Ciechanover, Aaron

Publication with MATCHING institution:

Ciechanover A, Orian A, Schwartz AL (2000) Ubiquitin-mediated proteolysis: biological regulation via destruction.
BioEssays. [IF=0.818, Cited=491, 10797484].
Ciechanover A, Orian A, Schwartz AL (2000) The ubiquitin-mediated proteolytic pathway: mode of action and clinical
implications. None. [IF=None, Cited=132, 10762014].
Ciechanover A (2005) Intracellular protein degradation: from a vague idea, through the lysosome and the ubiquitin-
proteasome system, and onto human diseases and drug targeting (Nobel lecture). Angewandte Chemie - International
Edition. [IF=2.456, Cited=82, 16142822].
Livneh I, Kravtsova-Ivantsiv Y, Braten O, ..., Ciechanover A (2017) Monoubiquitination joins polyubiquitination as an
esteemed proteasomal targeting signal. BioEssays. [IF=0.818, Cited=21, 28493408].
Huang Y, Nawatha M, Livneh I, ..., Suga H (2020) Affinity Maturation of Macrocyclic Peptide Modulators of Lys48-Linked
Diubiquitin by a Twofold Strategy. Chemistry - A European Journal. [IF=0.899, Cited=10, 32105365].
Ciechanover A (1994) The ubiquitin-proteasome proteolytic pathway. Cell. [IF=8.479, Cited=1000, 7923371].
Ahmed Q, Avidan AY, Ciechanover A, ..., Lavie P (2014) Israel-Gaza conflict. The Lancet. [IF=25.787, Cited=2, 25145777].
Beyar R, Blazer S, Breuer E, ..., Skorecki K (2024) Moral clarity at WHO needs to be clearer. The Lancet. [IF=25.787,
Cited=1, 38373434].
Cohen-Kaplan V, Livneh I, Kwon YT, Ciechanover A (2019) Monitoring stress-induced autophagic engulfment and degradation
of the 26S proteasome in mammalian cells. None. [IF=None, Cited=2, 30910028].
Ciechanover A, Schwartz AL (2004) The ubiquitin system: pathogenesis of human diseases and drug targeting. None.
[IF=None, Cited=102, 15571805].
Ciechanover A, Stanhill A (2013) The complexity of recognition of ubiquitinated substrates by the 26S proteasome. None.
[IF=None, Cited=83, 23872423].
Ciechanover A (2011) Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome
system and onto human diseases and drug targeting. None. [IF=None, Cited=74, 21435401].
Ciechanover A (2009) Tracing the history of the ubiquitin proteolytic system: the pioneering article. Biochemical and
Biophysical Research Communications. [IF=0.643, Cited=16, 19539608].
Ciechanover A (2009) Interview with Aaron Ciechanover. Biochemical and Biophysical Research Communications. [IF=0.643,
Cited=0, 19549505].
Lehmann G, Udasin RG, Ciechanover A (2016) On the linkage between the ubiquitin-proteasome system and the mitochondria.
Biochemical and Biophysical Research Communications. [IF=0.643, Cited=19, 26996128].
Lahav-Baratz S, Kravtsova-Ivantsiv Y, Golan S, Ciechanover A (2016) The testis-specific USP26 is a deubiquitinating
enzyme of the ubiquitin ligase Mdm2. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=12, 27810359].
Lehmann G, Udasin RG, Livneh I, Ciechanover A (2017) Identification of UBact, a ubiquitin-like protein, along with other
homologous components of a conjugation system and the proteasome in different gram-negative bacteria. Biochemical and
Biophysical Research Communications. [IF=0.643, Cited=8, 28087277].
Fabre B, Livneh I, Ziv T, Ciechanover A (2019) Modulation of the cell cycle regulating transcription factor E2F1 pathway
by the proteasome following amino acid starvation. Biochemical and Biophysical Research Communications. [IF=0.643,
Cited=3, 30992132].
Fabre B, Livneh I, Ziv T, Ciechanover A (2019) Identification of proteins regulated by the proteasome following
induction of endoplasmic reticulum stress. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=9, 31327494].
Udasin RG, Gottfried Y, Fabre B, ..., Ciechanover A (2020) The p105 NF-ĸB precursor is a pseudo substrate of the
ubiquitin ligase FBXO7, and its binding to the ligase stabilizes it and results in stimulated cell proliferation.
Biochemical and Biophysical Research Communications. [IF=0.643, Cited=4, 32933748].
Ciechanover A (2017) Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome
system and onto human diseases and drug targeting. Best Practice and Research in Clinical Haematology. [IF=0.689,
Cited=40, 29156207].
Cohen-Kaplan V, Livneh I, Avni N, ..., Ciechanover A (2016) The ubiquitin-proteasome system and autophagy: Coordinated
and independent activities. International Journal of Biochemistry and Cell Biology. [IF=0.949, Cited=86, 27448843].
Drula R, Iluta S, Gulei D, ..., Tomuleasa C (2022) Exploiting the ubiquitin system in myeloid malignancies. From basic
research to drug discovery in MDS and AML. Blood Reviews. [IF=2.684, Cited=1, 35595613].
Kegyes D, Gulei D, Drula R, ..., Tomuleasa C (2023) Proteasome inhibition in combination with immunotherapies: State-of-
the-Art in multiple myeloma. Blood Reviews. [IF=2.684, Cited=4, 37291017].
Ciechanover A (2013) Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-
proteasome system and onto human diseases and drug targeting. Bioorganic and Medicinal Chemistry. [IF=0.86, Cited=61, 23485445].
Mollereau B, Rzechorzek NM, Roussel BD, ..., Hetz C (2016) Adaptive preconditioning in neurological diseases -
therapeutic insights from proteostatic perturbations. Brain Research. [IF=0.766, Cited=32, 26923166].
Kravtsova-Ivantsiv Y, Shomer I, Cohen-Kaplan V, ..., Ciechanover A (2015) KPC1-mediated ubiquitination and proteasomal
processing of NF-κB1 p105 to p50 restricts tumor growth. Cell. [IF=8.479, Cited=60, 25860612].
Nataraj NB, Noronha A, Lee JS, ..., Yarden Y (2022) Nucleoporin-93 reveals a common feature of aggressive breast
cancers: robust nucleocytoplasmic transport of transcription factors. Cell Reports. [IF=1.738, Cited=10, 35196484].
Kudriaeva AA, Livneh I, Baranov MS, ..., Belogurov AA (2021) In-depth characterization of ubiquitin turnover in
mammalian cells by fluorescence tracking. Cell Chemical Biology. [IF=1.446, Cited=2, 33675681].
Wang J, Liang B, Chen Y, ..., Xu Y (2021) A new class of α-ketoamide derivatives with potent anticancer and anti-SARS-
CoV-2 activities. European Journal of Medicinal Chemistry. [IF=1.568, Cited=8, 33639344].
Fang X, Meng Q, Zhang H, ..., Huang Z (2022) A fragment integrational approach to GPCR inhibition: Identification of a
high affinity small molecule CXCR4 antagonist. European Journal of Medicinal Chemistry. [IF=1.568, Cited=2, 35124530].
Fan T, Liang B, Nie L, ..., Huang Z (2022) A synthetic bivalent peptide ligand of EphB4 with potent agonistic activity.
European Journal of Medicinal Chemistry. [IF=1.568, Cited=2, 36208510].
Barac YD, Emrich F, Krutzwakd-Josefson E, ..., Taylor DA (2017) The ubiquitin-proteasome system: A potential therapeutic
target for heart failure. Journal of Heart and Lung Transplantation. [IF=2.926, Cited=19, 28341100].
Etzioni A, Ciechanover A, Pikarsky E (2017) Immune defects caused by mutations in the ubiquitin system. Journal of
Allergy and Clinical Immunology. [IF=2.533, Cited=9, 28270366].
Ben-Saadon R, Zaaroor D, Ziv T, Ciechanover A (2006) The polycomb protein Ring1B generates self atypical mixed ubiquitin
chains required for its in vitro histone H2A ligase activity. Molecular Cell. [IF=2.773, Cited=159, 17157253].
