Kobilka, Brian K

Publication with MATCHING institution:

Wang H, Hetzer F, Huang W, ..., Gmeiner P (2022) Structure-Based Evolution of G Protein-Biased μ-Opioid Receptor
Agonists. Angewandte Chemie - International Edition. [IF=2.456, Cited=16, 35385593].
Ehsan M, Kumar A, Mortensen JS, ..., Chae PS (2019) Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its
Application for Membrane Protein Study. Chemistry - An Asian Journal. [IF=0.736, Cited=3, 30969484].
Cho KH, Hariharan P, Mortensen JS, ..., Chae PS (2016) Isomeric Detergent Comparison for Membrane Protein Stability:
Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length. ChemBioChem. [IF=0.691, Cited=13, 27981750].
Ehsan M, Das M, Stern V, ..., Chae PS (2018) Steroid-Based Amphiphiles for Membrane Protein Study: The Importance of
Alkyl Spacers for Protein Stability. ChemBioChem. [IF=0.691, Cited=1, 29660780].
Das M, Du Y, Mortensen JS, ..., Chae PS (2018) Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane
Protein Stabilization Efficacy. ChemBioChem. [IF=0.691, Cited=2, 30070754].
Ehsan M, Wang H, Katsube S, ..., Chae PS (2022) Glyco-Steroidal Amphiphiles (GSAs) for Membrane Protein Structural
Study. ChemBioChem. [IF=0.691, Cited=1, 35129249].
Cho KH, Du Y, Scull NJ, ..., Chae PS (2015) Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein
Stabilisation. Chemistry - A European Journal. [IF=0.899, Cited=13, 26013293].
Hussain H, Du Y, Scull NJ, ..., Chae PS (2016) Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein
Solubilisation and Stabilisation. Chemistry - A European Journal. [IF=0.899, Cited=33, 27072057].
Hussain H, Du Y, Tikhonova E, ..., Chae PS (2017) Resorcinarene-Based Facial Glycosides: Implication of Detergent
Flexibility on Membrane-Protein Stability. Chemistry - A European Journal. [IF=0.899, Cited=15, 28303608].
Ghani L, Kim S, Wang H, ..., Chae PS (2022) Foldable Detergents for Membrane Protein Study: Importance of Detergent Core
Flexibility in Protein Stabilization. Chemistry - A European Journal. [IF=0.899, Cited=5, 35238091].
Hinkle RT, Hodge KMB, Cody DB, ..., Isfort RJ (2002) Skeletal muscle hypertrophy and anti-atrophy effects of clenbuterol
are mediated by the beta2-adrenergic receptor. Muscle and Nerve. [IF=1.236, Cited=98, 11994968].
Kobilka BK (1995) Amino and carboxyl terminal modifications to facilitate the production and purification of a G
protein-coupled receptor. Analytical Biochemistry. [IF=0.706, Cited=103, 8678314].
Duc NM, Du Y, Zhang C, ..., Chung KY (2015) Effective application of bicelles for conformational analysis of G protein-
coupled receptors by hydrogen/deuterium exchange mass spectrometry. Journal of the American Society for Mass
Spectrometry. [IF=0.827, Cited=29, 25740347].
Bae HE, Cecchetti C, Du Y, ..., Chae PS (2020) Pendant-bearing glucose-neopentyl glycol (P-GNG) amphiphiles for membrane
protein manipulation: Importance of detergent pendant chain for protein stabilization. None. [IF=None, Cited=10, 32522715].
Sadaf A, Kim S, Bae HE, ..., Chae PS (2021) Conformationally flexible core-bearing detergents with a hydrophobic or
hydrophilic pendant: Effect of pendant polarity on detergent conformation and membrane protein stability. None.
[IF=None, Cited=6, 33933694].
Kobilka BK (2006) G protein coupled receptor structure and activation. None. [IF=None, Cited=280, 17188232].
Manglik A, Kim TH, Masureel M, ..., Kobilka BK (2015) Structural Insights into the Dynamic Process of β2-Adrenergic
Receptor Signaling. Cell. [IF=8.479, Cited=333, 25981665].
Komolov KE, Du Y, Duc NM, ..., Benovic JL (2017) Structural and Functional Analysis of a β₂-Adrenergic
Receptor Complex with GRK5. Cell. [IF=8.479, Cited=93, 28431242].
Krishna Kumar K, Shalev-Benami M, Robertson MJ, ..., Skiniotis G (2019) Structure of a Signaling Cannabinoid Receptor
1-G Protein Complex. Cell. [IF=8.479, Cited=172, 30639101].
Wingler LM, Elgeti M, Hilger D, ..., Lefkowitz RJ (2019) Angiotensin Analogs with Divergent Bias Stabilize Distinct
Receptor Conformations. Cell. [IF=8.479, Cited=117, 30639099].
Liu X, Xu X, Hilger D, ..., Kobilka BK (2019) Structural Insights into the Process of GPCR-G Protein Complex Formation.
Cell. [IF=8.479, Cited=72, 31080070].
Du Y, Duc NM, Rasmussen SGF, ..., Chung KY (2019) Assembly of a GPCR-G Protein Complex. Cell. [IF=8.479, Cited=85, 31080064].
Latorraca NR, Masureel M, Hollingsworth SA, ..., Dror RO (2020) How GPCR Phosphorylation Patterns Orchestrate Arrestin-
Mediated Signaling. Cell. [IF=8.479, Cited=58, 33296703].
Wei TT, Chandy M, Nishiga M, ..., Wu JC (2022) Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced
vascular inflammation. Cell. [IF=8.479, Cited=23, 35489334].
Janetzko J, Kise R, Barsi-Rhyne B, ..., Kobilka BK (2022) Membrane phosphoinositides regulate GPCR-β-arrestin complex
assembly and dynamics. Cell. [IF=8.479, Cited=16, 36368322].
Krishna Kumar K, O'Brien ES, Habrian CH, ..., Kobilka BK (2023) Negative allosteric modulation of the glucagon receptor
by RAMP2. Cell. [IF=8.479, Cited=9, 37001505].
Seven AB, Hilger D, Papasergi-Scott MM, ..., Skiniotis G (2020) Structures of Gα Proteins in Complex with Their
Chaperone Reveal Quality Control Mechanisms. Cell Reports. [IF=1.738, Cited=10, 32126208].
Kruse AC, Hu J, Kobilka BK, Wess J (2014) Muscarinic acetylcholine receptor X-ray structures: potential implications for
drug development. Current Opinion in Pharmacology. [IF=0.854, Cited=21, 24662799].
Tsutsumi N, Qu Q, Mavri M, ..., Garcia KC (2021) Structural basis for the constitutive activity and immunomodulatory
properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1. Immunity. [IF=5.119, Cited=13, 34216564].
Xu J, Hu Y, Kaindl J, ..., Kobilka BK (2019) Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by
NMR Spectroscopy. Molecular Cell. [IF=2.773, Cited=31, 31103421].
Thorsen TS, Matt R, Weis WI, Kobilka BK (2014) Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled
Receptor Crystallogenesis. Structure. [IF=1.155, Cited=70, 25450769].
Spoerri PM, Kato HE, Pfreundschuh M, ..., Müller DJ (2018) Structural Properties of the Human Protease-Activated
Receptor 1 Changing by a Strong Antagonist. Structure. [IF=1.155, Cited=8, 29731231].
Spoerri PM, Sapra KT, Zhang C, ..., Müller DJ (2019) Conformational Plasticity of Human Protease-Activated Receptor 1
upon Antagonist- and Agonist-Binding. Structure. [IF=1.155, Cited=4, 31422910].
Kobilka BK, Deupi X (2007) Conformational complexity of G-protein-coupled receptors. Trends in Pharmacological Sciences.
[IF=2.377, Cited=387, 17629961].
