reviews. [IF=11.712, Cited=128, 22424059].
Sando S, Kool E (2002) Quencher as leaving group: efficient detection of DNA-joining reactions. Journal of the American
Chemical Society. [IF=2.573, Cited=71, 11878946].
Sando S, Kool E (2002) Imaging of RNA in bacteria with self-ligating quenched probes. Journal of the American Chemical
Society. [IF=2.573, Cited=69, 12175209].
Gao J, Strässler C, Tahmassebi D, Kool E (2002) Libraries of composite polyfluors built from fluorescent deoxyribosides.
Journal of the American Chemical Society. [IF=2.573, Cited=63, 12296712].
Francis AW, Helquist SA, Kool E, David SS (2003) Probing the requirements for recognition and catalysis in Fpg and MutY
with nonpolar adenine isosteres. Journal of the American Chemical Society. [IF=2.573, Cited=32, 14692765].
Liu H, Gao J, Maynard L, ..., Kool E (2004) Toward a new genetic system with expanded dimensions: size-expanded
analogues of deoxyadenosine and thymidine. Journal of the American Chemical Society. [IF=2.573, Cited=53, 14746479].
Sando S, Abe H, Kool E (2004) Quenched auto-ligating DNAs: multicolor identification of nucleic acids at single
nucleotide resolution. Journal of the American Chemical Society. [IF=2.573, Cited=64, 14746476].
Lai JS, Kool E (2004) Selective pairing of polyfluorinated DNA bases. Journal of the American Chemical Society.
[IF=2.573, Cited=25, 15012120].
Lee AHF, Kool E (2005) A new four-base genetic helix, yDNA, composed of widened benzopyrimidine-purine pairs. Journal of
the American Chemical Society. [IF=2.573, Cited=33, 15755149].
Yoshina-Ishii C, Miller GP, Kraft ML, ..., Boxer SG (2005) General method for modification of liposomes for encoded
assembly on supported bilayers. Journal of the American Chemical Society. [IF=2.573, Cited=61, 15686351].
Liu H, Gao J, Kool E (2005) Helix-forming properties of size-expanded DNA, an alternative four-base genetic form.
Journal of the American Chemical Society. [IF=2.573, Cited=32, 15686371].
Abe H, Kool E (2004) Destabilizing universal linkers for signal amplification in self-ligating probes for RNA. Journal
of the American Chemical Society. [IF=2.573, Cited=54, 15506759].
Gao J, Watanabe S, Kool E (2004) Modified DNA analogues that sense light exposure with color changes. Journal of the
American Chemical Society. [IF=2.573, Cited=59, 15469249].
Gao J, Liu H, Kool E (2004) Expanded-size bases in naturally sized DNA: evaluation of steric effects in Watson-Crick
pairing. Journal of the American Chemical Society. [IF=2.573, Cited=40, 15382917].
Liu H, Lynch SR, Kool E (2004) Solution structure of xDNA: a paired genetic helix with increased diameter. Journal of
the American Chemical Society. [IF=2.573, Cited=28, 15174859].
Devaraj NK, Miller GP, Ebina W, ..., Chidsey CED (2005) Chemoselective covalent coupling of oligonucleotide probes to
self-assembled monolayers. Journal of the American Chemical Society. [IF=2.573, Cited=76, 15954758].
Sintim HO, Kool E (2006) Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of
thymidine. Journal of the American Chemical Society. [IF=2.573, Cited=32, 16402811].
Kim SJ, Kool E (2006) Sensing metal ions with DNA building blocks: fluorescent pyridobenzimidazole nucleosides. Journal
of the American Chemical Society. [IF=2.573, Cited=25, 16669686].
Lee AHF, Kool E (2006) Exploring the limits of DNA size: naphtho-homologated DNA bases and pairs. Journal of the
American Chemical Society. [IF=2.573, Cited=32, 16834396].
Lynch SR, Liu H, Gao J, Kool E (2006) Toward a designed, functioning genetic system with expanded-size base pairs:
solution structure of the eight-base xDNA double helix. Journal of the American Chemical Society. [IF=2.573, Cited=30, 17090058].
Taniguchi Y, Kool E (2007) Nonpolar isosteres of damaged DNA bases: effective mimicry of mutagenic properties of
8-oxopurines. Journal of the American Chemical Society. [IF=2.573, Cited=12, 17592846].
Silverman AP, Kool E (2007) RNA probes of steric effects in active sites: high flexibility of HIV-1 reverse
transcriptase. Journal of the American Chemical Society. [IF=2.573, Cited=9, 17696348].
Wilson JN, Teo YN, Kool E (2007) Efficient quenching of oligomeric fluorophores on a DNA backbone. Journal of the
American Chemical Society. [IF=2.573, Cited=31, 18027944].
Krueger AT, Kool E (2008) Fluorescence of size-expanded DNA bases: reporting on DNA sequence and structure with an
unnatural genetic set. Journal of the American Chemical Society. [IF=2.573, Cited=38, 18311973].
Tan SS, Kim SJ, Kool E (2011) Differentiating between fluorescence-quenching metal ions with polyfluorophore sensors
built on a DNA backbone. Journal of the American Chemical Society. [IF=2.573, Cited=54, 21294558].
Krueger AT, Peterson LW, Chelliserry J, ..., Kool E (2011) Encoding phenotype in bacteria with an alternative genetic
set. Journal of the American Chemical Society. [IF=2.573, Cited=31, 21981660].
McKibbin PL, Kobori A, Taniguchi Y, ..., David SS (2012) Surprising repair activities of nonpolar analogs of 8-oxoG
expose features of recognition and catalysis by base excision repair glycosylases. Journal of the American Chemical
Society. [IF=2.573, Cited=23, 22175854].
Khakshoor O, Wheeler SE, Houk KN, Kool E (2012) Measurement and theory of hydrogen bonding contribution to isosteric DNA
base pairs. Journal of the American Chemical Society. [IF=2.573, Cited=19, 22300089].
Kellinger MW, Ulrich S, Chong J, ..., Wang D (2012) Dissecting chemical interactions governing RNA polymerase II
transcriptional fidelity. Journal of the American Chemical Society. [IF=2.573, Cited=27, 22509745].
Singh V, Wang S, Chan KM, ..., Kool E (2013) Genetically encoded multispectral labeling of proteins with
polyfluorophores on a DNA backbone. Journal of the American Chemical Society. [IF=2.573, Cited=27, 23590213].
