Arnold, Frances H

Publication with MATCHING institution:

Meyer MM, Hiraga K, Arnold FH (2006) Combinatorial recombination of gene fragments to construct a library of chimeras.
Current Protocols in Protein Science. [IF=1.128, Cited=1, 18429308].
Prier CK, Hyster TK, Farwell CC, ..., Arnold FH (2016) Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic
Rearrangement Strategy. Angewandte Chemie - International Edition. [IF=2.456, Cited=24, 26970325].
Murciano-Calles J, Romney DK, Brinkmann-Chen S, ..., Arnold FH (2016) A Panel of TrpB Biocatalysts Derived from
Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation. Angewandte Chemie -
International Edition. [IF=2.456, Cited=33, 27510733].
Arnold FH (2017) Directed Evolution: Bringing New Chemistry to Life. Angewandte Chemie - International Edition.
[IF=2.456, Cited=242, 29064156].
Boville CE, Scheele RA, Koch P, ..., Arnold FH (2018) Engineered Biosynthesis of β-Alkyl Tryptophan Analogues.
Angewandte Chemie - International Edition. [IF=2.456, Cited=20, 30215880].
Cho I, Prier CK, Jia ZJ, ..., Arnold FH (2019) Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an
Engineered Hemoprotein. Angewandte Chemie - International Edition. [IF=2.456, Cited=24, 30600873].
Arnold FH (2019) Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture). Angewandte Chemie -
International Edition. [IF=2.456, Cited=102, 31433107].
Bähr S, Brinkmann-Chen S, Garcia-Borràs M, ..., Arnold FH (2020) Selective Enzymatic Oxidation of Silanes to Silanols.
Angewandte Chemie - International Edition. [IF=2.456, Cited=8, 32212229].
Watkins-Dulaney EJ, Dunham NP, Straathof S, ..., Buller AR (2021) Asymmetric Alkylation of Ketones Catalyzed by
Engineered TrpB. Angewandte Chemie - International Edition. [IF=2.456, Cited=7, 34269506].
Athavale SV, Gao S, Liu Z, ..., Arnold FH (2021) Biocatalytic, Intermolecular C-H Bond Functionalization for the
Synthesis of Enantioenriched Amides. Angewandte Chemie - International Edition. [IF=2.456, Cited=13, 34534409].
Schaus L, Das A, Knight AM, ..., Huang X (2022) Protoglobin-Catalyzed Formation of cis-Trifluoromethyl-Substituted
Cyclopropanes by Carbene Transfer. Angewandte Chemie - International Edition. [IF=2.456, Cited=3, 36533936].
Calvó-Tusell C, Liu Z, Chen K, ..., Garcia-Borràs M (2023) Reversing the Enantioselectivity of Enzymatic Carbene N-H
Insertion Through Mechanism-Guided Protein Engineering. Angewandte Chemie - International Edition. [IF=2.456, Cited=2, 37260412].
Trudeau DL, Lee TM, Arnold FH (2014) Engineered thermostable fungal cellulases exhibit efficient synergistic cellulose
hydrolysis at elevated temperatures. Biotechnology and Bioengineering. [IF=0.932, Cited=19, 24916885].
Watkins EJ, Almhjell PJ, Arnold FH (2019) Direct Enzymatic Synthesis of a Deep-Blue Fluorescent Noncanonical Amino Acid
from Azulene and Serine. ChemBioChem. [IF=0.691, Cited=10, 31513332].
Cahn JKB, Brinkmann-Chen S, Buller AR, Arnold FH (2015) Artificial domain duplication replicates evolutionary history of
ketol-acid reductoisomerases. Protein Science. [IF=1.97, Cited=2, 26644020].
Cahn JKB, Brinkmann-Chen S, Arnold FH (2018) Enzyme Nicotinamide Cofactor Specificity Reversal Guided by Automated
Structural Analysis and Library Design. Methods in Molecular Biology. [IF=0.413, Cited=2, 29170950].
Arnold FH, Moore JC (1997) Optimizing industrial enzymes by directed evolution. None. [IF=None, Cited=37, 9103909].
Arnold FH (1990) Engineering enzymes for non-aqueous solvents. Trends in Biotechnology. [IF=2.875, Cited=44, 1366732].
Arnold FH, Zhang JH (1994) Metal-mediated protein stabilization. Trends in Biotechnology. [IF=2.875, Cited=26, 7764902].
Arnold FH (1993) Protein engineering for unusual environments. Current Opinion in Biotechnology. [IF=1.815, Cited=14, 7763976].
Das A, Gao S, Athavale SV, ..., Arnold FH (2023) Directed evolution of P411 enzymes for amination of inert C-H bonds.
None. [IF=None, Cited=0, 37977727].
Fulton TJ, Sarai NS, O'Meara RL, Arnold FH (2023) Directed evolution for Si-C bond cleavage of volatile siloxanes in
glass bioreactors. None. [IF=None, Cited=0, 37977737].
McIntosh JA, Farwell CC, Arnold FH (2014) Expanding P450 catalytic reaction space through evolution and engineering.
Current Opinion in Chemical Biology. [IF=1.51, Cited=60, 24658056].
Zhang RK, Huang X, Arnold FH (2018) Selective CH bond functionalization with engineered heme proteins: new tools to
generate complexity. Current Opinion in Chemical Biology. [IF=1.51, Cited=37, 30343008].
Wu Z, Johnston KE, Arnold FH, Yang KK (2021) Protein sequence design with deep generative models. Current Opinion in
Chemical Biology. [IF=1.51, Cited=36, 34051682].
Wittmann BJ, Yue Y, Arnold FH (2021) Informed training set design enables efficient machine learning-assisted directed
protein evolution. None. [IF=None, Cited=34, 34416172].
Bedbrook CN, Kato M, Ravindra Kumar S, ..., Gradinaru V (2015) Genetically Encoded Spy Peptide Fusion System to Detect
Plasma Membrane-Localized Proteins In Vivo. None. [IF=None, Cited=31, 26211362].
Herwig L, Rice AJ, Bedbrook CN, ..., Arnold FH (2017) Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin
Using a Synthetic Chromophore. Cell Chemical Biology. [IF=1.446, Cited=33, 28262559].
Alfonzo E, Das A, Arnold FH (2022) New Additions to the Arsenal of Biocatalysts for Noncanonical Amino Acid Synthesis.
Current Opinion in Green and Sustainable Chemistry. [IF=1.539, Cited=4, 36561208].
Brandenberg OF, Fasan R, Arnold FH (2017) Exploiting and engineering hemoproteins for abiological carbene and nitrene
transfer reactions. Current Opinion in Biotechnology. [IF=1.815, Cited=98, 28711855].
Liu Z, Arnold FH (2020) New-to-nature chemistry from old protein machinery: carbene and nitrene transferases. Current
Opinion in Biotechnology. [IF=1.815, Cited=21, 33370622].
Engqvist MKM, McIsaac RS, Dollinger P, ..., Arnold FH (2014) Directed evolution of Gloeobacter violaceus rhodopsin
spectral properties. Journal of Molecular Biology. [IF=1.281, Cited=45, 24979679].
McIsaac RS, Bedbrook CN, Arnold FH (2015) Recent advances in engineering microbial rhodopsins for optogenetics. Current
Opinion in Structural Biology. [IF=1.4, Cited=25, 26038227].
Wittmann BJ, Johnston KE, Wu Z, Arnold FH (2021) Advances in machine learning for directed evolution. Current Opinion in
Structural Biology. [IF=1.4, Cited=39, 33647531].
Lin PP, Rabe KS, Takasumi JL, ..., Liao JC (2014) Isobutanol production at elevated temperatures in thermophilic
Geobacillus thermoglucosidasius. Metabolic Engineering. [IF=1.846, Cited=53, 24721011].
Brinkmann-Chen S, Cahn JKB, Arnold FH (2014) Uncovering rare NADH-preferring ketol-acid reductoisomerases. Metabolic
Engineering. [IF=1.846, Cited=13, 25172159].
Arnold FH, Wintrode PL, Miyazaki K, Gershenson A (2001) How enzymes adapt: lessons from directed evolution. Trends in
Biochemical Sciences. [IF=2.462, Cited=172, 11166567].
Arnold FH, Volkov AA (1999) Directed evolution of biocatalysts. Current Opinion in Chemical Biology. [IF=1.51,
Cited=158, 10021399].
Arnold FH (2015) The nature of chemical innovation: new enzymes by evolution. Quarterly Reviews of Biophysics.
[IF=1.372, Cited=41, 26537398].
Fu AY, Chou HP, Spence C, ..., Quake SR (2002) An integrated microfabricated cell sorter. Analytical Chemistry.
[IF=1.41, Cited=198, 12069222].
Yang Y, Arnold FH (2021) Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective
Carbene and Nitrene Transfer. Accounts of Chemical Research. [IF=3.533, Cited=49, 33491448].