Kobilka BK (2011) Structural insights into adrenergic receptor function and pharmacology. Trends in Pharmacological
Sciences. [IF=2.377, Cited=105, 21414670].
Kobilka BK, Gether U (2002) Use of fluorescence spectroscopy to study conformational changes in the beta 2-adrenoceptor.
None. [IF=None, Cited=18, 11665566].
Kobilka BK, Gether U (1998) Examination of ligand-induced conformational changes in the beta 2-adrenergic receptor by
fluorescence spectroscopy. None. [IF=None, Cited=3, 9327941].
Whelan RJ, Wohland T, Neumann L, ..., Zare RN (2002) Analysis of biomolecular interactions using a miniaturized surface
plasmon resonance sensor. Analytical Chemistry. [IF=1.41, Cited=18, 12236371].
Ehsan M, Katsube S, Cecchetti C, ..., Chae PS (2020) New Malonate-Derived Tetraglucoside Detergents for Membrane Protein
Stability. ACS Chemical Biology. [IF=0.963, Cited=6, 32501004].
Ehsan M, Wang H, Cecchetti C, ..., Chae PS (2021) Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-
tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability. ACS Chemical Biology. [IF=0.963, Cited=2, 34445864].
Sadaf A, Ramos M, Mortensen JS, ..., Chae PS (2019) Conformationally Restricted Monosaccharide-Cored Glycoside
Amphiphiles: The Effect of Detergent Headgroup Variation on Membrane Protein Stability. ACS Chemical Biology. [IF=0.963,
Cited=7, 31305987].
Lin S, Gether U, Kobilka BK (1996) Ligand stabilization of the beta 2 adrenergic receptor: effect of DTT on receptor
conformation monitored by circular dichroism and fluorescence spectroscopy. Biochemistry. [IF=0.753, Cited=17, 8931540].
Lee TW, Seifert R, Guan X, Kobilka BK (1999) Restricting the mobility of Gs alpha: impact on receptor and effector
coupling. Biochemistry. [IF=0.753, Cited=10, 10529225].
Kim TH, Chung KY, Manglik A, ..., Prosser RS (2013) The role of ligands on the equilibria between functional states of a
G protein-coupled receptor. Journal of the American Chemical Society. [IF=2.573, Cited=96, 23721409].
Das M, Mahler F, Hariharan P, ..., Chae PS (2020) Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for
Membrane Protein Study. Journal of the American Chemical Society. [IF=2.573, Cited=5, 33315387].
Li Y, Heng J, Sun D, ..., Liu L (2021) Chemical Synthesis of a Full-Length G-Protein-Coupled Receptor
β₂-Adrenergic Receptor with Defined Modification Patterns at the C-Terminus. Journal of the American Chemical
Society. [IF=2.573, Cited=8, 34663067].
Ehsan M, Du Y, Scull NJ, ..., Chae PS (2016) Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein
Studies. Journal of the American Chemical Society. [IF=2.573, Cited=36, 26966956].
Das M, Du Y, Ribeiro O, ..., Chae PS (2017) Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for
Membrane Protein Study: Implications of Detergent Kink for Micellar Properties. Journal of the American Chemical
Society. [IF=2.573, Cited=27, 28218862].
Ghani L, Munk CF, Zhang X, ..., Chae PS (2019) 1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein
Extraction and Stabilization. Journal of the American Chemical Society. [IF=2.573, Cited=8, 31809039].
Bockenhauer S, Fürstenberg A, Yao XJ, ..., Moerner WE (2011) Conformational dynamics of single G protein-coupled
receptors in solution. Journal of Physical Chemistry B. [IF=0.893, Cited=45, 21928818].
Kobilka BK (2002) Agonist-induced conformational changes in the beta2 adrenergic receptor. None. [IF=None, Cited=32, 12464109].
Ring AM, Manglik A, Kruse AC, ..., Kobilka BK (2013) Adrenaline-activated structure of β2-adrenoceptor stabilized by an
engineered nanobody. Nature. [IF=11.591, Cited=268, 24056936].
Shukla AK, Westfield GH, Xiao K, ..., Lefkowitz RJ (2014) Visualization of arrestin recruitment by a G-protein-coupled
receptor. Nature. [IF=11.591, Cited=291, 25043026].
Sounier R, Mas C, Steyaert J, ..., Granier S (2015) Propagation of conformational changes during μ-opioid receptor
activation. Nature. [IF=11.591, Cited=140, 26245377].
Huang W, Manglik A, Venkatakrishnan AJ, ..., Kobilka BK (2015) Structural insights into µ-opioid receptor activation.
Nature. [IF=11.591, Cited=440, 26245379].
Thal DM, Sun B, Feng D, ..., Christopoulos A (2016) Crystal structures of the M1 and M4 muscarinic acetylcholine
receptors. Nature. [IF=11.591, Cited=156, 26958838].
Manglik A, Lin H, Aryal DK, ..., Shoichet BK (2016) Structure-based discovery of opioid analgesics with reduced side
effects. Nature. [IF=11.591, Cited=434, 27533032].
Liang YL, Khoshouei M, Radjainia M, ..., Sexton PM (2017) Phase-plate cryo-EM structure of a class B GPCR-G-protein
complex. Nature. [IF=11.591, Cited=239, 28437792].
Gregorio GG, Masureel M, Hilger D, ..., Blanchard SC (2017) Single-molecule analysis of ligand efficacy in
β₂AR-G-protein activation. Nature. [IF=11.591, Cited=159, 28607487].
Zhang Y, Sun B, Feng D, ..., Skiniotis G (2017) Cryo-EM structure of the activated GLP-1 receptor in complex with a G
protein. Nature. [IF=11.591, Cited=271, 28538729].
Liu X, Ahn S, Kahsai AW, ..., Kobilka BK (2017) Mechanism of intracellular allosteric β₂AR antagonist
revealed by X-ray crystal structure. Nature. [IF=11.591, Cited=82, 28813418].
Dawaliby R, Trubbia C, Delporte C, ..., Govaerts C (2015) Allosteric regulation of G protein-coupled receptor activity
by phospholipids. Nature Chemical Biology. [IF=2.623, Cited=151, 26571351].
Pfreundschuh M, Alsteens D, Wieneke R, ..., Müller DJ (2015) Identifying and quantifying two ligand-binding sites while
imaging native human membrane receptors by AFM. Nature Communications. [IF=3.268, Cited=28, 26561004].
Alsteens D, Pfreundschuh M, Zhang C, ..., Müller DJ (2015) Imaging G protein-coupled receptors while quantifying their
ligand-binding free-energy landscape. Nature Methods. [IF=10.009, Cited=33, 26167642].
Pardon E, Laeremans T, Triest S, ..., Steyaert J (2014) A general protocol for the generation of Nanobodies for
structural biology. None. [IF=None, Cited=356, 24577359].
Ma P, Weichert D, Aleksandrov LA, ..., Caffrey M (2017) The cubicon method for concentrating membrane proteins in the
cubic mesophase. None. [IF=None, Cited=15, 28771236].
Kruse AC, Kobilka BK, Gautam D, ..., Wess J (2014) Muscarinic acetylcholine receptors: novel opportunities for drug
development. Nature Reviews Drug Discovery. [IF=18.471, Cited=199, 24903776].
Xu X, Kaindl J, Clark MJ, ..., Liu X (2020) Binding pathway determines norepinephrine selectivity for the human
β₁AR over β₂AR. Cell Research. [IF=3.826, Cited=40, 33093660].
Heyder NA, Kleinau G, Speck D, ..., Scheerer P (2021) Structures of active melanocortin-4 receptor-Gs-protein complexes
with NDP-α-MSH and setmelanotide. Cell Research. [IF=3.826, Cited=24, 34561620].