Kool E, Park DH, Crisalli P (2013) Fast hydrazone reactants: electronic and acid/base effects strongly influence rate at
biological pH. Journal of the American Chemical Society. [IF=2.573, Cited=61, 24224646].
Harcourt EM, Ehrenschwender T, Batista PJ, ..., Kool E (2013) Identification of a selective polymerase enables detection
of N(6)-methyladenosine in RNA. Journal of the American Chemical Society. [IF=2.573, Cited=56, 24328136].
Yuen LH, Franzini RM, Tan SS, Kool E (2014) Large-scale detection of metals with a small set of fluorescent DNA-like
chemosensors. Journal of the American Chemical Society. [IF=2.573, Cited=15, 25255102].
Roost C, Lynch SR, Batista PJ, ..., Kool E (2015) Structure and thermodynamics of N6-methyladenosine in RNA: a spring-
loaded base modification. Journal of the American Chemical Society. [IF=2.573, Cited=235, 25611135].
Teo YN, Wilson JN, Kool E (2009) Polyfluorophores on a DNA backbone: a multicolor set of labels excited at one
wavelength. Journal of the American Chemical Society. [IF=2.573, Cited=61, 19254023].
Jarchow-Choy SK, Sjuvarsson E, Sintim HO, ..., Kool E (2009) Nonpolar nucleoside mimics as active substrates for human
thymidine kinases. Journal of the American Chemical Society. [IF=2.573, Cited=10, 20560637].
Loakes D, Gallego J, Pinheiro VB, ..., Holliger P (2009) Evolving a polymerase for hydrophobic base analogues. Journal
of the American Chemical Society. [IF=2.573, Cited=48, 19778048].
Franzini RM, Kool E (2009) Efficient nucleic acid detection by templated reductive quencher release. Journal of the
American Chemical Society. [IF=2.573, Cited=78, 19886694].
Xiao L, Habibian M, Kool E (2020) Site-Selective RNA Functionalization via DNA-Induced Structure. Journal of the
American Chemical Society. [IF=2.573, Cited=14, 32865995].
Xiao L, Fang L, Chatterjee S, Kool E (2022) Diverse Reagent Scaffolds Provide Differential Selectivity of 2'-OH
Acylation in RNA. Journal of the American Chemical Society. [IF=2.573, Cited=6, 36542611].
Beharry AA, Lacoste S, O'Connor TR, Kool E (2016) Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation
Damage by ALKBH3, a Prostate Cancer Marker. Journal of the American Chemical Society. [IF=2.573, Cited=27, 26967262].
Ji D, Beharry AA, Ford JM, Kool E (2016) A Chimeric ATP-Linked Nucleotide Enables Luminescence Signaling of Damage
Surveillance by MTH1, a Cancer Target. Journal of the American Chemical Society. [IF=2.573, Cited=12, 27413803].
Velema WA, Kool E (2017) Fluorogenic Templated Reaction Cascades for RNA Detection. Journal of the American Chemical
Society. [IF=2.573, Cited=12, 28345912].
Chan KM, Xu W, Kwon H, ..., Kool E (2017) Luminescent Carbon Dot Mimics Assembled on DNA. Journal of the American
Chemical Society. [IF=2.573, Cited=6, 28841010].
Kietrys AM, Velema WA, Kool E (2017) Fingerprints of Modified RNA Bases from Deep Sequencing Profiles. Journal of the
American Chemical Society. [IF=2.573, Cited=21, 29111692].
Tahara YK, Auld D, Ji D, ..., Kool E (2018) Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase. Journal of
the American Chemical Society. [IF=2.573, Cited=37, 29376367].
Velema WA, Kietrys AM, Kool E (2018) RNA Control by Photoreversible Acylation. Journal of the American Chemical Society.
[IF=2.573, Cited=26, 29474085].
Wilson DL, Kool E (2019) Ultrafast Oxime Formation Enables Efficient Fluorescence Light-up Measurement of DNA Base
Excision. Journal of the American Chemical Society. [IF=2.573, Cited=13, 31774658].
Marques SM, Slanska M, Chmelova K, ..., Prokop Z (2022) Mechanism-Based Strategy for Optimizing HaloTag Protein
Labeling. JACS Au. [IF=1.606, Cited=4, 35783171].
O'Neill BM, Ratto JE, Good KL, ..., Kool E (2002) A highly effective nonpolar isostere of deoxyguanosine: synthesis,
structure, stacking, and base pairing. Journal of Organic Chemistry. [IF=0.885, Cited=18, 12182615].
Miller GP, Kool E (2004) Versatile 5'-functionalization of oligonucleotides on solid support: amines, azides, thiols,
and thioethers via phosphorus chemistry. Journal of Organic Chemistry. [IF=0.885, Cited=22, 15049637].
Kim TW, Kool E (2005) A series of nonpolar thymidine analogues of increasing size: DNA base pairing and stacking
properties. Journal of Organic Chemistry. [IF=0.885, Cited=30, 15760186].
Liu H, Gao J, Kool E (2005) Size-expanded analogues of dG and dC: synthesis and pairing properties in DNA. Journal of
Organic Chemistry. [IF=0.885, Cited=35, 15651812].
Lee AHF, Kool E (2005) Novel benzopyrimidines as widened analogues of DNA bases. Journal of Organic Chemistry.
[IF=0.885, Cited=27, 15624915].
Crisalli P, Kool E (2013) Water-soluble organocatalysts for hydrazone and oxime formation. Journal of Organic Chemistry.
[IF=0.885, Cited=78, 23289546].
Pomerantz AK, Moerner WE, Moerner WE, ..., Kool ET (2008) Visualization of long human telomere mimics by single-molecule
fluorescence imaging. Journal of Physical Chemistry B. [IF=0.893, Cited=8, 18817431].
Miller GP, Kool E (2002) A simple method for electrophilic functionalization of DNA. Organic Letters. [IF=1.091,
Cited=16, 12375897].
Morales-Rojas H, Kool E (2002) A porphyrin C-nucleoside incorporated into DNA. Organic Letters. [IF=1.091, Cited=20, 12465891].
Kim TW, Kool E (2004) A set of nonpolar thymidine nucleoside analogues with gradually increasing size. Organic Letters.
[IF=1.091, Cited=14, 15496071].
Tan SS, Teo YN, Kool E (2010) Selective sensor for silver ions built from polyfluorophores on a DNA backbone. Organic
Letters. [IF=1.091, Cited=14, 20883041].
Hernández AR, Kool E (2011) The components of xRNA: synthesis and fluorescence of a full genetic set of size-expanded
ribonucleosides. Organic Letters. [IF=1.091, Cited=13, 21214222].