Buller AR, van Roye P, Murciano-Calles J, Arnold FH (2016) Tryptophan Synthase Uses an Atypical Mechanism To Achieve
Substrate Specificity. Biochemistry. [IF=0.753, Cited=13, 27935677].
Boville CE, Romney DK, Almhjell PJ, ..., Arnold FH (2018) Improved Synthesis of 4-Cyanotryptophan and Other Tryptophan
Analogues in Aqueous Solvent Using Variants of TrpB from Thermotoga maritima. Journal of Organic Chemistry. [IF=0.885,
Cited=27, 29651849].
Romney DK, Arnold FH, Lipshutz BH, Li CJ (2018) Chemistry Takes a Bath: Reactions in Aqueous Media. Journal of Organic
Chemistry. [IF=0.885, Cited=15, 30025465].
Wittmann BJ, Knight AM, Hofstra JL, ..., Arnold FH (2020) Diversity-Oriented Enzymatic Synthesis of Cyclopropane
Building Blocks. ACS Catalysis. [IF=2.134, Cited=8, 33282460].
Dunham NP, Arnold FH (2020) Nature's Machinery, Repurposed: Expanding the Repertoire of Iron-Dependent Oxygenases. ACS
Catalysis. [IF=2.134, Cited=31, 33282461].
Hernandez KE, Renata H, Lewis RD, ..., Arnold FH (2016) Highly Stereoselective Biocatalytic Synthesis of Key
Cyclopropane Intermediate to Ticagrelor. ACS Catalysis. [IF=2.134, Cited=16, 28286694].
Romney DK, Sarai NS, Arnold FH (2019) Nitroalkanes as Versatile Nucleophiles for Enzymatic Synthesis of Noncanonical
Amino Acids. ACS Catalysis. [IF=2.134, Cited=15, 33274115].
Brandenberg OF, Miller DC, Markel U, ..., Arnold FH (2019) Engineering Chemoselectivity in Hemoprotein-Catalyzed Indole
Amidation. ACS Catalysis. [IF=2.134, Cited=6, 31938573].
Sarai NS, Levin BJ, Roberts JM, ..., Arnold FH (2021) Biocatalytic Transformations of Silicon-the Other Group 14
Element. ACS Central Science. [IF=2.363, Cited=7, 34235255].
Qin ZY, Gao S, Zou Y, ..., Arnold FH (2023) Biocatalytic Construction of Chiral Pyrrolidines and Indolines via
Intramolecular C(sp³)-H Amination. ACS Central Science. [IF=2.363, Cited=0, 38161360].
Yang J, Li FZ, Arnold FH (2024) Opportunities and Challenges for Machine Learning-Assisted Enzyme Engineering. ACS
Central Science. [IF=2.363, Cited=0, 38435522].
Farwell CC, Zhang RK, McIntosh JA, ..., Arnold FH (2015) Enantioselective Enzyme-Catalyzed Aziridination Enabled by
Active-Site Evolution of a Cytochrome P450. ACS Central Science. [IF=2.363, Cited=61, 26405689].
Knight AM, Kan SBJ, Lewis RD, ..., Arnold FH (2018) Diverse Engineered Heme Proteins Enable Stereodivergent
Cyclopropanation of Unactivated Alkenes. ACS Central Science. [IF=2.363, Cited=47, 29632883].
Huang X, Garcia-Borràs M, Miao K, ..., Arnold FH (2019) A Biocatalytic Platform for Synthesis of Chiral
α-Trifluoromethylated Organoborons. ACS Central Science. [IF=2.363, Cited=24, 30834315].
Wu Z, Yang KK, Liszka MJ, ..., Arnold FH (2020) Signal Peptides Generated by Attention-Based Neural Networks. ACS
Synthetic Biology. [IF=0.96, Cited=33, 32649182].
Wittmann BJ, Johnston KE, Almhjell PJ, Arnold FH (2022) evSeq: Cost-Effective Amplicon Sequencing of Every Variant in a
Protein Library. ACS Synthetic Biology. [IF=0.96, Cited=8, 35172576].
Yang J, Ducharme J, Johnston KE, ..., Arnold FH (2023) DeCOIL: Optimization of Degenerate Codon Libraries for Machine
Learning-Assisted Protein Engineering. ACS Synthetic Biology. [IF=0.96, Cited=1, 37524064].
Cahn JKB, Werlang CA, Baumschlager A, ..., Arnold FH (2016) A General Tool for Engineering the NAD/NADP Cofactor
Preference of Oxidoreductases. ACS Synthetic Biology. [IF=0.96, Cited=43, 27648601].
Gershenson A, Schauerte JA, Giver L, Arnold FH (2000) Tryptophan phosphorescence study of enzyme flexibility and
unfolding in laboratory-evolved thermostable esterases. Biochemistry. [IF=0.753, Cited=31, 10769121].
Udit AK, Hindoyan N, Hill MG, ..., Gray HB (2005) Protein-surfactant film voltammetry of wild-type and mutant cytochrome
P450 BM3. Inorganic Chemistry. [IF=0.986, Cited=19, 15934729].
Peters MW, Meinhold P, Glieder A, Arnold FH (2003) Regio- and enantioselective alkane hydroxylation with engineered
cytochromes P450 BM-3. Journal of the American Chemical Society. [IF=2.573, Cited=146, 14583039].
Udit AK, Hill MG, Bittner VG, ..., Gray HB (2004) Reduction of dioxygen catalyzed by pyrene-wired heme domain cytochrome
P450 BM3 electrodes. Journal of the American Chemical Society. [IF=2.573, Cited=24, 15315414].
Landwehr M, Hochrein L, Otey CR, ..., Arnold FH (2006) Enantioselective alpha-hydroxylation of 2-arylacetic acid
derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3. Journal of the American Chemical Society.
[IF=2.573, Cited=55, 16669674].
Lelyveld VS, Brustad E, Arnold FH, Jasanoff A (2011) Metal-substituted protein MRI contrast agents engineered for
enhanced relaxivity and ligand sensitivity. Journal of the American Chemical Society. [IF=2.573, Cited=35, 21171606].
Zhang WB, Sun F, Tirrell DA, Arnold FH (2013) Controlling macromolecular topology with genetically encoded SpyTag-
SpyCatcher chemistry. Journal of the American Chemical Society. [IF=2.573, Cited=70, 23964715].
Farwell CC, McIntosh JA, Hyster TK, ..., Arnold FH (2014) Enantioselective imidation of sulfides via enzyme-catalyzed
intermolecular nitrogen-atom transfer. Journal of the American Chemical Society. [IF=2.573, Cited=43, 24901646].
Hyster TK, Farwell CC, Buller AR, ..., Arnold FH (2014) Enzyme-controlled nitrogen-atom transfer enables regiodivergent
C-H amination. Journal of the American Chemical Society. [IF=2.573, Cited=54, 25325618].
Chen K, Arnold FH (2020) Engineering Cytochrome P450s for Enantioselective Cyclopropenation of Internal Alkynes. Journal
of the American Chemical Society. [IF=2.573, Cited=17, 32223130].
Jia ZJ, Gao S, Arnold FH (2020) Enzymatic Primary Amination of Benzylic and Allylic C(sp³)-H Bonds. Journal
of the American Chemical Society. [IF=2.573, Cited=38, 32450692].
Pluchinsky AJ, Wackelin DJ, Huang X, ..., Mrksich M (2020) High Throughput Screening with SAMDI Mass Spectrometry for
Directed Evolution. Journal of the American Chemical Society. [IF=2.573, Cited=7, 33174742].
Garcia-Borràs M, Kan SBJ, Lewis RD, ..., Houk KN (2021) Origin and Control of Chemoselectivity in Cytochrome c
Catalyzed Carbene Transfer into Si-H and N-H bonds. Journal of the American Chemical Society. [IF=2.573, Cited=11, 33909977].
Liu Z, Qin ZY, Zhu L, ..., Arnold FH (2021) An Enzymatic Platform for Primary Amination of 1-Aryl-2-alkyl Alkynes.
Journal of the American Chemical Society. [IF=2.573, Cited=17, 34941252].
Miller DC, Lal RG, Marchetti LA, Arnold FH (2022) Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via
a Highly Enantioselective [1,2]-Stevens Rearrangement. Journal of the American Chemical Society. [IF=2.573, Cited=9, 35258294].
Porter NJ, Danelius E, Gonen T, Arnold FH (2022) Biocatalytic Carbene Transfer Using Diazirines. Journal of the American
Chemical Society. [IF=2.573, Cited=9, 35561334].
Athavale SV, Gao S, Das A, ..., Arnold FH (2022) Enzymatic Nitrogen Insertion into Unactivated C-H Bonds. Journal of the
American Chemical Society. [IF=2.573, Cited=13, 36194202].
Danelius E, Porter NJ, Unge J, ..., Gonen T (2023) MicroED Structure of a Protoglobin Reactive Carbene Intermediate.
