Khosla, Chaitan

Publication with MATCHING institution:

Khosla C, Caren R, Kao CM, ..., Wang SW (1996) Evolutionally guided enzyme design. Biotechnology and Bioengineering.
[IF=0.932, Cited=4, 18629858].
Hilmer AJ, Jeffrey RB, Park WG, Khosla C (2016) Cholestyramine as a promising, strong anion exchange resin for direct
capture of genetic biomarkers from raw pancreatic fluids. Biotechnology and Bioengineering. [IF=0.932, Cited=2, 27800600].
Abadie V, Khosla C, Jabri B (2022) A Mouse Model of Celiac Disease. Current Protocols. [IF=0.921, Cited=0, 35994521].
Khosla C (2018) From Active Sites to Machines: A Challenge for Enzyme Chemists. Israel Journal of Chemistry. [IF=0.673,
Cited=1, 31762490].
Syage JA, Green PHR, Khosla C, ..., Murray JA (2019) Latiglutenase Treatment for Celiac Disease: Symptom and Quality of
Life Improvement for Seropositive Patients on a Gluten-Free Diet. None. [IF=None, Cited=13, 32313451].
Melkonian AV, Weng N, Palanski BA, Khosla C (2019) In Vivo Measurement of Redox-Regulated TG2 Activity. Methods in
Molecular Biology. [IF=0.413, Cited=2, 31069776].
Syage JA, Murray JA, Green PHR, Khosla C (2017) Latiglutenase Improves Symptoms in Seropositive Celiac Disease Patients
While on a Gluten-Free Diet. Digestive Diseases and Sciences. [IF=1.075, Cited=35, 28755266].
Guo S, Palanski BA, Kloeck C, ..., Cui B (2016) Intracellular TG2 Activity Increases Microtubule Stability but is not
Sufficient to Prompt Neurite Growth. None. [IF=None, Cited=1, 27815680].
Khosla C, Zawada RJ (1996) Generation of polyketide libraries via combinatorial biosynthesis. Trends in Biotechnology.
[IF=2.875, Cited=42, 8818287].
Zhuang R, Khosla C (2019) Substrates, inhibitors, and probes of mammalian transglutaminase 2. Analytical Biochemistry.
[IF=0.706, Cited=19, 31874171].
Yi MC, Palanski BA, Quintero SA, ..., Khosla C (2015) An unprecedented dual antagonist and agonist of human
Transglutaminase 2. Bioorganic and Medicinal Chemistry Letters. [IF=0.704, Cited=6, 26004580].
Okesli-Armlovich A, Gupta A, Jimenez M, ..., Khosla C (2019) Discovery of small molecule inhibitors of human uridine-
cytidine kinase 2 by high-throughput screening. Bioorganic and Medicinal Chemistry Letters. [IF=0.704, Cited=7, 31420268].
Plugis NM, Khosla C (2015) Therapeutic approaches for celiac disease. None. [IF=None, Cited=24, 26060114].
Khosla C, Kapur S, Cane DE (2009) Revisiting the modularity of modular polyketide synthases. Current Opinion in Chemical
Biology. [IF=1.51, Cited=53, 19217343].
Xiao X, Sankaranarayanan K, Khosla C (2017) Biosynthesis and structure-activity relationships of the lipid a family of
glycolipids. Current Opinion in Chemical Biology. [IF=1.51, Cited=16, 28942130].
Bunning B, Hedlin H, Purington N, ..., Desai M (2021) The COVID-19 Outpatient Pragmatic Platform Study (COPPS): Study
design of a multi-center pragmatic platform trial. Contemporary Clinical Trials. [IF=0.824, Cited=4, 34274494].
Cooke TF, Fischer CR, Wu P, ..., Bustamante CD (2017) Genetic Mapping and Biochemical Basis of Yellow Feather
Pigmentation in Budgerigars. Cell. [IF=8.479, Cited=50, 28985565].
Liu Q, Gupta A, Okesli-Armlovich A, ..., Khosla C (2020) Enhancing the Antiviral Efficacy of RNA-Dependent RNA
Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism. Cell Chemical Biology. [IF=1.446,
Cited=11, 32442424].
Loppinet E, Besser HA, Sewa AS, ..., Khosla C (2023) LRP-1 links post-translational modifications to efficient
presentation of celiac disease-specific T cell antigens. Cell Chemical Biology. [IF=1.446, Cited=4, 36608691].
Xu H, Feely SL, Wang X, ..., Sestak K (2013) Gluten-sensitive enteropathy coincides with decreased capability of
intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease. Clinical Immunology. [IF=1.324,
Cited=11, 23518597].
Okesli A, Khosla C, Bassik MC (2017) Human pyrimidine nucleotide biosynthesis as a target for antiviral chemotherapy.
Current Opinion in Biotechnology. [IF=1.815, Cited=34, 28458037].
Hsu J, Fatuzzo N, Weng N, ..., Khosla C (2022) Carnitine octanoyltransferase is important for the assimilation of
exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells. Journal of Biological Chemistry. [IF=1.122, Cited=7, 36587768].
Garber ME, Saldanha A, Parker JS, ..., Mäki M (2017) A B-Cell Gene Signature Correlates With the Extent of Gluten-
Induced Intestinal Injury in Celiac Disease. Cellular and Molecular Gastroenterology and Hepatology. [IF=1.429,
Cited=7, 28508029].
Edwards AL, Matsui T, Weiss TM, Khosla C (2014) Architectures of whole-module and bimodular proteins from the
6-deoxyerythronolide B synthase. Journal of Molecular Biology. [IF=1.281, Cited=45, 24704088].
Yuet KP, Khosla C (2019) Challenges and opportunities for engineering assembly-line polyketide biosynthesis in
Escherichia coli. Metabolic Engineering Communications. [IF=1.017, Cited=2, 32547924].
Robbins T, Liu YC, Cane DE, Khosla C (2016) Structure and mechanism of assembly line polyketide synthases. Current
Opinion in Structural Biology. [IF=1.4, Cited=66, 27266330].
Guzman KM, Khosla C (2021) Fragment antigen binding domains (F_abs) as tools to study assembly-line polyketide
synthases. Synthetic and Systems Biotechnology. [IF=0.826, Cited=2, 34977395].
Besser HA, Khosla C (2023) Celiac disease: mechanisms and emerging therapeutics. Trends in Pharmacological Sciences.
[IF=2.377, Cited=3, 37839914].
Kuo J, Khosla C (2014) The initiation ketosynthase (FabH) is the sole rate-limiting enzyme of the fatty acid synthase of
Synechococcus sp. PCC 7002. Metabolic Engineering. [IF=1.846, Cited=15, 24395007].
Khosla C (1996) Combinatorial chemistry and biology: an opportunity for engineers. Current Opinion in Biotechnology.
[IF=1.815, Cited=2, 8791337].
Santín O, Yuet K, Khosla C, Moncalián G (2020) Structure and Mechanism of the Ketosynthase-Chain Length Factor Didomain
from a Prototypical Polyunsaturated Fatty Acid Synthase. Biochemistry. [IF=0.753, Cited=2, 33283513].
Mashayekh S, Stunkard LM, Kienle M, ..., Khosla C (2022) Structure-Based Prototyping of Allosteric Inhibitors of Human
Uridine/Cytidine Kinase 2 (UCK2). Biochemistry. [IF=0.753, Cited=1, 36190114].
Guzman KM, Cogan DP, Brodsky KL, ..., Khosla C (2023) Discovery and Characterization of Antibody Probes of Module 2 of
the 6-Deoxyerythronolide B Synthase. Biochemistry. [IF=0.753, Cited=1, 37184546].
Xie X, Garg A, Keatinge-Clay AT, ..., Cane DE (2016) Epimerase and Reductase Activities of Polyketide Synthase
Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues. Biochemistry. [IF=0.753, Cited=18, 26863427].
Robbins T, Kapilivsky J, Cane DE, Khosla C (2016) Roles of Conserved Active Site Residues in the Ketosynthase Domain of
an Assembly Line Polyketide Synthase. Biochemistry. [IF=0.753, Cited=31, 27441852].
Lowry B, Li X, Robbins T, ..., Khosla C (2016) A Turnstile Mechanism for the Controlled Growth of Biosynthetic
Intermediates on Assembly Line Polyketide Synthases. ACS Central Science. [IF=2.363, Cited=29, 26878060].
Kuo J, Lynch SR, Liu CW, ..., Khosla C (2016) Partial In Vitro Reconstitution of an Orphan Polyketide Synthase
Associated with Clinical Cases of Nocardiosis. ACS Chemical Biology. [IF=0.963, Cited=12, 27384917].
Khosla C (2017) Celiac Disease: Lessons for and from Chemical Biology. ACS Chemical Biology. [IF=0.963, Cited=7, 28165712].
Wibowo A, Park JM, Liu SC, ..., Spielman DM (2017) Real-Time in Vivo Detection of H₂O₂ Using
Hyperpolarized ¹³C-Thiourea. ACS Chemical Biology. [IF=0.963, Cited=10, 28452454].
Klaus M, D'Souza AD, Nivina A, ..., Grininger M (2019) Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking
Domains. ACS Chemical Biology. [IF=0.963, Cited=13, 30682239].
Das A, Khosla C (2009) Biosynthesis of aromatic polyketides in bacteria. Accounts of Chemical Research. [IF=3.533,
Cited=80, 19292437].
Lau J, Cane DE, Khosla C (2000) Substrate specificity of the loading didomain of the erythromycin polyketide synthase.
Biochemistry. [IF=0.753, Cited=24, 10956042].
Tsuji SY, Wu N, Khosla C (2001) Intermodular communication in polyketide synthases: comparing the role of protein-
protein interactions to those in other multidomain proteins. Biochemistry. [IF=0.753, Cited=23, 11327851].