Crisalli P, Kool E (2013) Importance of ortho proton donors in catalysis of hydrazone formation. Organic Letters.
[IF=1.091, Cited=45, 23477719].
Kool E, Crisalli P, Chan KM (2014) Fast alpha nucleophiles: structures that undergo rapid hydrazone/oxime formation at
neutral pH. Organic Letters. [IF=1.091, Cited=31, 24559274].
Larsen D, Pittelkow M, Karmakar S, Kool E (2014) New organocatalyst scaffolds with high activity in promoting hydrazone
and oxime formation at neutral pH. Organic Letters. [IF=1.091, Cited=36, 25545888].
Franzini RM, Kool E (2008) Organometallic activation of a fluorogen for templated nucleic acid detection. Organic
Letters. [IF=1.091, Cited=23, 18549220].
Kietrys AM, Kool E (2016) Epigenetics: A new methyl mark on messengers. Nature. [IF=11.591, Cited=5, 26911777].
Spitale RC, Flynn RA, Zhang QC, ..., Chang HY (2015) Structural imprints in vivo decode RNA regulatory mechanisms.
Nature. [IF=11.591, Cited=426, 25799993].
Harcourt EM, Kietrys AM, Kool E (2017) Chemical and structural effects of base modifications in messenger RNA. Nature.
[IF=11.591, Cited=97, 28102265].
Karmakar S, Harcourt EM, Hewings DS, ..., Kool E (2015) Organocatalytic removal of formaldehyde adducts from RNA and DNA
bases. Nature Chemistry. [IF=3.667, Cited=23, 26291948].
Xu W, Chan KM, Kool E (2017) Fluorescent nucleobases as tools for studying DNA and RNA. Nature Chemistry. [IF=3.667,
Cited=84, 29064490].
Kool E, Waters ML (2007) The model student: what chemical model systems can teach us about biology. Nature Chemical
Biology. [IF=2.623, Cited=12, 17235337].
Flynn RA, Do BT, Rubin AJ, ..., Chang HY (2016) 7SK-BAF axis controls pervasive transcription at enhancers. Nature
Structural and Molecular Biology. [IF=2.542, Cited=61, 26878240].
Jun YW, Harcourt EM, Xiao L, ..., Kool E (2022) Efficient DNA fluorescence labeling via base excision trapping. Nature
Communications. [IF=3.268, Cited=3, 36028479].
Fang L, Xiao L, Jun YW, ..., Kool E (2023) Reversible 2'-OH acylation enhances RNA stability. Nature Chemistry.
[IF=3.667, Cited=8, 37365334].
Fang L, Velema WA, Lee Y, ..., Kool E (2023) Pervasive transcriptome interactions of protein-targeted drugs. Nature
Chemistry. [IF=3.667, Cited=9, 37653232].
Velema WA, Kool E (2019) The chemistry and applications of RNA 2'-OH acylation. Nature Reviews Chemistry. [IF=5.727,
Cited=28, 32984545].
Kuljanin M, Mitchell DC, Schweppe DK, ..., Gygi SP (2021) Reimagining high-throughput profiling of reactive cysteines
for cell-based screening of large electrophile libraries. Nature Biotechnology. [IF=8.861, Cited=67, 33398154].
Sun L, Fazal FM, Li P, ..., Zhang QC (2019) RNA structure maps across mammalian cellular compartments. Nature Structural
and Molecular Biology. [IF=2.542, Cited=123, 30886404].
Kwon H, Jiang W, Kool E (2015) Pattern-Based Detection of Anion Pollutants in Water with DNA Polyfluorophores. Chemical
Science. [IF=1.563, Cited=9, 26146537].
Kool E, Sintim HO (2006) The difluorotoluene debate--a decade later. Chemical Communications. [IF=0.902, Cited=44, 17047807].
Kwon H, Jiang W, Kool E (2015) Correction: Pattern-based detection of anion pollutants in water with DNA
polyfluorophores. Chemical Science. [IF=1.563, Cited=0, 30123454].
Kölmel DK, Barandun LJ, Kool E (2016) Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling
for the preparation of DNA-based polyfluorophores. Organic and Biomolecular Chemistry. [IF=0.77, Cited=2, 27296353].
Kwon H, Chan KM, Kool E (2017) DNA as an environmental sensor: detection and identification of pesticide contaminants in
water with fluorescent nucleobases. Organic and Biomolecular Chemistry. [IF=0.77, Cited=6, 28150837].
Larsen D, Kietrys AM, Clark SA, ..., Kool E (2018) Exceptionally rapid oxime and hydrazone formation promoted by
catalytic amine buffers with low toxicity. Chemical Science. [IF=1.563, Cited=22, 29997880].
Mohsen MG, Ji D, Kool E (2019) Polymerase-amplified release of ATP (POLARA) for detecting single nucleotide variants in
RNA and DNA. Chemical Science. [IF=1.563, Cited=5, 30996911].
Park HS, Kietrys AM, Kool E (2019) Simple alkanoyl acylating agents for reversible RNA functionalization and control.
Chemical Communications. [IF=0.902, Cited=14, 30977472].
Jun YW, Hebenbrock M, Kool E (2019) A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of
vitamin B6 status. Chemical Communications. [IF=0.902, Cited=1, 31808778].
Habibian M, McKinlay C, Blake TR, ..., Kool ET (2019) Reversible RNA acylation for control of CRISPR-Cas9 gene editing.
Chemical Science. [IF=1.563, Cited=20, 34084356].
Park HS, Jash B, Xiao L, ..., Kool E (2021) Control of RNA with quinone methide reversible acylating reagents. Organic
and Biomolecular Chemistry. [IF=0.77, Cited=4, 34528657].
Jash B, Kool E (2022) Conjugation of RNA via 2'-OH acylation: Mechanisms determining nucleotide reactivity.
Chemical Communications. [IF=0.902, Cited=4, 35226025].
Shioi R, Xiao L, Fang L, Kool E (2023) Efficient post-synthesis incorporation and conjugation of reactive ketones in RNA
via 2'-acylation. Chemical Communications. [IF=0.902, Cited=0, 38054242].
Shioi R, Xiao L, Chatterjee S, Kool E (2023) Stereoselective RNA reaction with chiral 2'-OH acylating agents. Chemical
Science. [IF=1.563, Cited=1, 38023505].
Ohmichi T, Maki A, Kool E (2001) Efficient bacterial transcription of DNA nanocircle vectors with optimized single-
stranded promoters. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=19, 11752404].