Ji CH, Kim HY, Heo AJ, ..., Kwon YT (2019) The N-Degron Pathway Mediates ER-phagy. Molecular Cell. [IF=2.773, Cited=60, 31375263].
Livneh I, Cohen-Kaplan V, Fabre B, ..., Ciechanover A (2023) Regulation of nucleo-cytosolic 26S proteasome translocation
by aromatic amino acids via mTOR is essential for cell survival under stress. Molecular Cell. [IF=2.773, Cited=2, 37738964].
Ciechanover A, Ben-Saadon R (2004) N-terminal ubiquitination: more protein substrates join in. Trends in Cell Biology.
[IF=3.592, Cited=228, 15055197].
Kwon YT, Ciechanover A (2017) The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy. Trends in Biochemical
Sciences. [IF=2.462, Cited=332, 28947091].
Ciechanover A, Brundin P (2003) The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken,
sometimes the egg. Neuron. [IF=3.346, Cited=600, 14556719].
Hemantha HP, Bavikar SN, Herman-Bachinsky Y, ..., Brik A (2014) Nonenzymatic polyubiquitination of expressed proteins.
Journal of the American Chemical Society. [IF=2.573, Cited=48, 24437386].
Ciechanover A, Hargrove JL, Gross-Mesilaty S (1997) Ubiquitin-mediated degradation of tyrosine aminotransferase (TAT) in
vitro and in vivo. Molecular Biology Reports. [IF=0.735, Cited=2, 9228277].
Ciechanover A, Breitschopf K, Hatoum OA, Bengal E (1999) Degradation of MyoD by the ubiquitin pathway: regulation by
specific DNA-binding and identification of a novel site for ubiquitination. Molecular Biology Reports. [IF=0.735,
Cited=15, 10363648].
Galluzzi L, Bravo-San Pedro JM, Vitale I, ..., Kroemer G (2014) Essential versus accessory aspects of cell death:
recommendations of the NCCD 2015. Cell Death and Differentiation. [IF=2.211, Cited=477, 25236395].
Rossi M, Rotblat B, Ansell K, ..., Melino G (2014) High throughput screening for inhibitors of the HECT ubiquitin E3
ligase ITCH identifies antidepressant drugs as regulators of autophagy. Cell Death and Disease. [IF=1.567, Cited=85, 24787015].
Ciechanover A, Kwon YT (2015) Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and
strategies. Experimental and Molecular Medicine. [IF=2.341, Cited=416, 25766616].
Cha-Molstad H, Sung KS, Hwang J, ..., Kwon YT (2015) Amino-terminal arginylation targets endoplasmic reticulum chaperone
BiP for autophagy through p62 binding. Nature Cell Biology. [IF=3.908, Cited=144, 26075355].
Ciechanover A (2005) Proteolysis: from the lysosome to ubiquitin and the proteasome. Nature Reviews Molecular Cell
Biology. [IF=19.213, Cited=594, 15688069].
Ciechanover A (2015) The unravelling of the ubiquitin system. Nature Reviews Molecular Cell Biology. [IF=19.213,
Cited=136, 25907614].
Galluzzi L, Vitale I, Aaronson SA, ..., Kroemer G (2018) Molecular mechanisms of cell death: recommendations of the
Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. [IF=2.211, Cited=1000, 29362479].
Ziv NE, Ciechanover A (2020) A possible non-proteolytic role of ubiquitin conjugation in alleviating the pathology of
Huntingtin's aggregation. Cell Death and Differentiation. [IF=2.211, Cited=3, 32913226].
Vitale I, Pietrocola F, Guilbaud E, ..., Galluzzi L (2023) Apoptotic cell death in disease-Current understanding of the
NCCD 2023. Cell Death and Differentiation. [IF=2.211, Cited=54, 37100955].
Cohen-Kaplan V, Livneh I, Ciechanover A (2020) Proteasome phase separation: a novel layer of quality control. Cell
Research. [IF=3.826, Cited=1, 32265504].
Cha-Molstad H, Yu JE, Feng Z, ..., Kim BY (2017) p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway
which modulates autophagosome biogenesis. Nature Communications. [IF=3.268, Cited=116, 28740232].
Nawatha M, Rogers JM, Bonn SM, ..., Brik A (2019) De novo macrocyclic peptides that specifically modulate Lys48-linked
ubiquitin chains. Nature Chemistry. [IF=3.667, Cited=34, 31182821].
Boulos A, Maroun D, Ciechanover A, Ziv NE (2024) Peripheral sequestration of huntingtin delays neuronal death and
depends on N-terminal ubiquitination. Communications Biology. [IF=1.359, Cited=0, 39155290].
Ciechanover A (2005) Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome
system and onto human diseases and drug targeting. Cell Death and Differentiation. [IF=2.211, Cited=191, 16094394].
Rogers JM, Nawatha M, Lemma B, ..., Brik A (2020) In vivo modulation of ubiquitin chains by N-methylated non-
proteinogenic cyclic peptides. RSC Chemical Biology. [IF=0.993, Cited=13, 34179781].
Rogers JM, Nawatha M, Lemma B, ..., Brik A (2021) Correction: In vivo modulation of ubiquitin chains by
N-methylated non-proteinogenic cyclic peptides. RSC Chemical Biology. [IF=0.993, Cited=1, 34458819].
Braten O, Shabek N, Kravtsova-Ivantsiv Y, Ciechanover A (2012) Generation of free ubiquitin chains is up-regulated in
stress and facilitated by the HECT domain ubiquitin ligases UFD4 and HUL5. Biochemical Journal. [IF=0.852, Cited=14, 22497224].
Meng Q, Zhu R, Mao Y, ..., Huang Z (2023) Biological and mutational analyses of CXCR4-antagonist interactions and design
of new antagonistic analogs. Bioscience Reports. [IF=0.84, Cited=0, 38131305].
Grenfell SJ, Trausch-Azar JS, Handley-Gearhart PM, ..., Schwartz AL (1994) Nuclear localization of the ubiquitin-
activating enzyme, E1, is cell-cycle-dependent. Biochemical Journal. [IF=0.852, Cited=20, 8010951].
Handley-Gearhart PM, Trausch-Azar JS, Ciechanover A, Schwartz AL (1994) Rescue of the complex temperature-sensitive
phenotype of Chinese hamster ovary E36ts20 cells by expression of the human ubiquitin-activating enzyme cDNA.
Biochemical Journal. [IF=0.852, Cited=18, 7818464].
Ciechanover A (2003) The ubiquitin proteolytic system and pathogenesis of human diseases: a novel platform for
mechanism-based drug targeting. Biochemical Society Transactions. [IF=0.925, Cited=69, 12653666].
Ciechanover A, Schwartz AL (2002) Ubiquitin-mediated degradation of cellular proteins in health and disease. Hepatology.
[IF=2.917, Cited=45, 11786953].
Shabek N, Herman-Bachinsky Y, Ciechanover A (2009) Ubiquitin degradation with its substrate, or as a monomer in a
ubiquitination-independent mode, provides clues to proteasome regulation. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=41, 19581590].
Zaaroor-Regev D, de Bie P, Scheffner M, ..., Ciechanover A (2010) Regulation of the polycomb protein Ring1B by self-
ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=65, 20351251].
Haj-Yahya M, Fauvet B, Herman-Bachinsky Y, ..., Brik A (2013) Synthetic polyubiquitinated α-Synuclein reveals important
insights into the roles of the ubiquitin chain in regulating its pathophysiology. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=79, 24043770].
Braten O, Livneh I, Ziv T, ..., Ciechanover A (2016) Numerous proteins with unique characteristics are degraded by the
26S proteasome following monoubiquitination. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=83, 27385826].
Cohen-Kaplan V, Livneh I, Avni N, ..., Ciechanover A (2016) p62- and ubiquitin-dependent stress-induced autophagy of the
mammalian 26S proteasome. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=137, 27791183].
Yoo YD, Mun SR, Ji CH, ..., Kwon YT (2018) N-terminal arginylation generates a bimodal degron that modulates autophagic
proteolysis. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=37, 29507222].
Sun H, Mali SM, Singh SK, ..., Ciechanover A (2019) Diverse fate of ubiquitin chain moieties: The proximal is degraded
with the target, and the distal protects the proximal from removal and recycles. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=22, 30867293].