Tsuji SY, Cane DE, Khosla C (2001) Selective protein-protein interactions direct channeling of intermediates between
polyketide synthase modules. Biochemistry. [IF=0.753, Cited=76, 11327852].
Admiraal SJ, Walsh CT, Walsh CT, ..., Khosla C (2001) The loading module of rifamycin synthetase is an adenylation-
thiolation didomain with substrate tolerance for substituted benzoates. Biochemistry. [IF=0.753, Cited=36, 11352749].
Dreier J, Li Q, Khosla C (2001) Malonyl-CoA:ACP transacylase from Streptomyces coelicolor has two alternative
catalytically active nucleophiles. Biochemistry. [IF=0.753, Cited=17, 11591161].
Meadows ES, Khosla C (2001) In vitro reconstitution and analysis of the chain initiating enzymes of the R1128 polyketide
synthase. Biochemistry. [IF=0.753, Cited=31, 11732905].
Piper JL, Gray GM, Khosla C (2002) High selectivity of human tissue transglutaminase for immunoactive gliadin peptides:
implications for celiac sprue. Biochemistry. [IF=0.753, Cited=84, 11772038].
Wu N, Cane DE, Khosla C (2002) Quantitative analysis of the relative contributions of donor acyl carrier proteins,
acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases.
Biochemistry. [IF=0.753, Cited=77, 11939803].
Dayem LC, Carney JR, Santi DV, ..., Kealey JT (2002) Metabolic engineering of a methylmalonyl-CoA mutase-epimerase
pathway for complex polyketide biosynthesis in Escherichia coli. Biochemistry. [IF=0.753, Cited=46, 11955068].
Admiraal SJ, Khosla C, Walsh CT (2002) The loading and initial elongation modules of rifamycin synthetase collaborate to
produce mixed aryl ketide products. Biochemistry. [IF=0.753, Cited=16, 11955082].
Lu H, Tsai SC, Khosla C, Cane DE (2002) Expression, site-directed mutagenesis, and steady state kinetic analysis of the
terminal thioesterase domain of the methymycin/picromycin polyketide synthase. Biochemistry. [IF=0.753, Cited=37, 12379101].
Tsai SC, Lu H, Cane DE, ..., Stroud RM (2002) Insights into channel architecture and substrate specificity from crystal
structures of two macrocycle-forming thioesterases of modular polyketide synthases. Biochemistry. [IF=0.753, Cited=72, 12379102].
Liou GF, Lau J, Cane DE, Khosla C (2003) Quantitative analysis of loading and extender acyltransferases of modular
polyketide synthases. Biochemistry. [IF=0.753, Cited=25, 12515555].
Li Q, Khosla C, Puglisi JD, Liu CW (2003) Solution structure and backbone dynamics of the holo form of the frenolicin
acyl carrier protein. Biochemistry. [IF=0.753, Cited=56, 12705828].
Tang Y, Lee TS, Kobayashi S, Khosla C (2003) Ketosynthases in the initiation and elongation modules of aromatic
polyketide synthases have orthogonal acyl carrier protein specificity. Biochemistry. [IF=0.753, Cited=40, 12767243].
Koppisch AT, Khosla C (2003) Structure-based mutagenesis of the malonyl-CoA:acyl carrier protein transacylase from
Streptomyces coelicolor. Biochemistry. [IF=0.753, Cited=13, 12974642].
Xia J, Sollid LM, Khosla C (2005) Equilibrium and kinetic analysis of the unusual binding behavior of a highly
immunogenic gluten peptide to HLA-DQ2. Biochemistry. [IF=0.753, Cited=33, 15766274].
Wu J, Kinoshita K, Khosla C, Cane DE (2004) Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl
carrier protein synthase domain of module 2 of the erythromycin polyketide synthase. Biochemistry. [IF=0.753, Cited=23, 15610024].
Kim CY, Alekseyev VY, Chen AY, ..., Khosla C (2004) Reconstituting modular activity from separated domains of
6-deoxyerythronolide B synthase. Biochemistry. [IF=0.753, Cited=33, 15518537].
Diacovich L, Mitchell DL, Pham H, ..., Tsai SC (2004) Crystal structure of the beta-subunit of acyl-CoA carboxylase:
structure-based engineering of substrate specificity. Biochemistry. [IF=0.753, Cited=46, 15518551].
Tang Y, Koppisch AT, Khosla C (2004) The acyltransferase homologue from the initiation module of the R1128 polyketide
synthase is an acyl-ACP thioesterase that edits acetyl primer units. Biochemistry. [IF=0.753, Cited=29, 15260498].
Schnarr NA, Chen AY, Cane DE, Khosla C (2005) Analysis of covalently bound polyketide intermediates on
6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry. Biochemistry. [IF=0.753, Cited=18, 16128585].
Tang Y, Lee HY, Tang Y, ..., Khosla C (2006) Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier
protein reductase from Streptomyces coelicolor A3(2). Biochemistry. [IF=0.753, Cited=23, 17115703].
Tse ML, Watts RE, Khosla C (2007) Substrate tolerance of module 6 of the epothilone synthetase. Biochemistry. [IF=0.753,
Cited=2, 17315981].
Javidpour P, Das A, Khosla C, Tsai SC (2011) Structural and biochemical studies of the hedamycin type II polyketide
ketoreductase (HedKR): molecular basis of stereo- and regiospecificities. Biochemistry. [IF=0.753, Cited=13, 21776967].
Xiao X, Yu X, Khosla C (2013) Metabolic flux between unsaturated and saturated fatty acids is controlled by the
FabA:FabB ratio in the fully reconstituted fatty acid biosynthetic pathway of Escherichia coli. Biochemistry. [IF=0.753,
Cited=14, 24147979].
Khosla C, Herschlag D, Cane DE, Walsh CT (2014) Assembly line polyketide synthases: mechanistic insights and unsolved
problems. Biochemistry. [IF=0.753, Cited=62, 24779441].
Pieper R, Ebert-Khosla S, Cane D, Khosla C (1996) Erythromycin biosynthesis: kinetic studies on a fully active modular
polyketide synthase using natural and unnatural substrates. Biochemistry. [IF=0.753, Cited=21, 8652546].
Fu H, Alvarez MA, Khosla C, Bailey JE (1996) Engineered biosynthesis of novel polyketides: regiospecific methylation of
an unnatural substrate by the tcmO O-methyltransferase. Biochemistry. [IF=0.753, Cited=8, 8639600].
Kao CM, Pieper R, Cane DE, Khosla C (1996) Evidence for two catalytically independent clusters of active sites in a
functional modular polyketide synthase. Biochemistry. [IF=0.753, Cited=56, 8823171].
Tsukamoto N, Chuck JA, Luo G, ..., Cane DE (1996) 6-deoxyerythronolide B synthase 1 is specifically acylated by a
diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2. Biochemistry. [IF=0.753,
Cited=10, 8952473].
Pieper R, Gokhale RS, Luo G, ..., Khosla C (1997) Purification and characterization of bimodular and trimodular
derivatives of the erythromycin polyketide synthase. Biochemistry. [IF=0.753, Cited=23, 9048569].
Carreras CW, Gehring AM, Walsh CT, ..., Khosla C (1997) Utilization of enzymatically phosphopantetheinylated acyl
carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthase. Biochemistry. [IF=0.753,
Cited=23, 9305965].
Gokhale RS, Lau J, Cane DE, Khosla C (1998) Functional orientation of the acyltransferase domain in a module of the
erythromycin polyketide synthase. Biochemistry. [IF=0.753, Cited=28, 9485401].
Carreras CW, Khosla C (1998) Purification and in vitro reconstitution of the essential protein components of an aromatic
polyketide synthase. Biochemistry. [IF=0.753, Cited=45, 9518007].
Jacobsen JR, Cane DE, Khosla C (1998) Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase
leads to polyketide biosynthesis. Biochemistry. [IF=0.753, Cited=17, 9538011].
Lau J, Fu H, Cane DE, Khosla C (1999) Dissecting the role of acyltransferase domains of modular polyketide synthases in
the choice and stereochemical fate of extender units. Biochemistry. [IF=0.753, Cited=46, 9931032].
Dreier J, Khosla C (2000) Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the beta-
ketoacyl synthase-chain length factor heterodimer. Biochemistry. [IF=0.753, Cited=33, 10684659].
Ridley CP, Khosla C (2007) Synthesis and biological activity of novel pyranopyrones derived from engineered aromatic
polyketides. ACS Chemical Biology. [IF=0.963, Cited=5, 17256996].
Schnarr NA, Khosla C (2006) Trapping transient protein-protein interactions in polyketide biosynthesis. ACS Chemical
Biology. [IF=0.963, Cited=2, 17184129].
Khosla C (1997) Harnessing the Biosynthetic Potential of Modular Polyketide Synthases. Chemical Reviews. [IF=11.712,
Cited=91, 11851472].
Pohl NL, Hans M, Lee HY, ..., Khosla C (2001) Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme
capable of intracellular synthesis of polyketide precursors. Journal of the American Chemical Society. [IF=2.573,
Cited=23, 11403625].
Kinoshita K, Williard PG, Khosla C, Cane DE (2001) Precursor-directed biosynthesis of 16-membered macrolides by the
erythromycin polyketide synthase. Journal of the American Chemical Society. [IF=2.573, Cited=20, 11456917].
Wu N, Tsuji SY, Cane DE, Khosla C (2001) Assessing the balance between protein-protein interactions and enzyme-substrate
interactions in the channeling of intermediates between polyketide synthase modules. Journal of the American Chemical
Society. [IF=2.573, Cited=75, 11439032].
Hans M, Hornung A, Dziarnowski A, ..., Khosla C (2003) Mechanistic analysis of acyl transferase domain exchange in
polyketide synthase modules. Journal of the American Chemical Society. [IF=2.573, Cited=42, 12720450].