Kim TW, Delaney JC, Essigmann JM, Kool E (2005) Probing the active site tightness of DNA polymerase in subangstrom
increments. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=83, 16249340].
Abe H, Kool E (2005) Flow cytometric detection of specific RNAs in native human cells with quenched autoligating FRET
probes. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=75, 16384914].
Delaney JC, Henderson PT, Helquist SA, ..., Kool E (2003) High-fidelity in vivo replication of DNA base shape mimics
without Watson-Crick hydrogen bonds. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=41, 12676985].
Guo J, Wang S, Dai N, ..., Kool E (2011) Multispectral labeling of antibodies with polyfluorophores on a DNA backbone
and application in cellular imaging. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=39, 21321224].
Oertell K, Harcourt EM, Mohsen MG, ..., Goodman MF (2016) Kinetic selection vs. free energy of DNA base pairing in
control of polymerase fidelity. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=16, 27044101].
Saiki JP, Cao H, Van Wassenhove LD, ..., Mochly-Rosen D (2018) Aldehyde dehydrogenase 3A1 activation prevents radiation-
induced xerostomia by protecting salivary stem cells from toxic aldehydes. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=12, 29794221].
Rausch JW, Qu J, Yi-Brunozzi HY, ..., Le Grice SFJ (2003) Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine
isosteres defines regions essential for HIV type 1 polypurine tract selection. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=18, 12972638].
Lindstrom UM, Chandrasekaran RA, Orbai L, ..., Kool E (2002) Artificial human telomeres from DNA nanocircle templates.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=28, 12444252].
Gao S, Tahara Y, Kool E, Greenberg MM (2024) Promoter dependent RNA polymerase II bypass of the epimerizable DNA lesion,
Fapy•dG and 8-Oxo-2'-deoxyguanosine. Nucleic Acids Research. [IF=4.663, Cited=0, 38908029].
Ono T, Edwards SK, Wang S, ..., Kool E (2013) Monitoring eukaryotic and bacterial UDG repair activity with DNA-
multifluorophore sensors. Nucleic Acids Research. [IF=4.663, Cited=16, 23644286].
Xu L, Butler KV, Chong J, ..., Wang D (2014) Dissecting the chemical interactions and substrate structural signatures
governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues. Nucleic Acids Research. [IF=4.663,
Cited=12, 24692664].
Hwang CS, Xu L, Wang W, ..., Wang D (2016) Functional interplay between NTP leaving group and base pair recognition
during RNA polymerase II nucleotide incorporation revealed by methylene substitution. Nucleic Acids Research. [IF=4.663,
Cited=3, 27060150].
Kent T, Rusanov TD, Hoang TM, ..., Pomerantz RT (2016) DNA polymerase θ specializes in incorporating synthetic expanded-
size (xDNA) nucleotides. Nucleic Acids Research. [IF=4.663, Cited=13, 27591252].
Ji D, Stepchenkova EI, Cui J, ..., Kool E (2017) Measuring deaminated nucleotide surveillance enzyme ITPA activity with
an ATP-releasing nucleotide chimera. Nucleic Acids Research. [IF=4.663, Cited=4, 29036687].
Mohsen MG, Ji D, Kool E (2019) Polymerase synthesis of four-base DNA from two stable dimeric nucleotides. Nucleic Acids
Research. [IF=4.663, Cited=5, 31504784].
Kool E, Lu H, Kim SJ, ..., Liu H (2006) New designs for DNA bases: expanded DNAs and oligofluorosides. None. [IF=None,
Cited=6, 17150794].
Xiao L, Fang L, Kool E (2023) RNA Infrastructure Profiling Illuminates Transcriptome Structure in Crowded Spaces. None.
[IF=None, Cited=0, 37873487].
Kool E (2000) Roles of Watson-Crick and minor groove hydrogen bonds in DNA replication. Cold Spring Harbor Symposia on
Quantitative Biology. [IF=0.889, Cited=4, 12760024].
Liu H, Gao J, Lynch SR, ..., Kool E (2003) A four-base paired genetic helix with expanded size. Science. [IF=7.729,
Cited=103, 14593180].
Washington MT, Helquist SA, Kool E, ..., Prakash S (2003) Requirement of Watson-Crick hydrogen bonding for DNA synthesis
by yeast DNA polymerase eta. Molecular and Cellular Biology. [IF=1.026, Cited=49, 12832493].
Niimi A, Limsirichaikul S, Yoshida S, ..., Suzuki M (2004) Palm mutants in DNA polymerases alpha and eta alter DNA
replication fidelity and translesion activity. Molecular and Cellular Biology. [IF=1.026, Cited=65, 15024063].
Wolfle WT, Washington MT, Kool E, ..., Prakash S (2005) Evidence for a Watson-Crick hydrogen bonding requirement in DNA
synthesis by human DNA polymerase kappa. Molecular and Cellular Biology. [IF=1.026, Cited=36, 16055723].
Kool E (2001) Active site tightness and substrate fit in DNA replication. Annual Review of Biochemistry. [IF=5.273,
Cited=228, 12045095].
Kool E (2001) Hydrogen bonding, base stacking, and steric effects in dna replication. None. [IF=None, Cited=211, 11340050].
Samaranayake GJ, Troccoli CI, Zhang L, ..., Rai P (2019) The Existence of MTH1-independent 8-oxodGTPase Activity in
Cancer Cells as a Compensatory Mechanism against On-target Effects of MTH1 Inhibitors. Molecular Cancer Therapeutics.
[IF=1.04, Cited=6, 31744893].
Lee B, Flynn RA, Kadina A, ..., Chang HY (2016) Comparison of SHAPE reagents for mapping RNA structures inside living
cells. RNA. [IF=0.956, Cited=47, 27879433].
Beharry AA, Nagel ZD, Samson LD, Kool E (2016) Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical
Predictor of Antitumor Drug Response. PLoS ONE. [IF=1.253, Cited=11, 27035132].
Nagel ZD, Beharry AA, Mazzucato P, ..., Samson LD (2019) Fluorescent reporter assays provide direct, accurate,
quantitative measurements of MGMT status in human cells. PLoS ONE. [IF=1.253, Cited=8, 30811507].
Thomas D, Palczewski M, Kuschman H, ..., Sierk M (2024) Nitric oxide inhibits ten-eleven translocation DNA demethylases
to regulate 5mC and 5hmC across the genome. None. [IF=None, Cited=0, 38645113].