Hakim-Eshed V, Boulos A, Cohen-Rosenzweig C, ..., Ciechanover A (2020) Site-specific ubiquitination of pathogenic
huntingtin attenuates its deleterious effects. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=14, 32675242].
Kravtsova-Ivantsiv Y, Goldhirsh G, Ivantsiv A, ..., Ciechanover A (2020) Excess of the NF-ĸB p50 subunit generated by
the ubiquitin ligase KPC1 suppresses tumors via PD-L1- and chemokines-mediated mechanisms. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=11, 33168738].
Linares LK, Hengstermann A, Ciechanover A, ..., Scheffner M (2003) HdmX stimulates Hdm2-mediated ubiquitination and
degradation of p53. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=225, 14507994].
Fu A, Cohen-Kaplan V, Avni N, ..., Ciechanover A (2021) p62-containing, proteolytically active nuclear condensates,
increase the efficiency of the ubiquitin-proteasome system. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=35, 34385323].
Heo AJ, Kim SB, Ji CH, ..., Kwon YT (2021) The N-terminal cysteine is a dual sensor of oxygen and oxidative stress.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=15, 34893540].
Goldhirsh G, Kravtsova-Ivantsiv Y, Satish G, ..., Ciechanover A (2021) A short binding site in the KPC1 ubiquitin ligase
mediates processing of NF-κB1 p105 to p50: A potential for a tumor-suppressive PROTAC. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=1, 34873064].
Ciechanover A, DiGiuseppe JA, Bercovich B, ..., Brodeur GM (1991) Degradation of nuclear oncoproteins by the ubiquitin
system in vitro. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=182, 1846034].
Gonen H, Smith CE, Siegel NR, ..., Ciechanover A (1994) Protein synthesis elongation factor EF-1 alpha is essential for
ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial
elongation factor EF-Tu. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=96, 8052636].
Levitskaya J, Sharipo A, Leonchiks A, ..., Masucci MG (1997) Inhibition of ubiquitin/proteasome-dependent protein
degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. Proceedings of the National
Academy of Sciences of the United States of America. [IF=2.765, Cited=308, 9356498].
Gross-Mesilaty S, Reinstein E, Bercovich B, ..., Ciechanover A (1998) Basal and human papillomavirus E6 oncoprotein-
induced degradation of Myc proteins by the ubiquitin pathway. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=130, 9653139].
Ciechanover A, Schwartz AL (1998) The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins
death. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=252, 9501156].
Hengstermann A, Linares LK, Ciechanover A, ..., Scheffner M (2001) Complete switch from Mdm2 to human papillomavirus
E6-mediated degradation of p53 in cervical cancer cells. Proceedings of the National Academy of Sciences of the United
States of America. [IF=2.765, Cited=121, 11158620].
Belogurov A, Kudriaeva A, Kuzina E, ..., Gabibov A (2014) Multiple sclerosis autoantigen myelin basic protein escapes
control by ubiquitination during proteasomal degradation. Journal of Biological Chemistry. [IF=1.122, Cited=21, 24739384].
Jaitovich A, Mehta S, Na N, ..., Ridge KM (2008) Ubiquitin-proteasome-mediated degradation of keratin intermediate
filaments in mechanically stimulated A549 cells. Journal of Biological Chemistry. [IF=1.122, Cited=36, 18617517].
Ciechanover A, Iwai K (2004) The ubiquitin system: from basic mechanisms to the patient bed. IUBMB Life. [IF=0.917,
Cited=59, 15230346].
Cha-Molstad H, Yu JE, Lee SH, ..., Kwon YT (2016) Modulation of SQSTM1/p62 activity by N-terminal arginylation of the
endoplasmic reticulum chaperone HSPA5/GRP78/BiP. None. [IF=None, Cited=17, 26797053].
Cohen-Kaplan V, Ciechanover A, Livneh I (2017) Stress-induced polyubiquitination of proteasomal ubiquitin receptors
targets the proteolytic complex for autophagic degradation. None. [IF=None, Cited=12, 28121483].
Cha-Molstad H, Lee SH, Kim JG, ..., Kwon YT (2018) Regulation of autophagic proteolysis by the N-recognin SQSTM1/p62 of
the N-end rule pathway. None. [IF=None, Cited=26, 29261001].
Kravtsova-Ivantsiv Y, Ciechanover A (2015) The ubiquitin-proteasome system and activation of NF-κB: involvement of the
ubiquitin ligase KPC1 in p105 processing and tumor suppression. Molecular and Cellular Oncology. [IF=0.193, Cited=18, 27308511].
Fu A, Livneh I, Ciechanover A, Cohen-Kaplan V (2021) How multi-component cascades operate in cells: lessons from the
ubiquitin system-containing liquid-separated condensates. Molecular and Cellular Oncology. [IF=0.193, Cited=0, 34859148].
Buchsbaum S, Bercovich B, Ciechanover A (2011) FAT10 is a proteasomal degradation signal that is itself regulated by
ubiquitination. Molecular Biology of the Cell. [IF=0.848, Cited=26, 22072791].
Ciechanover A (1998) The ubiquitin-proteasome pathway: on protein death and cell life. EMBO Journal. [IF=2.114,
Cited=792, 9857172].
Ciechanover A, Schwartz AL (1994) The ubiquitin-mediated proteolytic pathway: mechanisms of recognition of the
proteolytic substrate and involvement in the degradation of native cellular proteins. FASEB Journal. [IF=1.029,
Cited=112, 8119489].
Hermann J, Gulati R, Napoli C, ..., Lerman A (2003) Oxidative stress-related increase in ubiquitination in early
coronary atherogenesis. FASEB Journal. [IF=1.029, Cited=36, 12958191].
Zhou G, Dada LA, Chandel NS, ..., Sznajder JI (2007) Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau
protein. FASEB Journal. [IF=1.029, Cited=27, 18073334].
Ciechanover A, Laszlo A, Bercovich B, ..., Orian A (1995) The ubiquitin-mediated proteolytic system: involvement of
molecular chaperones, degradation of oncoproteins, and activation of transcriptional regulators. Cold Spring Harbor
Symposia on Quantitative Biology. [IF=0.889, Cited=14, 8824422].
Ciechanover A (1993) The ubiquitin-mediated proteolytic pathway. Brain Pathology. [IF=1.576, Cited=22, 8269085].
Mayer A, Siegel NR, Schwartz AL, Ciechanover A (1989) Degradation of proteins with acetylated amino termini by the
ubiquitin system. Science. [IF=7.729, Cited=64, 2544030].
Kosik KS, Sejnowski TJ, Raichle ME, ..., Baltimore D (2016) A path toward understanding neurodegeneration. Science.
[IF=7.729, Cited=7, 27563087].
Shim SM, Choi HR, Sung KW, ..., Kwon YT (2018) The endoplasmic reticulum-residing chaperone BiP is short-lived and
metabolized through N-terminal arginylation. Science Signaling. [IF=1.6, Cited=25, 29295953].
Stancovski I, Gonen H, Orian A, ..., Ciechanover A (1995) Degradation of the proto-oncogene product c-Fos by the
ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes.
Molecular and Cellular Biology. [IF=1.026, Cited=101, 8524278].
Sancho E, Vilá MR, Sánchez-Pulido L, ..., Thomson TM (1998) Role of UEV-1, an inactive variant of the E2 ubiquitin-
conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.
Molecular and Cellular Biology. [IF=1.026, Cited=82, 9418904].
Abu Hatoum O, Gross-Mesilaty S, Breitschopf K, ..., Bengal E (1998) Degradation of myogenic transcription factor MyoD by
the ubiquitin pathway in vivo and in vitro: regulation by specific DNA binding. Molecular and Cellular Biology.
[IF=1.026, Cited=67, 9742084].
Sionov RV, Coen S, Goldberg Z, ..., Haupt Y (2001) c-Abl regulates p53 levels under normal and stress conditions by
preventing its nuclear export and ubiquitination. Molecular and Cellular Biology. [IF=1.026, Cited=58, 11486026].
Cohen S, Achbert-Weiner H, Ciechanover A (2004) Dual effects of IkappaB kinase beta-mediated phosphorylation on p105
Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing. Molecular and Cellular Biology.