Kumar P, Li Q, Cane DE, Khosla C (2003) Intermodular communication in modular polyketide synthases: structural and
mutational analysis of linker mediated protein-protein recognition. Journal of the American Chemical Society. [IF=2.573,
Cited=22, 12670230].
Boddy CN, Schneider TL, Hotta K, ..., Khosla C (2003) Epothilone C macrolactonization and hydrolysis are catalyzed by
the isolated thioesterase domain of epothilone polyketide synthase. Journal of the American Chemical Society. [IF=2.573,
Cited=31, 12643694].
Yin Y, Lu H, Khosla C, Cane DE (2003) Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of
the picromycin/methymycin polyketide synthase. Journal of the American Chemical Society. [IF=2.573, Cited=15, 12733905].
Kumar P, Koppisch AT, Cane DE, Khosla C (2003) Enhancing the modularity of the modular polyketide synthases:
transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase. Journal of the American
Chemical Society. [IF=2.573, Cited=35, 14624579].
Tang Y, Tsai SC, Khosla C (2003) Polyketide chain length control by chain length factor. Journal of the American
Chemical Society. [IF=2.573, Cited=58, 14558809].
Admiraal SJ, Khosla C, Walsh CT (2003) A Switch for the transfer of substrate between nonribosomal peptide and
polyketide modules of the rifamycin synthetase assembly line. Journal of the American Chemical Society. [IF=2.573,
Cited=10, 14599196].
Boddy CN, Hotta K, Tse ML, ..., Khosla C (2004) Precursor-directed biosynthesis of epothilone in Escherichia coli.
Journal of the American Chemical Society. [IF=2.573, Cited=26, 15198579].
Lee HY, Chung HS, Hang C, ..., Walker S (2004) Reconstitution and characterization of a new desosaminyl transferase,
EryCIII, from the erythromycin biosynthetic pathway. Journal of the American Chemical Society. [IF=2.573, Cited=12, 15303858].
Lee TS, Khosla C, Tang Y (2005) Engineered biosynthesis of aklanonic acid analogues. Journal of the American Chemical
Society. [IF=2.573, Cited=20, 16131203].
Hartung IV, Rude MA, Schnarr NA, ..., Khosla C (2005) Stereochemical assignment of intermediates in the rifamycin
biosynthetic pathway by precursor-directed biosynthesis. Journal of the American Chemical Society. [IF=2.573, Cited=8, 16089423].
Wu J, Zaleski TJ, Valenzano C, ..., Cane DE (2005) Polyketide double bond biosynthesis. Mechanistic analysis of the
dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase. Journal of the American Chemical
Society. [IF=2.573, Cited=54, 16332089].
Xia J, Siegel M, Bergseng E, ..., Khosla C (2006) Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a
high affinity 33-residue peptide from alpha2-gliadin. Journal of the American Chemical Society. [IF=2.573, Cited=37, 16464085].
Chen AY, Schnarr NA, Kim CY, ..., Khosla C (2006) Extender unit and acyl carrier protein specificity of ketosynthase
domains of the 6-deoxyerythronolide B synthase. Journal of the American Chemical Society. [IF=2.573, Cited=68, 16506788].
Castonguay R, He W, Chen AY, ..., Cane DE (2007) Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide
B synthase. Journal of the American Chemical Society. [IF=2.573, Cited=54, 17918944].
Das A, Szu PH, Fitzgerald JT, Khosla C (2010) Mechanism and engineering of polyketide chain initiation in fredericamycin
biosynthesis. Journal of the American Chemical Society. [IF=2.573, Cited=12, 20540492].
Zaleta-Rivera K, Charkoudian LK, Ridley CP, Khosla C (2010) Cloning, sequencing, heterologous expression, and
mechanistic analysis of A-74528 biosynthesis. Journal of the American Chemical Society. [IF=2.573, Cited=14, 20550125].
Valenzano CR, You YO, Garg A, ..., Cane DE (2010) Stereospecificity of the dehydratase domain of the erythromycin
polyketide synthase. Journal of the American Chemical Society. [IF=2.573, Cited=45, 20925342].
Fitzgerald JT, Charkoudian LK, Watts KR, Khosla C (2013) Analysis and refactoring of the A-74528 biosynthetic pathway.
Journal of the American Chemical Society. [IF=2.573, Cited=7, 23442197].
You YO, Khosla C, Cane DE (2013) Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of
polyketide synthases. Journal of the American Chemical Society. [IF=2.573, Cited=15, 23659177].
Garg A, Khosla C, Cane DE (2013) Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase
domains. Ketoreductase-catalyzed equilibrium isotope exchange. Journal of the American Chemical Society. [IF=2.573,
Cited=18, 24161343].
Garg A, Xie X, Keatinge-Clay A, ..., Cane DE (2014) Elucidation of the cryptic epimerase activity of redox-inactive
ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange. Journal of the American
Chemical Society. [IF=2.573, Cited=19, 25004372].
Castonguay R, Valenzano CR, Chen AY, ..., Cane DE (2008) Stereospecificity of ketoreductase domains 1 and 2 of the
tylactone modular polyketide synthase. Journal of the American Chemical Society. [IF=2.573, Cited=32, 18693734].
Valenzano CR, Lawson RJ, Chen AY, ..., Cane DE (2009) The biochemical basis for stereochemical control in polyketide
biosynthesis. Journal of the American Chemical Society. [IF=2.573, Cited=52, 19928853].
Cogan DP, Li X, Sevillano N, ..., Khosla C (2020) Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase
Reveal an Extended Conformation During Ketoreduction. Journal of the American Chemical Society. [IF=2.573, Cited=7, 32786753].
Loppinet E, Besser HA, Lee CE, ..., Khosla C (2023) Targeted Lysosomal Degradation of Secreted and Cell Surface Proteins
through the LRP-1 Pathway. Journal of the American Chemical Society. [IF=2.573, Cited=3, 37590164].
Kishore S, Del Rio Flores A, Lynch SR, ..., Khosla C (2024) Discovery and Characterization of the Fully Decorated
Nocardiosis-Associated Polyketide Natural Product. Journal of the American Chemical Society. [IF=2.573, Cited=0, 38295028].
Xie X, Garg A, Khosla C, Cane DE (2017) Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group
Epimerization in Polyether Biosynthesis. Journal of the American Chemical Society. [IF=2.573, Cited=10, 28157306].
Xie X, Khosla C, Cane DE (2017) Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide
Synthases. Journal of the American Chemical Society. [IF=2.573, Cited=8, 28430424].
Xie X, Garg A, Khosla C, Cane DE (2017) Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase
Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay. Journal of the American Chemical
Society. [IF=2.573, Cited=7, 28682630].
Klaus M, Rossini E, Linden A, ..., Grininger M (2021) Solution Structure and Conformational Flexibility of a Polyketide
Synthase Module. JACS Au. [IF=1.606, Cited=6, 34977887].
Watts RE, Siegel M, Khosla C (2006) Structure-activity relationship analysis of the selective inhibition of
transglutaminase 2 by dihydroisoxazoles. Journal of Medicinal Chemistry. [IF=1.655, Cited=46, 17149878].
DiRaimondo TR, Plugis NM, Jin X, Khosla C (2013) Selective inhibition of extracellular thioredoxin by asymmetric
disulfides. Journal of Medicinal Chemistry. [IF=1.655, Cited=18, 23327656].
Klöck C, Herrera Z, Albertelli M, Khosla C (2014) Discovery of potent and specific dihydroisoxazole inhibitors of human
transglutaminase 2. Journal of Medicinal Chemistry. [IF=1.655, Cited=21, 25333388].
Khosla C (2000) Natural product biosynthesis: a new interface between enzymology and medicine. Journal of Organic
Chemistry. [IF=0.885, Cited=22, 11101363].
Khosla C (2009) Structures and mechanisms of polyketide synthases. Journal of Organic Chemistry. [IF=0.885, Cited=46, 19711990].
Salomon AR, Zhang Y, Seto H, Khosla C (2001) Structure-activity relationships within a family of selectively cytotoxic
macrolide natural products. Organic Letters. [IF=1.091, Cited=22, 11429871].
Shan L, Qiao SW, Arentz-Hansen H, ..., Khosla C (2005) Identification and analysis of multivalent proteolytically
resistant peptides from gluten: implications for celiac sprue. Journal of Proteome Research. [IF=0.952, Cited=143, 16212427].
Khosla C, Harbury PB (2001) Modular enzymes. Nature. [IF=11.591, Cited=57, 11196653].
Lebwohl B, Murray JA, Verdú EF, ..., Khosla C (2015) Gluten Introduction, Breastfeeding, and Celiac Disease: Back to the
Drawing Board. American Journal of Gastroenterology. [IF=2.479, Cited=13, 26259710].
O'Brien RV, Davis RW, Khosla C, Hillenmeyer ME (2013) Computational identification and analysis of orphan assembly-line
polyketide synthases. Journal of Antibiotics. [IF=0.805, Cited=36, 24301183].
Ostrowski MP, Cane DE, Khosla C (2016) Recognition of acyl carrier proteins by ketoreductases in assembly line
polyketide synthases. Journal of Antibiotics. [IF=0.805, Cited=9, 27118242].
Vandova GA, O'Brien RV, Lowry B, ..., Hillenmeyer ME (2017) Heterologous expression of diverse propionyl-CoA
carboxylases affects polyketide production in Escherichia coli. Journal of Antibiotics. [IF=0.805, Cited=5, 28400575].
Khosla C (2015) Quo vadis, enzymology? Nature Chemical Biology. [IF=2.623, Cited=7, 26083060].
Deans RM, Morgens DW, Ökesli A, ..., Bassik MC (2016) Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug
target identification. Nature Chemical Biology. [IF=2.623, Cited=103, 27018887].