Qin S, Lin P, Wu Q, ..., Wu M (2020) Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory
Responses during Pseudomonas aeruginosa Infection. Journal of Immunology. [IF=0.939, Cited=23, 32929043].

Publication with MISSING institution:

Strässler C, Davis NE, Kool E (1999) Novel Nucleoside Analogues with Fluorophores Replacing the DNA Base. Helvetica
Chimica Acta. [IF=0.467, Cited=16, 20016809].
Smietana M, Kool E (2002) Efficient and simple solid-phase synthesis of short cyclic oligodeoxynucleotides bearing a
phosphorothioate linkage. Angewandte Chemie - International Edition. [IF=2.456, Cited=9, 12370937].
Rubin E, Kool E (1994) Strong, Specific Binding of Six Different DNA Sequences by a Single Conformation-Switching DNA
Macrocycle. Angewandte Chemie - International Edition. [IF=2.456, Cited=2, 20808717].
Ren XF, Schweitzer BA, Sheils CJ, Kool E (1996) Formation of Stable DNA Loops by Incorporation of Nonpolar, Non-
Hydrogen-Bonding Nucleoside Isosteres. Angewandte Chemie - International Edition. [IF=2.456, Cited=9, 20882114].
Guckian KM, Kool E (1997) Highly Precise Shape Mimicry by a Difluorotoluene Deoxynucleoside, a Replication-Competent
Substitute for Thymidine. Angewandte Chemie - International Edition. [IF=2.456, Cited=24, 20882112].
Lai JS, Qu J, Kool E (2003) Fluorinated DNA bases as probes of electrostatic effects in DNA base stacking. Angewandte
Chemie - International Edition. [IF=2.456, Cited=27, 14679546].
Lu H, He K, Kool E (2004) yDNA: a new geometry for size-expanded base pairs. Angewandte Chemie - International Edition.
[IF=2.456, Cited=25, 15523708].
Gao J, Liu H, Kool E (2005) Assembly of the complete eight-base artificial genetic helix, xDNA, and its interaction with
the natural genetic system. Angewandte Chemie - International Edition. [IF=2.456, Cited=26, 15834852].
Sintim HO, Kool E (2006) Remarkable sensitivity to DNA base shape in the DNA polymerase active site. Angewandte Chemie -
International Edition. [IF=2.456, Cited=32, 16506248].
Somoza A, Chelliserrykattil J, Kool E (2006) The roles of hydrogen bonding and sterics in RNA interference. Angewandte
Chemie - International Edition. [IF=2.456, Cited=16, 16802393].
Delaney JC, Gao J, Liu H, ..., Kool E (2009) Efficient replication bypass of size-expanded DNA base pairs in bacterial
cells. Angewandte Chemie - International Edition. [IF=2.456, Cited=25, 19444841].
Samain F, Ghosh S, Teo YN, Kool E (2010) Polyfluorophores on a DNA backbone: sensors of small molecules in the vapor
phase. Angewandte Chemie - International Edition. [IF=2.456, Cited=16, 20721995].
Dai N, Guo J, Teo YN, Kool E (2011) Protease probes built from DNA: multispectral fluorescent DNA-peptide conjugates as
caspase chemosensors. Angewandte Chemie - International Edition. [IF=2.456, Cited=11, 21455915].
Ono T, Wang S, Koo CK, ..., Kool E (2012) Direct fluorescence monitoring of DNA base excision repair. Angewandte Chemie
- International Edition. [IF=2.456, Cited=26, 22241823].
Wang S, Guo J, Ono T, Kool E (2012) DNA polyfluorophores for real-time multicolor tracking of dynamic biological
systems. Angewandte Chemie - International Edition. [IF=2.456, Cited=11, 22684777].
Winnacker M, Kool E (2013) Artificial genetic sets composed of size-expanded base pairs. Angewandte Chemie -
International Edition. [IF=2.456, Cited=22, 24249550].
Yuen LH, Franzini RM, Wang S, ..., Kool E (2014) Pattern-based detection of toxic metals in surface water with DNA
polyfluorophores. Angewandte Chemie - International Edition. [IF=2.456, Cited=15, 24756982].
Hartig JS, Fernandez-Lopez S, Kool E (2005) Guanine-rich DNA nanocircles for the synthesis and characterization of long
cytosine-rich telomeric DNAs. ChemBioChem. [IF=0.691, Cited=7, 16052615].
Cho Y, Kool E (2006) Enzymatic synthesis of fluorescent oligomers assembled on a DNA backbone. ChemBioChem. [IF=0.691,
Cited=32, 16502476].
Silverman AP, Baron EJ, Kool E (2006) RNA-templated chemistry in cells: discrimination of Escherichia, Shigella and
Salmonella bacterial strains with a new two-color FRET strategy. ChemBioChem. [IF=0.691, Cited=18, 17031884].
Wilson JN, Cho Y, Tan S, ..., Kool E (2008) Quenching of fluorescent nucleobases by neighboring DNA: the "insulator"
concept. ChemBioChem. [IF=0.691, Cited=49, 18072185].
Chelliserrykattil J, Lu H, Lee AHF, Kool E (2008) Polymerase amplification, cloning, and gene expression of benzo-
homologous "yDNA" base pairs. ChemBioChem. [IF=0.691, Cited=17, 19053129].
Franzini RM, Kool E (2008) 7-Azidomethoxy-coumarins as profluorophores for templated nucleic acid detection.
ChemBioChem. [IF=0.691, Cited=34, 19035374].
Lu H, Lynch SR, Lee AHF, Kool E (2009) Structure and replication of yDNA: a novel genetic set widened by benzo-
homologation. ChemBioChem. [IF=0.691, Cited=8, 19780073].
Li H, Franzini RM, Bruner C, Kool E (2010) Templated chemistry for sequence-specific fluorogenic detection of duplex
DNA. ChemBioChem. [IF=0.691, Cited=14, 20859985].
Jung JW, Edwards SK, Kool E (2013) Selective fluorogenic chemosensors for distinct classes of nucleases. ChemBioChem.
[IF=0.691, Cited=7, 23371801].
Smietana M, Johnson RB, Wang QM, Kool E (2004) Solid-phase synthesis and screening of macrocyclic nucleotide-hybrid
compounds targeted to hepatitis C NS5B. Chemistry - A European Journal. [IF=0.899, Cited=4, 14695562].
Lai JS, Kool E (2005) Fluorous base-pairing effects in a DNA polymerase active site. Chemistry - A European Journal.
[IF=0.899, Cited=5, 15744767].