[IF=1.026, Cited=23, 14673179].
Hershko A, Hershko A, Ciechanover A, Ciechanover A (1998) The ubiquitin system. Annual Review of Biochemistry.
[IF=5.273, Cited=1000, 9759494].
Schwartz AL, Ciechanover A (2009) Targeting proteins for destruction by the ubiquitin system: implications for human
pathobiology. Annual Review of Pharmacology and Toxicology. [IF=2.886, Cited=279, 18834306].
Glickman MH, Ciechanover A (2002) The ubiquitin-proteasome proteolytic pathway: destruction for the sake of
construction. Physiological Reviews. [IF=11.448, Cited=1000, 11917093].
Gulei D, Drula R, Ghiaur G, ..., Ciechanover A (2023) The Tumor Suppressor Functions of Ubiquitin Ligase KPC1: From
Cell-Cycle Control to NF-κB Regulator. Cancer Research. [IF=1.624, Cited=3, 36880841].
Iida Y, Ciechanover A, Marzese DM, ..., Hoon DSB (2017) Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB
Pathway in Melanoma. Clinical Cancer Research. [IF=2.156, Cited=23, 28389511].
Ciechanover A (2012) Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-
proteasome system and onto human diseases and drug targeting. Neurodegenerative Diseases. [IF=0.914, Cited=24, 22327508].
Comellas AP, Dada LA, Lecuona E, ..., Sznajder JI (2006) Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial
reactive oxygen species and the ubiquitin-conjugating system. Circulation Research. [IF=3.534, Cited=73, 16614303].
Sznajder JI, Ciechanover A (2012) Personalized medicine: the road ahead. American Journal of Respiratory and Critical
Care Medicine. [IF=4.582, Cited=5, 23155214].
Queisser MA, Dada LA, Deiss-Yehiely N, ..., Sznajder JI (2014) HOIL-1L functions as the PKCζ ubiquitin ligase to promote
lung tumor growth. American Journal of Respiratory and Critical Care Medicine. [IF=4.582, Cited=25, 25118570].
Schwartz AL, Ciechanover A (1992) Ubiquitin-mediated protein modification and degradation. American Journal of
Respiratory Cell and Molecular Biology. [IF=1.129, Cited=13, 1329865].
Ciechanover A (2006) Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome
system and onto human diseases and drug targeting. Experimental Biology and Medicine. [IF=0.715, Cited=36, 16816126].
Eisenberg-Lerner A, Ciechanover A, Merbl Y (2016) Post-translational modification profiling - A novel tool for mapping
the protein modification landscape in cancer. Experimental Biology and Medicine. [IF=0.715, Cited=13, 27229346].
Ciechanover A (2006) Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome
system and onto human diseases and drug targeting. Hematology. American Society of Hematology. Education Program.
[IF=0.856, Cited=11, 17124032].
Kravtsova-Ivantsiv Y, Goldhirsh G, Tomuleasa C, ..., Ciechanover A (2023) The NF-ĸB p50 subunit generated by
KPC1-mediated ubiquitination and limited proteasomal processing, suppresses tumor growth. Cancer Cell International.
[IF=0.994, Cited=1, 37055826].
Fang X, Fang X, Mao Y, ..., Huang Z (2021) A novel small molecule CXCR4 antagonist potently mobilizes hematopoietic stem
cells in mice and monkeys. Stem Cell Research and Therapy. [IF=1.44, Cited=4, 33413613].
Ciechanover A (2007) Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-
proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004. Annals of the New York
Academy of Sciences. [IF=1.878, Cited=31, 18083918].
Ciechanover A (2006) The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human
diseases and drug targeting. Neurology. [IF=2.47, Cited=107, 16432150].
Kravtsova-Ivantsiv Y, Ciechanover A (2012) Non-canonical ubiquitin-based signals for proteasomal degradation. Journal of
Cell Science. [IF=0.99, Cited=134, 22389393].
Ciechanover A (2005) N-terminal ubiquitination. Methods in Molecular Biology. [IF=0.413, Cited=17, 15917637].
Ciechanover A (2006) The ubiquitin proteolytic system: from an idea to the patient bed. None. [IF=None, Cited=16, 16493148].
Ciechanover A (2010) The ubiquitin system: historical perspective. None. [IF=None, Cited=1, 20160143].
Ciechanover A (1994) The ubiquitin-mediated proteolytic pathway: mechanisms of action and cellular physiology. None.
[IF=None, Cited=37, 7840898].
Yoo YD, Lee DH, Cha-Molstad H, ..., Kwon YT (2016) Glioma-derived cancer stem cells are hypersensitive to proteasomal
inhibition. EMBO Reports. [IF=1.375, Cited=22, 27993939].
Ciechanover A, Kwon YT (2017) Protein Quality Control by Molecular Chaperones in Neurodegeneration. Frontiers in
Neuroscience. [IF=1.221, Cited=148, 28428740].
Pasca S, Tomuleasa C, Teodorescu P, ..., Einsele H (2019) KRAS/NRAS/BRAF Mutations as Potential Targets in Multiple
Myeloma. Frontiers in Oncology. [IF=0.994, Cited=10, 31709194].
Wang X, Bustos MA, Zhang X, ..., Hoon DSB (2020) Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation
of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors. Cancers. [IF=1.086, Cited=15, 32349217].
Lazar I, Livneh I, Ciechanover A, Fabre B (2024) Tryptophanyl-Transfer RNA Synthetase Is Involved in a Negative Feedback
Loop Mitigating Interferon-γ-Induced Gene Expression. Cells. [IF=1.213, Cited=0, 38247871].
Nahum-Ankonina O, Kurtzwald-Josefson E, Ciechanover A, ..., Barac YD (2023) Ubiquitin Proteasome System Role in
Diabetes-Induced Cardiomyopathy. International Journal of Molecular Sciences. [IF=1.263, Cited=0, 37895057].
Neeman-Egozi S, Livneh I, Dolgopyat I, ..., Binah O (2024) Stress-Induced Proteasome Sub-Cellular Translocation in
Cardiomyocytes Causes Altered Intracellular Calcium Handling and Arrhythmias. International Journal of Molecular
Sciences. [IF=1.263, Cited=0, 38732146].
Ciechanover A (2012) Intracellular Protein Degradation: From a Vague Idea through the Lysosome and the Ubiquitin-
Proteasome System and onto Human Diseases and Drug Targeting. Rambam Maimonides Medical Journal. [IF=0.535, Cited=3, 23908826].
Reinstein E, Ciechanover A (2006) Narrative review: protein degradation and human diseases: the ubiquitin connection.
Annals of Internal Medicine. [IF=5.157, Cited=135, 17088581].
Ciechanover A (2001) Ubiquitin-mediated degradation of cellular proteins: why destruction is essential for construction,
and how it got from the test tube to the patient's bed. Israel Medical Association Journal. [IF=0.526, Cited=6, 11411194].
Ciechanover A, DiGiuseppe JA, Schwartz AL, Brodeur GM (1991) Degradation of MYCN oncoprotein by the ubiquitin system.
None. [IF=None, Cited=12, 1648744].
Ciechanover A, Gropper R, Schwartz AL (1991) The ubiquitin-activating enzyme is required for lysosomal degradation of
cellular proteins under stress. None. [IF=None, Cited=6, 1801698].
Ciechanover A (2010) Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-
proteasome system and onto human diseases and drug targeting. Medicina. [IF=0.312, Cited=3, 20447892].
Ciechanover A, Gonen H, Elias S, Mayer A (1990) Degradation of proteins by the ubiquitin-mediated proteolytic pathway.
None. [IF=None, Cited=11, 2177651].
Ciechanover A, Ciechanover A, Ferber S, ..., Arfin S (1988) Purification and characterization of arginyl-tRNA-protein
transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2
termini substrates of the ubiquitin pathway. Journal of Biological Chemistry. [IF=1.122, Cited=36, 2841321].
Ciechanover A, Shkedy D, Oren M, Bercovich B (1994) Degradation of the tumor suppressor protein p53 by the ubiquitin-
mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2. Journal of Biological Chemistry.
[IF=1.122, Cited=50, 8144545].