Maeda S, Koehl A, Matile H, ..., Kobilka BK (2018) Development of an antibody fragment that stabilizes GPCR/G-protein
complexes. Nature Communications. [IF=3.268, Cited=106, 30213947].
Strohman MJ, Maeda S, Hilger D, ..., Kobilka BK (2019) Local membrane charge regulates β₂ adrenergic receptor
coupling to G_i3. Nature Communications. [IF=3.268, Cited=44, 31110175].
Sun B, Feng D, Chu MLH, ..., Kobilka BK (2021) Crystal structure of dopamine D1 receptor in complex with G protein and a
non-catechol agonist. Nature Communications. [IF=3.268, Cited=20, 34083522].
Xu J, Wang Q, Hübner H, ..., Kobilka BK (2023) Structural and dynamic insights into supra-physiological activation and
allosteric modulation of a muscarinic acetylcholine receptor. Nature Communications. [IF=3.268, Cited=7, 36690613].
Heng J, Hu Y, Pérez-Hernández G, ..., Kobilka BK (2023) Function and dynamics of the intrinsically disordered carboxyl
terminus of β2 adrenergic receptor. Nature Communications. [IF=3.268, Cited=8, 37037825].
Xu X, Shonberg J, Kaindl J, ..., Gmeiner P (2023) Constrained catecholamines gain β₂AR selectivity through
allosteric effects on pocket dynamics. Nature Communications. [IF=3.268, Cited=3, 37059717].
Xu X, Shonberg J, Kaindl J, ..., Gmeiner P (2023) Author Correction: Constrained catecholamines gain β₂AR
selectivity through allosteric effects on pocket dynamics. Nature Communications. [IF=3.268, Cited=0, 37225685].
Toyoda Y, Zhu A, Kong F, ..., Liu X (2023) Structural basis of α_1A-adrenergic receptor activation and
recognition by an extracellular nanobody. Nature Communications. [IF=3.268, Cited=4, 37339967].
Koehl A, Hu H, Maeda S, ..., Kobilka BK (2018) Structure of the µ-opioid receptor-G_i protein complex. Nature.
[IF=11.591, Cited=312, 29899455].
Kato HE, Kim YS, Paggi JM, ..., Deisseroth K (2018) Structural mechanisms of selectivity and gating in anion
channelrhodopsins. Nature. [IF=11.591, Cited=36, 30158697].
Kim YS, Kato HE, Yamashita K, ..., Deisseroth K (2018) Crystal structure of the natural anion-conducting
channelrhodopsin GtACR1. Nature. [IF=11.591, Cited=45, 30158696].
Koehl A, Hu H, Feng D, ..., Kobilka BK (2019) Structural insights into the activation of metabotropic glutamate
receptors. Nature. [IF=11.591, Cited=127, 30675062].
Koehl A, Hu H, Feng D, ..., Kobilka BK (2019) Author Correction: Structural insights into the activation of metabotropic
glutamate receptors. Nature. [IF=11.591, Cited=3, 30814739].
Kato HE, Zhang Y, Hu H, ..., Skiniotis G (2019) Conformational transitions of a neurotensin
receptor 1-G_i1 complex. Nature. [IF=11.591, Cited=120, 31243364].
Huang W, Masureel M, Qu Q, ..., Kobilka BK (2020) Structure of the neurotensin receptor 1 in complex with β-arrestin 1.
Nature. [IF=11.591, Cited=151, 31945771].
Huang W, Manglik A, Venkatakrishnan AJ, ..., Kobilka BK (2020) Author Correction: Structural insights into μ-opioid
receptor activation. Nature. [IF=11.591, Cited=4, 32724208].
Seven AB, Barros-Álvarez X, de Lapeyrière M, ..., Skiniotis G (2021) G-protein activation by a metabotropic glutamate
receptor. Nature. [IF=11.591, Cited=51, 34194039].
Faouzi A, Wang H, Zaidi SA, ..., Majumdar S (2022) Structure-based design of bitopic ligands for the µ-opioid receptor.
Nature. [IF=11.591, Cited=18, 36450356].
Papasergi-Scott MM, Pérez-Hernández G, Batebi H, ..., Skiniotis G (2024) Time-resolved cryo-EM of G-protein activation
by a GPCR. Nature. [IF=11.591, Cited=1, 38480881].
Zhao J, Elgeti M, O'Brien ES, ..., Chen C (2024) Ligand efficacy modulates conformational dynamics of the µ-opioid
receptor. Nature. [IF=11.591, Cited=2, 38600384].
Krishna Kumar K, Wang H, Habrian C, ..., Kobilka BK (2024) Stepwise activation of a metabotropic glutamate receptor.
Nature. [IF=11.591, Cited=0, 38632403].
Krishna Kumar K, Wang H, Habrian C, ..., Kobilka BK (2024) Author Correction: Stepwise activation of a metabotropic
glutamate receptor. Nature. [IF=11.591, Cited=0, 38702522].
O'Brien ES, Rangari VA, El Daibani A, ..., Kobilka BK (2024) A µ-opioid receptor modulator that works cooperatively with
naloxone. Nature. [IF=11.591, Cited=0, 38961287].
Masureel M, Zou Y, Picard LP, ..., Kobilka BK (2018) Structural insights into binding specificity, efficacy and bias of
a β₂AR partial agonist. Nature Chemical Biology. [IF=2.623, Cited=76, 30327561].
Suno R, Lee S, Maeda S, ..., Kobayashi T (2018) Structural insights into the subtype-selective antagonist binding to the
M₂ muscarinic receptor. Nature Chemical Biology. [IF=2.623, Cited=34, 30420692].
Masureel M, Zou Y, Picard LP, ..., Kobilka BK (2019) Publisher Correction: Structural insights into binding specificity,
efficacy and bias of a β₂AR partial agonist. Nature Chemical Biology. [IF=2.623, Cited=0, 30504785].
Yuan D, Liu Z, Kaindl J, ..., Kobilka BK (2020) Activation of the α_2B adrenoceptor by the sedative
sympatholytic dexmedetomidine. Nature Chemical Biology. [IF=2.623, Cited=31, 32152538].
Liu X, Kaindl J, Korczynska M, ..., Gmeiner P (2020) An allosteric modulator binds to a conformational hub in the
β₂ adrenergic receptor. Nature Chemical Biology. [IF=2.623, Cited=31, 32483378].
Qu Q, Huang W, Aydin D, ..., Skiniotis G (2022) Insights into distinct signaling profiles of the µOR activated by
diverse agonists. Nature Chemical Biology. [IF=2.623, Cited=26, 36411392].
Hilger D, Masureel M, Kobilka BK (2018) Structure and dynamics of GPCR signaling complexes. Nature Structural and
Molecular Biology. [IF=2.542, Cited=363, 29323277].
Batebi H, Pérez-Hernández G, Rahman SN, ..., Hildebrand PW (2024) Mechanistic insights into G-protein coupling with an
agonist-bound G-protein-coupled receptor. Nature Structural and Molecular Biology. [IF=2.542, Cited=0, 38867113].
Hussain H, Mortensen JS, Du Y, ..., Chae PS (2017) Tandem malonate-based glucosides (TMGs) for membrane protein
structural studies. Scientific Reports. [IF=1.312, Cited=7, 28638082].
Uchański T, Zögg T, Yin J, ..., Steyaert J (2019) An improved yeast surface display platform for the screening of
nanobody immune libraries. Scientific Reports. [IF=1.312, Cited=42, 30674983].
Banister SD, Krishna Kumar K, Kumar V, ..., Malhotra SV (2019) Selective modulation of the cannabinoid type 1
(CB₁) receptor as an emerging platform for the treatment of neuropathic pain. None. [IF=None, Cited=7, 31191856].