Somoza A, Silverman AP, Miller RM, ..., Kool E (2008) Steric effects in RNA interference: probing the influence of
nucleobase size and shape. Chemistry - A European Journal. [IF=0.899, Cited=13, 18624291].
Teo YN, Wilson JN, Kool E (2009) Polyfluorophore labels on DNA: dramatic sequence dependence of quenching. Chemistry - A
European Journal. [IF=0.899, Cited=9, 19780115].
Franzini RM, Kool E (2011) Two successive reactions on a DNA template: a strategy for improving background fluorescence
and specificity in nucleic acid detection. Chemistry - A European Journal. [IF=0.899, Cited=15, 21294182].
Samain F, Dai N, Kool E (2010) Differentiating a diverse range of volatile organic compounds with polyfluorophore
sensors built on a DNA scaffold. Chemistry - A European Journal. [IF=0.899, Cited=12, 21207614].
Sun W, Hattman S, Kool E (1997) Interaction of the bacteriophage Mu transcriptional activator protein, C, with its
target site in the mom promoter. Journal of Molecular Biology. [IF=1.281, Cited=7, 9367769].
Hansma HG, Golan R, Hsieh W, ..., Kool E (1999) Polymerase activities and RNA structures in the atomic force microscope.
Journal of Structural Biology. [IF=0.773, Cited=17, 10544049].
Silverman AP, Abe H, Kool E (2008) Quenched autoligation probes. Methods in Molecular Biology. [IF=0.413, Cited=3, 18695965].
Thomson NH, Smith BL, Almqvist N, ..., Hansma PK (1999) Oriented, active Escherichia coli RNA polymerase: an atomic
force microscope study. Biophysical Journal. [IF=0.842, Cited=19, 9916034].
Xu Y, Kool E (1997) A Novel 5'-Iodonucleoside Allows Efficient Nonenzymatic Ligation of Single-stranded and Duplex DNAs.
Tetrahedron Letters. [IF=0.515, Cited=28, 19924262].
Diegelman AM, Kool E (1999) Mimicry of the hepatitis delta virus replication cycle mediated by synthetic circular
oligodeoxynucleotides. None. [IF=None, Cited=8, 10421762].
Miller GP, Silverman AP, Kool E (2007) New, stronger nucleophiles for nucleic acid-templated chemistry: Synthesis and
application in fluorescence detection of cellular RNA. Bioorganic and Medicinal Chemistry. [IF=0.86, Cited=21, 17502150].
Krueger AT, Kool E (2007) Model systems for understanding DNA base pairing. Current Opinion in Chemical Biology.
[IF=1.51, Cited=43, 17967435].
Krueger AT, Kool E (2009) Redesigning the architecture of the base pair: toward biochemical and biological function of
new genetic sets. None. [IF=None, Cited=34, 19318205].
Garforth SJ, Kim TW, Parniak MA, ..., Prasad VR (2006) Site-directed mutagenesis in the fingers subdomain of HIV-1
reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection. Journal of Molecular
Biology. [IF=1.281, Cited=17, 17055529].
Wilson JN, Gao J, Kool E (2007) Oligodeoxyfluorosides: Strong Sequence Dependence of Fluorescence Emission. Tetrahedron.
[IF=0.579, Cited=37, 17940588].
Silverman AP, Kool E (2005) Quenched probes for highly specific detection of cellular RNAs. Trends in Biotechnology.
[IF=2.875, Cited=52, 15865999].
Wang S, Xu Y, Kool E (1997) Recognition of RNA by triplex formation: divergent effects of pyrimidine C-5 methylation.
Bioorganic and Medicinal Chemistry. [IF=0.86, Cited=4, 9222497].
Liu D, Moran S, Kool E (1997) Bi-stranded, multisite replication of a base pair between difluorotoluene and adenine:
confirmation by 'inverse' sequencing. None. [IF=None, Cited=15, 9427657].
Ryan K, Kool E (1998) Triplex-directed self-assembly of an artificial sliding clamp on duplex DNA. None. [IF=None,
Cited=21, 9495829].
Begley TJ, Haas BJ, Morales JC, ..., Cunningham RP (2003) Kinetics and binding of the thymine-DNA mismatch glycosylase,
Mig-Mth, with mismatch-containing DNA substrates. DNA Repair. [IF=0.925, Cited=5, 12509271].
Wang S, Kool E (1995) Origins of the large differences in stability of DNA and RNA helices: C-5 methyl and 2'-hydroxyl
effects. Biochemistry. [IF=0.753, Cited=88, 7535100].
Wang S, Friedman AE, Kool E (1995) Origins of high sequence selectivity: a stopped-flow kinetics study of DNA/RNA
hybridization by duplex- and triplex-forming oligonucleotides. Biochemistry. [IF=0.753, Cited=31, 7542923].
Wang S, Booher MA, Kool E (1994) Stabilities of nucleotide loops bridging the pyrimidine strands in DNA
pyrimidine.purine.pyrimidine triplexes: special stability of the CTTTG loop. Biochemistry. [IF=0.753, Cited=18, 8161520].
Booher MA, Wang S, Kool E (1994) Base pairing and steric interactions between pyrimidine strand bridging loops and the
purine strand in DNA pyrimidine.purine.pyrimidine triplexes. Biochemistry. [IF=0.753, Cited=15, 8161521].
Rubin E, McKee TL, Kool E (1993) Binding of Two Different DNA Sequences by Conformational Switching. Journal of the
American Chemical Society. [IF=2.573, Cited=4, 20808716].
Wang S, Kool E (1994) Recognition of Single-Stranded Nucleic Acids by Triplex Formation: The Binding of Pyrimidine-Rich
Sequences. Journal of the American Chemical Society. [IF=2.573, Cited=18, 20882109].
Schweitzer BA, Kool E (1995) Hydrophobic, Non-Hydrogen-Bonding Bases and Base Pairs in DNA. Journal of the American
Chemical Society. [IF=2.573, Cited=96, 20882111].
Rumney S, Kool E (1995) Structural Optimization of Non-Nucleotide Loop Replacements for Duplex and Triplex DNAs. Journal
of the American Chemical Society. [IF=2.573, Cited=32, 20871801].
Chaudhuri NC, Kool E (1995) Very High Affinity DNA Recognition by Bicyclic and Cross-Linked Oligonucleotides. Journal of
the American Chemical Society. [IF=2.573, Cited=20, 20882118].
Roost C, Lynch SR, Batista PJ, ..., Kool E (2015) Correction to "Structure and Thermodynamics of N(6)-Methyladenosine in
RNA: A Spring-Loaded Base Modification". Journal of the American Chemical Society. [IF=2.573, Cited=3, 26087989].