Publication with MISSING institution:

Kornitzer D, Ciechanover A (2000) Modes of regulation of ubiquitin-mediated protein degradation. Journal of Cellular
Physiology. [IF=1.265, Cited=160, 10567911].
Kravtsova-Ivantsiv Y, Sommer T, Ciechanover A (2012) The lysine48-based polyubiquitin chain proteasomal signal: not a
single child anymore. Angewandte Chemie - International Edition. [IF=2.456, Cited=32, 23124625].
Haj-Yahya N, Haj-Yahya M, Castañeda CA, ..., Brik A (2013) Modifying the vicinity of the isopeptide bond to reveal
differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins.
Angewandte Chemie - International Edition. [IF=2.456, Cited=13, 24006204].
Kashuba E, Yurchenko M, Yenamandra SP, ..., Klein G (2011) Epstein-Barr virus-encoded EBNA-5 forms trimolecular protein
complexes with MDM2 and p53 and inhibits the transactivating function of p53. International Journal of Cancer.
[IF=1.931, Cited=12, 20473904].
Schwartz AL, Ciechanover A, Brandt RA, Geuze HJ (1988) Immunoelectron microscopic localization of ubiquitin in hepatoma
cells. EMBO Journal. [IF=2.114, Cited=45, 2846272].
Ciechanover A, Schwartz AL, Lodish HF (1983) Sorting and recycling of cell surface receptors and endocytosed ligands:
the asialoglycoprotein and transferrin receptors. Journal of Cellular Biochemistry. [IF=0.787, Cited=78, 6327736].
Ciechanover A, Finley D, Varshavsky A (1984) The ubiquitin-mediated proteolytic pathway and mechanisms of energy-
dependent intracellular protein degradation. Journal of Cellular Biochemistry. [IF=0.787, Cited=110, 6327743].
Ciechanover A (1987) Regulation of the ubiquitin-mediated proteolytic pathway: role of the substrate alpha-NH2 group and
of transfer RNA. Journal of Cellular Biochemistry. [IF=0.787, Cited=6, 3036896].
Kravtsova-Ivantsiv Y, Cohen S, Ciechanover A (2011) Modification by single ubiquitin moieties rather than
polyubiquitination is sufficient for proteasomal processing of the p105 NF-κB precursor. Advances in Experimental
Medicine and Biology. [IF=0.945, Cited=4, 21153313].
Gonen H, Dickman D, Schwartz AL, Ciechanover A (1996) Protein synthesis elongation factor EF-1 alpha is an isopeptidase
essential for ubiquitin-dependent degradation of certain proteolytic substrates. Advances in Experimental Medicine and
Biology. [IF=0.945, Cited=21, 8861013].
Kravtsova-Ivantsiv Y, Ciechanover A (2011) Ubiquitination and degradation of proteins. Methods in Molecular Biology.
[IF=0.413, Cited=11, 21604134].
Ciechanover A, Ciechanover A, Hershko A, Hershko A (1976) Early effects of serum on phospholipid metabolism in
untransformed and oncogenic virus-transformed cultured fibroblasts. Biochemical and Biophysical Research Communications.
[IF=0.643, Cited=9, 187191].
Shkedy D, Gonen H, Bercovich B, Ciechanover A (1994) Complete reconstitution of conjugation and subsequent degradation
of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system. FEBS Letters. [IF=0.871,
Cited=24, 8034027].
Fischer M, Hilt W, Richter-Ruoff B, ..., Wolf DH (1994) The 26S proteasome of the yeast Saccharomyces cerevisiae. FEBS
Letters. [IF=0.871, Cited=20, 7957966].
Ciechanover A, Schwartz AL, Lodish HF (1983) The asialoglycoprotein receptor internalizes and recycles independently of
the transferrin and insulin receptors. Cell. [IF=8.479, Cited=91, 6297785].
Finley D, Ciechanover A, Varshavsky A (1984) Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle
mutant ts85. Cell. [IF=8.479, Cited=281, 6327059].
Ciechanover A, Finley D, Varshavsky A (1984) Ubiquitin dependence of selective protein degradation demonstrated in the
mammalian cell cycle mutant ts85. Cell. [IF=8.479, Cited=294, 6327060].
Wöstmann C, Liakopoulos D, Ciechanover A, Bakker-Grunwald T (1996) Characterization of ubiquitin genes and -transcripts
and demonstration of a ubiquitin-conjugating system in Entamoeba histolytica. Molecular and Biochemical Parasitology.
[IF=0.541, Cited=12, 8943152].
DeMartino GN, McCullough ML, Reckelhoff JF, ..., McGuire MJ (1991) ATP-stimulated degradation of endogenous proteins in
cell-free extracts of BHK 21/C13 fibroblasts. A key role for the proteinase, macropain, in the ubiquitin-dependent
degradation of short-lived proteins. None. [IF=None, Cited=9, 1849005].
Ciechanover A, Schwartz AL (1989) How are substrates recognized by the ubiquitin-mediated proteolytic system? Trends in
Biochemical Sciences. [IF=2.462, Cited=57, 2696178].
Ciechanover A, Shoenfeld Y, Shemer J, ..., Borow M (2011) Response to health in the Occupied Palestinian Territory. The
Lancet. [IF=25.787, Cited=0, 22035555].
Fajerman I, Schwartz AL, Ciechanover A (2004) Degradation of the Id2 developmental regulator: targeting via N-terminal
ubiquitination. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=46, 14733935].
Cohen S, Lahav-Baratz S, Ciechanover A (2006) Two distinct ubiquitin-dependent mechanisms are involved in NF-kappaB p105
proteolysis. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=16, 16678126].
Shabek N, Iwai K, Ciechanover A (2007) Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its
conjugated target. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=18, 17870054].
Cohen S, Ciechanover A, Kravtsova-Ivantsiv Y, ..., Lahav-Baratz S (2009) ABIN-1 negatively regulates NF-kappaB by
inhibiting processing of the p105 precursor. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=19, 19695220].
de Bie P, Zaaroor-Regev D, Ciechanover A (2010) Regulation of the Polycomb protein RING1B ubiquitination by USP7.
Biochemical and Biophysical Research Communications. [IF=0.643, Cited=50, 20800574].
Zoabi M, Sadeh R, de Bie P, ..., Ciechanover A (2011) PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2
proteins. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=39, 21513699].
Noy T, Suad O, Taglicht D, Ciechanover A (2012) HUWE1 ubiquitinates MyoD and targets it for proteasomal degradation.
Biochemical and Biophysical Research Communications. [IF=0.643, Cited=25, 22277673].
Ciechanover A, Hod Y, Hershko A (2012) A heat-stable polypeptide component of an ATP-dependent proteolytic system from
reticulocytes. 1978. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=8, 22925675].
de Bie P, Ciechanover A (2012) RING1B ubiquitination and stability are regulated by ARF. Biochemical and Biophysical
Research Communications. [IF=0.643, Cited=0, 22910419].
Buchsbaum S, Bercovich B, Ziv T, Ciechanover A (2012) Modification of the inflammatory mediator LRRFIP2 by the
ubiquitin-like protein FAT10 inhibits its activity during cellular response to LPS. Biochemical and Biophysical Research
Communications. [IF=0.643, Cited=11, 23036196].
Herrmann J, Ciechanover A, Lerman LO, Lerman A (2004) The ubiquitin-proteasome system in cardiovascular diseases-a
hypothesis extended. Cardiovascular Research. [IF=1.982, Cited=120, 14732197].
Bernassola F, Karin M, Ciechanover A, Melino G (2008) The HECT family of E3 ubiquitin ligases: multiple players in
cancer development. Cancer Cell. [IF=5.274, Cited=357, 18598940].
Dada LA, Welch LC, Zhou G, ..., Sznajder JI (2007) Phosphorylation and ubiquitination are necessary for Na,K-ATPase
endocytosis during hypoxia. Cellular Signalling. [IF=0.941, Cited=32, 17532187].
Cech TR, Charpentier E, Ciechanover A, ..., Wüthrich K (2024) Reflections from Nobel laureates in chemistry. Cell
Chemical Biology. [IF=1.446, Cited=0, 39151404].