Das M, Du Y, Mortensen JS, ..., Chae PS (2019) Trehalose-cored amphiphiles for membrane protein stabilization:
importance of the detergent micelle size in GPCR stability. Organic and Biomolecular Chemistry. [IF=0.77, Cited=6, 30843907].
Das M, Du Y, Mortensen JS, ..., Seok Chae P (2019) Correction: Trehalose-cored amphiphiles for membrane protein
stabilization: importance of the detergent micelle size in GPCR stability. Organic and Biomolecular Chemistry. [IF=0.77,
Cited=0, 31062815].
Jain MK, Cheung VG, Utz PJ, ..., Lefkowitz R (2019) Saving the Endangered Physician-Scientist - A Plan for Accelerating
Medical Breakthroughs. New England Journal of Medicine. [IF=17.194, Cited=64, 31365796].
Cohen BE, Pralle A, Yao X, ..., Jan LY (2005) A fluorescent probe designed for studying protein conformational change.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=48, 15657131].
Kolb P, Rosenbaum DM, Irwin JJ, ..., Shoichet BK (2009) Structure-based discovery of beta2-adrenergic receptor ligands.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=151, 19342484].
Ghanouni P, Steenhuis JJ, Farrens DL, Kobilka BK (2001) Agonist-induced conformational changes in the G-protein-coupling
domain of the beta 2 adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=194, 11353823].
Westfield GH, Rasmussen SGF, Su M, ..., Skiniotis G (2011) Structural flexibility of the G alpha s alpha-helical domain
in the beta2-adrenoceptor Gs complex. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=146, 21914848].
Zocher M, Zhang C, Rasmussen SGF, ..., Müller DJ (2012) Cholesterol increases kinetic, energetic, and mechanical
stability of the human β2-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=85, 23151510].
Tan CM, Wilson MH, MacMillan LB, ..., Limbird LE (2002) Heterozygous alpha 2A-adrenergic receptor mice unveil unique
therapeutic benefits of partial agonists. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=40, 12205290].
Weichert D, Kruse AC, Manglik A, ..., Gmeiner P (2014) Covalent agonists for studying G protein-coupled receptor
activation. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=40, 25006259].
Peleg G, Ghanouni P, Kobilka BK, ..., Zare RN (2001) Single-molecule spectroscopy of the beta(2) adrenergic receptor:
observation of conformational substates in a membrane protein. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=54, 11438704].
Sun B, Bachhawat P, Chu MLH, ..., Kobilka BK (2017) Crystal structure of the adenosine A_2A receptor bound to
an antagonist reveals a potential allosteric pocket. Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=65, 28167788].
Korczynska M, Clark MJ, Valant C, ..., Sunahara RK (2018) Structure-based discovery of selective positive allosteric
modulators of antagonists for the M₂ muscarinic acetylcholine receptor. Proceedings of the National Academy
of Sciences of the United States of America. [IF=2.765, Cited=31, 29453275].
Venkatakrishnan AJ, Ma AK, Fonseca R, ..., Dror RO (2019) Diverse GPCRs exhibit conserved water networks for
stabilization and activation. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=56, 30728297].
Liu H, Hofmann J, Fish I, ..., Gmeiner P (2018) Structure-guided development of selective M3 muscarinic acetylcholine
receptor antagonists. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=37, 30404914].
Ma X, Hu Y, Batebi H, ..., Kobilka BK (2020) Analysis of β₂AR-G_s and β₂AR-G_i
complex formation by NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=32, 32868434].
Lerch MT, Matt RA, Masureel M, ..., Hubbell WL (2020) Viewing rare conformations of the β₂ adrenergic
receptor with pressure-resolved DEER spectroscopy. Proceedings of the National Academy of Sciences of the United States
of America. [IF=2.765, Cited=17, 33257561].
Rohrer DK, Desai KH, Jasper JR, ..., Kobilka BK (1996) Targeted disruption of the mouse beta1-adrenergic receptor gene:
developmental and cardiovascular effects. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=176, 8693001].
Hein L, Stevens ME, Barsh GS, ..., Dzau VJ (1997) Overexpression of angiotensin AT1 receptor transgene in the mouse
myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=130, 9177228].
Zhu WZ, Zheng M, Koch WJ, ..., Xiao RP (2001) Dual modulation of cell survival and cell death by beta(2)-adrenergic
signaling in adult mouse cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=277, 11171998].
Carr R, Du Y, Quoyer J, ..., Benovic JL (2014) Development and characterization of pepducins as Gs-biased allosteric
agonists. Journal of Biological Chemistry. [IF=1.122, Cited=45, 25395624].
Shcherbakova OG, Hurt CM, Xiang Y, ..., Kobilka BK (2007) Organization of beta-adrenoceptor signaling compartments by
sympathetic innervation of cardiac myocytes. Journal of Cell Biology. [IF=1.509, Cited=56, 17296797].
Kingery WS, Agashe GS, Guo TZ, ..., Maze M (2002) Isoflurane and nociception: spinal alpha2A adrenoceptors mediate
antinociception while supraspinal alpha1 adrenoceptors mediate pronociception. Anesthesiology. [IF=2.702, Cited=69, 11818770].
Zhao J, Elgeti M, O'Brien ES, ..., Chen C (2023) Conformational dynamics of the μ-opioid receptor determine ligand
intrinsic efficacy. None. [IF=None, Cited=0, 37163120].
Kumar KK, Wang H, Habrian C, ..., Kobilka BK (2023) Step-wise activation of a Family C GPCR. None. [IF=None, Cited=0, 37693614].
Baxter EL, Aguila L, Alonso-Mori R, ..., Cohen AE (2016) High-density grids for efficient data collection from multiple
crystals. Acta Crystallographica Section D: Structural Biology. [IF=1.47, Cited=22, 26894529].
Tsutsumi N, Maeda S, Qu Q, ..., Garcia KC (2022) Atypical structural snapshots of human cytomegalovirus GPCR
interactions with host G proteins. Science advances. [IF=2.861, Cited=9, 35061538].
Bachman ES, Dhillon H, Zhang CY, ..., Lowell BB (2002) betaAR signaling required for diet-induced thermogenesis and
obesity resistance. Science. [IF=7.729, Cited=492, 12161655].
Huang B, Wu H, Bhaya D, ..., Zare RN (2007) Counting low-copy number proteins in a single cell. Science. [IF=7.729,
Cited=193, 17204646].
Cherezov V, Rosenbaum DM, Hanson MA, ..., Stevens RC (2007) High-resolution crystal structure of an engineered human
beta2-adrenergic G protein-coupled receptor. Science. [IF=7.729, Cited=1000, 17962520].
Rosenbaum DM, Cherezov V, Hanson MA, ..., Kobilka BK (2007) GPCR engineering yields high-resolution structural insights
into beta2-adrenergic receptor function. Science. [IF=7.729, Cited=815, 17962519].
Link RE, Desai K, Hein L, ..., Kobilka BK (1996) Cardiovascular regulation in mice lacking alpha2-adrenergic receptor
subtypes b and c. Science. [IF=7.729, Cited=277, 8670422].
Dror RO, Mildorf TJ, Hilger D, ..., Shaw DE (2015) SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in
heterotrimeric G proteins. Science. [IF=7.729, Cited=153, 26089515].
Maeda S, Qu Q, Robertson MJ, ..., Kobilka BK (2019) Structures of the M1 and M2 muscarinic acetylcholine
receptor/G-protein complexes. Science. [IF=7.729, Cited=145, 31073061].
Maeda S, Xu J, N Kadji FM, ..., Kobilka BK (2020) Structure and selectivity engineering of the M₁ muscarinic
receptor toxin complex. Science. [IF=7.729, Cited=22, 32646996].
Hilger D, Kumar KK, Hu H, ..., Kobilka BK (2020) Structural insights into differences in G protein activation by family
A and family B GPCRs. Science. [IF=7.729, Cited=66, 32732395].