Khosla C, Keasling JD (2003) Metabolic engineering for drug discovery and development. Nature Reviews Drug Discovery.
[IF=18.471, Cited=88, 14654799].
Jagannathan P, Andrews JR, Bonilla H, ..., Singh U (2021) Peginterferon Lambda-1a for treatment of outpatients with
uncomplicated COVID-19: a randomized placebo-controlled trial. Nature Communications. [IF=3.268, Cited=82, 33785743].
Palanski BA, Weng N, Zhang L, ..., Elias JE (2022) An efficient urine peptidomics workflow identifies chemically defined
dietary gluten peptides from patients with celiac disease. Nature Communications. [IF=3.268, Cited=9, 35173144].
Abadie V, Kim SM, Lejeune T, ..., Jabri B (2020) IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease.
Nature. [IF=11.591, Cited=65, 32051586].
Sirirungruang S, Ad O, Privalsky TM, ..., Chang MCY (2022) Engineering site-selective incorporation of fluorine into
polyketides. Nature Chemical Biology. [IF=2.623, Cited=11, 35817967].
Murray JA, Syage JA, Wu TT, ..., Sealey-Voyksner JA (2022) Latiglutenase Protects the Mucosa and Attenuates Symptom
Severity in Patients With Celiac Disease Exposed to a Gluten Challenge. Gastroenterology. [IF=5.156, Cited=15, 35931103].
Silvester JA, Elli L, Khosla C, Tye-Din JA (2024) Past, Present, and Future of Noninvasive Tests to Assess Gluten
Exposure, Celiac Disease Activity, and End-Organ Damage. Gastroenterology. [IF=5.156, Cited=0, 38670279].
Meling MT, Kleppa L, Besser HA, ..., Sollid LM (2024) Enterocyte-Derived and Catalytically Active Transglutaminase 2 in
the Gut Lumen of Mice: Implications for Celiac Disease. Gastroenterology. [IF=5.156, Cited=0, 38825048].
Lowry B, Walsh CT, Khosla C (2015) In Vitro Reconstitution of Metabolic Pathways: Insights into Nature's Chemical
Logic. Synlett. [IF=0.473, Cited=10, 26207083].
Tsai SC, Miercke LJ, Krucinski J, ..., Stroud RM (2001) Crystal structure of the macrocycle-forming thioesterase domain
of the erythromycin polyketide synthase: versatility from a unique substrate channel. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=128, 11752428].
Kim CY, Quarsten H, Bergseng E, ..., Sollid LM (2004) Structural basis for HLA-DQ2-mediated presentation of gluten
epitopes in celiac disease. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=238, 15020763].
Shan L, Mathews II, Khosla C (2005) Structural and mechanistic analysis of two prolyl endopeptidases: role of
interdomain dynamics in catalysis and specificity. Proceedings of the National Academy of Sciences of the United States
of America. [IF=2.765, Cited=80, 15738423].
Tang Y, Kim CY, Mathews II, ..., Khosla C (2006) The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of
the 6-deoxyerythronolide B synthase. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=169, 16844787].
Ridley CP, Lee HY, Khosla C (2008) Evolution of polyketide synthases in bacteria. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=99, 18250311].
Kapur S, Chen AY, Cane DE, Khosla C (2010) Molecular recognition between ketosynthase and acyl carrier protein domains
of the 6-deoxyerythronolide B synthase. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=58, 21127271].
Yu X, Liu T, Zhu F, Khosla C (2011) In vitro reconstitution and steady-state analysis of the fatty acid synthase from
Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=84, 22042840].
Kapur S, Lowry B, Yuzawa S, ..., Khosla C (2012) Reprogramming a module of the 6-deoxyerythronolide B synthase for
iterative chain elongation. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=60, 22371562].
Chiu HT, Hubbard BK, Shah AN, ..., Khosla C (2001) Molecular cloning and sequence analysis of the complestatin
biosynthetic gene cluster. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=91, 11447274].
Watanabe K, Rude MA, Walsh CT, Khosla C (2003) Engineered biosynthesis of an ansamycin polyketide precursor in
Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=45, 12888623].
Plugis NM, Weng N, Zhao Q, ..., Khosla C (2018) Interleukin 4 is inactivated via selective disulfide-bond reduction by
extracellular thioredoxin. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=13, 30104382].
Nivina A, Herrera Paredes S, Fraser HB, Khosla C (2021) GRINS: Genetic elements that recode assembly-line polyketide
synthases and accelerate their diversification. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=8, 34162709].
Sewa AS, Besser HA, Mathews II, Khosla C (2024) Structural and mechanistic analysis of Ca²⁺-dependent
regulation of transglutaminase 2 activity using a Ca²⁺-bound intermediate state. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=0, 38959038].
McDaniel R, Ebert-Khosla S, Fu H, ..., Khosla C (1994) Engineered biosynthesis of novel polyketides: influence of a
downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=72, 7972098].
Salomon AR, Voehringer DW, Herzenberg LA, Khosla C (2000) Understanding and exploiting the mechanistic basis for
selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=61, 11121076].
Klaus M, Ostrowski MP, Austerjost J, ..., Khosla C (2016) Protein-Protein Interactions, Not Substrate Recognition,
Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases. Journal of Biological Chemistry. [IF=1.122,
Cited=33, 27246853].
Plugis NM, Palanski BA, Weng CH, ..., Khosla C (2016) Thioredoxin-1 Selectively Activates Transglutaminase 2 in the
Extracellular Matrix of the Small Intestine: IMPLICATIONS FOR CELIAC DISEASE. Journal of Biological Chemistry.
[IF=1.122, Cited=25, 28003361].
Khosla C (2010) Thematic minireview series on antibacterial natural products: new tricks for old dogs. Journal of
Biological Chemistry. [IF=1.122, Cited=0, 20522550].
Yi MC, Melkonian AV, Ousey JA, Khosla C (2018) Endoplasmic reticulum-resident protein 57 (ERp57) oxidatively inactivates
human transglutaminase 2. Journal of Biological Chemistry. [IF=1.122, Cited=22, 29305423].
Gupta A, Ökesli-Armlovich A, Morgens D, ..., Khosla C (2020) A genome-wide analysis of targets of macrolide antibiotics
in mammalian cells. Journal of Biological Chemistry. [IF=1.122, Cited=6, 31915244].
Holubar M, Subramanian A, Purington N, ..., Maldonado Y (2022) Favipiravir for Treatment of Outpatients With
Asymptomatic or Uncomplicated Coronavirus Disease 2019: A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial.
Clinical Infectious Diseases. [IF=2.495, Cited=22, 35446944].
Verma R, Kim E, Martínez-Colón GJ, ..., Andrews JR (2021) SARS-CoV-2 Subgenomic RNA Kinetics in Longitudinal Clinical
Samples. Open Forum Infectious Diseases. [IF=1.114, Cited=17, 34295944].
Walter KS, Kim E, Verma R, ..., Andrews JR (2023) Challenges in Harnessing Shared Within-Host Severe Acute Respiratory
Syndrome Coronavirus 2 Variation for Transmission Inference. Open Forum Infectious Diseases. [IF=1.114, Cited=1, 36751652].
Dunn BJ, Khosla C (2013) Engineering the acyltransferase substrate specificity of assembly line polyketide synthases.
Journal of the Royal Society Interface. [IF=1.305, Cited=59, 23720536].
Kishore S, Khosla C (2023) Genomic mining and diversity of assembly line polyketide synthases. Open Biology. [IF=1.384,
Cited=3, 37528731].
Hu Z, Hunziker D, Hutchinson CR, Khosla C (1999) A host-vector system for analysis and manipulation of rifamycin
polyketide biosynthesis in Amycolatopsis mediterranei. Microbiology (United Kingdom). [IF=0.832, Cited=7, 10517586].
Hu Z, Pfeifer BA, Chao E, ..., Hutchinson CR (2003) A specific role of the Saccharopolyspora erythraea thioesterase II
gene in the function of modular polyketide synthases. Microbiology (United Kingdom). [IF=0.832, Cited=31, 12904561].
Harvey CJB, Tang M, Schlecht U, ..., Hillenmeyer ME (2018) HEx: A heterologous expression platform for the discovery of
fungal natural products. Science advances. [IF=2.861, Cited=82, 29651464].
Pfeifer BA, Admiraal SJ, Gramajo H, ..., Khosla C (2001) Biosynthesis of complex polyketides in a metabolically
engineered strain of E. coli. Science. [IF=7.729, Cited=382, 11230695].
Shan L, Molberg Ø, Parrot I, ..., Khosla C (2002) Structural basis for gluten intolerance in celiac sprue. Science.
[IF=7.729, Cited=797, 12351792].
Khosla C, Tang Y (2005) Chemistry. A new route to designer antibiotics. Science. [IF=7.729, Cited=12, 15831747].
Liu T, Khosla C (2010) Chemistry. A balancing act for Taxol precursor pathways in E. coli. Science. [IF=7.729,
Cited=10, 20929799].
Walker MC, Thuronyi BW, Charkoudian LK, ..., Chang MCY (2013) Expanding the fluorine chemistry of living systems using
engineered polyketide synthase pathways. Science. [IF=7.729, Cited=85, 24009388].
Jacobsen JR, Hutchinson CR, Cane DE, Khosla C (1997) Precursor-directed biosynthesis of erythromycin analogs by an
engineered polyketide synthase. Science. [IF=7.729, Cited=127, 9219693].
Cane DE, Walsh CT, Walsh CT, ..., Khosla C (1998) Harnessing the biosynthetic code: combinations, permutations, and
mutations. Science. [IF=7.729, Cited=320, 9756477].
Gokhale RS, Tsuji SY, Cane DE, Khosla C (1999) Dissecting and exploiting intermodular communication in polyketide
synthases. Science. [IF=7.729, Cited=181, 10205055].