Journal of the American Chemical Society. [IF=2.573, Cited=4, 36948184].
Mao R, Wackelin DJ, Jamieson CS, ..., Arnold FH (2023) Enantio- and Diastereoenriched Enzymatic Synthesis of
1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates. Journal of the American
Chemical Society. [IF=2.573, Cited=1, 37433085].
Rogge T, Zhou Q, Porter NJ, ..., Houk KN (2024) Iron Heme Enzyme-Catalyzed Cyclopropanations with Diazirines as Carbene
Precursors: Computational Explorations of Diazirine Activation and Cyclopropanation Mechanism. Journal of the American
Chemical Society. [IF=2.573, Cited=0, 38270588].
Gao S, Das A, Alfonzo E, ..., Arnold FH (2023) Enzymatic Nitrogen Incorporation Using Hydroxylamine. Journal of the
American Chemical Society. [IF=2.573, Cited=0, 37671894].
Wackelin DJ, Mao R, Sicinski KM, ..., Arnold FH (2024) Enzymatic Assembly of Diverse Lactone Structures: An
Intramolecular C-H Functionalization Strategy. Journal of the American Chemical Society. [IF=2.573, Cited=0, 38166100].
Hanley D, Li ZQ, Gao S, ..., Alfonzo E (2024) Stereospecific Enzymatic Conversion of Boronic Acids to Amines. Journal of
the American Chemical Society. [IF=2.573, Cited=0, 38958264].
Das A, Gao S, Lal RG, ..., Arnold FH (2024) Reaction Discovery Using Spectroscopic Insights from an Enzymatic C-H
Amination Intermediate. Journal of the American Chemical Society. [IF=2.573, Cited=0, 39037870].
McIntosh JA, Heel T, Buller AR, ..., Arnold FH (2015) Structural Adaptability Facilitates Histidine Heme Ligation in a
Cytochrome P450. Journal of the American Chemical Society. [IF=2.573, Cited=16, 26299431].
Prier CK, Arnold FH (2015) Chemomimetic biocatalysis: exploiting the synthetic potential of cofactor-dependent enzymes
to create new catalysts. Journal of the American Chemical Society. [IF=2.573, Cited=50, 26502343].
Herger M, van Roye P, Romney DK, ..., Arnold FH (2016) Synthesis of β-Branched Tryptophan Analogues Using an Engineered
Subunit of Tryptophan Synthase. Journal of the American Chemical Society. [IF=2.573, Cited=37, 27355405].
Renata H, Lewis RD, Sweredoski MJ, ..., Arnold FH (2016) Identification of Mechanism-Based Inactivation in
P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes. Journal of the American Chemical Society.
[IF=2.573, Cited=21, 27573353].
Romney DK, Murciano-Calles J, Wehrmüller JE, Arnold FH (2017) Unlocking Reactivity of TrpB: A General Biocatalytic
Platform for Synthesis of Tryptophan Analogues. Journal of the American Chemical Society. [IF=2.573, Cited=43, 28708383].
Loskot SA, Romney DK, Arnold FH, Stoltz BM (2017) Enantioselective Total Synthesis of Nigelladine A via Late-Stage C-H
Oxidation Enabled by an Engineered P450 Enzyme. Journal of the American Chemical Society. [IF=2.573, Cited=50, 28721734].
Buller AR, van Roye P, Cahn JKB, ..., Arnold FH (2018) Directed Evolution Mimics Allosteric Activation by Stepwise
Tuning of the Conformational Ensemble. Journal of the American Chemical Society. [IF=2.573, Cited=44, 29712420].
Chen K, Zhang SQ, Brandenberg OF, ..., Arnold FH (2018) Alternate Heme Ligation Steers Activity and Selectivity in
Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions. Journal of the American Chemical Society. [IF=2.573,
Cited=21, 30372623].
Brandenberg OF, Chen K, Arnold FH (2019) Directed Evolution of a Cytochrome P450 Carbene Transferase for Selective
Functionalization of Cyclic Compounds. Journal of the American Chemical Society. [IF=2.573, Cited=28, 31070908].
Zhang J, Huang X, Zhang RK, Arnold FH (2019) Enantiodivergent α-Amino C-H Fluoroalkylation Catalyzed by Engineered
Cytochrome P450s. Journal of the American Chemical Society. [IF=2.573, Cited=26, 31187993].
Dick M, Sarai NS, Martynowycz MW, ..., Arnold FH (2019) Tailoring Tryptophan Synthase TrpB for Selective Quaternary
Carbon Bond Formation. Journal of the American Chemical Society. [IF=2.573, Cited=22, 31747522].
Arnold FH (2001) Combinatorial and computational challenges for biocatalyst design. Nature. [IF=11.591, Cited=155, 11196654].
Silver PA, Way JC, Arnold FH, Meyerowitz JT (2014) Synthetic biology: Engineering explored. Nature. [IF=11.591,
Cited=20, 24805338].
Balagaddé FK, Song H, Ozaki J, ..., You L (2008) A synthetic Escherichia coli predator-prey ecosystem. Molecular Systems
Biology. [IF=2.015, Cited=202, 18414488].
Bloom JD, Arnold FH, Wilke CO (2007) Breaking proteins with mutations: threads and thresholds in evolution. Molecular
Systems Biology. [IF=2.015, Cited=22, 17262035].
Kan SBJ, Huang X, Gumulya Y, ..., Arnold FH (2017) Genetically programmed chiral organoborane synthesis. Nature.
[IF=11.591, Cited=65, 29186119].
Arnold FH (1991) Metal-affinity separations: a new dimension in protein processing. None. [IF=None, Cited=155, 1369316].
Dodani SC, Kiss G, Cahn JKB, ..., Arnold FH (2016) Discovery of a regioselectivity switch in nitrating P450s guided by
molecular dynamics simulations and Markov models. Nature Chemistry. [IF=3.667, Cited=57, 27102675].
Prier CK, Zhang RK, Buller AR, ..., Arnold FH (2017) Enantioselective, intermolecular benzylic C-H amination catalysed
by an engineered iron-haem enzyme. Nature Chemistry. [IF=3.667, Cited=99, 28644476].
Flytzanis NC, Bedbrook CN, Chiu H, ..., Gradinaru V (2014) Archaerhodopsin variants with enhanced voltage-sensitive
fluorescence in mammalian and Caenorhabditis elegans neurons. Nature Communications. [IF=3.268, Cited=77, 25222271].
Rix G, Watkins-Dulaney EJ, Almhjell PJ, ..., Liu CC (2020) Scalable continuous evolution for the generation of diverse
enzyme variants encompassing promiscuous activities. Nature Communications. [IF=3.268, Cited=36, 33159067].
Yang Y, Cho I, Qi X, ..., Arnold FH (2019) An enzymatic platform for the asymmetric amination of primary, secondary and
tertiary C(sp³)-H bonds. Nature Chemistry. [IF=3.667, Cited=39, 31611634].
Liu Z, Calvó-Tusell C, Zhou AZ, ..., Arnold FH (2021) Dual-function enzyme catalysis for enantioselective carbon-
nitrogen bond formation. Nature Chemistry. [IF=3.667, Cited=20, 34663919].
Zhang RK, Chen K, Huang X, ..., Arnold FH (2018) Enzymatic assembly of carbon-carbon bonds via iron-catalysed
sp³ C-H functionalization. Nature. [IF=11.591, Cited=73, 30568304].
Almhjell PJ, Johnston KE, Porter NJ, ..., Arnold FH (2024) The β-subunit of tryptophan synthase is a latent tyrosine
synthase. Nature Chemical Biology. [IF=2.623, Cited=0, 38744987].
Yang KK, Wu Z, Arnold FH (2019) Machine-learning-guided directed evolution for protein engineering. Nature Methods.
[IF=10.009, Cited=235, 31308553].
Bedbrook CN, Yang KK, Robinson JE, ..., Arnold FH (2019) Machine learning-guided channelrhodopsin engineering enables
minimally invasive optogenetics. Nature Methods. [IF=10.009, Cited=71, 31611694].
Zhang J, Maggiolo AO, Alfonzo E, ..., Arnold FH (2023) Chemodivergent C(sp³)-H and C(sp²)-H
Cyanomethylation Using Engineered Carbene Transferases. Nature Catalysis. [IF=5.117, Cited=3, 36875868].
Mao R, Gao S, Qin ZY, ..., Arnold FH (2024) Biocatalytic, Enantioenriched Primary Amination of Tertiary C-H Bonds.
Nature Catalysis. [IF=5.117, Cited=0, 39006156].
Molina RS, Rix G, Mengiste AA, ..., Liu CC (2022) In vivo hypermutation and continuous evolution. Nature Reviews Methods
Primers. [IF=10.589, Cited=20, 37073402].
Miller DC, Athavale SV, Arnold FH (2022) Combining chemistry and protein engineering for new-to-nature biocatalysis.