Heydenreich FM, Marti-Solano M, Sandhu M, ..., Babu MM (2023) Molecular determinants of ligand efficacy and potency in
GPCR signaling. Science. [IF=7.729, Cited=0, 38127743].
Serdiuk T, Manna M, Zhang C, ..., Müller DJ (2022) A cholesterol analog stabilizes the human β₂-adrenergic
receptor nonlinearly with temperature. Science Signaling. [IF=1.6, Cited=6, 35671340].
Weis WI, Kobilka BK (2018) The Molecular Basis of G Protein-Coupled Receptor Activation. Annual Review of Biochemistry.
[IF=5.273, Cited=413, 29925258].
Manglik A, Kobilka BK, Steyaert J (2016) Nanobodies to Study G Protein-Coupled Receptor Structure and Function. Annual
Review of Pharmacology and Toxicology. [IF=2.886, Cited=116, 27959623].
Rohrer DK, Kobilka BK (1998) Insights from in vivo modification of adrenergic receptor gene expression. Annual Review of
Pharmacology and Toxicology. [IF=2.886, Cited=45, 9597159].
Desai KH, Sato R, Schauble E, ..., Bernstein D (1997) Cardiovascular indexes in the mouse at rest and with exercise: new
tools to study models of cardiac disease. None. [IF=None, Cited=93, 9124413].
Rohrer DK, Schauble EH, Desai KH, ..., Bernstein D (1998) Alterations in dynamic heart rate control in the beta
1-adrenergic receptor knockout mouse. None. [IF=None, Cited=23, 9575921].
Zhou YY, Wang SQ, Zhu WZ, ..., Xiao RP (2000) Culture and adenoviral infection of adult mouse cardiac myocytes: methods
for cellular genetic physiology. American Journal of Physiology - Heart and Circulatory Physiology. [IF=1.161,
Cited=187, 10899083].
Deupi X, Kobilka BK (2010) Energy landscapes as a tool to integrate GPCR structure, dynamics, and function. Physiology.
[IF=2.212, Cited=157, 20940434].
Dzau VJ, Gibbons GH, Kobilka BK, ..., Pratt RE (1995) Genetic models of human vascular disease. Circulation. [IF=6.144,
Cited=14, 7805258].

Publication with MISSING institution:

Neumann L, Wohland T, Whelan RJ, ..., Kobilka BK (2002) Functional immobilization of a ligand-activated G-protein-
coupled receptor. ChemBioChem. [IF=0.691, Cited=23, 12362365].
Chen MQ, Whittington RH, Day PW, ..., Kovacs GTA (2010) A device for separated and reversible co-culture of
cardiomyocytes. Biotechnology Progress. [IF=0.785, Cited=2, 20730771].
Chae PS, Rasmussen SGF, Rana RR, ..., Gellman SH (2012) A new class of amphiphiles bearing rigid hydrophobic groups for
solubilization and stabilization of membrane proteins. Chemistry - A European Journal. [IF=0.899, Cited=79, 22730191].
Chae PS, Kruse AC, Gotfryd K, ..., Gellman SH (2013) Novel tripod amphiphiles for membrane protein analysis. Chemistry -
A European Journal. [IF=0.899, Cited=32, 24123610].
Parola AL, Lin S, Kobilka BK (1997) Site-specific fluorescence labeling of the beta2 adrenergic receptor amino terminus.
Analytical Biochemistry. [IF=0.706, Cited=7, 9398350].
Link RE, Kobilka BK, Barsh GS (1993) Linkage mapping of alpha-2 adrenergic receptor genes to mouse chromosomes 2 and 5.
Mammalian Genome. [IF=0.583, Cited=0, 8281014].
Kruse AC, Li J, Hu J, ..., Wess J (2013) Novel insights into M3 muscarinic acetylcholine receptor physiology and
structure. Journal of Molecular Neuroscience. [IF=0.76, Cited=14, 24068573].
Lefkowitz RJ, Lefkowitz RJ, Kobilka BK, ..., Caron MG (1989) The new biology of drug receptors. Biochemical
Pharmacology. [IF=1.155, Cited=17, 2551299].
Hein L, Kobilka BK (1995) Adrenergic receptor signal transduction and regulation. Neuropharmacology. [IF=1.12,
Cited=70, 7566466].
Jasper JR, Link RE, Chruscinski AJ, ..., Bernstein D (1993) Primary structure of the mouse beta 1-adrenergic receptor
gene. None. [IF=None, Cited=5, 8395893].
Hein L, Kobilka BK (1997) Adrenergic Receptors From Molecular Structure to in vivo function. Trends in Cardiovascular
Medicine. [IF=2.356, Cited=24, 21235877].
Nygaard R, Zou Y, Dror RO, ..., Kobilka BK (2013) The dynamic process of β(2)-adrenergic receptor activation. Cell.
[IF=8.479, Cited=451, 23374348].
Wei TT, Chandy M, Nishiga M, ..., Wu JC (2022) Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced
vascular inflammation. Cell. [IF=8.479, Cited=0, 35750035].
Weis WI, Kobilka BK (2008) Structural insights into G-protein-coupled receptor activation. Current Opinion in Structural
Biology. [IF=1.4, Cited=51, 18957321].
Steyaert J, Kobilka BK (2011) Nanobody stabilization of G protein-coupled receptor conformational states. Current
Opinion in Structural Biology. [IF=1.4, Cited=137, 21782416].
Zocher M, Fung JJ, Kobilka BK, Müller DJ (2012) Ligand-specific interactions modulate kinetic, energetic, and mechanical
properties of the human β2 adrenergic receptor. Structure. [IF=1.155, Cited=54, 22748765].
Shoichet BK, Kobilka BK (2012) Structure-based drug screening for G-protein-coupled receptors. Trends in Pharmacological
Sciences. [IF=2.377, Cited=160, 22503476].
Seifert R, Wenzel-Seifert K, Arthur JM, ..., Kobilka BK (2002) Efficient adenylyl cyclase activation by a
beta2-adrenoceptor-G(i)alpha2 fusion protein. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=5, 12419329].
Sasamura H, Hein L, Krieger JE, ..., Dzau VJ (1992) Cloning, characterization, and expression of two angiotensin
receptor (AT-1) isoforms from the mouse genome. Biochemical and Biophysical Research Communications. [IF=0.643,
Cited=163, 1599461].
Chruscinski AJ, Link RE, Daunt DA, ..., Kobilka BK (1992) Cloning and expression of the mouse homolog of the human alpha
2-C2 adrenergic receptor. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=17, 1354956].
MacDonald E, Kobilka BK, Scheinin M (1997) Gene targeting--homing in on alpha 2-adrenoceptor-subtype function. Trends in
Pharmacological Sciences. [IF=2.377, Cited=195, 9227000].
Seifert R, Wenzel-Seifert K, Kobilka BK (1999) GPCR-Galpha fusion proteins: molecular analysis of receptor-G-protein
coupling. Trends in Pharmacological Sciences. [IF=2.377, Cited=82, 10462762].
Lähdesmäki J, Sallinen J, MacDonald E, ..., Scheinin M (2002) Behavioral and neurochemical characterization of
alpha(2A)-adrenergic receptor knockout mice. Neuroscience. [IF=0.846, Cited=71, 12127086].
Sallinen J, Haapalinna A, Viitamaa T, ..., Scheinin M (1998) D-amphetamine and L-5-hydroxytryptophan-induced behaviours
in mice with genetically-altered expression of the alpha2C-adrenergic receptor subtype. Neuroscience. [IF=0.846,
Cited=49, 9692731].
Björklund M, Sirviö J, Sallinen J, ..., Riekkinen P (1999) Alpha2C-adrenoceptor overexpression disrupts execution of
spatial and non-spatial search patterns. Neuroscience. [IF=0.846, Cited=39, 10336129].