Yuen LH, Franzini RM, Tan SS, Kool E (2015) Correction to "Large-Scale Detection of Metals with a Small Set of
Fluorescent DNA-Like Chemosensors". Journal of the American Chemical Society. [IF=2.573, Cited=0, 26088103].
Singh V, Wang S, Chan KM, ..., Kool E (2017) Correction to "Genetically Encoded Multispectral Labeling of Proteins with
Polyfluorophores on a DNA Backbone". Journal of the American Chemical Society. [IF=2.573, Cited=0, 28128555].
Schweitzer BA, Kool E (1994) Aromatic Nonpolar Nucleosides as Hydrophobic Isosteres of Pyrimidine and Purine
Nucleosides. Journal of Organic Chemistry. [IF=0.885, Cited=80, 20882116].
Soliday E, Kool E, Lande MB (2001) Family environment, child behavior, and medical indicators in children with kidney
disease. Child Psychiatry and Human Development. [IF=1.292, Cited=23, 11227988].
Matray TJ, Kool E (1999) A specific partner for abasic damage in DNA. Nature. [IF=11.591, Cited=103, 10385125].
Morales JC, Kool E (1998) Efficient replication between non-hydrogen-bonded nucleoside shape analogs. None. [IF=None,
Cited=124, 9808038].
Guckian KM, Krugh TR, Kool E (1998) Solution structure of a DNA duplex containing a replicable difluorotoluene-adenine
pair. None. [IF=None, Cited=63, 9808039].
Xu Y, Karalkar NB, Kool E (2001) Nonenzymatic autoligation in direct three-color detection of RNA and DNA point
mutations. Nature Biotechnology. [IF=8.861, Cited=86, 11175729].
Spitale RC, Flynn RA, Zhang QC, ..., Chang HY (2015) Erratum: Structural imprints in vivo decode RNA regulatory
mechanisms. Nature. [IF=11.591, Cited=7, 26416736].
Daubendiek SL, Kool E (1997) Generation of catalytic RNAs by rolling transcription of synthetic DNA nanocircles. Nature
Biotechnology. [IF=8.861, Cited=42, 9062929].
Karmakar S, Harcourt EM, Hewings DS, ..., Kool E (2015) Corrigendum: Organocatalytic removal of formaldehyde adducts
from RNA and DNA bases. Nature Chemistry. [IF=3.667, Cited=0, 26587722].
Spitale RC, Crisalli P, Flynn RA, ..., Chang HY (2012) RNA SHAPE analysis in living cells. Nature Chemical Biology.
[IF=2.623, Cited=255, 23178934].
Livingston AL, O'Shea VL, Kim T, ..., David SS (2007) Unnatural substrates reveal the importance of 8-oxoguanine for in
vivo mismatch repair by MutY. Nature Chemical Biology. [IF=2.623, Cited=27, 18026095].
Jiang W, Wang S, Yuen LH, ..., Kool E (2013) DNA-polyfluorophore Chemosensors for Environmental Remediation: Vapor-phase
Identification of Petroleum Products in Contaminated Soil. Chemical Science. [IF=1.563, Cited=8, 23878719].
Wilson JN, Kool E (2006) Fluorescent DNA base replacements: Reporters and sensors for biological systems. Organic and
Biomolecular Chemistry. [IF=0.77, Cited=115, 17102869].
Dai N, Teo YN, Kool E (2010) DNA-polyfluorophore excimers as sensitive reporters for esterases and lipases. Chemical
Communications. [IF=0.902, Cited=13, 20449256].
Lu H, Krueger AT, Gao J, ..., Kool E (2010) Toward a designed genetic system with biochemical function: polymerase
synthesis of single and multiple size-expanded DNA base pairs. Organic and Biomolecular Chemistry. [IF=0.77, Cited=16, 20407680].
Kleinbaum DJ, Kool E (2010) Sandwich probes: two simultaneous reactions for templated nucleic acid detection. Chemical
Communications. [IF=0.902, Cited=8, 20927470].
Dai N, Kool E (2011) Fluorescent DNA-based enzyme sensors. Chemical Society Reviews. [IF=8.116, Cited=62, 21290032].
Khakshoor O, Kool E (2011) Chemistry of nucleic acids: impacts in multiple fields. Chemical Communications. [IF=0.902,
Cited=20, 21483917].
Koo CK, Wang S, Gaur RL, ..., Kool E (2011) Fluorescent DNA chemosensors: identification of bacterial species by their
volatile metabolites. Chemical Communications. [IF=0.902, Cited=6, 21935547].
Lee SH, Wang S, Kool E (2012) Templated chemistry for monitoring damage and repair directly in duplex DNA. Chemical
Communications. [IF=0.902, Cited=5, 22782065].
Chaudhuri NC, Ren RXF, Kool E (1997) C-Nucleosides Derived from Simple Aromatic Hydrocarbons. Synlett. [IF=0.473,
Cited=15, 20336193].
Schofield MJ, Brownewell FE, Nayak S, ..., Hsieh P (2001) The Phe-X-Glu DNA binding motif of MutS. The role of hydrogen
bonding in mismatch recognition. Journal of Biological Chemistry. [IF=1.122, Cited=61, 11602569].
Drotschmann K, Yang W, Brownewell FE, ..., Kunkel TA (2001) Asymmetric recognition of DNA local distortion. Structure-
based functional studies of eukaryotic Msh2-Msh6. Journal of Biological Chemistry. [IF=1.122, Cited=44, 11641390].
Kim TW, Brieba LG, Ellenberger T, Kool E (2005) Functional evidence for a small and rigid active site in a high fidelity
DNA polymerase: probing T7 DNA polymerase with variably sized base pairs. Journal of Biological Chemistry. [IF=1.122,
Cited=45, 16311403].
Yakovleva L, Lai J, Kool E, Shuman S (2006) Nonpolar nucleobase analogs illuminate requirements for site-specific DNA
cleavage by vaccinia topoisomerase. Journal of Biological Chemistry. [IF=1.122, Cited=7, 17005552].
Lee HR, Helquist SA, Kool E, Johnson KA (2007) Base pair hydrogen bonds are essential for proofreading selectivity by
the human mitochondrial DNA polymerase. Journal of Biological Chemistry. [IF=1.122, Cited=10, 17650503].
Lee HR, Helquist SA, Kool E, Johnson KA (2007) Importance of hydrogen bonding for efficiency and specificity of the
human mitochondrial DNA polymerase. Journal of Biological Chemistry. [IF=1.122, Cited=28, 17650502].