Kravtsova-Ivantsiv Y, Cohen S, Ciechanover A (2009) Modification by single ubiquitin moieties rather than
polyubiquitination is sufficient for proteasomal processing of the p105 NF-kappaB precursor. Molecular Cell. [IF=2.773,
Cited=60, 19250910].
Moyal L, Lerenthal Y, Gana-Weisz M, ..., Shiloh Y (2011) Requirement of ATM-dependent monoubiquitylation of histone H2B
for timely repair of DNA double-strand breaks. Molecular Cell. [IF=2.773, Cited=266, 21362549].
Shabek N, Herman-Bachinsky Y, Buchsbaum S, ..., Ciechanover A (2012) The size of the proteasomal substrate determines
whether its degradation will be mediated by mono- or polyubiquitylation. Molecular Cell. [IF=2.773, Cited=101, 22902562].
Bagola K, von Delbrück M, Dittmar G, ..., Sommer T (2013) Ubiquitin binding by a CUE domain regulates ubiquitin chain
formation by ERAD E3 ligases. Molecular Cell. [IF=2.773, Cited=39, 23665229].
Ciechanover A (2013) An interview with Aaron Ciechanover. Trends in Biochemical Sciences. [IF=2.462, Cited=0, 23608642].
Nadav E, Shmueli A, Barr H, ..., Reiss Y (2003) A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to
the yeast Hrd1. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=80, 12646171].
Gross-Mesilaty S, Hargrove JL, Ciechanover A (1997) Degradation of tyrosine aminotransferase (TAT) via the ubiquitin-
proteasome pathway. FEBS Letters. [IF=0.871, Cited=18, 9089286].
Gonen H, Shkedy D, Barnoy S, ..., Ciechanover A (1997) On the involvement of calpains in the degradation of the tumor
suppressor protein p53. FEBS Letters. [IF=0.871, Cited=45, 9109377].
Hershko A, Hershko A, Ciechanover A, Ciechanover A (1986) The ubiquitin pathway for the degradation of intracellular
proteins. None. [IF=None, Cited=86, 3025922].
Finley D, Ciechanover A, Varshavsky A (2004) Ubiquitin as a central cellular regulator. Cell. [IF=8.479, Cited=81, 15055578].
Herrmann J, Edwards WD, Holmes DR, ..., Lerman A (2002) Increased ubiquitin immunoreactivity in unstable atherosclerotic
plaques associated with acute coronary syndromes. Journal of the American College of Cardiology. [IF=6.424, Cited=44, 12475450].
Cummings CJ, Reinstein E, Sun Y, ..., Zoghbi HY (1999) Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion
frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron. [IF=3.346, Cited=301, 10624951].
Levkowitz G, Waterman H, Ettenberg SA, ..., Yarden Y (1999) Ubiquitin ligase activity and tyrosine phosphorylation
underlie suppression of growth factor signaling by c-Cbl/Sli-1. Molecular Cell. [IF=2.773, Cited=625, 10635327].
Sun XM, Butterworth M, MacFarlane M, ..., Cohen GM (2004) Caspase activation inhibits proteasome function during
apoptosis. Molecular Cell. [IF=2.773, Cited=126, 15068805].
Ferber S, Ciechanover A (None) Role of arginine-tRNA in protein degradation by the ubiquitin pathway. Nature.
[IF=11.591, Cited=88, 3033511].
Ciechanover A (2011) On the wings of imagination. Nature. [IF=11.591, Cited=0, 21993824].
Hershko A, Hershko A, Ciechanover A, ..., Varshavsky A (2000) Basic Medical Research Award. The ubiquitin system. Nature
Medicine. [IF=11.877, Cited=400, 11017125].
Melino G, Gallagher E, Aqeilan RI, ..., Bernassola F (2008) Itch: a HECT-type E3 ligase regulating immunity, skin and
cancer. Cell Death and Differentiation. [IF=2.211, Cited=122, 18552861].
Galluzzi L, Aaronson SA, Abrams J, ..., Kroemer G (2009) Guidelines for the use and interpretation of assays for
monitoring cell death in higher eukaryotes. Cell Death and Differentiation. [IF=2.211, Cited=383, 19373242].
de Bie P, Ciechanover A (2011) Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and
non-proteolytic mechanisms. Cell Death and Differentiation. [IF=2.211, Cited=165, 21372847].
Craxton A, Butterworth M, Harper N, ..., Cohen GM (2012) NOXA, a sensor of proteasome integrity, is degraded by 26S
proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1. Cell Death and Differentiation. [IF=2.211,
Cited=40, 22361683].
Ryoo HD, Bergmann A, Gonen H, ..., Steller H (2002) Regulation of Drosophila IAP1 degradation and apoptosis by reaper
and ubcD1. Nature Cell Biology. [IF=3.908, Cited=196, 12021769].
Ciechanover A (2001) Linking ubiquitin, parkin and synphilin-1. Nature Medicine. [IF=11.877, Cited=18, 11590431].
Ciechanover A (1996) Ubiquitin-mediated proteolysis and male sterility. Nature Medicine. [IF=11.877, Cited=10, 8898739].
Weissman AM, Shabek N, Ciechanover A (2011) The predator becomes the prey: regulating the ubiquitin system by
ubiquitylation and degradation. Nature Reviews Molecular Cell Biology. [IF=19.213, Cited=185, 21860393].
Ciechanover A (2005) Early work on the ubiquitin proteasome system, an interview with Aaron Ciechanover. Interview by
CDD. Cell Death and Differentiation. [IF=2.211, Cited=9, 16094393].
Herman-Bachinsky Y, Ryoo HD, Ciechanover A, Gonen H (2007) Regulation of the Drosophila ubiquitin ligase DIAP1 is
mediated via several distinct ubiquitin system pathways. Cell Death and Differentiation. [IF=2.211, Cited=45, 17205079].
Sadot E, Simcha I, Iwai K, ..., Ben-Ze'ev A (2000) Differential interaction of plakoglobin and beta-catenin with the
ubiquitin-proteasome system. Oncogene. [IF=1.523, Cited=49, 10803460].
Reinstein E, Scheffner M, Oren M, ..., Schwartz A (2000) Degradation of the E7 human papillomavirus oncoprotein by the
ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue. Oncogene. [IF=1.523, Cited=109, 11127826].
Amir RE, Haecker H, Karin M, Ciechanover A (2004) Mechanism of processing of the NF-kappa B2 p100 precursor:
identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of
NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase. Oncogene. [IF=1.523, Cited=69, 14676825].
Lingbeck JM, Trausch-Azar JS, Ciechanover A, Schwartz AL (2005) E12 and E47 modulate cellular localization and
proteasome-mediated degradation of MyoD and Id1. Oncogene. [IF=1.523, Cited=40, 16007194].
Sun L, Trausch-Azar JS, Ciechanover A, Schwartz AL (2006) E2A protein degradation by the ubiquitin-proteasome system is
stage-dependent during muscle differentiation. Oncogene. [IF=1.523, Cited=13, 16909127].
Hershko A, Hershko A, Ciechanover A, ..., Rose IA (1979) Resolution of the ATP-dependent proteolytic system from
reticulocytes: a component that interacts with ATP. Proceedings of the National Academy of Sciences of the United States
of America. [IF=2.765, Cited=95, 290989].
Ciechanover A, Ciechanover A, Heller H, ..., Hershko A (1980) ATP-dependent conjugation of reticulocyte proteins with
the polypeptide required for protein degradation. Proceedings of the National Academy of Sciences of the United States
of America. [IF=2.765, Cited=232, 6769112].
Hershko A, Hershko A, Ciechanover A, ..., Rose IA (1980) Proposed role of ATP in protein breakdown: conjugation of
protein with multiple chains of the polypeptide of ATP-dependent proteolysis. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=311, 6990414].
Ciechanover A, Ciechanover A, Heller H, ..., Hershko A (1981) Activation of the heat-stable polypeptide of the ATP-
dependent proteolytic system. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=106, 6262770].
Dautry-Varsat A, Ciechanover A, Lodish HF (1983) pH and the recycling of transferrin during receptor-mediated
endocytosis. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=594, 6300903].