Aravanis AM, DeBusschere BD, Chruscinski AJ, ..., Kovacs GT (2001) A genetically engineered cell-based biosensor for
functional classification of agents. Biosensors and Bioelectronics. [IF=1.844, Cited=27, 11544051].
Rohrer DK, Bernstein D, Chruscinski A, ..., Kobilka BK (1998) The developmental and physiological consequences of
disrupting genes encoding beta 1 and beta 2 adrenoceptors. None. [IF=None, Cited=8, 9327949].
Dixon RA, Kobilka BK, Kobilka BK, ..., Strader CD (None) Cloning of the gene and cDNA for mammalian beta-adrenergic
receptor and homology with rhodopsin. Nature. [IF=11.591, Cited=615, 3010132].
Kobilka BK, Kobilka BK, Frielle T, ..., Caron MG (None) An intronless gene encoding a potential member of the family of
receptors coupled to guanine nucleotide regulatory proteins. Nature. [IF=11.591, Cited=270, 3041227].
Bouvier M, Hausdorff WP, De Blasi A, ..., Lefkowitz RJ (1988) Removal of phosphorylation sites from the beta
2-adrenergic receptor delays onset of agonist-promoted desensitization. Nature. [IF=11.591, Cited=221, 2836733].
Fargin A, Raymond JR, Lohse MJ, ..., Lefkowitz RJ (1988) The genomic clone G-21 which resembles a beta-adrenergic
receptor sequence encodes the 5-HT1A receptor. Nature. [IF=11.591, Cited=322, 3138543].
Hein L, Barsh GS, Pratt RE, ..., Kobilka BK (1995) Behavioural and cardiovascular effects of disrupting the angiotensin
II type-2 receptor in mice. Nature. [IF=11.591, Cited=461, 7477266].
Hein L, Altman JD, Kobilka BK (1999) Two functionally distinct alpha2-adrenergic receptors regulate sympathetic
neurotransmission. Nature. [IF=11.591, Cited=308, 10647009].
Fung JJ, Deupi X, Pardo L, ..., Kobilka BK (2009) Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model
lipid bilayer. EMBO Journal. [IF=2.114, Cited=107, 19763081].
Rasmussen SGF, Choi HJ, Rosenbaum DM, ..., Kobilka BK (2007) Crystal structure of the human beta2 adrenergic G-protein-
coupled receptor. Nature. [IF=11.591, Cited=1000, 17952055].
Rosenbaum DM, Rasmussen SGF, Kobilka BK (2009) The structure and function of G-protein-coupled receptors. Nature.
[IF=11.591, Cited=1000, 19458711].
Bokoch MP, Zou Y, Rasmussen SGF, ..., Kobilka BK (2010) Ligand-specific regulation of the extracellular surface of a
G-protein-coupled receptor. Nature. [IF=11.591, Cited=268, 20054398].
Rasmussen SGF, Choi HJ, Fung JJ, ..., Kobilka BK (2011) Structure of a nanobody-stabilized active state of the β(2)
adrenoceptor. Nature. [IF=11.591, Cited=952, 21228869].
Rosenbaum DM, Zhang C, Lyons JA, ..., Kobilka BK (2011) Structure and function of an irreversible agonist-β(2)
adrenoceptor complex. Nature. [IF=11.591, Cited=444, 21228876].
Rasmussen SGF, DeVree BT, Zou Y, ..., Kobilka BK (2011) Crystal structure of the β2 adrenergic receptor-Gs protein
complex. Nature. [IF=11.591, Cited=1000, 21772288].
Chung KY, Rasmussen SGF, Liu T, ..., Sunahara RK (2011) Conformational changes in the G protein Gs induced by the β2
adrenergic receptor. Nature. [IF=11.591, Cited=228, 21956331].
Haga K, Kruse AC, Asada H, ..., Kobayashi T (2012) Structure of the human M2 muscarinic acetylcholine receptor bound to
an antagonist. Nature. [IF=11.591, Cited=419, 22278061].
Kruse AC, Hu J, Pan AC, ..., Kobilka BK (2012) Structure and dynamics of the M3 muscarinic acetylcholine receptor.
Nature. [IF=11.591, Cited=428, 22358844].
Manglik A, Kruse AC, Kobilka TS, ..., Granier S (2012) Crystal structure of the µ-opioid receptor bound to a morphinan
antagonist. Nature. [IF=11.591, Cited=773, 22437502].
Granier S, Manglik A, Kruse AC, ..., Kobilka BK (2012) Structure of the δ-opioid receptor bound to naltrindole. Nature.
[IF=11.591, Cited=374, 22596164].
Zhang C, Srinivasan Y, Arlow DH, ..., Kobilka BK (2012) High-resolution crystal structure of human protease-activated
receptor 1. Nature. [IF=11.591, Cited=264, 23222541].
Shukla AK, Manglik A, Kruse AC, ..., Lefkowitz RJ (2013) Structure of active β-arrestin-1 bound to a G-protein-coupled
receptor phosphopeptide. Nature. [IF=11.591, Cited=265, 23604254].
Kruse AC, Ring AM, Manglik A, ..., Kobilka BK (2013) Activation and allosteric modulation of a muscarinic acetylcholine
receptor. Nature. [IF=11.591, Cited=481, 24256733].
DeVree BT, Mahoney JP, Vélez-Ruiz GA, ..., Sunahara RK (2016) Allosteric coupling from G protein to the agonist-binding
pocket in GPCRs. Nature. [IF=11.591, Cited=147, 27362234].
Staus DP, Strachan RT, Manglik A, ..., Lefkowitz RJ (2016) Allosteric nanobodies reveal the dynamic range and diverse
mechanisms of G-protein-coupled receptor activation. Nature. [IF=11.591, Cited=169, 27409812].
Day PW, Rasmussen SGF, Parnot C, ..., Kobilka BK (2007) A monoclonal antibody for G protein-coupled receptor
crystallography. Nature Methods. [IF=10.009, Cited=70, 17952087].
Sun Y, Huang J, Xiang Y, ..., Huang XY (2006) Dosage-dependent switch from G protein-coupled to G protein-independent
signaling by a GPCR. EMBO Journal. [IF=2.114, Cited=69, 17170700].
Sallinen J, Haapalinna A, MacDonald E, ..., Scheinin M (1999) Genetic alteration of the alpha2-adrenoceptor subtype c in
mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels.
Molecular Psychiatry. [IF=2.603, Cited=67, 10523817].
Huang B, Wu H, Kim S, ..., Zare RN (2006) Phospholipid biotinylation of polydimethylsiloxane (PDMS) for protein
immobilization. Lab on a Chip. [IF=1.218, Cited=20, 16511619].
Wenzel-Seifert K, Lee TW, Seifert R, Kobilka BK (1998) Restricting mobility of Gsalpha relative to the
beta2-adrenoceptor enhances adenylate cyclase activity by reducing Gsalpha GTPase activity. Biochemical Journal.
[IF=0.852, Cited=18, 9729456].
Seifert R, Lee TW, Lam VT, Kobilka BK (1998) Reconstitution of beta2-adrenoceptor-GTP-binding-protein interaction in Sf9
cells--high coupling efficiency in a beta2-adrenoceptor-G(s alpha) fusion protein. None. [IF=None, Cited=59, 9716378].
Seifert R, Wenzel-Seifert K, Gether U, ..., Kobilka BK (1999) Examining the efficiency of receptor/G-protein coupling
with a cleavable beta2-adrenoceptor-gsalpha fusion protein. None. [IF=None, Cited=19, 10102993].
Kobilka BK, Kobilka BK, Dixon RA, ..., Lefkowitz RJ (1987) cDNA for the human beta 2-adrenergic receptor: a protein with
multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor
for platelet-derived growth factor. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=330, 3025863].