None. [IF=None, Cited=32, 35415721].
Mao R, Taylor DM, Wackelin DJ, ..., Arnold FH (2023) Biocatalytic, Stereoconvergent Alkylation of
(Z/E)-Trisubstituted Silyl Enol Ethers. None. [IF=None, Cited=0, 39130128].
Wang ZJ, Peck NE, Renata H, Arnold FH (2014) Cytochrome P450-Catalyzed Insertion of Carbenoids into N-H Bonds. Chemical
Science. [IF=1.563, Cited=62, 24490022].
Renata H, Wang ZJ, Kitto RZ, Arnold FH (2014) P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins
under aerobic conditions. Catalysis Science and Technology. [IF=0.958, Cited=22, 25221671].
Almhjell PJ, Boville CE, Arnold FH (2018) Engineering enzymes for noncanonical amino acid synthesis. Chemical Society
Reviews. [IF=8.116, Cited=38, 30280154].
Cahn JKB, Brinkmann-Chen S, Spatzal T, ..., Arnold FH (2015) Cofactor specificity motifs and the induced fit mechanism
in class I ketol-acid reductoisomerases. Biochemical Journal. [IF=0.852, Cited=10, 25849365].
Chen K, Huang X, Zhang SQ, ..., Arnold FH (2019) Engineered Cytochrome c-Catalyzed Lactone-Carbene B-H Insertion.
Synlett. [IF=0.473, Cited=9, 30930550].
Bloom JD, Silberg JJ, Wilke CO, ..., Arnold FH (2005) Thermodynamic prediction of protein neutrality. Proceedings of the
National Academy of Sciences of the United States of America. [IF=2.765, Cited=213, 15644440].
Drummond DA, Silberg JJ, Meyer MM, ..., Arnold FH (2005) On the conservative nature of intragenic recombination.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=60, 15809422].
Drummond DA, Bloom JD, Adami C, ..., Arnold FH (2005) Why highly expressed proteins evolve slowly. Proceedings of the
National Academy of Sciences of the United States of America. [IF=2.765, Cited=506, 16176987].
Voigt CA, Mayo SL, Arnold FH, Wang ZG (2001) Computational method to reduce the search space for directed protein
evolution. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=90, 11274394].
Brenner K, Karig DK, Weiss R, Arnold FH (2007) Engineered bidirectional communication mediates a consensus in a
microbial biofilm consortium. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=113, 17959781].
Heinzelman P, Snow CD, Wu I, ..., Arnold FH (2009) A family of thermostable fungal cellulases created by structure-
guided recombination. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=122, 19307582].
Bloom JD, Arnold FH (2009) In the light of directed evolution: pathways of adaptive protein evolution. Proceedings of
the National Academy of Sciences of the United States of America. [IF=2.765, Cited=233, 19528653].
Lewis JC, Bastian S, Bennett CS, ..., Arnold FH (2009) Chemoenzymatic elaboration of monosaccharides using engineered
cytochrome P450BM3 demethylases. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=39, 19805336].
Romero PA, Krause A, Arnold FH (2012) Navigating the protein fitness landscape with Gaussian processes. Proceedings of
the National Academy of Sciences of the United States of America. [IF=2.765, Cited=105, 23277561].
Brinkmann-Chen S, Flock T, Cahn JKB, ..., Arnold FH (2013) General approach to reversing ketol-acid reductoisomerase
cofactor dependence from NADPH to NADH. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=48, 23776225].
Sun F, Zhang WB, Mahdavi A, ..., Tirrell DA (2014) Synthesis of bioactive protein hydrogels by genetically encoded
SpyTag-SpyCatcher chemistry. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=95, 25049400].
McIsaac RS, Engqvist MKM, Wannier T, ..., Arnold FH (2014) Directed evolution of a far-red fluorescent rhodopsin.
Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=46, 25157169].
Buller AR, Brinkmann-Chen S, Romney DK, ..., Arnold FH (2015) Directed evolution of the tryptophan synthase β-subunit
for stand-alone function recapitulates allosteric activation. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=71, 26553994].
Bedbrook CN, Rice AJ, Yang KK, ..., Arnold FH (2017) Structure-guided SCHEMA recombination generates diverse chimeric
channelrhodopsins. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765,
Cited=22, 28283661].
Lewis RD, Garcia-Borràs M, Chalkley MJ, ..., Arnold FH (2018) Catalytic iron-carbene intermediate revealed in a
cytochrome c carbene transferase. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=37, 29946033].
Wu Z, Kan SBJ, Lewis RD, ..., Arnold FH (2019) Machine learning-assisted directed protein evolution with combinatorial
libraries. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=135, 30979809].
Johnston KE, Almhjell PJ, Watkins-Dulaney EJ, ..., Arnold FH (2024) A combinatorially complete epistatic fitness
landscape in an enzyme active site. Proceedings of the National Academy of Sciences of the United States of America.
[IF=2.765, Cited=0, 39074291].
Yokobayashi Y, Weiss R, Arnold FH (2002) Directed evolution of a genetic circuit. Proceedings of the National Academy of
Sciences of the United States of America. [IF=2.765, Cited=209, 12451174].
Chen K, Arnold FH (1993) Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of
subtilisin E for catalysis in dimethylformamide. Proceedings of the National Academy of Sciences of the United States of
America. [IF=2.765, Cited=212, 8516309].
Zhao H, Arnold FH (1997) Functional and nonfunctional mutations distinguished by random recombination of homologous
genes. Proceedings of the National Academy of Sciences of the United States of America. [IF=2.765, Cited=35, 9223302].
Giver L, Gershenson A, Freskgard PO, Arnold FH (1998) Directed evolution of a thermostable esterase. Proceedings of the
National Academy of Sciences of the United States of America. [IF=2.765, Cited=242, 9788996].
Arnold FH (1998) Enzyme engineering reaches the boiling point. Proceedings of the National Academy of Sciences of the
United States of America. [IF=2.765, Cited=20, 9482832].
Spiller B, Gershenson A, Arnold FH, Stevens RC (1999) A structural view of evolutionary divergence. Proceedings of the
National Academy of Sciences of the United States of America. [IF=2.765, Cited=97, 10535917].
Yang KK, Wu Z, Bedbrook CN, Arnold FH (2018) Learned protein embeddings for machine learning. Bioinformatics. [IF=1.954,
Cited=74, 29584811].
Arnold FH (1988) Protein design for non-aqueous solvents. None. [IF=None, Cited=19, 3253733].
Cahn JKB, Baumschlager A, Brinkmann-Chen S, Arnold FH (2015) Mutations in adenine-binding pockets enhance catalytic
properties of NAD(P)H-dependent enzymes. Protein Engineering, Design and Selection. [IF=0.545, Cited=21, 26512129].
Arnold FH (1993) Engineering proteins for nonnatural environments. FASEB Journal. [IF=1.029, Cited=33, 8330682].
Arnold FH (2010) How proteins adapt: lessons from directed evolution. Cold Spring Harbor Symposia on Quantitative
Biology. [IF=0.889, Cited=18, 20413708].
Smith MA, Rentmeister A, Snow CD, ..., Arnold FH (2012) A diverse set of family 48 bacterial glycoside hydrolase
cellulases created by structure-guided recombination. None. [IF=None, Cited=20, 23075376].
Arnold FH, Giver L, Gershenson A, ..., Miyazaki K (1999) Directed evolution of mesophilic enzymes into their
thermophilic counterparts. Annals of the New York Academy of Sciences. [IF=1.878, Cited=14, 10415508].
Balagaddé FK, You L, Hansen CL, ..., Quake SR (2005) Long-term monitoring of bacteria undergoing programmed population
control in a microchemostat. Science. [IF=7.729, Cited=290, 15994559].
Acar M, Pando BF, Arnold FH, ..., van Oudenaarden A (2010) A general mechanism for network-dosage compensation in gene
circuits. Science. [IF=7.729, Cited=68, 20929850].
Coelho PS, Brustad EM, Kannan A, Arnold FH (2012) Olefin cyclopropanation via carbene transfer catalyzed by engineered
cytochrome P450 enzymes. Science. [IF=7.729, Cited=273, 23258409].
Arnold FH, Haymore BL (1991) Engineered metal-binding proteins: purification to protein folding. Science. [IF=7.729,
Cited=112, 1648261].
Kan SBJ, Lewis RD, Chen K, Arnold FH (2016) Directed evolution of cytochrome c for carbon-silicon bond formation:
Bringing silicon to life. Science. [IF=7.729, Cited=160, 27885032].
Hammer SC, Kubik G, Watkins E, ..., Arnold FH (2017) Anti-Markovnikov alkene oxidation by metal-oxo-mediated enzyme
catalysis. Science. [IF=7.729, Cited=39, 29026041].
Chen K, Huang X, Kan SBJ, ..., Arnold FH (2018) Enzymatic construction of highly strained carbocycles. Science.