D'Souza DJ, Kool E (1992) Strong binding of single-stranded DNA by stem-loop oligonucleotides. Journal of Biomolecular
Structure and Dynamics. [IF=1.22, Cited=16, 1418737].
Barsky D, Kool E, Colvin ME (1999) Interaction and solvation energies of nonpolar DNA base analogues and their role in
polymerase insertion fidelity. Journal of Biomolecular Structure and Dynamics. [IF=1.22, Cited=18, 10447197].
Soliday E, Kool E, Lande MB (2000) Psychosocial adjustment in children with kidney disease. Journal of Pediatric
Psychology. [IF=1.269, Cited=40, 10820947].
Wang S, Kool E (1994) Circular RNA oligonucleotides. Synthesis, nucleic acid binding properties, and a comparison with
circular DNAs. Nucleic Acids Research. [IF=4.663, Cited=44, 7518582].
Vo T, Wang S, Kool E (1995) Targeting pyrimidine single strands by triplex formation: structural optimization of
binding. Nucleic Acids Research. [IF=4.663, Cited=13, 7544889].
Rubin E, Rumney S, Wang S, Kool E (1995) Convergent DNA synthesis: a non-enzymatic dimerization approach to circular
oligodeoxynucleotides. Nucleic Acids Research. [IF=4.663, Cited=34, 7567468].
Wang S, Kool E (1995) Relative stabilities of triple helices composed of combinations of DNA, RNA and 2'-O-methyl-RNA
backbones: chimeric circular oligonucleotides as probes. Nucleic Acids Research. [IF=4.663, Cited=31, 7537873].
Moran S, Ren RX, Sheils CJ, ..., Kool E (1996) Non-hydrogen bonding 'terminator' nucleosides increase the 3'-end
homogeneity of enzymatic RNA and DNA synthesis. Nucleic Acids Research. [IF=4.663, Cited=34, 8668534].
Xu Y, Kool E (1998) Chemical and enzymatic properties of bridging 5'-S-phosphorothioester linkages in DNA. Nucleic Acids
Research. [IF=4.663, Cited=29, 9628913].
Diegelman AM, Kool E (1998) Generation of circular RNAs and trans-cleaving catalytic RNAs by rolling transcription of
circular DNA oligonucleotides encoding hairpin ribozymes. Nucleic Acids Research. [IF=4.663, Cited=31, 9628924].
Paris PL, Langenhan JM, Kool E (1998) Probing DNA sequences in solution with a monomer-excimer fluorescence color
change. Nucleic Acids Research. [IF=4.663, Cited=88, 9685497].
Xu Y, Kool E (1999) High sequence fidelity in a non-enzymatic DNA autoligation reaction. Nucleic Acids Research.
[IF=4.663, Cited=36, 9889286].
Ohmichi T, Kool E (2000) The virtues of self-binding: high sequence specificity for RNA cleavage by self-processed
hammerhead ribozymes. Nucleic Acids Research. [IF=4.663, Cited=10, 10637330].
Smirnov S, Matray TJ, Kool E, de los Santos C (2002) Integrity of duplex structures without hydrogen bonding: DNA with
pyrene paired at abasic sites. Nucleic Acids Research. [IF=4.663, Cited=31, 12490724].
Maki A, Brownewell FE, Liu D, Kool E (2003) DNA curvature at A tracts containing a non-polar thymine mimic. Nucleic
Acids Research. [IF=4.663, Cited=6, 12560504].
Hartig JS, Kool E (2005) Efficient isothermal expansion of human telomeric and minisatellite repeats by Thermococcus
litoralis DNA polymerase. Nucleic Acids Research. [IF=4.663, Cited=2, 16284196].
Silverman AP, Kool E (2005) Quenched autoligation probes allow discrimination of live bacterial species by single
nucleotide differences in rRNA. Nucleic Acids Research. [IF=4.663, Cited=40, 16284198].
Terrazas M, Kool E (2008) RNA major groove modifications improve siRNA stability and biological activity. Nucleic Acids
Research. [IF=4.663, Cited=50, 19042976].
Jarchow-Choy SK, Krueger AT, Liu H, ..., Kool E (2010) Fluorescent xDNA nucleotides as efficient substrates for a
template-independent polymerase. Nucleic Acids Research. [IF=4.663, Cited=19, 20947563].
Harcourt EM, Kool E (2012) Amplified microRNA detection by templated chemistry. Nucleic Acids Research. [IF=4.663,
Cited=44, 22278881].
Lindström UM, Kool E (2002) An orthogonal oligonucleotide protecting group strategy that enables assembly of repetitive
or highly structured DNAs. Nucleic Acids Research. [IF=4.663, Cited=10, 12364618].
Hartig JS, Kool E (2004) Small circular DNAs for synthesis of the human telomere repeat: varied sizes, structures and
telomere-encoding activities. Nucleic Acids Research. [IF=4.663, Cited=14, 15520461].
Sando S, Kool E (2002) Nonenzymatic DNA ligation in Escherichia coli cells. None. [IF=None, Cited=0, 12903135].
Abe H, Kool E (2005) Universal linkers for signal amplification in auto-ligating probes. None. [IF=None, Cited=0, 17150621].
Taniguchi Y, Kool E (2007) Syntheses and properties of low-polarity shape mimics of 8-oxopurines. None. [IF=None,
Cited=0, 18029664].
Teo YN, Kool E (2008) Studies of oligodeoxyfluorosides (ODFs) as FRET probes for DNA hybridization. None. [IF=None,
Cited=1, 18776339].
Krueger AT, Lu H, Højland T, ..., Kool E (2008) Towards the replication of xDNA, a size-expanded unnatural genetic
system. None. [IF=None, Cited=1, 18776450].
Drotschmann K, Hall MC, Shcherbakova PV, ..., Kunkel TA (2002) DNA binding properties of the yeast Msh2-Msh6 and
Mlh1-Pms1 heterodimers. Biological Chemistry. [IF=0.824, Cited=25, 12222686].
Rowley PT, Kosciolek BA, Kool E (1999) Circular antisense oligonucleotides inhibit growth of chronic myeloid leukemia
cells. Molecular Medicine. [IF=1.026, Cited=0, 10602778].
Silverman AP, Kool E (2007) Oligonucleotide probes for RNA-targeted fluorescence in situ hybridization. Advances in
Clinical Chemistry. [IF=0.907, Cited=0, 17249381].

Kool, Eric

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