Kao CM, Katz L, Khosla C (1994) Engineered biosynthesis of a complete macrolactone in a heterologous host. Science.
[IF=7.729, Cited=110, 8036492].
McDaniel R, Ebert-Khosla S, Hopwood DA, Khosla C (1993) Engineered biosynthesis of novel polyketides. Science.
[IF=7.729, Cited=218, 8248802].
Bouziat R, Hinterleitner R, Brown JJ, ..., Jabri B (2017) Reovirus infection triggers inflammatory responses to dietary
antigens and development of celiac disease. Science. [IF=7.729, Cited=220, 28386004].
Cogan DP, Zhang K, Li X, ..., Khosla C (2021) Mapping the catalytic conformations of an assembly-line polyketide
synthase module. Science. [IF=7.729, Cited=21, 34735239].
Li J, Zaslavsky M, Su Y, ..., Davis MM (2022) KIR⁺CD8⁺ T cells suppress pathogenic T cells and are
active in autoimmune diseases and COVID-19. Science. [IF=7.729, Cited=92, 35258337].
Chakraborty S, Gonzalez JC, Sievers BL, ..., Wang TT (2022) Early non-neutralizing, afucosylated antibody responses are
associated with COVID-19 severity. Science Translational Medicine. [IF=2.778, Cited=55, 35040666].
Hu Z, Hopwood DA, Khosla C (2000) Directed transfer of large DNA fragments between Streptomyces species. Applied and
Environmental Microbiology. [IF=1.103, Cited=8, 10788417].
Pfeifer B, Hu Z, Licari P, Khosla C (2002) Process and metabolic strategies for improved production of Escherichia coli-
derived 6-deoxyerythronolide B. Applied and Environmental Microbiology. [IF=1.103, Cited=56, 12089005].
Pfeifer BA, Wang CCC, Walsh CT, Khosla C (2003) Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal
peptide, using Escherichia coli as a heterologous host. Applied and Environmental Microbiology. [IF=1.103, Cited=58, 14602630].
Pfeifer BA, Khosla C (2001) Biosynthesis of polyketides in heterologous hosts. Microbiology and Molecular Biology
Reviews. [IF=2.842, Cited=116, 11238987].
Bedford DJ, Schweizer E, Hopwood DA, Khosla C (1995) Expression of a functional fungal polyketide synthase in the
bacterium Streptomyces coelicolor A3(2). Journal of Bacteriology. [IF=0.898, Cited=51, 7635840].
Soohoo AM, Cogan DP, Brodsky KL, Khosla C (2024) Structure and Mechanisms of Assembly-Line Polyketide Synthases. Annual
Review of Biochemistry. [IF=5.273, Cited=0, 38663033].
Yi MC, Khosla C (2016) Thiol-Disulfide Exchange Reactions in the Mammalian Extracellular Environment. Annual Review of
Chemical and Biomolecular Engineering. [IF=2.338, Cited=38, 27023663].
Liu T, Khosla C (2010) Genetic engineering of Escherichia coli for biofuel production. Annual Review of Genetics.
[IF=2.79, Cited=48, 20822440].
Khosla C, Gokhale RS, Jacobsen JR, Cane DE (1999) Tolerance and specificity of polyketide synthases. Annual Review of
Biochemistry. [IF=5.273, Cited=162, 10872449].
Khosla C, Tang Y, Chen AY, ..., Cane DE (2007) Structure and mechanism of the 6-deoxyerythronolide B synthase. Annual
Review of Biochemistry. [IF=5.273, Cited=159, 17328673].
Hausch F, Shan L, Santiago NA, ..., Khosla C (2002) Intestinal digestive resistance of immunodominant gliadin peptides.
American Journal of Physiology - Gastrointestinal and Liver Physiology. [IF=1.04, Cited=159, 12223360].
Penumatsa KC, Toksoz D, Warburton RR, ..., Fanburg BL (2014) Role of hypoxia-induced transglutaminase 2 in pulmonary
artery smooth muscle cell proliferation. American Journal of Physiology - Lung Cellular and Molecular Physiology.
[IF=0.96, Cited=21, 25128524].
Penumatsa KC, Toksoz D, Warburton RR, ..., Fanburg BL (2017) Transglutaminase 2 in pulmonary and cardiac tissue
remodeling in experimental pulmonary hypertension. American Journal of Physiology - Lung Cellular and Molecular
Physiology. [IF=0.96, Cited=18, 28775095].
Yuan L, Choi K, Khosla C, ..., Rich KM (2005) Tissue transglutaminase 2 inhibition promotes cell death and
chemosensitivity in glioblastomas. Molecular Cancer Therapeutics. [IF=1.04, Cited=58, 16170020].
Goodyer WR, Beyersdorf BM, Duan L, ..., Wu SM (2022) In vivo visualization and molecular targeting of the cardiac
conduction system. Journal of Clinical Investigation. [IF=2.423, Cited=5, 35951416].
Matic I, Sacchi A, Rinaldi A, ..., Piacentini M (2010) Characterization of transglutaminase type II role in dendritic
cell differentiation and function. Journal of Leukocyte Biology. [IF=1.219, Cited=25, 20371597].
Lord-Dufour S, Copland IB, Levros LC, ..., Annabi B (2009) Evidence for transcriptional regulation of the
glucose-6-phosphate transporter by HIF-1alpha: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal
cells. Stem Cells. [IF=0.985, Cited=36, 19074414].
Qiao SW, Bergseng E, Molberg Ø, ..., Sollid LM (2004) Antigen presentation to celiac lesion-derived T cells of a 33-mer
gliadin peptide naturally formed by gastrointestinal digestion. Journal of Immunology. [IF=0.939, Cited=85, 15265905].
Qiao SW, Piper J, Haraldsen G, ..., Sollid LM (2005) Tissue transglutaminase-mediated formation and cleavage of
histamine-gliadin complexes: biological effects and implications for celiac disease. Journal of Immunology. [IF=0.939,
Cited=23, 15661929].
Hu Z, van der Ploeg K, Chakraborty S, ..., Jagannathan P (2022) Early immune markers of clinical, virological, and
immunological outcomes in patients with COVID-19: a multi-omics study. eLife. [IF=1.743, Cited=7, 36239699].

Publication with MISSING institution:

Hopwood DA, Khosla C (1992) Genes for polyketide secondary metabolic pathways in microorganisms and plants. None.
[IF=None, Cited=13, 1302187].
Wu J, He W, Khosla C, Cane DE (2005) Chain elongation, macrolactonization, and hydrolysis of natural and reduced
hexaketide substrates by the picromycin/methymycin polyketide synthase. Angewandte Chemie - International Edition.
[IF=2.456, Cited=6, 16247819].
Walsh CT, O'Brien RV, Khosla C (2013) Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid
polyketide scaffolds. Angewandte Chemie - International Edition. [IF=2.456, Cited=129, 23729217].
Wang J, Jin X, Liu J, ..., Xia J (2012) Resolving multiple protein-peptide binding events: implication for HLA-DQ2
mediated antigen presentation in celiac disease. Chemistry - An Asian Journal. [IF=0.736, Cited=6, 22411856].
Dordick JS, Khosla C (2002) Engineering of molecular and cellular biocatalysts: selected contributions by James E.
Bailey. Biotechnology and Bioengineering. [IF=0.932, Cited=0, 12209820].
Gass J, Ehren J, Strohmeier G, ..., Khosla C (2005) Fermentation, purification, formulation, and pharmacological
evaluation of a prolyl endopeptidase from Myxococcus xanthus: implications for Celiac Sprue therapy. Biotechnology and
Bioengineering. [IF=0.932, Cited=46, 16136593].
Vora H, McIntire J, Kumar P, ..., Khosla C (2007) A scaleable manufacturing process for pro-EP-B2, a cysteine protease
from barley indicated for celiac sprue. Biotechnology and Bioengineering. [IF=0.932, Cited=15, 17385743].
Hicks LM, Mazur MT, Miller LM, ..., Kelleher NL (2006) Investigating nonribosomal peptide and polyketide biosynthesis by
direct detection of intermediates on >70 kDa polypeptides by using Fourier-transform mass spectrometry. ChemBioChem.
[IF=0.691, Cited=13, 16642537].
Klöck C, Khosla C (2012) Regulation of the activities of the mammalian transglutaminase family of enzymes. Protein
Science. [IF=1.97, Cited=36, 23011841].
Charkoudian LK, Liu CW, Capone S, ..., Khosla C (2011) Probing the interactions of an acyl carrier protein domain from
the 6-deoxyerythronolide B synthase. Protein Science. [IF=1.97, Cited=27, 21563224].
Richardson MT, Pohl NL, Kealey JT, Khosla C (1999) Tolerance and specificity of recombinant 6-methylsalicyclic acid
synthase. Metabolic Engineering. [IF=1.846, Cited=17, 10935930].
McDaniel R, Licari P, Khosla C (2001) Process development and metabolic engineering for the overproduction of natural
and unnatural polyketides. None. [IF=None, Cited=13, 11816811].
Fu H, Khosla C (1996) Antibiotic activity of polyketide products derived from combinatorial biosynthesis: implications
for directed evolution. Molecular Diversity. [IF=1.059, Cited=4, 9237201].
Gass J, Khosla C (2007) Prolyl endopeptidases. Cellular and Molecular Life Sciences. [IF=1.825, Cited=79, 17160352].
Alvarez-Sieiro P, Martin MC, Redruello B, ..., Alvarez MA (2014) Generation of food-grade recombinant Lactobacillus
casei delivering Myxococcus xanthus prolyl endopeptidase. Applied Microbiology and Biotechnology. [IF=1.275, Cited=14, 24752841].
Klöck C, Diraimondo TR, Khosla C (2012) Role of transglutaminase 2 in celiac disease pathogenesis. Seminars in
Immunopathology. [IF=2.2, Cited=50, 22437759].