[IF=7.729, Cited=58, 29622650].
Cho I, Jia ZJ, Arnold FH (2019) RETRACTED: Site-selective enzymatic C‒H amidation for synthesis of diverse lactams.
Science. [IF=7.729, Cited=10, 31073063].
Cho I, Jia ZJ, Arnold FH (2020) Retraction. Science. [IF=7.729, Cited=1, 31896662].
Sarai NS, Fulton TJ, O'Meara RL, ..., Arnold FH (2024) Directed evolution of enzymatic silicon-carbon bond cleavage in
siloxanes. Science. [IF=7.729, Cited=0, 38271505].
Hawkins AC, Arnold FH, Stuermer R, ..., Leadbetter JR (2007) Directed evolution of Vibrio fischeri LuxR for improved
response to butanoyl-homoserine lactone. Applied and Environmental Microbiology. [IF=1.103, Cited=29, 17675429].
Haseltine EL, Arnold FH (2007) Implications of rewiring bacterial quorum sensing. Applied and Environmental
Microbiology. [IF=1.103, Cited=37, 18039819].
Koch DJ, Chen MM, van Beilen JB, Arnold FH (2008) In vivo evolution of butane oxidation by terminal alkane hydroxylases
AlkB and CYP153A6. Applied and Environmental Microbiology. [IF=1.103, Cited=41, 19011057].
Mingardon F, Bagert JD, Maisonnier C, ..., Arnold FH (2010) Comparison of family 9 cellulases from mesophilic and
thermophilic bacteria. Applied and Environmental Microbiology. [IF=1.103, Cited=28, 21169454].
Sakamoto T, Joern JM, Arisawa A, Arnold FH (2001) Laboratory evolution of toluene dioxygenase to accept 4-picoline as a
substrate. Applied and Environmental Microbiology. [IF=1.103, Cited=40, 11525981].
Bulter T, Alcalde M, Sieber V, ..., Arnold FH (2003) Functional expression of a fungal laccase in Saccharomyces
cerevisiae by directed evolution. Applied and Environmental Microbiology. [IF=1.103, Cited=119, 12571021].
Umeno D, Arnold FH (2003) A C35 carotenoid biosynthetic pathway. Applied and Environmental Microbiology. [IF=1.103,
Cited=23, 12788765].
Umeno D, Tobias AV, Arnold FH (2002) Evolution of the C30 carotenoid synthase CrtM for function in a C40 pathway.
Journal of Bacteriology. [IF=0.898, Cited=39, 12426357].
Umeno D, Arnold FH (2004) Evolution of a pathway to novel long-chain carotenoids. Journal of Bacteriology. [IF=0.898,
Cited=30, 14973014].
Umeno D, Tobias AV, Arnold FH (2005) Diversifying carotenoid biosynthetic pathways by directed evolution. Microbiology
and Molecular Biology Reviews. [IF=2.842, Cited=93, 15755953].
Haseltine EL, Arnold FH (2007) Synthetic gene circuits: design with directed evolution. None. [IF=None, Cited=63, 17243895].
Moraïs S, Stern J, Kahn A, ..., Bayer EA (2016) Enhancement of cellulosome-mediated deconstruction of cellulose by
improving enzyme thermostability. Biotechnology for Biofuels. [IF=1.749, Cited=20, 27493686].
Bedbrook CN, Yang KK, Rice AJ, ..., Arnold FH (2017) Machine learning to design integral membrane channelrhodopsins for
efficient eukaryotic expression and plasma membrane localization. PLoS Computational Biology. [IF=1.278, Cited=42, 29059183].
Chang CJ, Lee CC, Chan YT, ..., Chao YC (2016) Exploring the Mechanism Responsible for Cellulase Thermostability by
Structure-Guided Recombination. PLoS ONE. [IF=1.253, Cited=12, 26986867].
Mao R, Wackelin DJ, Jamieson CS, ..., Arnold FH (2023) Enantio- and Diastereoenriched Enzymatic Synthesis of
1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates. None. [IF=None, Cited=0, 37090661].

Publication with MISSING institution:

Sun L, Bulter T, Alcalde M, ..., Arnold FH (2002) Modification of galactose oxidase to introduce glucose 6-oxidase
activity. ChemBioChem. [IF=0.691, Cited=41, 12203977].
Cirino PC, Arnold FH (2003) A self-sufficient peroxide-driven hydroxylation biocatalyst. Angewandte Chemie -
International Edition. [IF=2.456, Cited=90, 12876749].
Fasan R, Chen MM, Crook NC, Arnold FH (2007) Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike
catalytic properties. Angewandte Chemie - International Edition. [IF=2.456, Cited=89, 17886313].
Lauchli R, Rabe KS, Kalbarczyk KZ, ..., Arnold FH (2013) High-throughput screening for terpene-synthase-cyclization
activity and directed evolution of a terpene synthase. Angewandte Chemie - International Edition. [IF=2.456, Cited=37, 23532864].
McIntosh JA, Coelho PS, Farwell CC, ..., Arnold FH (2013) Enantioselective intramolecular C-H amination catalyzed by
engineered cytochrome P450 enzymes in vitro and in vivo. Angewandte Chemie - International Edition. [IF=2.456,
Cited=84, 23893546].
Wang ZJ, Renata H, Peck NE, ..., Arnold FH (2014) Improved cyclopropanation activity of histidine-ligated
cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran. Angewandte Chemie - International
Edition. [IF=2.456, Cited=65, 24802161].
Renata H, Wang ZJ, Arnold FH (2015) Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided
directed evolution. Angewandte Chemie - International Edition. [IF=2.456, Cited=156, 25649694].
Cirino PC, Tang Y, Takahashi K, ..., Arnold FH (2003) Global incorporation of norleucine in place of methionine in
cytochrome P450 BM-3 heme domain increases peroxygenase activity. Biotechnology and Bioengineering. [IF=0.932,
Cited=38, 12889037].
Wong TS, Arnold FH, Schwaneberg U (2004) Laboratory evolution of cytochrome p450 BM-3 monooxygenase for organic
cosolvents. Biotechnology and Bioengineering. [IF=0.932, Cited=91, 14748091].
Morawski B, Quan S, Arnold FH (2001) Functional expression and stabilization of horseradish peroxidase by directed
evolution in Saccharomyces cerevisiae. Biotechnology and Bioengineering. [IF=0.932, Cited=59, 11505379].
Otey CR, Bandara G, Lalonde J, ..., Arnold FH (2006) Preparation of human metabolites of propranolol using laboratory-
evolved bacterial cytochromes P450. Biotechnology and Bioengineering. [IF=0.932, Cited=65, 16224788].
Fasan R, Crook NC, Peters MW, ..., Arnold FH (2010) Improved product-per-glucose yields in P450-dependent propane
biotransformations using engineered Escherichia coli. Biotechnology and Bioengineering. [IF=0.932, Cited=33, 21246504].
Wu I, Arnold FH (2013) Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently
at elevated temperatures. Biotechnology and Bioengineering. [IF=0.932, Cited=45, 23404363].
Suh SS, Arnold FH (1990) A mathematical model for metal affinity protein partitioning. Biotechnology and Bioengineering.
[IF=0.932, Cited=27, 18592564].
Martinez P, Van Dam ME, Robinson AC, ..., Arnold FH (1992) Stabilization of substilisin E in organic solvents by site-
directed mutagenesis. Biotechnology and Bioengineering. [IF=0.932, Cited=11, 18600924].
Economou C, Chen K, Arnold FH (1992) Random mutagenesis to enhance the activity of subtilisin in organic solvents:
Characterization of Q103R subtilisin E. Biotechnology and Bioengineering. [IF=0.932, Cited=4, 18600995].
Vidyasankar S, Dhal PK, Plunkett SD, Arnold FH (1995) Review: Selective ligand-exchange adsorbents prepared by template
polymerization. Biotechnology and Bioengineering. [IF=0.932, Cited=5, 18623506].
Johnson RD, Arnold FH (1995) Review: Multipoint binding and heterogeneity in immobilized metal affinity chromatography.
Biotechnology and Bioengineering. [IF=0.932, Cited=31, 18623507].
Salazar O, Cirino PC, Arnold FH (2003) Thermostabilization of a cytochrome p450 peroxygenase. ChemBioChem. [IF=0.691,
Cited=54, 12964165].
Meinhold P, Peters MW, Chen MMY, ..., Arnold FH (2005) Direct conversion of ethane to ethanol by engineered cytochrome
P450 BM3. ChemBioChem. [IF=0.691, Cited=61, 16080215].
Lewis JC, Mantovani SM, Fu Y, ..., Arnold FH (2010) Combinatorial alanine substitution enables rapid optimization of
cytochrome P450BM3 for selective hydroxylation of large substrates. ChemBioChem. [IF=0.691, Cited=46, 21108271].