Patel VP, Ciechanover A, Platt O, Lodish HF (1985) Mammalian reticulocytes lose adhesion to fibronectin during
maturation to erythrocytes. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=45, 3855563].
Ciechanover A, Wolin SL, Steitz JA, Lodish HF (1985) Transfer RNA is an essential component of the ubiquitin- and ATP-
dependent proteolytic system. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=23, 2983338].
Orian A, Whiteside S, Israël A, ..., Ciechanover A (1995) Ubiquitin-mediated processing of NF-kappa B transcriptional
activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2,
and a novel ubiquitin-protein ligase, E3, involved in conjugation. Journal of Biological Chemistry. [IF=1.122,
Cited=99, 7665588].
Gonen H, Stancovski I, Shkedy D, ..., Ciechanover A (1996) Isolation, characterization, and partial purification of a
novel ubiquitin-protein ligase, E3. Targeting of protein substrates via multiple and distinct recognition signals and
conjugating enzymes. Journal of Biological Chemistry. [IF=1.122, Cited=21, 8550577].
Stephen AG, Trausch-Azar JS, Ciechanover A, Schwartz AL (1996) The ubiquitin-activating enzyme E1 is phosphorylated and
localized to the nucleus in a cell cycle-dependent manner. Journal of Biological Chemistry. [IF=1.122, Cited=34, 8663123].
Bercovich B, Stancovski I, Mayer A, ..., Ciechanover A (1997) Ubiquitin-dependent degradation of certain protein
substrates in vitro requires the molecular chaperone Hsc70. Journal of Biological Chemistry. [IF=1.122, Cited=167, 9083024].
Stephen AG, Trausch-Azar JS, Handley-Gearhart PM, ..., Schwartz AL (1997) Identification of a region within the
ubiquitin-activating enzyme required for nuclear targeting and phosphorylation. Journal of Biological Chemistry.
[IF=1.122, Cited=25, 9099746].
Gonen H, Bercovich B, Orian A, ..., Ciechanover A (1999) Identification of the ubiquitin carrier proteins, E2s, involved
in signal-induced conjugation and subsequent degradation of IkappaBalpha. Journal of Biological Chemistry. [IF=1.122,
Cited=81, 10329681].
Aviel S, Winberg G, Massucci M, Ciechanover A (2000) Degradation of the epstein-barr virus latent membrane protein 1
(LMP1) by the ubiquitin-proteasome pathway. Targeting via ubiquitination of the N-terminal residue. Journal of
Biological Chemistry. [IF=1.122, Cited=102, 10807912].
Floyd ZE, Trausch-Azar JS, Reinstein E, ..., Schwartz AL (2001) The nuclear ubiquitin-proteasome system degrades MyoD.
Journal of Biological Chemistry. [IF=1.122, Cited=43, 11309375].
Gupta-Rossi N, Le Bail O, Gonen H, ..., Israël A (2001) Functional interaction between SEL-10, an F-box protein, and the
nuclear form of activated Notch1 receptor. Journal of Biological Chemistry. [IF=1.122, Cited=231, 11425854].
Cohen S, Orian A, Ciechanover A (2001) Processing of p105 is inhibited by docking of p50 active subunits to the ankyrin
repeat domain, and inhibition is alleviated by signaling via the carboxyl-terminal phosphorylation/ ubiquitin-ligase
binding domain. Journal of Biological Chemistry. [IF=1.122, Cited=16, 11350967].
Kühnle S, Kogel U, Glockzin S, ..., Scheffner M (2011) Physical and functional interaction of the HECT ubiquitin-protein
ligases E6AP and HERC2. Journal of Biological Chemistry. [IF=1.122, Cited=52, 21493713].
Amir RE, Iwai K, Ciechanover A (2002) The NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and
processing of the NF-kappa B precursor p105. Journal of Biological Chemistry. [IF=1.122, Cited=54, 11953428].
Lingbeck JM, Trausch-Azar JS, Ciechanover A, Schwartz AL (2002) Determinants of nuclear and cytoplasmic ubiquitin-
mediated degradation of MyoD. Journal of Biological Chemistry. [IF=1.122, Cited=37, 12397066].
Trausch-Azar JS, Lingbeck J, Ciechanover A, Schwartz AL (2004) Ubiquitin-Proteasome-mediated degradation of Id1 is
modulated by MyoD. Journal of Biological Chemistry. [IF=1.122, Cited=36, 15163661].
Ben-Saadon R, Fajerman I, Ziv T, ..., Ciechanover A (2004) The tumor suppressor protein p16(INK4a) and the human
papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system.
Direct evidence for ubiquitination at the N-terminal residue. Journal of Biological Chemistry. [IF=1.122, Cited=73, 15254040].
Sun L, Trausch-Azar JS, Ciechanover A, Schwartz AL (2005) Ubiquitin-proteasome-mediated degradation, intracellular
localization, and protein synthesis of MyoD and Id1 during muscle differentiation. Journal of Biological Chemistry.
[IF=1.122, Cited=39, 15888449].
Lotan R, Rotem A, Gonen H, ..., Larisch S (2005) Regulation of the proapoptotic ARTS protein by ubiquitin-mediated
degradation. Journal of Biological Chemistry. [IF=1.122, Cited=25, 15837787].
Navon A, Ciechanover A (2009) The 26 S proteasome: from basic mechanisms to drug targeting. Journal of Biological
Chemistry. [IF=1.122, Cited=118, 19812037].
Herrmann J, Ciechanover A, Lerman LO, Lerman A (2005) The ubiquitin-proteasome system--micro target for macro
intervention? None. [IF=None, Cited=5, 16019609].
Staub O, Gautschi I, Ishikawa T, ..., Rotin D (1997) Regulation of stability and function of the epithelial Na+ channel
(ENaC) by ubiquitination. EMBO Journal. [IF=2.114, Cited=440, 9351815].
Yaron A, Gonen H, Alkalay I, ..., Ben-Neriah Y (1997) Inhibition of NF-kappa-B cellular function via specific targeting
of the I-kappa-B-ubiquitin ligase. EMBO Journal. [IF=2.114, Cited=141, 9351830].
Breitschopf K, Bengal E, Ziv T, ..., Ciechanover A (1998) A novel site for ubiquitination: the N-terminal residue, and
not internal lysines of MyoD, is essential for conjugation and degradation of the protein. EMBO Journal. [IF=2.114,
Cited=179, 9774340].
Orian A, Gonen H, Bercovich B, ..., Ciechanover A (2000) SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-
kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. EMBO Journal. [IF=2.114, Cited=103, 10835356].
Lahav-Baratz S, Ben-Izhak O, Sabo E, ..., Dirnfeld M (2004) Decreased level of the cell cycle regulator p27 and
increased level of its ubiquitin ligase Skp2 in endometrial carcinoma but not in normal secretory or in hyperstimulated
endometrium. Molecular Human Reproduction. [IF=0.903, Cited=20, 15220466].
Ben-Izhak O, Lahav-Baratz S, Meretyk S, ..., Ciechanover A (2003) Inverse relationship between Skp2 ubiquitin ligase and
the cyclin dependent kinase inhibitor p27Kip1 in prostate cancer. Journal of Urology. [IF=2.411, Cited=53, 12796697].
Rosenberg-Hasson Y, Bercovich Z, Ciechanover A, Kahana C (1989) Degradation of ornithine decarboxylase in mammalian
cells is ATP dependent but ubiquitin independent. None. [IF=None, Cited=53, 2555193].
Gleick PH, Adams RM, Amasino RM, ..., Zoback ML (2010) Climate change and the integrity of science. Science. [IF=7.729,
Cited=12, 20448167].
Hershko A, Hershko A, Ciechanover A, Ciechanover A (1982) Mechanisms of intracellular protein breakdown. Annual Review
of Biochemistry. [IF=5.273, Cited=317, 6287917].
Hershko A, Hershko A, Ciechanover A, Ciechanover A (1992) The ubiquitin system for protein degradation. Annual Review of
Biochemistry. [IF=5.273, Cited=754, 1323239].
Schwartz AL, Ciechanover A (1999) The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annual Review of
Medicine. [IF=3.155, Cited=268, 10073263].