Yuan L, Behdad A, Siegel M, ..., Rich KM (2008) Tissue transgluaminase 2 expression in meningiomas. Journal of Neuro-
Oncology. [IF=1.338, Cited=13, 18587533].
Yuan L, Holmes TC, Watts RE, ..., Rich KM (2010) Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and
enhances cell death in glioblastomas. Journal of Neuro-Oncology. [IF=1.338, Cited=8, 20824305].
Luo G, Pieper R, Rosa A, ..., Cane DE (1996) Erythromycin biosynthesis: exploiting the catalytic versatility of the
modular polyketide synthase. Bioorganic and Medicinal Chemistry. [IF=0.86, Cited=11, 8831969].
Fu H, Hopwood DA, Khosla C (1994) Engineered biosynthesis of novel polyketides: evidence for temporal, but not
regiospecific, control of cyclization of an aromatic polyketide precursor. None. [IF=None, Cited=41, 9383392].
Tsoi CJ, Khosla C (1995) Combinatorial biosynthesis of 'unnatural' natural products: the polyketide example. None.
[IF=None, Cited=33, 9383437].
Bethune MT, Khosla C (2012) Oral enzyme therapy for celiac sprue. None. [IF=None, Cited=47, 22208988].
Kumar P, Khosla C, Tang Y (2004) Manipulation and analysis of polyketide synthases. None. [IF=None, Cited=11, 15289078].
Gokhale RS, Hunziker D, Cane DE, Khosla C (1999) Mechanism and specificity of the terminal thioesterase domain from the
erythromycin polyketide synthase. None. [IF=None, Cited=83, 10021418].
Lee TS, Das A, Khosla C (2007) Structure-activity relationships of semisynthetic mumbaistatin analogs. Bioorganic and
Medicinal Chemistry. [IF=0.86, Cited=7, 17524653].
Siegel M, Xia J, Khosla C (2007) Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as
modulators of HLA-DQ2 and transglutaminase 2. Bioorganic and Medicinal Chemistry. [IF=0.86, Cited=25, 17590341].
Xia J, Bergseng E, Fleckenstein B, ..., Sollid LM (2007) Cyclic and dimeric gluten peptide analogues inhibiting
DQ2-mediated antigen presentation in celiac disease. Bioorganic and Medicinal Chemistry. [IF=0.86, Cited=45, 17681795].
Kinoshita K, Pfeifer BA, Khosla C, Cane DE (2003) Precursor-Directed polyketide biosynthesis in Escherichia coli.
Bioorganic and Medicinal Chemistry Letters. [IF=0.704, Cited=11, 14552761].
Moffet DA, Khosla C, Cane DE (2005) Modular polyketide synthases: Investigating intermodular communication using 6
deoxyerythronolide B synthase module 2. Bioorganic and Medicinal Chemistry Letters. [IF=0.704, Cited=4, 16213712].
He W, Wu J, Khosla C, Cane DE (2005) Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase
of the picromycin/methymycin polyketide synthase. Bioorganic and Medicinal Chemistry Letters. [IF=0.704, Cited=15, 16249083].
Kapur S, Worthington A, Tang Y, ..., Khosla C (2008) Mechanism based protein crosslinking of domains from the
6-deoxyerythronolide B synthase. Bioorganic and Medicinal Chemistry Letters. [IF=0.704, Cited=22, 18243693].
Klöck C, Jin X, Choi K, ..., Griffin JH (2010) Acylideneoxoindoles: a new class of reversible inhibitors of human
transglutaminase 2. Bioorganic and Medicinal Chemistry Letters. [IF=0.704, Cited=30, 21215619].
Wong FT, Khosla C (2012) Combinatorial biosynthesis of polyketides--a perspective. Current Opinion in Chemical Biology.
[IF=1.51, Cited=67, 22342766].
Choi K, Siegel M, Piper JL, ..., Khosla C (2005) Chemistry and biology of dihydroisoxazole derivatives: selective
inhibitors of human transglutaminase 2. None. [IF=None, Cited=101, 15850984].
Bethune MT, Strop P, Tang Y, ..., Khosla C (2006) Heterologous expression, purification, refolding, and structural-
functional characterization of EP-B2, a self-activating barley cysteine endoprotease. None. [IF=None, Cited=69, 16793521].
Siegel M, Bethune MT, Gass J, ..., Khosla C (2006) Rational design of combination enzyme therapy for celiac sprue. None.
[IF=None, Cited=74, 16793522].
Chen AY, Cane DE, Khosla C (2007) Structure-based dissociation of a type I polyketide synthase module. None. [IF=None,
Cited=50, 17656315].
Tang Y, Chen AY, Kim CY, ..., Khosla C (2007) Structural and mechanistic analysis of protein interactions in module 3 of
the 6-deoxyerythronolide B synthase. None. [IF=None, Cited=101, 17719492].
Bethune MT, Crespo-Bosque M, Bergseng E, ..., Khosla C (2009) Noninflammatory gluten peptide analogs as biomarkers for
celiac sprue. None. [IF=None, Cited=11, 19716477].
Das A, Khosla C (2009) In vivo and in vitro analysis of the hedamycin polyketide synthase. None. [IF=None, Cited=19, 19942143].
Dafik L, Khosla C (2011) Dihydroisoxazole analogs for labeling and visualization of catalytically active
transglutaminase 2. None. [IF=None, Cited=16, 21276939].
Szu PH, Govindarajan S, Meehan MJ, ..., Khosla C (2011) Analysis of the ketosynthase-chain length factor heterodimer
from the fredericamycin polyketide synthase. None. [IF=None, Cited=8, 21867917].
Sealey-Voyksner JA, Khosla C, Voyksner RD, Jorgenson JW (2010) Novel aspects of quantitation of immunogenic wheat gluten
peptides by liquid chromatography-mass spectrometry/mass spectrometry. Journal of Chromatography A. [IF=1.02, Cited=23, 20181349].
Strnad P, Siegel M, Toivola DM, ..., Omary MB (2006) Pharmacologic transglutaminase inhibition attenuates drug-primed
liver hypertrophy but not Mallory body formation. FEBS Letters. [IF=0.871, Cited=9, 16616523].
Watanabe K, Khosla C, Stroud RM, Tsai SC (2003) Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide
biosynthetic pathway: insights into extender unit biosynthesis. Journal of Molecular Biology. [IF=1.281, Cited=23, 14623185].
Siegel M, Khosla C (2007) Transglutaminase 2 inhibitors and their therapeutic role in disease states. Pharmacology and
Therapeutics. [IF=2.796, Cited=123, 17582505].
Lu X, Vora H, Khosla C (2008) Overproduction of free fatty acids in E. coli: implications for biodiesel production.
Metabolic Engineering. [IF=1.846, Cited=187, 18812230].
Liu T, Vora H, Khosla C (2010) Quantitative analysis and engineering of fatty acid biosynthesis in E. coli. Metabolic
Engineering. [IF=1.846, Cited=114, 20184964].
Julien B, Shah S, Ziermann R, ..., Khosla C (2000) Isolation and characterization of the epothilone biosynthetic gene
cluster from Sorangium cellulosum. Gene. [IF=0.932, Cited=77, 10831849].
Yin Y, Gokhale R, Khosla C, Cane DE (2001) Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for
ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase. Bioorganic and Medicinal Chemistry
Letters. [IF=0.704, Cited=20, 11412964].
Jacobsen JR, Keatinge-Clay AT, Cane DE, Khosla C (1998) Precursor-directed biosynthesis of 12-ethyl erythromycin.
Bioorganic and Medicinal Chemistry. [IF=0.86, Cited=14, 9784859].
Pan H, Tsai Sc, Meadows ES, ..., Stroud RM (2002) Crystal structure of the priming beta-ketosynthase from the R1128
polyketide biosynthetic pathway. Structure. [IF=1.155, Cited=45, 12429097].
Keatinge-Clay AT, Shelat AA, Savage DF, ..., Stroud RM (2003) Catalysis, specificity, and ACP docking site of
Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure. [IF=1.155, Cited=71, 12575934].
Salomon AR, Voehringer DW, Herzenberg LA, Khosla C (2001) Apoptolidin, a selective cytotoxic agent, is an inhibitor of
F0F1-ATPase. None. [IF=None, Cited=63, 11182320].
Cane DE, Kudo F, Kinoshita K, Khosla C (2002) Precursor-directed biosynthesis: biochemical basis of the remarkable
selectivity of the erythromycin polyketide synthase toward unsaturated triketides. None. [IF=None, Cited=35, 11841945].
Hausch F, Halttunen T, Mäki M, Khosla C (2003) Design, synthesis, and evaluation of gluten peptide analogs as selective
inhibitors of human tissue transglutaminase. None. [IF=None, Cited=49, 12670536].
Bedford D, Jacobsen JR, Luo G, ..., Khosla C (1996) A functional chimeric modular polyketide synthase generated via
domain replacement. None. [IF=None, Cited=26, 8939701].
Lambalot RH, Gehring AM, Flugel RS, ..., Walsh CT (1996) A new enzyme superfamily - the phosphopantetheinyl
transferases. None. [IF=None, Cited=473, 8939709].
Blanco G, Fu H, Mendez C, ..., Salas JA (1996) Deciphering the biosynthetic origin of the aglycone of the aureolic acid
group of anti-tumor agents. None. [IF=None, Cited=18, 8807845].
McDaniel R, Kao CM, Hwang SJ, Khosla C (1997) Engineered intermodular and intramodular polyketide synthase fusions.
None. [IF=None, Cited=46, 9331407].
Chuck JA, McPherson M, Huang H, ..., Cane DE (1997) Molecular recognition of diketide substrates by a beta-ketoacyl-acyl
carrier protein synthase domain within a bimodular polyketide synthase. None. [IF=None, Cited=21, 9375254].