Dodani SC, Cahn JKB, Heinisch T, ..., Arnold FH (2014) Structural, functional, and spectroscopic characterization of the
substrate scope of the novel nitrating cytochrome P450 TxtE. ChemBioChem. [IF=0.691, Cited=24, 25182183].
Heel T, McIntosh JA, Dodani SC, ..., Arnold FH (2014) Non-natural olefin cyclopropanation catalyzed by diverse
cytochrome P450s and other hemoproteins. ChemBioChem. [IF=0.691, Cited=20, 25294253].
Kubo T, Peters MW, Meinhold P, Arnold FH (2006) Enantioselective epoxidation of terminal alkenes to (R)- and
(S)-epoxides by engineered cytochromes P450 BM-3. Chemistry - A European Journal. [IF=0.899, Cited=35, 16240317].
Sawayama AM, Chen MMY, Kulanthaivel P, ..., Arnold FH (2009) A panel of cytochrome P450 BM3 variants to produce drug
metabolites and diversify lead compounds. Chemistry - A European Journal. [IF=0.899, Cited=60, 19774562].
Voigt CA, Mayo SL, Arnold FH, Wang ZG (2001) Computationally focusing the directed evolution of proteins. None.
[IF=None, Cited=7, 11842429].
Smith MA, Romero PA, Wu T, ..., Arnold FH (2012) Chimeragenesis of distantly-related proteins by noncontiguous
recombination. Protein Science. [IF=1.97, Cited=16, 23225662].
Lee TM, Farrow MF, Arnold FH, Mayo SL (2011) A structural study of Hypocrea jecorina Cel5A. Protein Science. [IF=1.97,
Cited=18, 21898652].
Todd RJ, Van Dam ME, Casimiro D, ..., Arnold FH (1991) Cu(II)-binding properties of a cytochrome c with a synthetic
metal-binding site: His-X3-His in an alpha-helix. Proteins: Structure, Function and Bioinformatics. [IF=0.897,
Cited=30, 1654548].
Gillam EM, Aguinaldo AM, Notley LM, ..., Guengerich FP (1999) Formation of indigo by recombinant mammalian cytochrome
P450. Biochemical and Biophysical Research Communications. [IF=0.643, Cited=78, 10558891].
Moore JC, Jin HM, Kuchner O, Arnold FH (1997) Strategies for the in vitro evolution of protein function: enzyme
evolution by random recombination of improved sequences. Journal of Molecular Biology. [IF=1.281, Cited=69, 9325094].
Miyazaki K, Wintrode PL, Grayling RA, ..., Arnold FH (2000) Directed evolution study of temperature adaptation in a
psychrophilic enzyme. Journal of Molecular Biology. [IF=1.281, Cited=122, 10736234].
Joern JM, Meinhold P, Arnold FH (2002) Analysis of shuffled gene libraries. Journal of Molecular Biology. [IF=1.281,
Cited=43, 11866523].
Gershenson A, Arnold FH (2000) Enzyme stabilization by directed evolution. None. [IF=None, Cited=6, 11501381].
Smith MA, Arnold FH (2014) Designing libraries of chimeric proteins using SCHEMA recombination and RASPP. Methods in
Molecular Biology. [IF=0.413, Cited=5, 25055788].
Smith MA, Arnold FH (2014) Noncontiguous SCHEMA protein recombination. Methods in Molecular Biology. [IF=0.413,
Cited=2, 25055789].
Bastian S, Arnold FH (2012) Reversal of NAD(P)H cofactor dependence by protein engineering. Methods in Molecular
Biology. [IF=0.413, Cited=1, 22144350].
Romero PA, Shapiro MG, Arnold FH, Jasanoff A (2013) Directed evolution of protein-based neurotransmitter sensors for
MRI. Methods in Molecular Biology. [IF=0.413, Cited=3, 23494381].
Miyazaki K, Arnold FH (1999) Exploring nonnatural evolutionary pathways by saturation mutagenesis: rapid improvement of
protein function. Journal of Molecular Evolution. [IF=0.895, Cited=99, 10594172].
Todd RJ, Johnson RD, Arnold FH (1994) Multiple-site binding interactions in metal-affinity chromatography. I.
Equilibrium binding of engineered histidine-containing cytochromes c. Journal of Chromatography A. [IF=1.02, Cited=44, 8136917].
Plunkett SD, Arnold FH (1995) Molecularly imprinted polymers on silica: selective supports for high-performance ligand-
exchange chromatography. Journal of Chromatography A. [IF=1.02, Cited=10, 7647924].
Johnson RD, Todd RJ, Arnold FH (1996) Multipoint binding in metal-affinity chromatography II. Effect of pH and imidazole
on chromatographic retention of engineered histidine-containing cytochromes c. Journal of Chromatography A. [IF=1.02,
Cited=28, 8900574].
Chung BH, Bailey D, Arnold FH (1994) Metal affinity partitioning. None. [IF=None, Cited=2, 8047006].
Johnson RD, Arnold FH (1995) The Temkin isotherm describes heterogeneous protein adsorption. None. [IF=None, Cited=43, 7696322].
Heinzelman P, Romero PA, Arnold FH (2013) Efficient sampling of SCHEMA chimera families to identify useful sequence
elements. None. [IF=None, Cited=8, 23422438].
Bloom JD, Wilke CO, Arnold FH, Adami C (2004) Stability and the evolvability of function in a model protein. Biophysical
Journal. [IF=0.842, Cited=62, 15111394].
Silberg JJ, Endelman JB, Arnold FH (2004) SCHEMA-guided protein recombination. None. [IF=None, Cited=15, 15289059].
Kuchner O, Arnold FH (1997) Directed evolution of enzyme catalysts. Trends in Biotechnology. [IF=2.875, Cited=145, 9418307].
Tobias AV, Arnold FH (2006) Biosynthesis of novel carotenoid families based on unnatural carbon backbones: a model for
diversification of natural product pathways. None. [IF=None, Cited=23, 16478677].
Wu I, Heel T, Arnold FH (2013) Role of cysteine residues in thermal inactivation of fungal Cel6A cellobiohydrolases.
None. [IF=None, Cited=11, 23676789].
Tracewell CA, Arnold FH (2009) Directed enzyme evolution: climbing fitness peaks one amino acid at a time. Current
Opinion in Chemical Biology. [IF=1.51, Cited=146, 19249235].
Brustad EM, Arnold FH (2010) Optimizing non-natural protein function with directed evolution. Current Opinion in
Chemical Biology. [IF=1.51, Cited=105, 21185770].
Trudeau DL, Smith MA, Arnold FH (2013) Innovation by homologous recombination. Current Opinion in Chemical Biology.
[IF=1.51, Cited=13, 24182747].
Otey CR, Silberg JJ, Voigt CA, ..., Arnold FH (2004) Functional evolution and structural conservation in chimeric
cytochromes p450: calibrating a structure-guided approach. None. [IF=None, Cited=50, 15123260].
Landwehr M, Carbone M, Otey CR, ..., Arnold FH (2007) Diversification of catalytic function in a synthetic family of
chimeric cytochrome p450s. None. [IF=None, Cited=36, 17379142].
Collins CH, Yokobayashi Y, Umeno D, Arnold FH (2003) Engineering proteins that bind, move, make and break DNA. Current
Opinion in Biotechnology. [IF=1.815, Cited=8, 14662399].
Dougherty MJ, Arnold FH (2009) Directed evolution: new parts and optimized function. Current Opinion in Biotechnology.
[IF=1.815, Cited=63, 19720520].
Jung ST, Lauchli R, Arnold FH (2011) Cytochrome P450: taming a wild type enzyme. Current Opinion in Biotechnology.
[IF=1.815, Cited=129, 21411308].
Liu X, Bastian S, Snow CD, ..., Arnold FH (2012) Structure-guided engineering of Lactococcus lactis alcohol
dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol. Journal of Biotechnology. [IF=0.874,
Cited=8, 22974724].
Udit AK, Arnold FH, Gray HB (2004) Cobaltocene-mediated catalytic monooxygenation using holo and heme domain cytochrome
P450 BM3. Journal of Inorganic Biochemistry. [IF=0.935, Cited=24, 15337607].
Drummond DA, Iverson BL, Georgiou G, Arnold FH (2005) Why high-error-rate random mutagenesis libraries are enriched in
functional and improved proteins. Journal of Molecular Biology. [IF=1.281, Cited=88, 15939434].
Fasan R, Meharenna YT, Snow CD, ..., Arnold FH (2008) Evolutionary history of a specialized p450 propane monooxygenase.
Journal of Molecular Biology. [IF=1.281, Cited=108, 18619466].
Jäckel C, Bloom JD, Kast P, ..., Hilvert D (2010) Consensus protein design without phylogenetic bias. Journal of
Molecular Biology. [IF=1.281, Cited=41, 20433850].