Gether U, Lin S, Kobilka BK (1995) Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-
specific conformational changes. Journal of Biological Chemistry. [IF=1.122, Cited=75, 7499324].
Kudo M, Osuga Y, Kobilka BK, Hsueh AJ (1996) Transmembrane regions V and VI of the human luteinizing hormone receptor
are required for constitutive activation by a mutation in the third intracellular loop. Journal of Biological Chemistry.
[IF=1.122, Cited=45, 8798412].
Mizobe T, Maze M, Lam V, ..., Kobilka BK (1996) Arrangement of transmembrane domains in adrenergic receptors. Similarity
to bacteriorhodopsin. Journal of Biological Chemistry. [IF=1.122, Cited=35, 8576196].
Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997) A novel interaction between adrenergic receptors and the alpha-
subunit of eukaryotic initiation factor 2B. Journal of Biological Chemistry. [IF=1.122, Cited=39, 9235896].
Gether U, Ballesteros JA, Seifert R, ..., Kobilka BK (1997) Structural instability of a constitutively active G protein-
coupled receptor. Agonist-independent activation due to conformational flexibility. Journal of Biological Chemistry.
[IF=1.122, Cited=156, 9006889].
Gether U, Kobilka BK (1998) G protein-coupled receptors. II. Mechanism of agonist activation. Journal of Biological
Chemistry. [IF=1.122, Cited=270, 9660746].
Chruscinski AJ, Rohrer DK, Schauble E, ..., Kobilka BK (1999) Targeted disruption of the beta2 adrenergic receptor gene.
Journal of Biological Chemistry. [IF=1.122, Cited=216, 10358008].
Rohrer DK, Chruscinski A, Schauble EH, ..., Kobilka BK (1999) Cardiovascular and metabolic alterations in mice lacking
both beta1- and beta2-adrenergic receptors. Journal of Biological Chemistry. [IF=1.122, Cited=172, 10358009].
Ghanouni P, Schambye H, Seifert R, ..., Kobilka BK (2000) The effect of pH on beta(2) adrenoceptor function. Evidence
for protonation-dependent activation. Journal of Biological Chemistry. [IF=1.122, Cited=67, 10652295].
Ghanouni P, Gryczynski Z, Steenhuis JJ, ..., Kobilka BK (2001) Functionally different agonists induce distinct
conformations in the G protein coupling domain of the beta 2 adrenergic receptor. Journal of Biological Chemistry.
[IF=1.122, Cited=228, 11320077].
Zheng M, Zhang SJ, Zhu WZ, ..., Xiao RP (2000) beta 2-adrenergic receptor-induced p38 MAPK activation is mediated by
protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes. Journal of Biological Chemistry.
[IF=1.122, Cited=80, 11018034].
Chung KY, Kim TH, Manglik A, ..., Prosser RS (2012) Role of detergents in conformational exchange of a G protein-coupled
receptor. Journal of Biological Chemistry. [IF=1.122, Cited=47, 22893704].
Swaminath G, Xiang Y, Lee TW, ..., Kobilka BK (2003) Sequential binding of agonists to the beta2 adrenoceptor. Kinetic
evidence for intermediate conformational states. Journal of Biological Chemistry. [IF=1.122, Cited=210, 14559905].
Gether U, Lin S, Ghanouni P, ..., Kobilka BK (1997) Agonists induce conformational changes in transmembrane domains III
and VI of the beta2 adrenoceptor. EMBO Journal. [IF=2.114, Cited=214, 9362488].
Papasergi-Scott MM, Pérez-Hernández G, Batebi H, ..., Skiniotis G (2023) Time-resolved cryo-EM of G protein activation
by a GPCR. None. [IF=None, Cited=0, 36993214].
Casiraghi M, Wang H, Brennan P, ..., Kobilka BK (2024) Structure and dynamics determine G protein coupling specificity
at a class A GPCR. None. [IF=None, Cited=0, 38586060].
Lefkowitz RJ, Lefkowitz RJ, Kobilka BK, ..., Caron MG (1988) Molecular biology of adrenergic receptors. Cold Spring
Harbor Symposia on Quantitative Biology. [IF=0.889, Cited=10, 2855490].
Kruse AC, Manglik A, Kobilka BK, Weis WI (2013) Applications of molecular replacement to G protein-coupled receptors.
None. [IF=None, Cited=2, 24189241].
Hein L, Limbird LE, Eglen RM, Kobilka BK (1999) Gene substitution/knockout to delineate the role of alpha 2-adrenoceptor
subtypes in mediating central effects of catecholamines and imidazolines. Annals of the New York Academy of Sciences.
[IF=1.878, Cited=26, 10415924].
Wang Y, Lauffer B, Von Zastrow M, ..., Xiang Y (2007) N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor
trafficking and signaling in cardiomyocytes. Molecular Pharmacology. [IF=0.939, Cited=16, 17510209].
Kruse AC, Weiss DR, Rossi M, ..., Shoichet BK (2013) Muscarinic receptors as model targets and antitargets for
structure-based ligand discovery. Molecular Pharmacology. [IF=0.939, Cited=30, 23887926].
Staus DP, Wingler LM, Strachan RT, ..., Lefkowitz RJ (2013) Regulation of β2-adrenergic receptor function by
conformationally selective single-domain intrabodies. Molecular Pharmacology. [IF=0.939, Cited=77, 24319111].
Sallinen J, Link RE, Haapalinna A, ..., Scheinin M (1997) Genetic alteration of alpha 2C-adrenoceptor expression in
mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha
2-adrenoceptor agonist. Molecular Pharmacology. [IF=0.939, Cited=98, 9016344].
Daunt DA, Hurt C, Hein L, ..., Kobilka BK (1997) Subtype-specific intracellular trafficking of alpha2-adrenergic
receptors. Molecular Pharmacology. [IF=0.939, Cited=112, 9145909].
Björklund M, Sirviö J, Puoliväli J, ..., Riekkinen P (1998) Alpha2C-adrenoceptor-overexpressing mice are impaired in
executing nonspatial and spatial escape strategies. Molecular Pharmacology. [IF=0.939, Cited=26, 9730916].
Altman JD, Trendelenburg AU, MacMillan L, ..., Hein L (1999) Abnormal regulation of the sympathetic nervous system in
alpha2A-adrenergic receptor knockout mice. Molecular Pharmacology. [IF=0.939, Cited=202, 10385696].
Seifert R, Gether U, Wenzel-Seifert K, Kobilka BK (1999) Effects of guanine, inosine, and xanthine nucleotides on
beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations. Molecular Pharmacology.
[IF=0.939, Cited=76, 10419554].
Zhou YY, Yang D, Zhu WZ, ..., Xiao RP (2000) Spontaneous activation of beta(2)- but not beta(1)-adrenoceptors expressed
in cardiac myocytes from beta(1)beta(2) double knockout mice. Molecular Pharmacology. [IF=0.939, Cited=39, 11040034].
Chruscinski A, Brede ME, Meinel L, ..., Hein L (2001) Differential distribution of beta-adrenergic receptor subtypes in
blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors. Molecular Pharmacology. [IF=0.939,
Cited=64, 11641423].
Chakir K, Xiang Y, Yang D, ..., Xiao RP (2003) The third intracellular loop and the carboxyl terminus of
beta2-adrenergic receptor confer spontaneous activity of the receptor. Molecular Pharmacology. [IF=0.939, Cited=20, 14573753].
Bernstein D, Fajardo G, Zhao M, ..., Kobilka BK (2005) Differential cardioprotective/cardiotoxic effects mediated by
beta-adrenergic receptor subtypes. American Journal of Physiology - Heart and Circulatory Physiology. [IF=1.161,
Cited=62, 16040722].