Zawada RJ, Khosla C (1999) Heterologous expression, purification, reconstitution and kinetic analysis of an extended
type II polyketide synthase. None. [IF=None, Cited=25, 10467128].
Liou GF, Khosla C (2003) Building-block selectivity of polyketide synthases. Current Opinion in Chemical Biology.
[IF=1.51, Cited=30, 12714062].
Jacobsen JR, Khosla C (1998) New directions in metabolic engineering. Current Opinion in Chemical Biology. [IF=1.51,
Cited=9, 9667907].
Gokhale RS, Khosla C (2000) Role of linkers in communication between protein modules. Current Opinion in Chemical
Biology. [IF=1.51, Cited=109, 10679375].
Pyle GG, Paaso B, Anderson BE, ..., Gray GM (2005) Low-dose gluten challenge in celiac sprue: malabsorptive and antibody
responses. Clinical Gastroenterology and Hepatology. [IF=2.701, Cited=14, 16206501].
Pyle GG, Paaso B, Anderson BE, ..., Gray GM (2005) Effect of pretreatment of food gluten with prolyl endopeptidase on
gluten-induced malabsorption in celiac sprue. Clinical Gastroenterology and Hepatology. [IF=2.701, Cited=61, 16206502].
Privalsky TM, Soohoo AM, Wang J, ..., Khosla C (2021) Prospects for Antibacterial Discovery and Development. Journal of
the American Chemical Society. [IF=2.573, Cited=17, 34860516].
Mathews II, Allison K, Robbins T, ..., Cohen AE (2017) The Conformational Flexibility of the Acyltransferase from the
Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery
Method for Serial Crystallography. Biochemistry. [IF=0.753, Cited=8, 28832129].
Palanski BA, Khosla C (2018) Cystamine and Disulfiram Inhibit Human Transglutaminase 2 via an Oxidative Mechanism.
Biochemistry. [IF=0.753, Cited=15, 29570977].
Li X, Sevillano N, La Greca F, ..., Khosla C (2018) Discovery and Characterization of a Thioesterase-Specific Monoclonal
Antibody That Recognizes the 6-Deoxyerythronolide B Synthase. Biochemistry. [IF=0.753, Cited=4, 30289692].
Nivina A, Yuet KP, Hsu J, Khosla C (2019) Evolution and Diversity of Assembly-Line Polyketide Synthases. Chemical
Reviews. [IF=11.712, Cited=74, 31838842].
Guzman KM, Yuet KP, Lynch SR, ..., Khosla C (2021) Properties of a "Split-and-Stuttering" Module of an Assembly Line
Polyketide Synthase. Journal of Organic Chemistry. [IF=0.885, Cited=4, 33755455].
Fu H, McDaniel R, Hopwood DA, Khosla C (1994) Engineered biosynthesis of novel polyketides: stereochemical course of two
reactions catalyzed by a polyketide synthase. Biochemistry. [IF=0.753, Cited=22, 8049233].
Wong FT, Jin X, Mathews II, ..., Khosla C (2011) Structure and mechanism of the trans-acting acyltransferase from the
disorazole synthase. Biochemistry. [IF=0.753, Cited=47, 21707057].
Yuzawa S, Kapur S, Cane DE, Khosla C (2012) Role of a conserved arginine residue in linkers between the ketosynthase and
acyltransferase domains of multimodular polyketide synthases. Biochemistry. [IF=0.753, Cited=15, 22509729].
Dunn BJ, Cane DE, Khosla C (2013) Mechanism and specificity of an acyltransferase domain from a modular polyketide
synthase. Biochemistry. [IF=0.753, Cited=33, 23452124].
Dunn BJ, Watts KR, Robbins T, ..., Khosla C (2014) Comparative analysis of the substrate specificity of trans- versus
cis-acyltransferases of assembly line polyketide synthases. Biochemistry. [IF=0.753, Cited=26, 24871074].
Lombó F, Pfeifer B, Leaf T, ..., Khosla C (2001) Enhancing the atom economy of polyketide biosynthetic processes through
metabolic engineering. Biotechnology Progress. [IF=0.785, Cited=29, 11485419].
DiRaimondo TR, Klöck C, Warburton R, ..., Fanburg B (2013) Elevated transglutaminase 2 activity is associated with
hypoxia-induced experimental pulmonary hypertension in mice. ACS Chemical Biology. [IF=0.963, Cited=36, 24152195].
Harvey CJB, Puglisi JD, Pande VS, ..., Khosla C (2012) Precursor directed biosynthesis of an orthogonally functional
erythromycin analogue: selectivity in the ribosome macrolide binding pocket. Journal of the American Chemical Society.
[IF=2.573, Cited=36, 22741553].
Holmes TC, May AE, Zaleta-Rivera K, ..., Khosla C (2012) Molecular insights into the biosynthesis of guadinomine: a type
III secretion system inhibitor. Journal of the American Chemical Society. [IF=2.573, Cited=28, 23030602].
Lowry B, Robbins T, Weng CH, ..., Khosla C (2013) In vitro reconstitution and analysis of the 6-deoxyerythronolide B
synthase. Journal of the American Chemical Society. [IF=2.573, Cited=41, 24161212].
Yuet KP, Liu CW, Lynch SR, ..., Khosla C (2020) Complete Reconstitution and Deorphanization of the 3 MDa Nocardiosis-
Associated Polyketide Synthase. Journal of the American Chemical Society. [IF=2.573, Cited=7, 32182063].
Melkonian AV, Loppinet E, Martin R, ..., Khosla C (2021) An Unusual "OR" Gate for Allosteric Regulation of Mammalian
Transglutaminase 2 in the Extracellular Matrix. Journal of the American Chemical Society. [IF=2.573, Cited=3, 34232639].
Li X, Sevillano N, La Greca F, ..., Khosla C (2018) Structure-Function Analysis of the Extended Conformation of a
Polyketide Synthase Module. Journal of the American Chemical Society. [IF=2.573, Cited=22, 29762030].
Sankaranarayanan K, Antaris XX, Palanski BA, ..., Khosla C (2019) Tunable Enzymatic Synthesis of the Immunomodulator
Lipid IV_A To Enable Structure-Activity Analysis. Journal of the American Chemical Society. [IF=2.573,
Cited=3, 31184877].
Lee Y, Choi JY, Fu H, ..., Khosla C (2011) Chemistry and biology of macrolide antiparasitic agents. Journal of Medicinal
Chemistry. [IF=1.655, Cited=17, 21428405].
McDaniel R, Ebert-Khosla S, Hopwood DA, Khosla C (1995) Rational design of aromatic polyketide natural products by
recombinant assembly of enzymatic subunits. Nature. [IF=11.591, Cited=127, 7791871].
Pieper R, Luo G, Cane DE, Khosla C (1995) Cell-free synthesis of polyketides by recombinant erythromycin polyketide
synthases. Nature. [IF=11.591, Cited=41, 7477343].
Schnarr NA, Khosla C (2005) Biological chemistry: just add chlorine. Nature. [IF=11.591, Cited=1, 16121161].
Kapur S, Khosla C (2008) Biochemistry: Fit for an enzyme. Nature. [IF=11.591, Cited=5, 18704072].
Morón B, Verma AK, Das P, ..., Makharia GK (2013) CYP3A4-catalyzed simvastatin metabolism as a non-invasive marker of
small intestinal health in celiac disease. American Journal of Gastroenterology. [IF=2.479, Cited=25, 23732466].
Lee TS, Khosla C, Tang Y (2005) Orthogonal protein interactions in spore pigment producing and antibiotic producing
polyketide synthases. Journal of Antibiotics. [IF=0.805, Cited=4, 16392683].
Rude MA, Khosla C (2006) Production of ansamycin polyketide precursors in Escherichia coli. Journal of Antibiotics.
[IF=0.805, Cited=9, 17080682].
Lee HY, Harvey CJB, Cane DE, Khosla C (2010) Improved precursor-directed biosynthesis in E. coli via directed evolution.
Journal of Antibiotics. [IF=0.805, Cited=11, 21081955].
Fitzgerald JT, Ridley CP, Khosla C (2011) Engineered biosynthesis of the antiparasitic agent frenolicin B and rationally
designed analogs in a heterologous host. Journal of Antibiotics. [IF=0.805, Cited=8, 21934692].
Fitzgerald JT, Henrich PP, O'Brien C, ..., Khosla C (2011) In vitro and in vivo activity of frenolicin B against
Plasmodium falciparum and P berghei. Journal of Antibiotics. [IF=0.805, Cited=5, 22008701].
Alvarez MA, Fu H, Khosla C, ..., Bailey JE (1996) Engineered biosynthesis of novel polyketides: properties of the whiE
aromatase/cyclase. Nature Biotechnology. [IF=8.861, Cited=16, 9630896].
Katz L, Khosla C (2007) Antibiotic production from the ground up. Nature Biotechnology. [IF=8.861, Cited=6, 17420748].
Caren R, Mørkeberg R, Khosla C (1994) Efficient sampling of protein sequence space for multiple mutants. None. [IF=None,
Cited=2, 7764711].
Sollid LM, Khosla C (2005) Future therapeutic options for celiac disease. None. [IF=None, Cited=87, 16265155].
Keatinge-Clay AT, Maltby DA, Medzihradszky KF, ..., Stroud RM (2004) An antibiotic factory caught in action. Nature
Structural and Molecular Biology. [IF=2.542, Cited=94, 15286722].
Yuan L, Siegel M, Choi K, ..., Rich KM (2006) Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the
extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene. [IF=1.523, Cited=108, 17099729].
Shan L, Marti T, Sollid LM, ..., Khosla C (2004) Comparative biochemical analysis of three bacterial prolyl
endopeptidases: implications for coeliac sprue. Biochemical Journal. [IF=0.852, Cited=121, 15245330].