Brustad EM, Lelyveld VS, Snow CD, ..., Arnold FH (2012) Structure-guided directed evolution of highly selective
p450-based magnetic resonance imaging sensors for dopamine and serotonin. Journal of Molecular Biology. [IF=1.281,
Cited=24, 22659321].
Bloom JD, Meyer MM, Meinhold P, ..., Arnold FH (2005) Evolving strategies for enzyme engineering. Current Opinion in
Structural Biology. [IF=1.4, Cited=166, 16006119].
Carbone MN, Arnold FH (2007) Engineering by homologous recombination: exploring sequence and function within a conserved
fold. Current Opinion in Structural Biology. [IF=1.4, Cited=27, 17884462].
Brenner K, You L, Arnold FH (2008) Engineering microbial consortia: a new frontier in synthetic biology. Trends in
Biotechnology. [IF=2.875, Cited=337, 18675483].
Malliaros J, Quinn C, Arnold FH, ..., Macfarlan RI (2004) Association of antigens to ISCOMATRIX adjuvant using metal
chelation leads to improved CTL responses. Vaccine. [IF=1.264, Cited=12, 15364446].
Bastian S, Liu X, Meyerowitz JT, ..., Arnold FH (2011) Engineered ketol-acid reductoisomerase and alcohol dehydrogenase
enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli. Metabolic Engineering.
[IF=1.846, Cited=126, 21515217].
Pack DW, Arnold FH (1997) Langmuir monolayer characterization of metal chelating lipids for protein targeting to
membranes. Chemistry and Physics of Lipids. [IF=0.737, Cited=11, 9179995].
Wuenschell GE, Wen E, Todd R, ..., Arnold FH (1991) Chiral copper-chelate complexes alter selectivities in metal
affinity protein partitioning. None. [IF=None, Cited=2, 1880194].
Arnold FH, Blanch HW (1986) Analytical affinity chromatography. II. Rate theory and the measurement of biological
binding kinetics. None. [IF=None, Cited=23, 3700540].
Wintrode PL, Zhang D, Vaidehi N, ..., Goddard WA (2003) Protein dynamics in a family of laboratory evolved thermophilic
enzymes. Journal of Molecular Biology. [IF=1.281, Cited=45, 12634066].
Hiraga K, Arnold FH (2003) General method for sequence-independent site-directed chimeragenesis. Journal of Molecular
Biology. [IF=1.281, Cited=64, 12823968].
Arnold FH (2000) Advances in protein chemistry. Introduction. None. [IF=None, Cited=1, 11050930].
Wintrode PL, Arnold FH (2000) Temperature adaptation of enzymes: lessons from laboratory evolution. None. [IF=None,
Cited=76, 11050934].
Volkov AA, Arnold FH (2000) Methods for in vitro DNA recombination and random chimeragenesis. None. [IF=None, Cited=9, 11075359].
Volkov AA, Shao Z, Arnold FH (2000) Random chimeragenesis by heteroduplex recombination. None. [IF=None, Cited=5, 11075360].
Wintrode PL, Miyazaki K, Arnold FH (2001) Patterns of adaptation in a laboratory evolved thermophilic enzyme. None.
[IF=None, Cited=30, 11566363].
Schmidt-Dannert C, Arnold FH (1999) Directed evolution of industrial enzymes. Trends in Biotechnology. [IF=2.875,
Cited=82, 10203769].
Petrounia IP, Arnold FH (2000) Designed evolution of enzymatic properties. Current Opinion in Biotechnology. [IF=1.815,
Cited=72, 10975451].
Farinas ET, Bulter T, Arnold FH (2001) Directed enzyme evolution. Current Opinion in Biotechnology. [IF=1.815,
Cited=109, 11849936].
Collins CH, Yokobayashi Y, Umeno D, Arnold FH (2003) Engineering proteins that bind, move, make and break DNA. Current
Opinion in Biotechnology. [IF=1.815, Cited=11, 12943845].
Shao Z, Arnold FH (1996) Engineering new functions and altering existing functions. Current Opinion in Structural
Biology. [IF=1.4, Cited=48, 8794158].
Zhao H, Arnold FH (1997) Combinatorial protein design: strategies for screening protein libraries. Current Opinion in
Structural Biology. [IF=1.4, Cited=42, 9266168].
Joo H, Arisawa A, Lin Z, Arnold FH (1999) A high-throughput digital imaging screen for the discovery and directed
evolution of oxygenases. None. [IF=None, Cited=41, 10508682].
Cirino PC, Arnold FH (2002) Protein engineering of oxygenases for biocatalysis. Current Opinion in Chemical Biology.
[IF=1.51, Cited=44, 12038995].
Giver L, Arnold FH (1998) Combinatorial protein design by in vitro recombination. Current Opinion in Chemical Biology.
[IF=1.51, Cited=24, 9691067].
Yang J, Ducharme J, Johnston KE, ..., Arnold FH (2024) Correction to "DeCOIL: Optimization of Degenerate Codon Libraries
for Machine Learning-Assisted Protein Engineering". ACS Synthetic Biology. [IF=0.96, Cited=0, 38232764].
Chen KQ, Robinson AC, Van Dam ME, ..., Arnold FH (1991) Enzyme engineering for nonaqueous solvents. II. Additive effects
of mutations on the stability and activity of subtilisin E in polar organic media. Biotechnology Progress. [IF=0.785,
Cited=23, 1367168].
Lin Z, Thorsen T, Arnold FH (1999) Functional expression of horseradish peroxidase in E. coli by directed evolution.
Biotechnology Progress. [IF=0.785, Cited=38, 10356264].
Goldberg NW, Knight AM, Zhang RK, Arnold FH (2019) Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by
Non-Native Small-Molecule Ligands. Journal of the American Chemical Society. [IF=2.573, Cited=15, 31790588].
Romero PA, Stone E, Lamb C, ..., Georgiou G (2012) SCHEMA-designed variants of human Arginase I and II reveal sequence
elements important to stability and catalysis. ACS Synthetic Biology. [IF=0.96, Cited=25, 22737599].
Fu AY, Spence C, Scherer A, ..., Quake SR (1999) A microfabricated fluorescence-activated cell sorter. Nature
Biotechnology. [IF=8.861, Cited=294, 10545919].
Joo H, Lin Z, Arnold FH (1999) Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation. Nature.
[IF=11.591, Cited=191, 10385118].
Michnick SW, Arnold FH (1999) "Itching" for new strategies in protein engineering. Nature Biotechnology. [IF=8.861,
Cited=4, 10585708].
May O, Nguyen PT, Arnold FH (2000) Inverting enantioselectivity by directed evolution of hydantoinase for improved
production of L-methionine. Nature Biotechnology. [IF=8.861, Cited=122, 10700149].
Schmidt-Dannert C, Umeno D, Arnold FH (2000) Molecular breeding of carotenoid biosynthetic pathways. Nature
Biotechnology. [IF=8.861, Cited=164, 10888843].
Sieber V, Martinez CA, Arnold FH (2001) Libraries of hybrid proteins from distantly related sequences. Nature
Biotechnology. [IF=8.861, Cited=105, 11329016].
You L, Cox RS, Weiss R, Arnold FH (2004) Programmed population control by cell-cell communication and regulated killing.
Nature. [IF=11.591, Cited=304, 15064770].
Basu S, Gerchman Y, Collins CH, ..., Weiss R (2005) A synthetic multicellular system for programmed pattern formation.
Nature. [IF=11.591, Cited=497, 15858574].
Shapiro MG, Westmeyer GG, Romero PA, ..., Jasanoff A (2010) Directed evolution of a magnetic resonance imaging contrast
agent for noninvasive imaging of dopamine. Nature Biotechnology. [IF=8.861, Cited=99, 20190737].
Arnold FH (2006) Fancy footwork in the sequence space shuffle. Nature Biotechnology. [IF=8.861, Cited=18, 16525408].
Zhao H, Giver L, Shao Z, ..., Arnold FH (1998) Molecular evolution by staggered extension process (StEP) in vitro
recombination. Nature Biotechnology. [IF=8.861, Cited=317, 9528005].
Moore JC, Arnold FH (1996) Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents. Nature
Biotechnology. [IF=8.861, Cited=173, 9630920].
Chen G, Guan Z, Chen CT, ..., Arnold FH (1997) A glucose-sensing polymer. Nature Biotechnology. [IF=8.861, Cited=24, 9094137].
Arnold FH (1998) When blind is better: protein design by evolution. Nature Biotechnology. [IF=8.861, Cited=27, 9661188].
Kellis JT, Todd RJ, Arnold FH (1991) Protein stabilization by engineered metal chelation. None. [IF=None, Cited=31, 1369354].
Chen KQ, Arnold FH (1991) Enzyme engineering for nonaqueous solvents: random mutagenesis to enhance activity of
subtilisin E in polar organic media. None. [IF=None, Cited=72, 1367624].