Lecuona E, Sun H, Vohwinkel C, ..., Sznajder JI (2009) Ubiquitination participates in the lysosomal degradation of
Na,K-ATPase in steady-state conditions. American Journal of Respiratory Cell and Molecular Biology. [IF=1.129,
Cited=23, 19286978].
Ciechanover A (2013) A conversation with Aaron Ciechanover. Interview by Ushma S. Neill. Journal of Clinical
Investigation. [IF=2.423, Cited=0, 24084742].
Goodman SR, Ciechanover A, Hulse RA, ..., Fluckiger S (2006) Nobel round-table discussion #1: the future of
interdisciplinary research and training. Experimental Biology and Medicine. [IF=0.715, Cited=0, 16816128].
Ehringhaus SH, Ciechanover A, Hulse RA, ..., Goodman SR (2006) Nobel round-table discussion #2: conflicts of interest,
scientific misconduct, fair sharing, and intellectual property in an interdisciplinary/inter-institutional consortium.
Experimental Biology and Medicine. [IF=0.715, Cited=0, 16816129].
Neutra MR, Ciechanover A, Owen LS, Lodish HF (1985) Intracellular transport of transferrin- and asialoorosomucoid-
colloidal gold conjugates to lysosomes after receptor-mediated endocytosis. Journal of Histochemistry and Cytochemistry.
[IF=0.838, Cited=42, 2997327].
Nguyen LK, Muñoz-García J, Maccario H, ..., Kholodenko BN (2011) Switches, excitable responses and oscillations in the
Ring1B/Bmi1 ubiquitination system. PLoS Computational Biology. [IF=1.278, Cited=23, 22194680].
Yoo YD, Lee DH, Cha-Molstad H, ..., Kwon YT (2017) Glioma-derived cancer stem cells are hypersensitive to proteasomal
inhibition. EMBO Reports. [IF=1.375, Cited=4, 28864661].
Yoo YD, Lee DH, Cha-Molstad H, ..., Kwon YT (2018) Glioma-derived cancer stem cells are hypersensitive to proteasomal
inhibition. EMBO Reports. [IF=1.375, Cited=0, 30185565].
Ciechanover A (2009) The 2008 Lindau Nobel Laureate Meeting: Aaron Ciechanover, Chemistry 2004. Journal of Visualized
Experiments. [IF=0.398, Cited=1, 19571788].
Shabek N, Ciechanover A (2010) Degradation of ubiquitin: the fate of the cellular reaper. Cell Cycle. [IF=0.792,
Cited=57, 20107325].
Amir R, Ciechanover A, Cohen S (2001) [The ubiquitin-proteasome system: the relationship between protein degradation and
human diseases]. None. [IF=None, Cited=6, 11789303].
Gonen H, Schwartz AL, Ciechanover A (1991) Purification and characterization of a novel protein that is required for
degradation of N-alpha-acetylated proteins by the ubiquitin system. Journal of Biological Chemistry. [IF=1.122,
Cited=21, 1655778].
Stoorvogel W, Strous GJ, Ciechanover A, Schwartz AL (1991) Trafficking of the transferrin receptor. None. [IF=None,
Cited=4, 1797159].
Gropper R, Brandt RA, Elias S, ..., Ciechanover A (1991) The ubiquitin-activating enzyme, E1, is required for stress-
induced lysosomal degradation of cellular proteins. Journal of Biological Chemistry. [IF=1.122, Cited=56, 1847380].
Elias S, Ciechanover A (1990) Post-translational addition of an arginine moiety to acidic NH2 termini of proteins is
required for their recognition by ubiquitin-protein ligase. Journal of Biological Chemistry. [IF=1.122, Cited=26, 2168415].
Bercovich Z, Rosenberg-Hasson Y, Ciechanover A, Kahana C (1989) Degradation of ornithine decarboxylase in reticulocyte
lysate is ATP-dependent but ubiquitin-independent. Journal of Biological Chemistry. [IF=1.122, Cited=75, 2550429].
Mayer A, Gropper R, Schwartz AL, Ciechanover A (1989) Purification, characterization, and rapid inactivation of
thermolabile ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85. Journal of Biological Chemistry.
[IF=1.122, Cited=18, 2914892].
Ciechanover A, Finley D, Varshavsky A (1985) Mammalian cell cycle mutant defective in intracellular protein degradation
and ubiquitin-protein conjugation. None. [IF=None, Cited=7, 2994083].
Ferber S, Ciechanover A (1986) Transfer RNA is required for conjugation of ubiquitin to selective substrates of the
ubiquitin- and ATP-dependent proteolytic system. Journal of Biological Chemistry. [IF=1.122, Cited=31, 3005281].
Jahngen JH, Haas AL, Ciechanover A, ..., Taylor A (1986) The eye lens has an active ubiquitin-protein conjugation
system. Journal of Biological Chemistry. [IF=1.122, Cited=58, 3020046].
Schwartz AL, Ciechanover A, Merritt S, Turkewitz A (1986) Antibody-induced receptor loss. Different fates for
asialoglycoproteins and the asialoglycoprotein receptor in HepG2 cells. Journal of Biological Chemistry. [IF=1.122,
Cited=22, 3021767].
Kulka RG, Raboy B, Schuster R, ..., Marcus M (1988) A Chinese hamster cell cycle mutant arrested at G2 phase has a
temperature-sensitive ubiquitin-activating enzyme, E1. Journal of Biological Chemistry. [IF=1.122, Cited=101, 3049611].
Patel VP, Ciechanover A, Platt O, Lodish HF (1985) Loss of adhesion of erythrocyte precursors to fibronectin during
erythroid differentiation. None. [IF=None, Cited=2, 3863146].
Ciechanover A, Ciechanover A, Elias S, ..., Hershko A (1980) Characterization of the heat-stable polypeptide of the ATP-
dependent proteolytic system from reticulocytes. Journal of Biological Chemistry. [IF=1.122, Cited=98, 6249802].
Hershko A, Hershko A, Ciechanover A, ..., Rose IA (1981) Identification of the active amino acid residue of the
polypeptide of ATP-dependent protein breakdown. Journal of Biological Chemistry. [IF=1.122, Cited=49, 6257674].
Ciechanover A, Ciechanover A, Elias S, ..., Hershko A (1982) "Covalent affinity" purification of ubiquitin-activating
enzyme. Journal of Biological Chemistry. [IF=1.122, Cited=145, 6277904].
Hershko A, Hershko A, Eytan E, ..., Haas AL (1982) Immunochemical analysis of the turnover of ubiquitin-protein
conjugates in intact cells. Relationship to the breakdown of abnormal proteins. Journal of Biological Chemistry.
[IF=1.122, Cited=150, 6292216].
Hershko A, Hershko A, Heller H, ..., Ciechanover A (1983) Components of ubiquitin-protein ligase system. Resolution,
affinity purification, and role in protein breakdown. Journal of Biological Chemistry. [IF=1.122, Cited=592, 6305978].
Ciechanover A, Schwartz AL, Dautry-Varsat A, Lodish HF (1983) Kinetics of internalization and recycling of transferrin
and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents. Journal of Biological
Chemistry. [IF=1.122, Cited=308, 6309781].
Handley-Gearhart PM, Stephen AG, Trausch-Azar JS, ..., Schwartz AL (1994) Human ubiquitin-activating enzyme, E1.
Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs. Journal of
Biological Chemistry. [IF=1.122, Cited=39, 7528747].
Elias S, Bercovich B, Kahana C, ..., Ciechanover A (1995) Degradation of ornithine decarboxylase by the mammalian and
yeast 26S proteasome complexes requires all the components of the protease. None. [IF=None, Cited=24, 7744041].
Blumenfeld N, Gonen H, Mayer A, ..., Ciechanover A (1994) Purification and characterization of a novel species of
ubiquitin-carrier protein, E2, that is involved in degradation of non-"N-end rule" protein substrates. Journal of
Biological Chemistry. [IF=1.122, Cited=36, 8144544].
Strous GJ, van Kerkhof P, Govers R, ..., Schwartz AL (1996) The ubiquitin conjugation system is required for ligand-
induced endocytosis and degradation of the growth hormone receptor. EMBO Journal. [IF=2.114, Cited=174, 8670885].

Ciechanover, Aaron

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