Khosla C, Gray GM, Sollid LM (2005) Putative efficacy and dosage of prolyl endopeptidase for digesting and detoxifying
gliadin peptides. Gastroenterology. [IF=5.156, Cited=12, 16230098].
Strnad P, Harada M, Siegel M, ..., Omary MB (2007) Transglutaminase 2 regulates mallory body inclusion formation and
injury-associated liver enlargement. Gastroenterology. [IF=5.156, Cited=43, 17408647].
Gass J, Vora H, Hofmann AF, ..., Khosla C (2007) Enhancement of dietary protein digestion by conjugated bile acids.
Gastroenterology. [IF=5.156, Cited=49, 17631126].
Gass J, Bethune MT, Siegel M, ..., Khosla C (2007) Combination enzyme therapy for gastric digestion of dietary gluten in
patients with celiac sprue. Gastroenterology. [IF=5.156, Cited=129, 17681168].
Zawada RJ, Khosla C (1997) Domain analysis of the molecular recognition features of aromatic polyketide synthase
subunits. Journal of Biological Chemistry. [IF=1.122, Cited=17, 9195917].
Dreier J, Shah AN, Khosla C (1999) Kinetic analysis of the actinorhodin aromatic polyketide synthase. Journal of
Biological Chemistry. [IF=1.122, Cited=17, 10455191].
Marti T, Hu Z, Pohl NL, ..., Khosla C (2000) Cloning, nucleotide sequence, and heterologous expression of the
biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming
mechanism. Journal of Biological Chemistry. [IF=1.122, Cited=58, 10931852].
Stamnaes J, Pinkas DM, Fleckenstein B, ..., Sollid LM (2010) Redox regulation of transglutaminase 2 activity. Journal of
Biological Chemistry. [IF=1.122, Cited=119, 20547769].
Jin X, Stamnaes J, Klöck C, ..., Khosla C (2011) Activation of extracellular transglutaminase 2 by thioredoxin. Journal
of Biological Chemistry. [IF=1.122, Cited=68, 21908620].
Diacovich L, Peirú S, Kurth D, ..., Gramajo H (2002) Kinetic and structural analysis of a new group of Acyl-CoA
carboxylases found in Streptomyces coelicolor A3(2). Journal of Biological Chemistry. [IF=1.122, Cited=52, 12048195].
Parrot I, Huang PC, Khosla C (2002) Circular dichroism and nuclear magnetic resonance spectroscopic analysis of
immunogenic gluten peptides and their analogs. Journal of Biological Chemistry. [IF=1.122, Cited=20, 12324465].
Watanabe K, Wang CCC, Boddy CN, ..., Khosla C (2003) Understanding substrate specificity of polyketide synthase modules
by generating hybrid multimodular synthases. Journal of Biological Chemistry. [IF=1.122, Cited=40, 12923197].
Bergseng E, Xia J, Kim CY, ..., Sollid LM (2005) Main chain hydrogen bond interactions in the binding of proline-rich
gluten peptides to the celiac disease-associated HLA-DQ2 molecule. Journal of Biological Chemistry. [IF=1.122,
Cited=23, 15826953].
Ehren J, Govindarajan S, Morón B, ..., Khosla C (2008) Protein engineering of improved prolyl endopeptidases for celiac
sprue therapy. Protein Engineering, Design and Selection. [IF=0.545, Cited=33, 18836204].
Chakraborty S, Gonzalez JC, Sievers BL, ..., Wang TT (2021) Structurally and functionally distinct early antibody
responses predict COVID-19 disease trajectory and mRNA vaccine response. None. [IF=None, Cited=0, 34075376].
Li J, Zaslavsky M, Su Y, ..., Davis MM (2021) Human KIR ⁺ CD8 ⁺ T cells target pathogenic T cells
in Celiac disease and are active in autoimmune diseases and COVID-19. None. [IF=None, Cited=1, 34981055].
Alekseyev VY, Liu CW, Cane DE, ..., Khosla C (2007) Solution structure and proposed domain domain recognition interface
of an acyl carrier protein domain from a modular polyketide synthase. Protein Science. [IF=1.97, Cited=74, 17893358].
Sollid LM, Khosla C (2011) Novel therapies for coeliac disease. Journal of Internal Medicine. [IF=2.659, Cited=52, 21401739].
Tahanian E, Lord-Dufour S, Das A, ..., Annabi B (2010) Inhibition of tubulogenesis and of carcinogen-mediated signaling
in brain endothelial cells highlight the antiangiogenic properties of a mumbaistatin analog. None. [IF=None, Cited=8, 20486934].
Bailey JE, Birnbaum S, Galazzo JL, ..., Shanks JV (1990) Strategies and challenges in metabolic engineering. Annals of
the New York Academy of Sciences. [IF=1.878, Cited=10, 2192652].
Kramer PJ, Khosla C (1996) Engineering of novel polyketides. Progress and Prospects. Annals of the New York Academy of
Sciences. [IF=1.878, Cited=1, 8958070].
Piper JL, Gray GM, Khosla C (2004) Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo.
Journal of Pharmacology and Experimental Therapeutics. [IF=0.906, Cited=66, 15143130].
Marti T, Molberg O, Li Q, ..., Sollid LM (2004) Prolyl endopeptidase-mediated destruction of T cell epitopes in whole
gluten: chemical and immunological characterization. Journal of Pharmacology and Experimental Therapeutics. [IF=0.906,
Cited=74, 15358813].
Gass J, Vora H, Bethune MT, ..., Khosla C (2006) Effect of barley endoprotease EP-B2 on gluten digestion in the intact
rat. Journal of Pharmacology and Experimental Therapeutics. [IF=0.906, Cited=45, 16757540].
Bethune MT, Siegel M, Howles-Banerji S, Khosla C (2009) Interferon-gamma released by gluten-stimulated celiac disease-
specific intestinal T cells enhances the transepithelial flux of gluten peptides. Journal of Pharmacology and
Experimental Therapeutics. [IF=0.906, Cited=18, 19218531].
Diraimondo TR, Klöck C, Khosla C (2012) Interferon-γ activates transglutaminase 2 via a phosphatidylinositol-3-kinase-
dependent pathway: implications for celiac sprue therapy. Journal of Pharmacology and Experimental Therapeutics.
[IF=0.906, Cited=22, 22228808].
Roberts RJ, Varmus HE, Ashburner M, ..., Wold B (2001) Information access. Building a "GenBank" of the published
literature. Science. [IF=7.729, Cited=12, 11269300].
Le BV, Klöck C, Schatz A, ..., Baxter RHG (2014) Dihydroisoxazole inhibitors of Anopheles gambiae seminal
transglutaminase AgTG3. Malaria Journal. [IF=1.148, Cited=5, 24888439].
Tang Y, Lee TS, Khosla C (2004) Engineered biosynthesis of regioselectively modified aromatic polyketides using
bimodular polyketide synthases. PLoS Biology. [IF=2.285, Cited=34, 14966533].
Lee HY, Khosla C (2007) Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli. PLoS
Biology. [IF=2.285, Cited=23, 17298179].
Pinkas DM, Strop P, Brunger AT, Khosla C (2007) Transglutaminase 2 undergoes a large conformational change upon
activation. PLoS Biology. [IF=2.285, Cited=264, 18092889].
Charkoudian LK, Fitzgerald JT, Khosla C, Champlin A (2010) In living color: bacterial pigments as an untapped resource
in the classroom and beyond. PLoS Biology. [IF=2.285, Cited=12, 20957190].
Bethune MT, Borda JT, Ribka E, ..., Sestak K (2008) A non-human primate model for gluten sensitivity. PLoS ONE.
[IF=1.253, Cited=50, 18286171].
Bethune MT, Ribka E, Khosla C, Sestak K (2008) Transepithelial transport and enzymatic detoxification of gluten in
gluten-sensitive rhesus macaques. PLoS ONE. [IF=1.253, Cited=28, 18365012].
Siegel M, Strnad P, Watts RE, ..., Khosla C (2008) Extracellular transglutaminase 2 is catalytically inactive, but is
transiently activated upon tissue injury. PLoS ONE. [IF=1.253, Cited=133, 18365016].
Morón B, Bethune MT, Comino I, ..., Sousa C (2008) Toward the assessment of food toxicity for celiac patients:
characterization of monoclonal antibodies to a main immunogenic gluten peptide. PLoS ONE. [IF=1.253, Cited=76, 18509534].
Ehren J, Morón B, Martin E, ..., Khosla C (2009) A food-grade enzyme preparation with modest gluten detoxification
properties. PLoS ONE. [IF=1.253, Cited=50, 19621078].
Mazumdar K, Alvarez X, Borda JT, ..., Sestak K (2010) Visualization of transepithelial passage of the immunogenic
33-residue peptide from alpha-2 gliadin in gluten-sensitive macaques. PLoS ONE. [IF=1.253, Cited=22, 20419103].
Dafik L, Albertelli M, Stamnaes J, ..., Khosla C (2012) Activation and inhibition of transglutaminase 2 in mice. PLoS
ONE. [IF=1.253, Cited=38, 22319575].
Bethune MT, Khosla C (2008) Parallels between pathogens and gluten peptides in celiac sprue. PLoS Pathogens. [IF=1.423,
Cited=28, 18425213].
Cane DE, Luo G, Khosla C, ..., Katz L (1995) Erythromycin biosynthesis. Highly efficient incorporation of polyketide
chain elongation intermediates into 6-deoxyerythronolide B in an engineered Streptomyces host. Journal of Antibiotics.
[IF=0.805, Cited=7, 7649863].
Hughes DE, Curtis JE, Khosla C, Bailey JE (1989) A new oxygen-regulated promoter for the expression of proteins in
Escherichia coli. BioTechniques. [IF=0.626, Cited=0, 2698665].

Khosla, Chaitan

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