Collins CH, Leadbetter JR, Arnold FH (2006) Dual selection enhances the signaling specificity of a variant of the
quorum-sensing transcriptional activator LuxR. Nature Biotechnology. [IF=8.861, Cited=100, 16715074].
Li Y, Drummond DA, Sawayama AM, ..., Arnold FH (2007) A diverse family of thermostable cytochrome P450s created by
recombination of stabilizing fragments. Nature Biotechnology. [IF=8.861, Cited=66, 17721510].
Glieder A, Farinas ET, Arnold FH (2002) Laboratory evolution of a soluble, self-sufficient, highly active alkane
hydroxylase. Nature Biotechnology. [IF=8.861, Cited=183, 12368811].
Coelho PS, Wang ZJ, Ener ME, ..., Brustad EM (2013) A serine-substituted P450 catalyzes highly efficient carbene
transfer to olefins in vivo. Nature Chemical Biology. [IF=2.623, Cited=139, 23792734].
Rentmeister A, Arnold FH, Fasan R (2008) Chemo-enzymatic fluorination of unactivated organic compounds. Nature Chemical
Biology. [IF=2.623, Cited=65, 19011638].
Romero PA, Arnold FH (2009) Exploring protein fitness landscapes by directed evolution. Nature Reviews Molecular Cell
Biology. [IF=19.213, Cited=474, 19935669].
Voigt CA, Martinez C, Wang ZG, ..., Arnold FH (2002) Protein building blocks preserved by recombination. None. [IF=None,
Cited=183, 12042875].
Münzer DF, Meinhold P, Peters MW, ..., de Raadt A (2005) Stereoselective hydroxylation of an achiral
cyclopentanecarboxylic acid derivative using engineered P450s BM-3. Chemical Communications. [IF=0.902, Cited=17, 15900339].
Lewis JC, Coelho PS, Arnold FH (2010) Enzymatic functionalization of carbon-hydrogen bonds. Chemical Society Reviews.
[IF=8.116, Cited=117, 21079862].
Heinzelman P, Snow CD, Smith MA, ..., Arnold FH (2009) SCHEMA recombination of a fungal cellulase uncovers a single
mutation that contributes markedly to stability. Journal of Biological Chemistry. [IF=1.122, Cited=58, 19625252].
Wintrode PL, Miyazaki K, Arnold FH (2000) Cold adaptation of a mesophilic subtilisin-like protease by laboratory
evolution. Journal of Biological Chemistry. [IF=1.122, Cited=70, 10906329].
Yang KK, Wu Z, Bedbrook CN, Arnold FH (2018) Learned protein embeddings for machine learning. Bioinformatics. [IF=1.954,
Cited=11, 29933431].
Bloom JD, Drummond DA, Arnold FH, Wilke CO (2006) Structural determinants of the rate of protein evolution in yeast.
Molecular Biology and Evolution. [IF=3.197, Cited=116, 16782762].
Zhao H, Arnold FH (1997) Optimization of DNA shuffling for high fidelity recombination. Nucleic Acids Research.
[IF=4.663, Cited=118, 9092645].
Shao Z, Zhao H, Giver L, Arnold FH (1998) Random-priming in vitro recombination: an effective tool for directed
evolution. Nucleic Acids Research. [IF=4.663, Cited=64, 9421535].
Volkov AA, Shao Z, Arnold FH (1999) Recombination and chimeragenesis by in vitro heteroduplex formation and in vivo
repair. Nucleic Acids Research. [IF=4.663, Cited=17, 10471748].
Umeno D, Hiraga K, Arnold FH (2003) Method to protect a targeted amino acid residue during random mutagenesis. Nucleic
Acids Research. [IF=4.663, Cited=4, 12907743].
Zhao H, Arnold FH (1999) Directed evolution converts subtilisin E into a functional equivalent of thermitase. None.
[IF=None, Cited=159, 10065710].
Morawski B, Lin Z, Cirino P, ..., Arnold FH (2000) Functional expression of horseradish peroxidase in Saccharomyces
cerevisiae and Pichia pastoris. None. [IF=None, Cited=63, 10835112].
Sun L, Petrounia IP, Yagasaki M, ..., Arnold FH (2001) Expression and stabilization of galactose oxidase in Escherichia
coli by directed evolution. None. [IF=None, Cited=50, 11707617].
Suh SS, Haymore BL, Arnold FH (1991) Characterization of His-X3-His sites in alpha-helices of synthetic metal-binding
bovine somatotropin. None. [IF=None, Cited=42, 1713327].
You L, Arnold FH (1996) Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous
dimethylformamide. None. [IF=None, Cited=106, 9053906].
Endelman JB, Silberg JJ, Wang ZG, Arnold FH (2004) Site-directed protein recombination as a shortest-path problem.
Protein Engineering, Design and Selection. [IF=0.545, Cited=29, 15331774].
Meyer MM, Hochrein L, Arnold FH (2006) Structure-guided SCHEMA recombination of distantly related beta-lactamases.
Protein Engineering, Design and Selection. [IF=0.545, Cited=44, 17090554].
Chen MMY, Snow CD, Vizcarra CL, ..., Arnold FH (2012) Comparison of random mutagenesis and semi-rational designed
libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes. Protein Engineering, Design and
Selection. [IF=0.545, Cited=29, 22334757].
Komor RS, Romero PA, Xie CB, Arnold FH (2012) Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using
predictive methods. Protein Engineering, Design and Selection. [IF=0.545, Cited=34, 22961332].
Thorsen T, Roberts RW, Arnold FH, Quake SR (2001) Dynamic pattern formation in a vesicle-generating microfluidic device.
Physical Review Letters. [IF=2.288, Cited=539, 11328121].
Meyer MM, Silberg JJ, Voigt CA, ..., Arnold FH (2003) Library analysis of SCHEMA-guided protein recombination. Protein
Science. [IF=1.97, Cited=72, 12876318].
Collins CH, Arnold FH, Leadbetter JR (2005) Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a
broad spectrum of acyl-homoserine lactones. Molecular Microbiology. [IF=1.094, Cited=88, 15660998].
Zhao H, Li Y, Arnold FH (1996) Strategy for the directed evolution of a peptide ligase. Annals of the New York Academy
of Sciences. [IF=1.878, Cited=3, 8958065].
Schwaneberg U, Otey C, Cirino PC, ..., Arnold FH (2001) Cost-effective whole-cell assay for laboratory evolution of
hydroxylases in Escherichia coli. None. [IF=None, Cited=18, 11689105].
Joern JM, Sakamoto T, Arisawa A, Arnold FH (2001) A versatile high throughput screen for dioxygenase activity using
solid-phase digital imaging. None. [IF=None, Cited=9, 11689121].
Mayer KM, Arnold FH (2002) A colorimetric assay to quantify dehydrogenase activity in crude cell lysates. None.
[IF=None, Cited=27, 12006112].
Alcalde M, Bulter T, Arnold FH (2002) Colorimetric assays for biodegradation of polycyclic aromatic hydrocarbons by
fungal laccases. None. [IF=None, Cited=27, 14599353].
Alcalde M, Farinas ET, Arnold FH (2004) Colorimetric high-throughput assay for alkene epoxidation catalyzed by
cytochrome P450 BM-3 variant 139-3. None. [IF=None, Cited=31, 15006137].
Bloom JD, Lu Z, Chen D, ..., Arnold FH (2007) Evolution favors protein mutational robustness in sufficiently large
populations. BMC Biology. [IF=1.461, Cited=58, 17640347].
Bloom JD, Romero PA, Lu Z, Arnold FH (2007) Neutral genetic drift can alter promiscuous protein functions, potentially
aiding functional evolution. Biology Direct. [IF=0.893, Cited=97, 17598905].
Otey CR, Landwehr M, Endelman JB, ..., Arnold FH (2006) Structure-guided recombination creates an artificial family of
cytochromes P450. PLoS Biology. [IF=2.285, Cited=66, 16594730].
Romero PA, Arnold FH (2012) Random field model reveals structure of the protein recombinational landscape. PLoS
Computational Biology. [IF=1.278, Cited=4, 23055915].
Brenner K, Arnold FH (2011) Self-organization, layered structure, and aggregation enhance persistence of a synthetic
biofilm consortium. PLoS ONE. [IF=1.253, Cited=35, 21347422].
Aguinaldo AM, Arnold FH (2003) Staggered extension process (StEP) in vitro recombination. Methods in Molecular Biology.
[IF=0.413, Cited=16, 12824608].
Farrow MF, Arnold FH (2011) High throughput screening of fungal endoglucanase activity in Escherichia coli. Journal of
Visualized Experiments. [IF=0.398, Cited=0, 21860379].
Van Dam ME, Wuenschell GE, Arnold FH (1989) Metal affinity precipitation of proteins. Biotechnology and Applied
Biochemistry. [IF=0.669, Cited=28, 2508699].

Arnold, Frances H

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