Ecker PM, Lin CC, Powers J, ..., Bernstein D (2005) Effect of targeted deletions of beta1- and beta2-adrenergic-receptor
subtypes on heart rate variability. American Journal of Physiology - Heart and Circulatory Physiology. [IF=1.161,
Cited=30, 16113068].
Rohrer DK, Kobilka BK (1998) G protein-coupled receptors: functional and mechanistic insights through altered gene
expression. Physiological Reviews. [IF=11.448, Cited=68, 9457168].
Zhu WZ, Wang SQ, Chakir K, ..., Xiao RP (2003) Linkage of beta1-adrenergic stimulation to apoptotic heart cell death
through protein kinase A-independent activation of Ca2+/calmodulin kinase II. Journal of Clinical Investigation.
[IF=2.423, Cited=289, 12618516].
McGraw DW, Almoosa KF, Paul RJ, ..., Liggett SB (2003) Antithetic regulation by beta-adrenergic receptors of Gq receptor
signaling via phospholipase C underlies the airway beta-agonist paradox. Journal of Clinical Investigation. [IF=2.423,
Cited=84, 12925702].
Hein L, Meinel L, Pratt RE, ..., Kobilka BK (1997) Intracellular trafficking of angiotensin II and its AT1 and AT2
receptors: evidence for selective sorting of receptor and ligand. None. [IF=None, Cited=153, 9259318].
Zou Y, Weis WI, Kobilka BK (2012) N-terminal T4 lysozyme fusion facilitates crystallization of a G protein coupled
receptor. PLoS ONE. [IF=1.253, Cited=69, 23056231].
Chung KY, Day PW, Vélez-Ruiz G, ..., Kobilka BK (2013) Identification of GPCR-interacting cytosolic proteins using HDL
particles and mass spectrometry-based proteomic approach. PLoS ONE. [IF=1.253, Cited=18, 23372797].
Sallinen J, Haapalinna A, Viitamaa T, ..., Scheinin M (1998) Adrenergic alpha2C-receptors modulate the acoustic startle
reflex, prepulse inhibition, and aggression in mice. Journal of Neuroscience. [IF=1.471, Cited=101, 9526020].
Sawamura S, Kingery WS, Davies MF, ..., Maze M (2000) Antinociceptive action of nitrous oxide is mediated by stimulation
of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors. Journal of Neuroscience. [IF=1.471,
Cited=89, 11125002].
Franowicz JS, Kessler LE, Borja CMD, ..., Arnsten AFT (2002) Mutation of the alpha2A-adrenoceptor impairs working memory
performance and annuls cognitive enhancement by guanfacine. Journal of Neuroscience. [IF=1.471, Cited=132, 12351753].
Caron MG, Kobilka BK, Kobilka BK, ..., Lefkowitz RJ (1988) Cloning of the cDNA and genes for the hamster and human beta
2-adrenergic receptors. None. [IF=None, Cited=4, 2838630].
Seifert R, Wenzel-Seifert K, Gether U, Kobilka BK (2001) Functional differences between full and partial agonists:
evidence for ligand-specific receptor conformations. Journal of Pharmacology and Experimental Therapeutics. [IF=0.906,
Cited=70, 11356949].
Suryanarayana S, von Zastrow M, Kobilka BK (1992) Identification of intramolecular interactions in adrenergic receptors.
Journal of Biological Chemistry. [IF=1.122, Cited=26, 1331041].
Guan XM, Kobilka TS, Kobilka BK (1992) Enhancement of membrane insertion and function in a type IIIb membrane protein
following introduction of a cleavable signal peptide. Journal of Biological Chemistry. [IF=1.122, Cited=155, 1331042].
Guan XM, Peroutka SJ, Kobilka BK (1992) Identification of a single amino acid residue responsible for the binding of a
class of beta-adrenergic receptor antagonists to 5-hydroxytryptamine1A receptors. Molecular Pharmacology. [IF=0.939,
Cited=72, 1349154].
von Zastrow M, Kobilka BK (1992) Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors
between the plasma membrane and endosomes containing transferrin receptors. Journal of Biological Chemistry. [IF=1.122,
Cited=217, 1371121].
Suryanarayana S, Daunt DA, Von Zastrow M, Kobilka BK (1991) A point mutation in the seventh hydrophobic domain of the
alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists. Journal of Biological
Chemistry. [IF=1.122, Cited=69, 1678390].
Suryanarayana S, Daunt DA, Von Zastrow M, Kobilka BK (1991) A single point mutation in the seventh hydrophobic domain of
the alpha 2-adrenergic receptor changes antagonist binding specificity to that of a beta receptor. None. [IF=None,
Cited=0, 1688262].
Cotecchia S, Kobilka BK, Kobilka BK, ..., Regan JW (1990) Multiple second messenger pathways of alpha-adrenergic
receptor subtypes expressed in eukaryotic cells. Journal of Biological Chemistry. [IF=1.122, Cited=137, 2152928].
Bouvier M, Collins S, O'Dowd BF, ..., Lefkowitz RJ (1989) Two distinct pathways for cAMP-mediated down-regulation of the
beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. Journal of Biological
Chemistry. [IF=1.122, Cited=133, 2476447].
Bouvier M, Hnatowich M, Collins S, ..., Caron MG (1988) Expression of a human cDNA encoding the beta 2-adrenergic
receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors. Molecular
Pharmacology. [IF=0.939, Cited=41, 2828911].
Kobilka BK, Kobilka BK, Frielle T, ..., Lefkowitz RJ (1987) Delineation of the intronless nature of the genes for the
human and hamster beta 2-adrenergic receptor and their putative promoter regions. Journal of Biological Chemistry.
[IF=1.122, Cited=121, 3034889].
von Zastrow M, Kobilka BK (1994) Antagonist-dependent and -independent steps in the mechanism of adrenergic receptor
internalization. Journal of Biological Chemistry. [IF=1.122, Cited=82, 7518433].
Link RE, Stevens MS, Kulatunga M, ..., Kobilka BK (1995) Targeted inactivation of the gene encoding the mouse alpha
2c-adrenoceptor homolog. Molecular Pharmacology. [IF=0.939, Cited=65, 7623774].
Hein L, Ishii K, Coughlin SR, Kobilka BK (1994) Intracellular targeting and trafficking of thrombin receptors. A novel
mechanism for resensitization of a G protein-coupled receptor. Journal of Biological Chemistry. [IF=1.122, Cited=106, 7961693].
Suryanarayana S, Kobilka BK (1993) Amino acid substitutions at position 312 in the seventh hydrophobic segment of the
beta 2-adrenergic receptor modify ligand-binding specificity. Molecular Pharmacology. [IF=0.939, Cited=33, 8101966].
Parola AL, Kobilka BK (1994) The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor mRNA inhibits
receptor synthesis. Journal of Biological Chemistry. [IF=1.122, Cited=126, 8308019].
Mostafapour S, Kobilka BK, von Zastrow M (1996) Pharmacological sequestration of a chimeric beta 3/beta 2 adrenergic
receptor occurs without a corresponding amount of receptor internalization. None. [IF=None, Cited=8, 9259050].
Seifert R, Wenzel-Seifert K, Lee TW, ..., Kobilka BK (1998) Different effects of Gsalpha splice variants on
beta2-adrenoreceptor-mediated signaling. The beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has
properties of a constitutively active receptor. Journal of Biological Chemistry. [IF=1.122, Cited=71, 9478963].
Seifert R, Wenzel-Seifert K, Lee TW, ..., Kobilka BK (1998) Different effects of Gsalpha splice variants on
beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has
properties of a constitutively active receptor. Journal of Biological Chemistry. [IF=1.122, Cited=11, 9556548].

Kobilka, Brian K

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